PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L) - Rat Genome Database

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Gene: PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L) Canis lupus familiaris
Analyze
Symbol: PPM1L
Name: protein phosphatase, Mg2+/Mn2+ dependent 1L
RGD ID: 12249784
Description: ENCODES a protein that exhibits cation binding (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell surface receptor protein serine/threonine kinase signaling pathway (ortholog); MAPK cascade (ortholog); ASSOCIATED WITH genetic disease (ortholog); obesity (ortholog); FOUND IN cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein phosphatase 1L
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,770,442 - 27,060,892 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,770,569 - 27,057,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,813,316 - 31,106,275 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,827,264 - 27,122,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,827,377 - 27,121,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,757,747 - 27,050,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,717,524 - 27,005,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,957,884 - 27,284,254 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
genetic disease  (ISO)
obesity  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13426,770,442 - 27,060,892 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3426,770,569 - 27,057,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3430,813,316 - 31,106,275 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03426,827,264 - 27,122,050 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3426,827,377 - 27,121,061 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13426,757,747 - 27,050,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03426,717,524 - 27,005,848 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03426,957,884 - 27,284,254 (+)NCBIUU_Cfam_GSD_1.0
PPM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383160,756,231 - 161,078,902 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3160,755,602 - 161,078,902 (+)EnsemblGRCh38hg38GRCh38
GRCh373160,474,019 - 160,796,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,956,690 - 162,271,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 343162,042,702 - 162,271,518NCBI
Celera3158,896,208 - 159,211,045 (+)NCBICelera
Cytogenetic Map3q25.33-q26.1NCBI
HuRef3157,872,656 - 158,187,261 (+)NCBIHuRef
CHM1_13160,436,915 - 160,751,844 (+)NCBICHM1_1
T2T-CHM13v2.03163,530,851 - 163,853,639 (+)NCBIT2T-CHM13v2.0
Ppm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39369,224,251 - 69,468,131 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl369,224,194 - 69,468,135 (+)EnsemblGRCm39 Ensembl
GRCm38369,316,918 - 69,560,798 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl369,316,861 - 69,560,802 (+)EnsemblGRCm38mm10GRCm38
MGSCv37369,120,840 - 69,359,326 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36369,404,847 - 69,643,333 (+)NCBIMGSCv36mm8
Celera369,424,232 - 69,663,151 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map332.21NCBI
Ppm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82155,876,605 - 156,149,371 (+)NCBIGRCr8
mRatBN7.22153,566,653 - 153,839,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2153,566,653 - 153,839,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2160,709,923 - 160,983,202 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02158,760,422 - 159,033,713 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02153,393,224 - 153,666,515 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02165,932,240 - 166,218,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2166,140,112 - 166,218,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02185,291,754 - 185,575,777 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42159,385,829 - 159,662,846 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12159,335,793 - 159,605,142 (+)NCBI
Celera2147,916,729 - 148,187,619 (+)NCBICelera
Cytogenetic Map2q32NCBI
Ppm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544811,266,462 - 11,541,886 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544811,265,988 - 11,548,258 (+)NCBIChiLan1.0ChiLan1.0
PPM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22158,689,921 - 159,006,047 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13158,694,649 - 159,009,093 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03157,775,284 - 158,093,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13165,823,299 - 166,139,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3165,823,649 - 166,129,984 (+)Ensemblpanpan1.1panPan2
