RGD Reference Report - Remodeling of the residual gastric mucosa after roux-en-y gastric bypass or vertical sleeve gastrectomy in diet-induced obese rats. - Rat Genome Database

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Remodeling of the residual gastric mucosa after roux-en-y gastric bypass or vertical sleeve gastrectomy in diet-induced obese rats.

Authors: Arapis, Konstantinos  Cavin, Jean Baptiste  Gillard, Laura  Cluzeaud, Françoise  Lettéron, Philippe  Ducroc, Robert  Le Beyec, Johanne  Hourseau, Muriel  Couvelard, Anne  Marmuse, Jean-Pierre  Le Gall, Maude  Bado, André 
Citation: Arapis K, etal., PLoS One. 2015 Mar 30;10(3):e0121414. doi: 10.1371/journal.pone.0121414. eCollection 2015.
RGD ID: 14696745
Pubmed: PMID:25822172   (View Abstract at PubMed)
PMCID: PMC4379088   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0121414   (Journal Full-text)

Whereas the remodeling of intestinal mucosa after bariatric surgeries has been the matter of numerous studies to our knowledge, very few reported on the remodeling of the residual gastric mucosa. In this study, we analyzed remodeling of gastric mucosa after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) in rats. Diet-induced obese rats were subjected to RYGB, VSG or sham surgical procedures. All animals were assessed for food intake, body-weight, fasting blood, metabolites and hormones profiling, as well as insulin and glucose tolerance tests before and up to 5 weeks post-surgery. Remodeling of gastric tissues was analyzed by routine histology and immunohistochemistry studies, and qRT-PCR analyses of ghrelin and gastrin mRNA levels. In obese rats with impaired glucose tolerance, VSG and RYGB caused substantial weight loss and rats greatly improved their oral glucose tolerance. The remaining gastric mucosa after VSG and gastric pouch (GP) after RYGB revealed a hyperplasia of the mucous neck cells that displayed a strong immunoreactivity for parietal cell H+/K+-ATPase. Ghrelin mRNA levels were reduced by 2-fold in remaining fundic mucosa after VSG and 10-fold in GP after RYGB. In the antrum, gastrin mRNA levels were reduced after VSG in line with the reduced number of gastrin positive cells. This study reports novel and important observations dealing with the remaining gastric mucosa after RYGB and VSG. The data demonstrate, for the first time, a hyperplasia of the mucous neck cells, a transit cell population of the stomach bearing differentiating capacities into zymogenic and peptic cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ATP4BHumanobesity treatmentISOAtp4b (Rattus norvegicus) RGD 
Atp4bRatobesity treatmentIDA  RGD 
Atp4bMouseobesity treatmentISOAtp4b (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Atp4b  (ATPase H+/K+ transporting subunit beta)

Genes (Mus musculus)
Atp4b  (ATPase, H+/K+ exchanging, beta polypeptide)

Genes (Homo sapiens)
ATP4B  (ATPase H+/K+ transporting subunit beta)


Additional Information