RGD Reference Report - The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. - Rat Genome Database

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The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects.

Authors: Dahlman, I  Kaaman, M  Jiao, H  Kere, J  Laakso, M  Arner, P 
Citation: Dahlman I, etal., Diabetes. 2005 Oct;54(10):3032-4.
RGD ID: 1625390
Pubmed: PMID:16186410   (View Abstract at PubMed)

The cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) gene is implicated as an important regulator of body weight in mice and humans and is therefore a candidate gene for human obesity. Here, we characterize common CIDEA gene polymorphisms and investigate them for association with obesity in two independent Swedish samples; the first comprised 981 women and the second 582 men. Both samples display a large variation in BMI. The only detected coding polymorphism encodes an exon 4 V115F amino acid substitution, which is associated with BMI in both sexes (P = 0.021 for women, P = 0.023 for men, and P = 0.0015 for joint analysis). These results support a role for CIDEA alleles in human obesity. CIDEA-deficient mice display higher metabolic rate, and the gene cross-talks with tumor necrosis factor-alpha (TNF-alpha) in fat cells. We hypothesize that CIDEA alleles regulate human obesity through impact on basal metabolic rate and adipocyte TNF-alpha signaling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IAGP 1625390protein:amino acid substitution:V115FRGD 
obesity  ISOCIDEA (Homo sapiens)1625390; 1625390 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cidea  (cell death-inducing DFFA-like effector a)

Genes (Mus musculus)
Cidea  (cell death-inducing DNA fragmentation factor, alpha subunit-like effector A)

Genes (Homo sapiens)
CIDEA  (cell death inducing DFFA like effector a)


Additional Information