Rspo1 (R-spondin 1) - Rat Genome Database

Name: Rspo1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rspo1 (R-spondin 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Rspo1

Name:

R-spondin 1

RGD ID:

12570152

Description:

ENCODES a protein that exhibits G protein-coupled receptor binding (inferred); heparin binding (inferred); signaling receptor binding (inferred); INVOLVED IN male meiotic nuclear division (ortholog); positive regulation of non-canonical Wnt signaling pathway (ortholog); regulation of gene expression (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); ovarian carcinoma (ortholog); FOUND IN extracellular space (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

R-spondin-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RSPO1 (R-spondin 1)	NCBI	Ortholog
Mus musculus (house mouse):	Rspo1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rspo1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rspo1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RSPO1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RSPO1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RSPO1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RSPO1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rspo1 (R-spondin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	54,002,026 - 54,021,671 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	19,827,669 - 19,842,726 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	19,826,808 - 19,846,453 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease dominant intermediate C (ISO)

genetic disease (ISO)

ovarian carcinoma (ISO)

Palmoplantar Hyperkeratosis and True Hermaphroditism (ISO)

Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and Sex Reversal (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

male meiotic nuclear division (ISO)

positive regulation of canonical Wnt signaling pathway (IEA)

positive regulation of non-canonical Wnt signaling pathway (ISO)

positive regulation of protein phosphorylation (IEA)

positive regulation of Wnt signaling pathway (IEA)

regulation of gene expression (ISO)

regulation of male germ cell proliferation (ISO)

regulation of receptor internalization (IEA)

Wnt signaling pathway (IEA)

Cellular Component

extracellular space (ISO)

nucleus (ISO)

Molecular Function

G protein-coupled receptor binding (IEA)

heparin binding (IEA)

protein binding (ISO)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, canonical pathway (ISO)

References

Genomics

Comparative Map Data

Rspo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	54,002,026 - 54,021,671 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	19,827,669 - 19,842,726 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	19,826,808 - 19,846,453 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RSPO1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	37,611,350 - 37,634,892 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	37,611,350 - 37,634,892 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	38,076,951 - 38,100,564 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	37,849,538 - 37,873,078 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	36,354,952 - 36,378,499 (-)	NCBI		Celera
Cytogenetic Map	1	p34.3	NCBI
HuRef	1	36,194,247 - 36,217,890 (-)	NCBI		HuRef
CHM1_1	1	38,193,128 - 38,216,770 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	37,476,097 - 37,499,638 (-)	NCBI		T2T-CHM13v2.0

Rspo1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	124,880,197 - 124,902,895 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	124,880,223 - 124,902,892 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	124,986,401 - 125,009,102 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	124,986,430 - 125,009,099 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	124,663,674 - 124,686,343 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	124,488,734 - 124,511,403 (+)	NCBI		MGSCv36	mm8
Celera	4	123,309,280 - 123,331,929 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	57.96	NCBI

Rspo1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	142,536,162 - 142,557,611 (+)	NCBI		GRCr8
mRatBN7.2	5	137,251,629 - 137,273,273 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	137,251,659 - 137,272,933 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	139,955,621 - 139,976,971 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	141,725,633 - 141,746,983 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	141,732,808 - 141,754,160 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	142,986,526 - 143,007,847 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	142,986,526 - 143,007,831 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	146,755,088 - 146,776,423 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	144,332,302 - 144,353,646 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	135,769,647 - 135,791,192 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Rspo1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	15,415,932 - 15,435,656 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	15,415,417 - 15,435,616 (-)	NCBI	ChiLan1.0	ChiLan1.0

RSPO1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	189,204,370 - 189,227,895 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	188,333,438 - 188,356,126 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	36,885,176 - 36,907,821 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	38,233,693 - 38,256,903 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	38,231,764 - 38,256,903 (-)	Ensembl	panpan1.1		panPan2

RSPO1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	4,857,887 - 4,876,077 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	4,856,853 - 4,876,800 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	5,109,926 - 5,122,478 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	4,992,103 - 5,010,264 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	4,992,117 - 5,010,264 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	4,856,312 - 4,868,879 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	4,922,700 - 4,935,264 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	4,939,342 - 4,951,919 (+)	NCBI		UU_Cfam_GSD_1.0

RSPO1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	93,665,121 - 93,685,197 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	93,664,839 - 93,690,328 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RSPO1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	95,232,114 - 95,255,160 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	95,237,071 - 95,255,932 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	21,556,202 - 21,575,925 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rspo1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	20,341,756 - 20,359,279 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	20,342,629 - 20,363,498 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000005250 ⟹ ENSSTOP00000004710

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936474	19,827,669 - 19,842,726 (-)	Ensembl

