Nqo1 (NAD(P)H quinone dehydrogenase 1) - Rat Genome Database

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Gene: Nqo1 (NAD(P)H quinone dehydrogenase 1) Ictidomys tridecemlineatus
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Symbol: Nqo1
Name: NAD(P)H quinone dehydrogenase 1
RGD ID: 12455797
Description: ENCODES a protein that exhibits NAD(P)H dehydrogenase (quinone) activity (ortholog); superoxide dismutase activity (ortholog); INVOLVED IN aging (ortholog); cellular response to hydrogen peroxide (ortholog); cellular response to metal ion (ortholog); PARTICIPATES IN doxorubicin pharmacokinetics pathway; nuclear factor, erythroid 2 like 2 signaling pathway; oxidative stress response pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD(P)H dehydrogenase [quinone] 1; NAD(P)H quinone dehydrogenase 1, transcript variant X1; NAD(P)H quinone dehydrogenase 1, transcript variant X2; NAD(P)H quinone dehydrogenase 1, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,384 - 19,785,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
asthma  (ISO)
autosomal dominant dyskeratosis congenita 6  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chromosome 8, Trisomy  (ISO)
Chronic Experimental Pancreatitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
disease of cellular proliferation  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
fatty liver disease  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (ISO)
hyperglycemia  (ISO)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Lead Poisoning  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
liver benign neoplasm  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
macular degeneration  (ISO)
membranous glomerulonephritis  (ISO)
mental depression  (ISO)
Mercury Poisoning  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
neurodegenerative disease  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
Occupational Diseases  (ISO)
Overactive Urinary Bladder  (ISO)
papilloma  (ISO)
Parkinson's disease  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
pulmonary emphysema  (ISO)
renal fibrosis  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
toxic encephalopathy  (ISO)
transient cerebral ischemia  (ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
urinary system cancer  (ISO)
visual epilepsy  (ISO)
warfarin sensitivity  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
dendrite  (ISO)
neuronal cell body  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
Nqo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,384 - 19,785,034 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NQO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,709,401 - 69,726,560 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1669,706,996 - 69,726,668 (-)EnsemblGRCh38hg38GRCh38
GRCh371669,743,304 - 69,760,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,300,805 - 68,318,034 (-)NCBINCBI36hg18NCBI36
Build 341668,300,809 - 68,317,893NCBI
Celera1654,257,766 - 54,274,991 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,621,397 - 55,638,606 (-)NCBIHuRef
CHM1_11671,151,192 - 71,168,417 (-)NCBICHM1_1
T2T-CHM13v2.01675,511,583 - 75,528,719 (-)NCBI
Nqo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,114,856 - 108,139,012 (-)NCBIGRCm39mm39
GRCm39 Ensembl8108,114,857 - 108,129,838 (-)Ensembl
GRCm388107,388,225 - 107,403,205 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,388,225 - 107,403,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,912,125 - 109,927,105 (-)NCBIGRCm37mm9NCBIm37
MGSCv368110,277,349 - 110,292,395 (-)NCBImm8
Celera8111,617,929 - 111,633,856 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.08NCBI
Nqo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21935,295,633 - 35,310,528 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1935,295,573 - 35,310,557 (-)Ensembl
Rnor_6.01938,422,210 - 38,437,103 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,422,164 - 38,437,180 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01949,291,903 - 49,306,856 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41937,251,147 - 37,266,040 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11937,255,967 - 37,270,906 (-)NCBI
Celera1934,717,059 - 34,731,947 (-)NCBICelera
Cytogenetic Map19q12NCBI
Nqo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,012,506 - 7,027,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,012,373 - 7,028,182 (+)NCBIChiLan1.0ChiLan1.0
NQO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11669,472,529 - 69,489,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,470,288 - 69,489,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01650,090,696 - 50,106,495 (-)NCBIMhudiblu_PPA_v0panPan3
NQO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,979,593 - 79,990,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,978,865 - 79,989,860 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,968,342 - 79,979,690 (+)NCBI
ROS_Cfam_1.0580,409,927 - 80,421,414 (+)NCBI
ROS_Cfam_1.0 Ensembl580,409,969 - 80,420,809 (+)Ensembl
UMICH_Zoey_3.1580,237,718 - 80,249,198 (+)NCBI
UNSW_CanFamBas_1.0579,927,217 - 79,938,546 (+)NCBI
UU_Cfam_GSD_1.0580,560,166 - 80,571,660 (+)NCBI
NQO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,292,770 - 17,302,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,292,962 - 17,302,593 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,238,853 - 16,248,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NQO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1557,676,547 - 57,695,434 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl557,675,981 - 57,716,599 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604720,406,748 - 20,425,872 (+)NCBIVero_WHO_p1.0
Nqo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,684,407 - 16,697,479 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474616,684,620 - 16,698,194 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005318377   ⟹   XP_005318434
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934939,803,799 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,384 - 19,785,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013365714   ⟹   XP_013221168
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934939,803,804 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,384 - 19,785,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021720862   ⟹   XP_021576537
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934939,803,797 - 39,817,919 (+)NCBI
SpeTri2.0NW_00493647519,771,456 - 19,785,034 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005318434   ⟸   XM_005318377
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013221168   ⟸   XM_013365714
- Peptide Label: isoform X1
- UniProtKB: I3MQU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021576537   ⟸   XM_021720862
- Peptide Label: isoform X3
- Sequence:
Protein Domains
Flavodoxin_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000016054 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000014369 ENTREZGENE
  ENSSTOP00000014369.2 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000016056.3 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.360 UniProtKB/TrEMBL
InterPro Flavodoxin_fold UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/TrEMBL
NCBI Gene Nqo1 ENTREZGENE
Pfam Flavodoxin_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF52218 UniProtKB/TrEMBL
UniProt I3MQU6 ENTREZGENE, UniProtKB/TrEMBL