Tyk2 (tyrosine kinase 2) - Rat Genome Database

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Gene: Tyk2 (tyrosine kinase 2) Ictidomys tridecemlineatus
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Symbol: Tyk2
Name: tyrosine kinase 2
RGD ID: 12531129
Description: ENCODES a protein that exhibits growth hormone receptor binding (ortholog); protein tyrosine kinase activity (ortholog); type 1 angiotensin receptor binding (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Cocaine-Related Disorders (ortholog); Crohn's disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: non-receptor tyrosine-protein kinase TYK2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
Tyk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1910,350,529 - 10,380,572 (-)EnsemblGRCh38hg38GRCh38
GRCh381910,350,528 - 10,380,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371910,461,209 - 10,491,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,322,209 - 10,352,211 (-)NCBINCBI36hg18NCBI36
Build 341910,322,208 - 10,352,211NCBI
Celera1910,356,496 - 10,385,954 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef1910,041,213 - 10,071,290 (-)NCBIHuRef
CHM1_11910,461,760 - 10,491,969 (-)NCBICHM1_1
Tyk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,015,364 - 21,042,689 (-)NCBIGRCm39mm39
GRCm39 Ensembl921,015,364 - 21,042,539 (-)Ensembl
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBImm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
Tyk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,641,881 - 19,667,157 (-)NCBI
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
Tyk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,618,099 - 1,637,996 (-)NCBIChiLan1.0ChiLan1.0
TYK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,565,490 - 10,596,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,565,490 - 10,594,541 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,901,612 - 9,932,623 (-)NCBIMhudiblu_PPA_v0panPan3
TYK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,747,145 - 50,770,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,748,329 - 50,769,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,617,718 - 50,639,776 (+)NCBI
ROS_Cfam_1.02051,269,592 - 51,291,659 (+)NCBI
UMICH_Zoey_3.12050,475,504 - 50,497,770 (+)NCBI
UNSW_CanFamBas_1.02050,904,500 - 50,926,568 (+)NCBI
UU_Cfam_GSD_1.02051,145,386 - 51,167,670 (+)NCBI
TYK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,157,799 - 69,183,461 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,157,774 - 69,183,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,492,135 - 69,517,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,399,945 - 9,420,054 (-)NCBI
ChlSab1.1 Ensembl69,399,775 - 9,417,630 (-)Ensembl
Tyk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248282,499,811 - 2,518,817 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021733851   ⟹   XP_021589526
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733852   ⟹   XP_021589527
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733853   ⟹   XP_021589528
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733854   ⟹   XP_021589529
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733855   ⟹   XP_021589530
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936659683,652 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733856   ⟹   XP_021589531
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936659683,652 - 704,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040290469   ⟹   XP_040146403
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XM_040290470   ⟹   XP_040146404
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XM_040290471   ⟹   XP_040146405
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XM_040290472   ⟹   XP_040146406
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XM_040290474   ⟹   XP_040146408
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XM_040290475   ⟹   XP_040146409
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBI
RefSeq Acc Id: XR_005736000
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,672,149 (+)NCBI
RefSeq Acc Id: XR_005736001
RefSeq Status:
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118209,650,169 - 209,672,149 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_021589527   ⟸   XM_021733852
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021589528   ⟸   XM_021733853
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021589529   ⟸   XM_021733854
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021589526   ⟸   XM_021733851
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021589531   ⟸   XM_021733856
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_021589530   ⟸   XM_021733855
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040146406   ⟸   XM_040290472
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040146405   ⟸   XM_040290471
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040146409   ⟸   XM_040290475
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040146403   ⟸   XM_040290469
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040146408   ⟸   XM_040290474
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040146404   ⟸   XM_040290470
- Peptide Label: isoform X1
Protein Domains
FERM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003264 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000002949 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003298 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_TYK2_N UniProtKB/TrEMBL
NCBI Gene Tyk2 ENTREZGENE
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF TyrPK_Jak UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
  YKINASETYK2 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3M210_ICTTR UniProtKB/TrEMBL