Hmga2 (high mobility group AT-hook 2) - Rat Genome Database

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Gene: Hmga2 (high mobility group AT-hook 2) Ictidomys tridecemlineatus
Analyze
Symbol: Hmga2
Name: high mobility group AT-hook 2
RGD ID: 12602892
Description: ENCODES a protein that exhibits 5'-deoxyribose-5-phosphate lyase activity (ortholog); C2H2 zinc finger domain binding (ortholog); cAMP response element binding (ortholog); INVOLVED IN adipose tissue development (ortholog); adrenal gland development (ortholog); base-excision repair (ortholog); PARTICIPATES IN Ras mediated signaling pathway; ASSOCIATED WITH Birth Weight (ortholog); disease of cellular proliferation (ortholog); Hamartoma (ortholog); FOUND IN nuclear chromosome (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: high mobility group protein HMGI-C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBI
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISO)
adrenal gland development  (ISO)
base-excision repair  (ISO)
cell proliferation in forebrain  (ISO)
chondrocyte differentiation  (ISO)
chondrocyte proliferation  (ISO)
chromosome breakage  (ISO)
DNA damage response, detection of DNA damage  (ISO)
endodermal cell differentiation  (ISO)
epithelial to mesenchymal transition  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
fat cell differentiation  (ISO)
fat pad development  (ISO)
heterochromatin assembly  (ISO)
histone H2A-S139 phosphorylation  (ISO)
lung epithelium development  (ISO)
male gonad development  (ISO)
mesenchymal cell differentiation  (ISO)
mesodermal cell differentiation  (ISO)
mesodermal-endodermal cell signaling  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of double-strand break repair via nonhomologous end joining  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of receptor signaling pathway via JAK-STAT  (ISO)
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
oncogene-induced cell senescence  (ISO)
pituitary gland development  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cellular response to X-ray  (ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of response to DNA damage stimulus  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of cell cycle  (ISO)
regulation of cell cycle process  (ISO)
regulation of cellular response to drug  (ISO)
regulation of growth hormone secretion  (ISO)
regulation of peptide hormone secretion  (ISO)
regulation of stem cell population maintenance  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to virus  (ISO)
senescence-associated heterochromatin focus assembly  (ISO)
signal transduction  (ISO)
somatic stem cell population maintenance  (ISO)
spermatogenesis  (ISO)
stem cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Hmga2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBI
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1265,824,460 - 65,966,291 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1265,824,131 - 65,966,295 (+)EnsemblGRCh38hg38GRCh38
GRCh381265,824,460 - 65,966,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371266,218,240 - 66,360,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361264,504,507 - 64,646,338 (+)NCBINCBI36hg18NCBI36
Build 341264,504,457 - 64,646,266NCBI
Celera1265,883,845 - 66,025,902 (+)NCBI
Cytogenetic Map12q14.3NCBI
HuRef1263,271,242 - 63,413,086 (+)NCBIHuRef
CHM1_11266,185,507 - 66,327,350 (+)NCBICHM1_1
Hmga2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910120,197,173 - 120,312,374 (-)NCBIGRCm39mm39
GRCm39 Ensembl10120,197,180 - 120,312,374 (-)Ensembl
GRCm3810120,361,268 - 120,476,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10120,361,275 - 120,476,469 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710119,798,331 - 119,913,991 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610119,764,721 - 119,880,028 (-)NCBImm8
Celera10122,723,179 - 122,838,757 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1067.94NCBI
Hmga2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2755,877,145 - 55,998,813 (-)NCBI
Rnor_6.0 Ensembl765,159,944 - 65,275,408 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0765,159,944 - 65,275,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0765,375,936 - 65,490,635 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4759,638,555 - 59,753,791 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1759,659,284 - 59,774,521 (-)NCBI
Celera752,634,133 - 52,748,501 (-)NCBICelera
Cytogenetic Map7q22NCBI
Hmga2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545812,493,790 - 12,624,805 (+)NCBIChiLan1.0ChiLan1.0
HMGA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01222,954,946 - 23,096,623 (-)NCBIMhudiblu_PPA_v0panPan3
HMGA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1108,348,101 - 8,491,435 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha108,278,957 - 8,424,016 (+)NCBI
ROS_Cfam_1.0108,459,176 - 8,604,625 (+)NCBI
UMICH_Zoey_3.1108,335,596 - 8,480,987 (+)NCBI
UNSW_CanFamBas_1.0108,581,865 - 8,727,080 (+)NCBI
UU_Cfam_GSD_1.0108,703,471 - 8,848,741 (+)NCBI
HMGA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1530,188,521 - 30,329,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2533,375,397 - 33,516,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11161,509,114 - 61,655,633 (+)NCBI
Vero_WHO_p1.0NW_023666037184,069,350 - 184,211,090 (-)NCBI
Hmga2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248022,337,344 - 2,468,757 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021728712   ⟹   XP_021584387
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365453,944,419 - 3,958,289 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040281824   ⟹   XP_040137758
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494550,151,774 - 50,166,701 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040137758 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021584387   ⟸   XM_021728712
- Sequence:
RefSeq Acc Id: XP_040137758   ⟸   XM_040281824


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026964 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000023313 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020004 UniProtKB/TrEMBL
InterPro AT_hook_DNA-bd_motif UniProtKB/TrEMBL
  HMGA UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/TrEMBL
NCBI Gene Hmga2 ENTREZGENE
Pfam AT_hook UniProtKB/TrEMBL
PRINTS ATHOOK UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/TrEMBL
PROSITE HMGI_Y UniProtKB/TrEMBL
SMART AT_hook UniProtKB/TrEMBL
UniProt I3NG16_ICTTR UniProtKB/TrEMBL