RGD Reference Report - Influence of STAT4 polymorphism in primary Sjogren's syndrome. - Rat Genome Database

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Influence of STAT4 polymorphism in primary Sjogren's syndrome.

Authors: Palomino-Morales, RJ  Diaz-Gallo, LM  Witte, T  Anaya, JM  Martin, J 
Citation: Palomino-Morales RJ, etal., J Rheumatol. 2010 May;37(5):1016-9. doi: 10.3899/jrheum.091007. Epub 2010 Apr 1.
RGD ID: 8661709
Pubmed: PMID:20360187   (View Abstract at PubMed)
DOI: DOI:10.3899/jrheum.091007   (Journal Full-text)

OBJECTIVE: To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjogren's syndrome (SS). METHODS: Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. RESULTS: Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 x 10(-6), OR 1.40, 95% CI 1.21-1.62). CONCLUSION: These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
STAT4HumanSjogren's syndrome no_associationIAGP DNA:SNP:intron: (rs7574865) (human)RGD 
Stat4RatSjogren's syndrome no_associationISOSTAT4 (Homo sapiens)DNA:SNP:intron: (rs7574865) (human)RGD 
Stat4MouseSjogren's syndrome no_associationISOSTAT4 (Homo sapiens)DNA:SNP:intron: (rs7574865) (human)RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
STAT4HumanAnti-La/SS-B antibody positivity no_associationIAGP DNA:SNP:intron: (rs7574865)RGD 

Genes (Rattus norvegicus)
Stat4  (signal transducer and activator of transcription 4)

Genes (Mus musculus)
Stat4  (signal transducer and activator of transcription 4)

Genes (Homo sapiens)
STAT4  (signal transducer and activator of transcription 4)