Foxa2 (forkhead box A2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Foxa2 (forkhead box A2) Ictidomys tridecemlineatus
Analyze
Symbol: Foxa2
Name: forkhead box A2
RGD ID: 12706655
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN adult locomotory behavior (ortholog); anatomical structure formation involved in morphogenesis (ortholog); anatomical structure morphogenesis (ortholog); PARTICIPATES IN forkhead class A signaling pathway; Hedgehog signaling pathway; ASSOCIATED WITH Diaphragmatic Hernia (ortholog); Experimental Diabetes Mellitus (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN cell junction (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hepatocyte nuclear factor 3-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,544,748 - 149,549,068 (+)NCBI
SpeTri2.0NW_0049366202,966,341 - 2,969,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
anatomical structure formation involved in morphogenesis  (ISO)
anatomical structure morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
cell development  (ISO)
cell differentiation in hindbrain  (ISO)
cell fate specification  (ISO)
cellular response to cadmium ion  (ISO)
connective tissue development  (ISO)
dopaminergic neuron differentiation  (ISO)
dorsal/ventral neural tube patterning  (ISO)
dorsal/ventral pattern formation  (ISO)
ectoderm formation  (ISO)
endocrine pancreas development  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
in utero embryonic development  (ISO)
lung development  (ISO)
lung epithelial cell differentiation  (ISO)
mesendoderm development  (ISO)
negative regulation of detection of glucose  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial to mesenchymal transition  (ISO)
negative regulation of glucokinase activity  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of transcription from RNA polymerase II promoter by glucose  (ISO)
neuron fate specification  (ISO)
Notch signaling pathway  (ISO)
pattern specification process  (ISO)
positive regulation of embryonic development  (ISO)
positive regulation of gastrulation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of smoothened signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase III  (ISO)
positive regulation of transcription from RNA polymerase II promoter by glucose  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
primitive streak formation  (ISO)
regulation of blood coagulation  (ISO)
regulation of gene expression  (ISO)
regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
regulation of lipid metabolic process  (ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to insulin  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
somite rostral/caudal axis specification  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Foxa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640149,544,748 - 149,549,068 (+)NCBI
SpeTri2.0NW_0049366202,966,341 - 2,969,349 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2022,580,998 - 22,585,455 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2022,581,005 - 22,585,455 (-)EnsemblGRCh38hg38GRCh38
GRCh382022,580,998 - 22,585,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372022,561,636 - 22,566,128 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362022,509,823 - 22,514,102 (-)NCBINCBI36hg18NCBI36
Celera2022,635,086 - 22,639,544 (-)NCBI
Cytogenetic Map20p11.21NCBI
HuRef2022,523,682 - 22,527,950 (-)NCBIHuRef
CHM1_12022,562,253 - 22,566,723 (-)NCBICHM1_1
Foxa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392147,884,797 - 147,888,889 (-)NCBIGRCm39mm39
GRCm39 Ensembl2147,884,797 - 147,888,889 (-)Ensembl
GRCm382148,042,877 - 148,046,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2148,042,877 - 148,046,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv372147,868,614 - 147,872,705 (-)NCBIGRCm37mm9NCBIm37
MGSCv362147,734,364 - 147,738,410 (-)NCBImm8
Celera2149,306,403 - 149,310,523 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map273.38NCBI
Foxa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23135,470,123 - 135,474,326 (-)NCBI
Rnor_6.0 Ensembl3142,383,278 - 142,387,481 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03142,383,084 - 142,387,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03148,793,310 - 148,797,690 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43136,739,009 - 136,743,204 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13136,644,581 - 136,648,777 (-)NCBI
Celera3134,324,023 - 134,328,218 (-)NCBICelera
Cytogenetic Map3q41NCBI
Foxa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541529,982,940 - 29,986,255 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541529,982,940 - 29,987,093 (-)NCBIChiLan1.0ChiLan1.0
FOXA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12022,872,251 - 22,874,997 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02022,519,942 - 22,524,262 (-)NCBIMhudiblu_PPA_v0panPan3
FOXA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1241,010,370 - 1,013,791 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl241,010,651 - 1,013,072 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha241,034,459 - 1,038,788 (+)NCBI
ROS_Cfam_1.0241,413,104 - 1,417,432 (+)NCBI
UMICH_Zoey_3.1241,010,961 - 1,015,301 (+)NCBI
UNSW_CanFamBas_1.0241,114,770 - 1,118,263 (+)NCBI
UU_Cfam_GSD_1.0241,388,439 - 1,392,767 (+)NCBI
FOXA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1729,997,400 - 30,001,707 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11729,997,397 - 30,001,704 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,053,453 - 34,057,746 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1251,577,127 - 51,585,168 (-)NCBI
ChlSab1.1 Ensembl251,577,833 - 51,580,297 (-)Ensembl
Foxa2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474122,645,580 - 22,649,722 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005334607   ⟹   XP_005334664
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640149,545,883 - 149,549,068 (+)NCBI
SpeTri2.0NW_0049366202,966,341 - 2,969,349 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040276062   ⟹   XP_040131996
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640149,544,748 - 149,549,068 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005334664 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131996 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005334664   ⟸   XM_005334607
- Peptide Label: isoform X1
- UniProtKB: I3N796 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131996   ⟸   XM_040276062
- Peptide Label: isoform X2
Protein Domains
Fork-head


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020150 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000020242 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000023862 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Fork-head_N UniProtKB/TrEMBL
  Fork_head_dom UniProtKB/TrEMBL
  Forkhead_box_C UniProtKB/TrEMBL
  TF_fork_head_CS_1 UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene Foxa2 ENTREZGENE
Pfam Forkhead UniProtKB/TrEMBL
  Forkhead_N UniProtKB/TrEMBL
  HNF_C UniProtKB/TrEMBL
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_1 UniProtKB/TrEMBL
  FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt I3N796 ENTREZGENE, UniProtKB/TrEMBL