Apoa1 (apolipoprotein A1) - Rat Genome Database

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Gene: Apoa1 (apolipoprotein A1) Ictidomys tridecemlineatus
Analyze
Symbol: Apoa1
Name: apolipoprotein A1
RGD ID: 12568711
Description: ENCODES a protein that exhibits cholesterol transfer activity (ortholog); lipase inhibitor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN adrenal gland development (ortholog); animal organ regeneration (ortholog); axon regeneration (ortholog); PARTICIPATES IN altered lipoprotein metabolic pathway; forkhead class A signaling pathway; lipoprotein metabolic pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); Acute Tubulointerstitial Nephritis (ortholog); adenocarcinoma (ortholog); FOUND IN cell surface (ortholog); discoidal high-density lipoprotein particle (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: apolipoprotein A-I
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,189,637 - 99,191,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,111,052 - 2,112,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Acute Tubulointerstitial Nephritis  (ISO)
adenocarcinoma  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
atherosclerosis  (ISO)
Behcet's disease  (ISO)
Budd-Chiari syndrome  (ISO)
cardiomyopathy  (ISO)
CD3epsilon deficiency  (ISO)
cerebral amyloid angiopathy  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
Chronic Hepatitis B  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Death  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Drug Eruptions  (ISO)
Dwarfism  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
Familial Amyloidosis  (ISO)
familial isolated deficiency of vitamin E  (ISO)
familial visceral amyloidosis  (ISO)
genetic disease  (ISO)
hepatitis C  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary spastic paraplegia 50  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
Hyperlipoproteinemia Type II  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoalphalipoproteinemias  (ISO)
hypolipoproteinemia  (ISO)
Hypoproteinemia  (ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunodeficiency 17  (ISO)
immunodeficiency 18  (ISO)
immunodeficiency 19  (ISO)
Inflammation  (ISO)
inflammatory bowel disease 28  (ISO)
intellectual disability  (ISO)
isolated microphthalmia 5  (ISO)
Kidney Reperfusion Injury  (ISO)
lipid metabolism disorder  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung small cell carcinoma  (ISO)
major depressive disorder  (ISO)
malignant mesothelioma  (ISO)
membranous glomerulonephritis  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
nephronophthisis 15  (ISO)
nephrotic syndrome  (ISO)
Norum disease  (ISO)
obesity  (ISO)
ocular hypertension  (ISO)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Pediatric Obesity  (ISO)
polycystic kidney disease  (ISO)
primary hypoalphalipoproteinemia 1  (ISO)
primary hypoalphalipoproteinemia 2  (ISO)
pulmonary fibrosis  (ISO)
RASopathy  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
systemic lupus erythematosus  (ISO)
Tangier disease  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (IEA,ISO)
animal organ regeneration  (ISO)
axon regeneration  (ISO)
blood vessel endothelial cell migration  (IEA,ISO)
cholesterol biosynthetic process  (IEA,ISO)
cholesterol efflux  (IEA,ISO)
cholesterol homeostasis  (IEA)
cholesterol import  (IEA)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
endothelial cell proliferation  (IEA,ISO)
ERK1 and ERK2 cascade  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
glucocorticoid metabolic process  (IEA,ISO)
high-density lipoprotein particle assembly  (IEA)
high-density lipoprotein particle remodeling  (IEA)
integrin-mediated signaling pathway  (IEA)
lipid storage  (IEA,ISO)
lipid transport  (IEA)
lipoprotein biosynthetic process  (IEA,ISO)
lipoprotein metabolic process  (IEA)
negative chemotaxis  (IEA)
negative regulation of cell adhesion molecule production  (IEA)
negative regulation of cytokine production involved in immune response  (IEA)
negative regulation of heterotypic cell-cell adhesion  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of interleukin-1 beta production  (IEA)
negative regulation of lipase activity  (ISO)
negative regulation of response to cytokine stimulus  (IEA)
negative regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
negative regulation of very-low-density lipoprotein particle remodeling  (IEA)
peripheral nervous system axon regeneration  (ISO)
phosphatidylcholine biosynthetic process  (IEA)
phosphatidylcholine metabolic process  (IEA)
phospholipid efflux  (IEA)
phospholipid homeostasis  (IEA)
phospholipid metabolic process  (IEA,ISO)
phospholipid transport  (ISO)
positive regulation of cholesterol efflux  (IEA)
positive regulation of cholesterol metabolic process  (IEA)
positive regulation of phagocytosis  (IEA)
positive regulation of phospholipid efflux  (IEA)
positive regulation of Rho protein signal transduction  (IEA)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
protein localization  (ISO)
protein stabilization  (IEA)
regulation of Cdc42 protein signal transduction  (IEA)
regulation of intestinal cholesterol absorption  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
response to estrogen  (ISO)
response to nutrient  (ISO)
response to xenobiotic stimulus  (ISO)
reverse cholesterol transport  (IEA)
transforming growth factor beta receptor signaling pathway  (ISO)
triglyceride homeostasis  (IEA)
