Ppm1l (protein phosphatase, Mg2+/Mn2+ dependent 1L) - Rat Genome Database

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Gene: Ppm1l (protein phosphatase, Mg2+/Mn2+ dependent 1L) Ictidomys tridecemlineatus
Analyze
Symbol: Ppm1l
Name: protein phosphatase, Mg2+/Mn2+ dependent 1L
RGD ID: 12645462
Description: ENCODES a protein that exhibits cation binding (inferred); metal ion binding (inferred); phosphoprotein phosphatase activity (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH obesity (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560292,688,860 - 92,964,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936708727,610 - 996,607 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936708724,878 - 1,006,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ppm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560292,688,860 - 92,964,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936708727,610 - 996,607 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936708724,878 - 1,006,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,756,231 - 161,078,902 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3160,755,602 - 161,078,902 (+)EnsemblGRCh38hg38GRCh38
GRCh373160,474,019 - 160,796,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,956,690 - 162,271,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 343162,042,702 - 162,271,518NCBI
Celera3158,896,208 - 159,211,045 (+)NCBICelera
Cytogenetic Map3q25.33-q26.1NCBI
HuRef3157,872,656 - 158,187,261 (+)NCBIHuRef
CHM1_13160,436,915 - 160,751,844 (+)NCBICHM1_1
T2T-CHM13v2.03163,530,851 - 163,853,639 (+)NCBIT2T-CHM13v2.0
Ppm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39369,224,251 - 69,468,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl369,224,194 - 69,468,135 (+)EnsemblGRCm39 Ensembl
GRCm38369,316,918 - 69,560,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,316,861 - 69,560,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv37369,120,840 - 69,359,326 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36369,404,847 - 69,643,333 (+)NCBIMGSCv36mm8
Celera369,424,232 - 69,663,151 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map332.21NCBI
Ppm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,876,605 - 156,149,371 (+)NCBIGRCr8
mRatBN7.22153,566,653 - 153,839,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,566,653 - 153,839,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,709,923 - 160,983,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,760,422 - 159,033,713 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,393,224 - 153,666,515 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,932,240 - 166,218,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2166,140,112 - 166,218,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02185,291,754 - 185,575,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42159,385,829 - 159,662,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12159,335,793 - 159,605,142 (+)NCBI
Celera2147,916,729 - 148,187,619 (+)NCBICelera
Cytogenetic Map2q32NCBI
Ppm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544811,266,462 - 11,541,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544811,265,988 - 11,548,258 (+)NCBIChiLan1.0ChiLan1.0
PPM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22158,689,921 - 159,006,047 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13158,694,649 - 159,009,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,775,284 - 158,093,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,823,299 - 166,139,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,823,649 - 166,129,984 (+)Ensemblpanpan1.1panPan2
PPM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,770,442 - 27,060,892 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,770,569 - 27,057,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,813,316 - 31,106,275 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,827,264 - 27,122,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,827,377 - 27,121,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,757,747 - 27,050,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,717,524 - 27,005,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,957,884 - 27,284,254 (+)NCBIUU_Cfam_GSD_1.0
PPM1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,443,011 - 100,756,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113100,442,445 - 100,759,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,997,677 - 109,155,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11529,801,953 - 30,096,073 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1529,802,637 - 29,925,199 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660412,307,814 - 2,608,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473038,610,874 - 38,978,466 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473038,610,107 - 38,985,146 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005338294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000015016   ⟹   ENSSTOP00000013455
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936708727,610 - 996,607 (+)Ensembl
RefSeq Acc Id: XM_005338294   ⟹   XP_005338351
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560292,688,860 - 92,964,078 (+)NCBI
SpeTri2.0NW_004936708724,878 - 1,006,405 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005338351 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000013455.2
GenBank Protein KAG3270935 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005338351   ⟸   XM_005338294
- UniProtKB: I3MP03 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000013455   ⟸   ENSSTOT00000015016
Protein Domains
PPM-type phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000015017 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000015016.3 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
NCBI Gene Ppm1l ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1B UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART PP2C_SIG UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt I3MP03 ENTREZGENE, UniProtKB/TrEMBL