RGD Reference Report - De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. - Rat Genome Database

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De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.

Authors: Garrido-Sánchez, Lourdes  Vendrell, Joan  Fernández-García, Diego  Ceperuelo-Mallafré, Victoria  Chacón, Matilde R  Ocaña-Wilhelmi, Luis  Alcaide, Juan  Tinahones, Francisco J  García-Fuentes, Eduardo 
Citation: Garrido-Sánchez L, etal., PLoS One. 2012;7(2):e31280. doi: 10.1371/journal.pone.0031280. Epub 2012 Feb 23.
RGD ID: 13831306
Pubmed: PMID:22384010   (View Abstract at PubMed)
PMCID: PMC3285616   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0031280   (Journal Full-text)


OBJECTIVE: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes.
METHODS: We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT).
RESULTS: When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression >= P50 before bariatric surgery had a lower percentage hip circumference loss (CONCLUSIONS: A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ACSS2Humanmorbid obesity treatmentIEP  RGD 
Acss2Ratmorbid obesity treatmentISOACSS2 (Homo sapiens) RGD 
Acss2Mousemorbid obesity treatmentISOACSS2 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Acss2  (acyl-CoA synthetase short-chain family member 2)

Genes (Mus musculus)
Acss2  (acyl-CoA synthetase short-chain family member 2)

Genes (Homo sapiens)
ACSS2  (acyl-CoA synthetase short chain family member 2)