Apoa1 (apolipoprotein A1) - Rat Genome Database
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Gene: Apoa1 (apolipoprotein A1) Ictidomys tridecemlineatus
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Symbol: Apoa1
Name: apolipoprotein A1
RGD ID: 12568711
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); apolipoprotein A-I receptor binding (ortholog); apolipoprotein receptor binding (ortholog); INVOLVED IN adrenal gland development (ortholog); animal organ regeneration (ortholog); blood vessel endothelial cell migration (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Acute Tubulointerstitial Nephritis (ortholog); adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); discoidal high-density lipoprotein particle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: apolipoprotein A-I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
Apolipoprotein A-I, Deficiency of  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
Behcet's disease  (ISO)
Budd-Chiari syndrome  (ISO)
cardiomyopathy  (ISO)
cerebral amyloid angiopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
Chronic Hepatitis B  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Death  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Drug Eruptions  (ISO)
Dwarfism  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
Familial Amyloidosis  (ISO)
Familial HDL Deficiency  (ISO)
familial isolated deficiency of vitamin E  (ISO)
familial visceral amyloidosis  (ISO)
fatty liver disease  (ISO)
hepatitis C  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoalphalipoproteinemias  (ISO)
hypolipoproteinemia  (ISO)
Hypoproteinemia  (ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
lipid metabolism disorder  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
major depressive disorder  (ISO)
membranous glomerulonephritis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-alcoholic steatohepatitis  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Pediatric Obesity  (ISO)
polycystic kidney disease  (ISO)
pulmonary fibrosis  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
Tangier disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
animal organ regeneration  (ISO)
axon regeneration  (ISO)
blood vessel endothelial cell migration  (ISO)
cholesterol biosynthetic process  (ISO)
cholesterol efflux  (ISO)
cholesterol homeostasis  (ISO)
cholesterol import  (ISO)
cholesterol metabolic process  (ISO)
cholesterol transport  (ISO)
endothelial cell proliferation  (ISO)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
glucocorticoid metabolic process  (ISO)
high-density lipoprotein particle assembly  (ISO)
high-density lipoprotein particle remodeling  (ISO)
integrin-mediated signaling pathway  (ISO)
lipid storage  (ISO)
lipoprotein biosynthetic process  (ISO)
negative chemotaxis  (ISO)
negative regulation of cell adhesion molecule production  (ISO)
negative regulation of cytokine production involved in immune response  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of hydrolase activity  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of lipase activity  (ISO)
negative regulation of response to cytokine stimulus  (ISO)
negative regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
negative regulation of very-low-density lipoprotein particle remodeling  (ISO)
peptidyl-methionine modification  (ISO)
peripheral nervous system axon regeneration  (ISO)
phosphatidylcholine biosynthetic process  (ISO)
phospholipid efflux  (ISO)
phospholipid homeostasis  (ISO)
phospholipid metabolic process  (ISO)
phospholipid transport  (ISO)
positive regulation of cholesterol efflux  (ISO)
positive regulation of cholesterol esterification  (ISO)
positive regulation of hydrolase activity  (ISO)
positive regulation of phagocytosis  (ISO)
positive regulation of phospholipid efflux  (ISO)
positive regulation of Rho protein signal transduction  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
protein localization  (ISO)
protein oxidation  (ISO)
protein stabilization  (ISO)
regulation of Cdc42 protein signal transduction  (ISO)
regulation of intestinal cholesterol absorption  (ISO)
regulation of protein phosphorylation  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to nutrient  (ISO)
reverse cholesterol transport  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride homeostasis  (ISO)
vitamin transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Apoa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11116,835,751 - 116,837,950 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,835,751 - 116,837,622 (-)EnsemblGRCh38hg38GRCh38
GRCh3811116,835,751 - 116,837,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711116,706,467 - 116,708,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,211,679 - 116,213,548 (-)NCBINCBI36hg18NCBI36
Celera11113,864,272 - 113,866,141 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11112,638,728 - 112,640,597 (-)NCBIHuRef
CHM1_111116,591,219 - 116,593,418 (-)NCBICHM1_1
Apoa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,139,928 - 46,141,767 (+)NCBIGRCm39mm39
GRCm39 Ensembl946,139,878 - 46,141,764 (+)Ensembl
GRCm38946,228,630 - 46,230,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,228,580 - 46,230,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,036,713 - 46,038,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,979,705 - 45,981,461 (+)NCBImm8
Celera943,517,584 - 43,519,420 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,527,251 - 46,529,035 (+)NCBI
Rnor_6.0 Ensembl850,525,091 - 50,526,875 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0850,525,091 - 50,526,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0849,151,163 - 49,152,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera846,109,311 - 46,111,065 (+)NCBICelera
RH 3.4 Map8472.0RGD
Cytogenetic Map8q22NCBI
Apoa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,170,331 - 18,172,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,170,331 - 18,172,298 (-)NCBIChiLan1.0ChiLan1.0
APOA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,606,136 - 115,608,335 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,606,136 - 115,608,122 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,673,539 - 111,675,428 (-)NCBIMhudiblu_PPA_v0panPan3
APOA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl516,740,130 - 16,741,943 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1516,740,071 - 16,742,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
APOA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,216,393 - 44,218,978 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,216,481 - 44,218,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,288,730 - 49,290,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p12-p11NCBI
APOA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,201,967 - 108,203,902 (-)NCBI
ChlSab1.1 Ensembl1108,201,439 - 108,203,609 (-)Ensembl
Apoa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478412,249,283 - 12,251,215 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021728531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGTP01052890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_021728531   ⟹   XP_021584206
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021584206 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein I3M072 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021584206   ⟸   XM_021728531
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002328 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSSTOP00000002077 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSSTOT00000002322 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot
NCBI Gene Apoa1 ENTREZGENE
Pfam Apolipoprotein UniProtKB/Swiss-Prot
UniProt APOA1_ICTTR UniProtKB/Swiss-Prot, ENTREZGENE