vitamin transport  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Apoa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,189,637 - 99,191,475 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,111,052 - 2,112,854 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,835,751 - 116,837,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11116,835,751 - 116,837,622 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,706,467 - 116,708,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,211,679 - 116,213,548 (-)NCBINCBI36Build 36hg18NCBI36
Celera11113,864,272 - 113,866,141 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,638,728 - 112,640,597 (-)NCBIHuRef
CHM1_111116,591,221 - 116,593,090 (-)NCBICHM1_1
T2T-CHM13v2.011116,850,858 - 116,853,057 (-)NCBIT2T-CHM13v2.0
Apoa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,139,928 - 46,141,767 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,139,878 - 46,141,764 (+)EnsemblGRCm39 Ensembl
GRCm38946,228,630 - 46,230,469 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,228,580 - 46,230,466 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,036,713 - 46,038,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36945,979,705 - 45,981,461 (+)NCBIMGSCv36mm8
Celera943,517,584 - 43,519,420 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map925.36NCBI
Apoa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8855,423,945 - 55,425,729 (+)NCBIGRCr8
mRatBN7.2846,527,251 - 46,529,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,527,144 - 46,529,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,028,451 - 52,030,242 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0850,307,226 - 50,309,017 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0848,171,497 - 48,173,288 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0850,525,091 - 50,526,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,525,091 - 50,526,875 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,151,163 - 49,152,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera846,109,311 - 46,111,065 (+)NCBICelera
RH 3.4 Map8472.0RGD
Cytogenetic Map8q22NCBI
Apoa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,170,331 - 18,172,298 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,170,331 - 18,172,298 (-)NCBIChiLan1.0ChiLan1.0
APOA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29117,539,267 - 117,542,245 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111118,644,446 - 118,647,456 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011111,673,539 - 111,675,428 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111115,606,136 - 115,608,335 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,606,136 - 115,608,122 (-)Ensemblpanpan1.1panPan2
APOA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,740,071 - 16,742,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,740,130 - 16,741,943 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,792,234 - 16,794,244 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,686,357 - 16,688,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,686,468 - 16,688,346 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,823,454 - 16,825,453 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,726,037 - 16,728,039 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,768,944 - 16,770,956 (+)NCBIUU_Cfam_GSD_1.0
APOA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,216,392 - 44,218,713 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,216,481 - 44,218,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,288,730 - 49,290,611 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p12-p11NCBI
APOA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,201,967 - 108,203,902 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,201,439 - 108,203,609 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,846,715 - 17,848,683 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,249,283 - 12,251,136 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,249,283 - 12,251,215 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021728531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000002322   ⟹   ENSSTOP00000002077
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365422,111,052 - 2,112,854 (-)Ensembl
RefSeq Acc Id: XM_021728531   ⟹   XP_021584206
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494799,189,637 - 99,191,475 (-)NCBI
SpeTri2.0NW_0049365422,111,055 - 2,112,626 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021584206 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002077.2
GenBank Protein I3M072 (Get FASTA)   NCBI Sequence Viewer  
  KAG3286611 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021584206   ⟸   XM_021728531
- UniProtKB: I3M072 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSTOP00000002077   ⟸   ENSSTOT00000002322


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000002328 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSSTOT00000002322.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.20 UniProtKB/Swiss-Prot
  6.10.140.380 UniProtKB/Swiss-Prot
  Apolipoprotein UniProtKB/Swiss-Prot
InterPro ApoA_E UniProtKB/Swiss-Prot
NCBI Gene Apoa1 ENTREZGENE
PANTHER APOLIPOPROTEIN UniProtKB/Swiss-Prot
  APOLIPOPROTEIN A-I UniProtKB/Swiss-Prot
Pfam Apolipoprotein UniProtKB/Swiss-Prot
Superfamily-SCOP Apolipoprotein A-I UniProtKB/Swiss-Prot
UniProt APOA1_ICTTR UniProtKB/Swiss-Prot, ENTREZGENE