Stat4 (signal transducer and activator of transcription 4) - Rat Genome Database

Send us a Message



Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Stat4 (signal transducer and activator of transcription 4) Ictidomys tridecemlineatus
Analyze
Symbol: Stat4
Name: signal transducer and activator of transcription 4
RGD ID: 12655590
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to cytokine stimulus (ortholog); cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-23 signaling pathway; interleukin-27 signaling pathway; ASSOCIATED WITH anxiety disorder (ortholog); asthma (ortholog); autoimmune hepatitis (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: signal transducer and activator of transcription 4, transcript variant X1; signal transducer and activator of transcription 4, transcript variant X2; signal transducer and activator of transcription 4, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mIctTri1.hap1 - mIctTri1.hap1 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap17156,651,620 - 156,745,658 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024405303149,652,139 - 149,767,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,095,009 - 7,184,689 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,091,982 - 7,185,938 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0



Disease Annotations     Click to see Annotation Detail View
anxiety disorder  (ISO)
asthma  (ISO)
autoimmune hepatitis  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Breast Cancer, Familial  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholesteatoma  (ISO)
Chronic Hepatitis B  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
cutaneous leishmaniasis  (ISO)
Dermal Fibrosis  (ISO)
dermatomyositis  (ISO)
diffuse scleroderma  (ISO)
disabling pansclerotic morphea  (ISO)
disease by infectious agent  (ISO)
Disease Susceptibility  (ISO)
Eczema  (ISO)
esophageal cancer  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
gastric adenocarcinoma  (ISO)
genital herpes  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatitis B  (ISO)
hepatocellular carcinoma  (ISO)
Herpes Simplex Encephalitis  (ISO)
herpes simplex virus keratitis  (ISO)
IgA glomerulonephritis  (ISO)
limited scleroderma  (ISO)
lung squamous cell carcinoma  (ISO)
lupus nephritis  (ISO)
melanoma  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
multiple sclerosis  (ISO)
Neointima  (ISO)
Nervous System Malformations  (ISO)
nonpapillary renal cell carcinoma  (ISO)
obesity  (ISO)
Oral Ulcer  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
polymyositis  (ISO)
primary biliary cholangitis  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
rectum adenocarcinoma  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (ISO)
Sepsis  (ISO)
Sezary's disease  (ISO)
Sjogren's syndrome  (ISO)
steatotic liver disease  (ISO)
stomach cancer  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
uterine corpus endometrial carcinoma  (ISO)
viral hepatitis  (ISO)
visceral leishmaniasis  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Stat4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap17156,651,620 - 156,745,658 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024405303149,652,139 - 149,767,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,095,009 - 7,184,689 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,091,982 - 7,185,938 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382191,029,576 - 191,151,596 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2191,029,570 - 191,178,435 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh372191,894,302 - 192,016,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,602,551 - 191,724,170 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342191,719,811 - 191,841,431NCBI
Celera2185,488,908 - 185,610,548 (-)NCBICelera
Cytogenetic Map2q32.2-q32.3NCBI
HuRef2183,753,956 - 183,875,743 (-)NCBIHuRef
CHM1_12191,900,128 - 192,022,113 (-)NCBICHM1_1
T2T-CHM13v2.02191,518,699 - 191,663,236 (-)NCBIT2T-CHM13v2.0
Stat4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,026,265 - 52,146,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,026,307 - 52,151,423 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38151,987,106 - 52,107,189 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl151,987,148 - 52,107,189 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37152,065,088 - 52,164,028 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36151,952,789 - 52,051,729 (+)NCBIMGSCv36mm8
Celera152,546,764 - 52,645,629 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.67NCBI
Stat4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,964,617 - 57,080,523 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,911,523 - 57,077,346 (-)EnsemblGRCr8
mRatBN7.2949,472,660 - 49,588,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx958,021,896 - 58,130,745 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,144,732 - 63,253,572 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,440,716 - 61,549,562 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd960,766,106 - 60,874,952 (-)NCBI
Lyon_Normotensive956,541,537 - 56,650,381 (-)NCBI
Lyon_Hypertensive956,677,390 - 56,786,235 (-)NCBI
F344_StmMcwi958,592,966 - 58,701,817 (-)NCBI
Rnor_6.0954,340,649 - 54,457,753 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0954,051,154 - 54,167,491 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4946,510,251 - 46,650,076 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera947,135,713 - 47,243,684 (-)NCBICelera
RGSC_v3.1946,511,665 - 46,651,490 (-)NCBI
Cytogenetic Map9q22NCBI
Stat4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,061,471 - 8,144,276 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554038,061,471 - 8,144,252 (+)NCBIChiLan1.0ChiLan1.0
STAT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,711,969 - 93,930,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,727,052 - 93,945,611 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,331,402 - 78,549,231 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,247,617 - 196,394,154 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,247,881 - 196,366,011 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
STAT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,566,563 - 1,685,378 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,566,585 - 1,829,894 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha372,514,598 - 2,633,404 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0371,453,968 - 1,572,676 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,453,990 - 1,550,821 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,463,313 - 1,581,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,431,241 - 1,549,848 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,459,885 - 1,578,875 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
STAT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,656,077 - 95,763,472 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11595,656,206 - 95,764,099 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,914,582 - 106,960,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.215107,069,138 - 107,073,997 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11078,348,460 - 78,472,626 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040122,773,405 - 122,923,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11076,553,626 - 76,708,540 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,553,606 - 76,674,928 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Stat4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248544,975,724 - 5,056,940 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248544,976,507 - 5,057,391 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl356,405,327 - 56,490,541 (+)Ensembl
Stat4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14123,316,367 - 123,426,390 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000019733   ⟹   ENSSTOP00000016264
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365067,095,009 - 7,184,689 (+)Ensembl
RefSeq Acc Id: XM_005324364   ⟹   XP_005324421
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap17156,651,620 - 156,745,658 (-)NCBI
HiC_Itri_2NW_024405303149,652,139 - 149,746,114 (-)NCBI
SpeTri2.0NW_0049365067,091,982 - 7,185,938 (+)NCBI
Sequence:
RefSeq Acc Id: XM_078017759   ⟹   XP_077873885
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
mIctTri1.hap17156,651,620 - 156,745,414 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005324421 (Get FASTA)   NCBI Sequence Viewer  
  XP_077873885 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000016264.2
GenBank Protein KAG3274894 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274895 (Get FASTA)   NCBI Sequence Viewer  
  KAG3274896 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005324421   ⟸   XM_005324364
- UniProtKB: I3MVW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000016264   ⟸   ENSSTOT00000019733
RefSeq Acc Id: XP_077873885   ⟸   XM_078017759
- UniProtKB: I3MVW9 (UniProtKB/TrEMBL)
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027217 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00015009064 ENTREZGENE
Ensembl Transcript ENSSTOT00000019733.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT4 UniProtKB/TrEMBL
  STAT4_CCD UniProtKB/TrEMBL
  STAT4_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
NCBI Gene Stat4 ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt I3MVW9 ENTREZGENE, UniProtKB/TrEMBL