Ppm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560292,688,860 - 92,964,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936708727,610 - 996,607 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936708724,878 - 1,006,405 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13100,443,011 - 100,756,039 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113100,442,445 - 100,759,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213108,997,677 - 109,155,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11529,801,953 - 30,096,073 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1529,802,637 - 29,925,199 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660412,307,814 - 2,608,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473038,610,874 - 38,978,466 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473038,610,107 - 38,985,146 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPM1L
3487 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 4 3 6 5
Low 5 2 18 6 6 6 6 3 6 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000022754   ⟹   ENSCAFP00000021134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3426,770,569 - 27,057,910 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000064892   ⟹   ENSCAFP00000053731
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3426,849,391 - 27,057,910 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075068   ⟹   ENSCAFP00000062494
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3426,948,735 - 27,057,910 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049805   ⟹   ENSCAFP00845039060
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3426,827,377 - 27,121,061 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049826   ⟹   ENSCAFP00845039075
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3426,874,448 - 27,121,061 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845049848   ⟹   ENSCAFP00845039095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3426,907,973 - 27,121,061 (+)Ensembl
RefSeq Acc Id: XM_038445943   ⟹   XP_038301871
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03426,827,264 - 27,122,050 (+)NCBI
RefSeq Acc Id: XM_038520138   ⟹   XP_038376066
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13426,757,747 - 27,050,929 (+)NCBI
RefSeq Acc Id: XM_038583768   ⟹   XP_038439696
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03426,957,884 - 27,284,254 (+)NCBI
RefSeq Acc Id: XM_038648182   ⟹   XP_038504110
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03426,717,524 - 27,005,848 (+)NCBI
RefSeq Acc Id: XM_845816   ⟹   XP_850909
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13426,770,442 - 27,060,892 (+)NCBI
Dog10K_Boxer_Tasha3430,813,316 - 31,106,275 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_850909   ⟸   XM_845816
- UniProtKB: A0A8C0NBX2 (UniProtKB/TrEMBL),   A0A8C0LCS6 (UniProtKB/TrEMBL),   A0A8I3Q4M2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053731   ⟸   ENSCAFT00000064892
RefSeq Acc Id: ENSCAFP00000062494   ⟸   ENSCAFT00000075068
RefSeq Acc Id: ENSCAFP00000021134   ⟸   ENSCAFT00000022754
RefSeq Acc Id: XP_038376066   ⟸   XM_038520138
RefSeq Acc Id: XP_038504110   ⟸   XM_038648182
RefSeq Acc Id: XP_038301871   ⟸   XM_038445943
- UniProtKB: A0A8C0NBX2 (UniProtKB/TrEMBL),   A0A8C0LCS6 (UniProtKB/TrEMBL),   A0A8I3Q4M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038439696   ⟸   XM_038583768
- UniProtKB: A0A8C0LCS6 (UniProtKB/TrEMBL),   A0A8C0NBX2 (UniProtKB/TrEMBL),   A0A8I3Q4M2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845039060   ⟸   ENSCAFT00845049805
RefSeq Acc Id: ENSCAFP00845039075   ⟸   ENSCAFT00845049826
RefSeq Acc Id: ENSCAFP00845039095   ⟸   ENSCAFT00845049848
Protein Domains
PPM-type phosphatase

Promoters
RGD ID:13688930
Promoter ID:EPDNEW_C6997
Type:initiation region
Name:PPM1L_1
Description:protein phosphatase, Mg2+/Mn2+ dependent 1L
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13426,770,493 - 26,770,553EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014325 Ensembl
  ENSCAFG00000054555 UniProtKB/TrEMBL
  ENSCAFG00030014435 UniProtKB/TrEMBL
  ENSCAFG00040022223 UniProtKB/TrEMBL
  ENSCAFG00845028216 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000100308.1 UniProtKB/TrEMBL
  ENSCAFT00000100735.1 UniProtKB/TrEMBL
  ENSCAFT00000105030.1 UniProtKB/TrEMBL
  ENSCAFT00030026767.1 UniProtKB/TrEMBL
  ENSCAFT00030026812.1 UniProtKB/TrEMBL
  ENSCAFT00040041377.1 UniProtKB/TrEMBL
  ENSCAFT00040041390.1 UniProtKB/TrEMBL
  ENSCAFT00845049805 ENTREZGENE
  ENSCAFT00845049805.1 UniProtKB/TrEMBL
  ENSCAFT00845049826.1 UniProtKB/TrEMBL
  ENSCAFT00845049848.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.40.10 UniProtKB/TrEMBL
InterPro PP2C UniProtKB/TrEMBL
  PP2C_BS UniProtKB/TrEMBL
  PPM-type_dom_sf UniProtKB/TrEMBL
  PPM-type_phosphatase_dom UniProtKB/TrEMBL
KEGG Report cfa:608708 UniProtKB/TrEMBL
NCBI Gene PPM1L ENTREZGENE
PANTHER PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1B UniProtKB/TrEMBL
Pfam PP2C UniProtKB/TrEMBL
PROSITE PPM_1 UniProtKB/TrEMBL
  PPM_2 UniProtKB/TrEMBL
SMART PP2C_SIG UniProtKB/TrEMBL
  PP2Cc UniProtKB/TrEMBL
Superfamily-SCOP SSF81606 UniProtKB/TrEMBL
UniProt A0A8C0LCS6 ENTREZGENE
  A0A8C0NBX2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TES2_CANLF UniProtKB/TrEMBL
  A0A8I3Q051_CANLF UniProtKB/TrEMBL
  A0A8I3Q4M2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S6M6_CANLF UniProtKB/TrEMBL
  A0A8P0PND2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44871 ENTREZGENE