RGD Reference Report - Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. - Rat Genome Database

RGD Reference Report - Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. - Rat Genome Database

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Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice.
Authors:	Kushi, A Sasai, H Koizumi, H Takeda, N Yokoyama, M Nakamura, M
Citation:	Kushi A, etal., Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64.
RGD ID:	1642306
Pubmed:	PMID:9861026 (View Abstract at PubMed)
PMCID:	PMC28100 (View Article at PubMed Central)
To elucidate the role of neuropeptide Y (NPY)-Y1 receptor (Y1-R) in food intake, energy expenditure, and other possible functions, we have generated Y1-R-deficient mice (Y1-R-/-) by gene targeting. Contrary to our hypothesis that the lack of NPY signaling via Y1-R would result in impaired feeding and weight loss, Y1-R-/- mice showed a moderate obesity and mild hyperinsulinemia without hyperphagia. Although there was some variation between males and females, typical characteristics of Y1-R-/- mice include: greater body weight (females more than males), an increase in the weight of white adipose tissue (WAT) (approximately 4-fold in females), an elevated basal level of plasma insulin (approximately 2-fold), impaired insulin secretion in response to glucose administration, and a significant changes in mitochondrial uncoupling protein (UCP) gene expression (up-regulation of UCP1 in brown adipose tissue and down-regulation of UCP2 in WAT). These results suggest either that the Y1-R in the hypothalamus is not a key molecule in the leptin/NPY pathway, which controls feeding behavior, or that its deficiency is compensated by other receptors, such as NPY-Y5 receptor. We believe that the mild obesity found in Y1-R-/- mice (especially females) was caused by the impaired control of insulin secretion and/or low energy expenditure, including the lowered expression of UCP2 in WAT. This model will be useful for studying the mechanism of mild obesity and abnormal insulin metabolism in noninsulin-dependent diabetes mellitus.

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
NPY1R	Human	obesity	susceptibility	ISO	Npy1r (Mus musculus)	associated with Hyperinsulinemia	RGD
Npy1r	Rat	obesity	susceptibility	ISO	Npy1r (Mus musculus)	associated with Hyperinsulinemia	RGD
Npy1r	Mouse	obesity	susceptibility	IAGP		associated with Hyperinsulinemia	RGD

Genes (Rattus norvegicus)


Npy1r (neuropeptide Y receptor Y1)

Genes (Mus musculus)


Npy1r (neuropeptide Y receptor Y1)

Genes (Homo sapiens)


NPY1R (neuropeptide Y receptor Y1)