RGD Reference Report - [Study on plasma lipids, apolipoprotein A1, apolipoprotein B100 in simple obese children] - Rat Genome Database

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[Study on plasma lipids, apolipoprotein A1, apolipoprotein B100 in simple obese children]

Authors: Zhu, H  Wang, S  Xu, Y  Chen, Y 
Citation: Zhu H, etal., Wei Sheng Yan Jiu. 2000 Mar 30;29(2):104-5.
RGD ID: 1601185
Pubmed: PMID:12725089   (View Abstract at PubMed)

To investigate the disorder of lipid metabolism and explore the possible mechanism of increasing risk of atherosclerosis(AS) in simple childhood obesity, serum lipids and apolipoprotein were examined. 49 obese children were selected and another 49 non-obese children were selected as control. Their serum lipids (TG, TC, VLDL-ch, HDL-ch and LDL-ch) and apolipoprotein(apoA1 and apoB100) were measured. The results showed TG, VLDL-ch, apoB100, artherosclerosis index (AI) and LDL-ch/HDL-ch ratio in childhood obesity were significantly higher than that in normal children (P < 0.05), while HDL-ch, apoA1, HDL-ch/TC, apoA1/apoB100 ratio in obese children were obviously lower than that in normal ones(P < 0.05). The results suggested that metabolic disorder of lipid and apolipoprotein took place in obese children. The disorder which may increase the risk of AS should be paid great attention.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IEP 1601185protein:decreased expressionRGD 
obesity  ISOAPOA1 (Homo sapiens)1601185; 1601185protein:decreased expressionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apoa1  (apolipoprotein A1)

Genes (Mus musculus)
Apoa1  (apolipoprotein A-I)

Genes (Homo sapiens)
APOA1  (apolipoprotein A1)


Additional Information