LOC101970101 (cytochrome P450 1B1) - Rat Genome Database

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Gene: LOC101970101 (cytochrome P450 1B1) Ictidomys tridecemlineatus
Analyze
Symbol: LOC101970101 (Ensembl: CYP1B1)
Name: cytochrome P450 1B1 (Ensembl:cytochrome P450 family 1 subfamily B member 1)
RGD ID: 12634714
Description: ENCODES a protein that exhibits monooxygenase activity (ortholog); oxidoreductase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); angiogenesis (ortholog); benzene-containing compound metabolic process (ortholog); PARTICIPATES IN phase I biotransformation pathway via cytochrome P450; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); adenoma (ortholog); anterior segment dysgenesis (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
angiogenesis  (IEA,ISO)
arachidonate metabolic process  (IEA)
benzene-containing compound metabolic process  (IEA,ISO)
blood vessel endothelial cell migration  (IEA,ISO)
blood vessel morphogenesis  (IEA)
cell adhesion  (IEA)
cellular response to cAMP  (ISO)
cellular response to cortisol stimulus  (ISO)
cellular response to hydrogen peroxide  (IEA)
cellular response to luteinizing hormone stimulus  (ISO)
cellular response to organic cyclic compound  (IEA,ISO)
cellular response to progesterone stimulus  (ISO)
cellular response to toxic substance  (ISO)
cellular response to tumor necrosis factor  (ISO)
collagen fibril organization  (IEA)
dibenzo-p-dioxin metabolic process  (ISO)
DNA modification  (ISO)
endothelial cell migration  (IEA)
endothelial cell-cell adhesion  (IEA,ISO)
estrogen metabolic process  (IEA,ISO)
estrous cycle  (ISO)
ganglion development  (ISO)
hormone biosynthetic process  (IEA)
intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA)
male gonad development  (ISO)
membrane lipid catabolic process  (IEA)
negative regulation of cell adhesion mediated by integrin  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of NF-kappaB transcription factor activity  (ISO)
nitric oxide biosynthetic process  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
progesterone metabolic process  (IEA)
regulation of reactive oxygen species metabolic process  (IEA)
response to 3-methylcholanthrene  (ISO)
response to arsenic-containing substance  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to indole-3-methanol  (ISO)
response to nutrient  (ISO)
response to steroid hormone  (ISO)
response to toxic substance  (IEA,ISO)
retina vasculature development in camera-type eye  (IEA,ISO)
retinal blood vessel morphogenesis  (IEA)
retinal metabolic process  (IEA)
retinol metabolic process  (IEA)
steroid metabolic process  (IEA)
toxin metabolic process  (IEA,ISO)
trabecular meshwork development  (IEA)
xenobiotic metabolic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LOC101970101
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38238,067,509 - 38,076,151 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl238,066,973 - 38,109,902 (-)EnsemblGRCh38hg38GRCh38
GRCh37238,294,652 - 38,303,293 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36238,148,250 - 38,156,796 (-)NCBINCBI36Build 36hg18NCBI36
Build 34238,206,396 - 38,214,943NCBI
Celera238,135,623 - 38,144,201 (-)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef238,034,680 - 38,043,258 (-)NCBIHuRef
CHM1_1238,224,106 - 38,232,684 (-)NCBICHM1_1
T2T-CHM13v2.0238,074,395 - 38,083,037 (-)NCBIT2T-CHM13v2.0
Cyp1b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391780,014,369 - 80,022,490 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1780,008,966 - 80,022,490 (-)EnsemblGRCm39 Ensembl
GRCm381779,706,940 - 79,715,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,701,537 - 79,715,061 (-)EnsemblGRCm38mm10GRCm38
MGSCv371780,106,293 - 80,114,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361779,615,279 - 79,623,367 (-)NCBIMGSCv36mm8
Celera1784,018,414 - 84,026,502 (-)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1750.3NCBI
Cyp1b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,093,927 - 21,103,091 (+)NCBIGRCr8
mRatBN7.2615,342,312 - 15,350,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,342,344 - 15,350,917 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx615,640,765 - 15,646,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0615,962,952 - 15,968,669 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0615,459,216 - 15,464,934 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.062,308,179 - 2,316,739 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl62,307,808 - 2,316,722 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.062,294,952 - 2,300,644 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.462,548,224 - 2,553,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.162,545,648 - 2,553,767 (-)NCBI
Celera615,009,941 - 15,015,671 (+)NCBICelera
Cytogenetic Map6q12NCBI
LOC102009223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,803,032 - 5,812,131 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554415,803,397 - 5,812,131 (-)NCBIChiLan1.0ChiLan1.0
CYP1B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21288,409,864 - 88,419,099 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A88,413,479 - 88,423,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A38,087,863 - 38,096,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,851,000 - 38,859,883 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,851,000 - 38,859,824 (-)Ensemblpanpan1.1panPan2
CYP1B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11730,273,281 - 30,278,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1730,272,749 - 30,278,554 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1730,086,594 - 30,091,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,923,029 - 30,928,301 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,922,243 - 30,928,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11730,148,312 - 30,153,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01730,216,274 - 30,221,549 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01730,431,572 - 30,436,860 (-)NCBIUU_Cfam_GSD_1.0
CYP1B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,195,741 - 102,205,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13102,195,743 - 102,205,687 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP1B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11469,318,713 - 69,327,277 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1469,319,495 - 69,324,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604542,635,474 - 42,644,623 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701066
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473819,638,456 - 19,647,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473819,639,215 - 19,647,807 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000001645   ⟹   ENSSTOP00000001475
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936663348,368 - 355,191 (+)Ensembl
RefSeq Acc Id: XM_005336538   ⟹   XP_005336595
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629241,681,106 - 41,689,696 (+)NCBI
SpeTri2.0NW_004936663345,021 - 355,188 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040271127   ⟹   XP_040127061
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629241,681,103 - 41,689,696 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005336595 (Get FASTA)   NCBI Sequence Viewer  
  XP_040127061 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000001475.2
GenBank Protein KAG3267449 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005336595   ⟸   XM_005336538
- UniProtKB: I3LYZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127061   ⟸   XM_040271127
- UniProtKB: I3LYZ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000001475   ⟸   ENSSTOT00000001645


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000001650 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000001645.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC101970101 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 1 SUBFAMILY C POLYPEPTIDE 1 UniProtKB/TrEMBL
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt I3LYZ5 ENTREZGENE, UniProtKB/TrEMBL