RefSeq Acc Id:

XM_005318101 ⟹ XP_005318158

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405058	54,002,026 - 54,021,671 (-)	NCBI
SpeTri2.0	NW_004936474	19,826,808 - 19,846,453 (-)	NCBI

Sequence:

show sequence

CCCGGGCCTGCCCCCGCCGCGGCTGGCAGCGCCGAGGGCTTGGAACGCTTCTGATCCCAGAGGT
GAGGGAAGCCAGTGCCTCTTGCTCGGATGGAATTTGCATCTGGATCCCCCTCTTCATCTCCCAG
CTGAGACGGTGGTCCCTGGTGATTCCCGTGGGAGTGGGCCAGAAGCTCACTGCAGGCAGAGGCT
AGGTGGTTTTTGGGGGTAACTCCTGCTGAAGTGATGTGGAGGACTCCCATGTGACACTCTGAGG
TGGCTTTGAGGACCTCCATTTGGGCTGATGGAGGCTTCCCACGCCCTCTCTGTCCCCCGCTGAG
ATTATGGTGGATTTGGGTTCTGGCCCGGACCTGGGCCTCCTGCTGCTGACCCAGCCCCGGAGGC
GTTAGCAAGAGCCCTGCGCTGTGCACCCCCCAGCGACCACCCCTCCTGCGGGGGCCTGGAGCCG
GCCAGTGAGCATGCGGCTTGGGCTGTGTGTGGTGGCCCTGGTTCTGAGCTGGCTGCACCTGGCC
GTCGGCAGCCGGGGGATCAAGGGCAAGAGGCAGAGGCGGATCAGCGCCGAGGGGAGTCAGGCCT
GTGCCAAAGGCTGTGAGCTCTGCTCCGAGGTCAACGGCTGCCTCAAGTGCTCGCCCAAGCTCTT
CATCCTGCTGGAGAGGAACGACATCCGCCAGGTGGGCGTCTGCTTGCCGTCCTGCCCGCCCGGA
TACTTTGACGCCCGCAACCCTGAGATGAACAAGTGCATCAAATGCAAGATCGAGCACTGCGAGG
CCTGCTTCAGCCACAACTTCTGCACCAGGTGTCAGGAGGGCTTGTACTTGCACAAGGGCCGCTG
CTATCCGGCCTGTCCAGAGGGCTCCATCGCTGTCAACGGCACTACGGAGTGCAGCAGTCCTGCA
CCATGTGAAATGAGCGAGTGGTCCCCTTGGGGGCCCTGCTCCAAAAAGAAGAAGCTCTGTGGTT
TCCGGAAGGGCTCTGAGGAGCGGACGCGCAGGGTGCTTCATGCCCCTGGGGGGGACCACGCCGC
CTGCGCTGACACCAAGGAGACCCGGAGGTGCACAGTGCGGAGGACGCCGTGTCCTGAGGGGCAG
AAGAGGAGGAAGCAGGGCCAAGGCCGTCGAGAGAATACCAACAGGAACCCGGCCAGGAAGGAGG
GCAAGGAGACGGAATGCGGGCGGGCCGTGGACCGGCAGTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005318158	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004710.2
GenBank Protein	KAG3282774	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005318158 ⟸ XM_005318101

- UniProtKB:

I3M5R6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLGLCVVALVLSWLHLAVGSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILL
ERNDIRQVGVCLPSCPPGYFDARNPEMNKCIKCKIEHCEACFSHNFCTRCQEGLYLHKGRCYPA
CPEGSIAVNGTTECSSPAPCEMSEWSPWGPCSKKKKLCGFRKGSEERTRRVLHAPGGDHAACAD
TKETRRCTVRRTPCPEGQKRRKQGQGRRENTNRNPARKEGKETECGRAVDRQ

hide sequence

RefSeq Acc Id:

ENSSTOP00000004710 ⟸ ENSSTOT00000005250

Protein Domains

R-spondin Fu-CRD

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005254	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005250.3	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/TrEMBL
InterPro	Furin_repeat	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Rspo_Fu-CRD_dom	UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/TrEMBL
NCBI Gene	Rspo1	ENTREZGENE
PANTHER	NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN	UniProtKB/TrEMBL
	PTHR46987:SF5	UniProtKB/TrEMBL
Pfam	Furin-like_2	UniProtKB/TrEMBL
	TSP_1	UniProtKB/TrEMBL
PROSITE	TSP1	UniProtKB/TrEMBL
SMART	SM00261	UniProtKB/TrEMBL
	TSP1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/TrEMBL
	SSF82895	UniProtKB/TrEMBL
UniProt	I3M5R6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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RGD Manual Annotations