Cd40lg (CD40 ligand) - Rat Genome Database

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Gene: Cd40lg (CD40 ligand) Ictidomys tridecemlineatus
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Symbol: Cd40lg
Name: CD40 ligand
RGD ID: 12669933
Description: ENCODES a protein that exhibits CD40 receptor binding (ortholog); integrin binding (ortholog); INVOLVED IN activation of JUN kinase activity (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; obesity pathway; ASSOCIATED WITH acquired immunodeficiency syndrome (ortholog); Acute Coronary Syndrome (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBI
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acquired immunodeficiency syndrome  (ISO)
Acute Coronary Syndrome  (ISO)
acute lymphoblastic leukemia  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
antiphospholipid syndrome  (ISO)
Aortic Valve, Calcification of  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
CD40 ligand deficiency  (ISO)
Cholangiofibrosis  (ISO)
Chromosome Breakage  (ISO)
Chromosome Xq26.3 Duplication Syndrome  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic lymphocytic leukemia  (ISO)
Colonic Neoplasms  (ISO)
combined T cell and B cell immunodeficiency  (ISO)
common variable immunodeficiency  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
crescentic glomerulonephritis  (ISO)
cutaneous lupus erythematosus  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
Discoid Lupus Erythematosus  (ISO)
dysgammaglobulinemia  (ISO)
Ehrlich tumor carcinoma  (ISO)
end stage renal disease  (ISO)
eosinophilic esophagitis  (ISO)
erythema multiforme  (ISO)
essential thrombocythemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
factor VIII deficiency  (ISO)
familial hyperlipidemia  (ISO)
Fibrosis  (ISO)
follicular lymphoma  (ISO)
genetic disease  (ISO)
Graft vs Host Disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
hyper IgM syndrome  (ISO)
Hypercholesterolemia  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
lichen planus  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
malaria  (ISO)
membranous glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
Middle East respiratory syndrome  (ISO)
migraine  (ISO)
multiple myeloma  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
narcolepsy  (ISO)
Necrosis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
ovarian disease  (ISO)
Ovarian Neoplasms  (ISO)
Overactive Urinary Bladder  (ISO)
pemphigus  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontal disease  (ISO)
periodontitis  (ISO)
peritonitis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
Primary Graft Dysfunction  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
Shock  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
Subacute Combined Degeneration  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
tick-borne encephalitis  (ISO)
transient cerebral ischemia  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Vascular Calcification  (ISO)
Viral Myocarditis  (ISO)
visceral leishmaniasis  (ISO)
vitamin B12 deficiency  (ISO)
Wounds, Penetrating  (ISO)
X-linked hyper IgM syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Cd40lg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBI
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD40LG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX136,648,193 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX136,648,158 - 136,660,390 (+)EnsemblGRCh38hg38GRCh38
GRCh38X136,648,158 - 136,660,390 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X135,730,317 - 135,742,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,558,002 - 135,570,215 (+)NCBINCBI36hg18NCBI36
Build 34X135,455,855 - 135,468,068NCBI
CeleraX136,094,012 - 136,106,224 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX125,001,305 - 125,013,640 (+)NCBIHuRef
CHM1_1X135,641,985 - 135,654,211 (+)NCBICHM1_1
Cd40lg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X56,257,503 - 56,269,402 (+)NCBIGRCm39mm39
GRCm39 EnsemblX56,257,503 - 56,269,402 (+)Ensembl
GRCm38X57,212,143 - 57,224,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX57,212,143 - 57,224,042 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X54,465,320 - 54,477,219 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X53,558,927 - 53,570,826 (+)NCBImm8
CeleraX43,689,623 - 43,701,548 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX31.21NCBI
Cd40lg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X135,127,119 - 135,138,302 (+)NCBI
Rnor_6.0 EnsemblX159,703,578 - 159,716,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X159,703,703 - 159,714,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X154,330,893 - 154,341,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X141,925,019 - 141,937,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X141,998,451 - 142,010,616 (+)NCBI
CeleraX143,160,596 - 143,171,765 (+)NCBICelera
Cytogenetic MapXq37NCBI
Cd40lg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554898,465,164 - 8,477,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554898,465,571 - 8,477,714 (-)NCBIChiLan1.0ChiLan1.0
CD40LG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X136,042,849 - 136,055,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX136,042,849 - 136,058,202 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X125,776,138 - 125,788,820 (+)NCBIMhudiblu_PPA_v0panPan3
CD40LG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X107,001,421 - 107,023,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX107,010,890 - 107,023,006 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX92,832,126 - 92,844,241 (+)NCBI
ROS_Cfam_1.0X108,980,873 - 109,002,662 (+)NCBI
UMICH_Zoey_3.1X106,131,221 - 106,143,392 (+)NCBI
UNSW_CanFamBas_1.0X108,322,638 - 108,334,748 (+)NCBI
UU_Cfam_GSD_1.0X107,964,432 - 107,976,548 (+)NCBI
CD40LG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX111,778,493 - 111,789,711 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X111,778,666 - 111,788,901 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X127,636,797 - 127,647,035 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD40LG
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X111,655,301 - 111,667,602 (+)NCBI
ChlSab1.1 EnsemblX111,655,397 - 111,666,639 (+)Ensembl
Cd40lg
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480810,472,028 - 10,484,407 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005325173   ⟹   XP_005325230
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X104,994,220 - 105,007,112 (+)NCBI
SpeTri2.0NW_00493651310,607,617 - 10,620,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005325174   ⟹   XP_005325231
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X104,994,284 - 105,007,112 (+)NCBI
SpeTri2.0NW_00493651310,607,720 - 10,620,339 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005325230 (Get FASTA)   NCBI Sequence Viewer  
  XP_005325231 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005325230   ⟸   XM_005325173
- Peptide Label: isoform X1
- UniProtKB: I3M7D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005325231   ⟸   XM_005325174
- Peptide Label: isoform X2
- Sequence:
Protein Domains
TNF_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006163 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005508 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006157 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro CD40L UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_dom UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene Cd40lg ENTREZGENE
PANTHER PTHR11471:SF5 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PIRSF TNF_5 UniProtKB/TrEMBL
PRINTS CD40LIGAND UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/TrEMBL
UniProt I3M7D0 ENTREZGENE, UniProtKB/TrEMBL