Alox5ap (arachidonate 5-lipoxygenase activating protein) - Rat Genome Database

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Gene: Alox5ap (arachidonate 5-lipoxygenase activating protein) Ictidomys tridecemlineatus
Analyze
Symbol: Alox5ap
Name: arachidonate 5-lipoxygenase activating protein
RGD ID: 12642611
Description: ENCODES a protein that exhibits arachidonate 5-lipoxygenase activity (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN leukotriene biosynthetic process (ortholog); leukotriene production involved in inflammatory response (ortholog); lipoxygenase pathway (ortholog); PARTICIPATES IN leukotriene metabolic pathway; lipoxygenase mediated pathway of arachidonic acid metabolism; ASSOCIATED WITH arteriosclerosis (ortholog); atherosclerosis (ortholog); brain infarction (ortholog); FOUND IN nuclear envelope (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arachidonate 5-lipoxygenase activating protein, transcript variant X1; arachidonate 5-lipoxygenase activating protein, transcript variant X2; LOC101963472
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,449,329 - 170,475,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Alox5ap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,449,329 - 170,475,151 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5AP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,713,485 - 30,764,426 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1330,713,478 - 30,764,426 (+)EnsemblGRCh38hg38GRCh38
GRCh371331,287,622 - 31,338,563 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361330,207,669 - 30,236,556 (+)NCBINCBI36Build 36hg18NCBI36
Build 341330,207,668 - 30,236,556NCBI
Celera1312,378,644 - 12,407,516 (+)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1312,105,618 - 12,156,585 (+)NCBIHuRef
CHM1_11331,255,200 - 31,306,135 (+)NCBICHM1_1
T2T-CHM13v2.01329,935,580 - 29,986,538 (+)NCBIT2T-CHM13v2.0
Alox5ap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395149,201,814 - 149,224,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5149,201,577 - 149,224,963 (+)EnsemblGRCm39 Ensembl
GRCm385149,265,004 - 149,288,153 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,264,767 - 149,288,153 (+)EnsemblGRCm38mm10GRCm38
MGSCv375150,076,634 - 150,099,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,575,407 - 149,596,895 (+)NCBIMGSCv36mm8
Celera5147,280,239 - 147,303,063 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Alox5ap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,785,254 - 10,809,295 (-)NCBIGRCr8
mRatBN7.2125,748,941 - 5,772,986 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,748,944 - 5,772,986 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,415,168 - 6,438,995 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,038,642 - 7,062,468 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,066,300 - 6,090,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0126,854,930 - 6,879,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl126,854,920 - 6,879,154 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0128,950,727 - 8,974,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4126,245,808 - 6,269,796 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1126,245,808 - 6,269,796 (-)NCBI
Celera127,507,392 - 7,531,448 (-)NCBICelera
Cytogenetic Map12p11NCBI
Alox5ap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,069,089 - 15,097,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,071,535 - 15,097,496 (-)NCBIChiLan1.0ChiLan1.0
ALOX5AP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21430,318,849 - 30,348,046 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11321,425,689 - 21,454,792 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01312,012,399 - 12,041,557 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11330,425,510 - 30,476,607 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,425,510 - 30,476,607 (+)Ensemblpanpan1.1panPan2
ALOX5AP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,320,868 - 9,351,056 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,320,864 - 9,351,836 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,363,720 - 9,390,082 (-)NCBIDog10K_Boxer_Tasha
ALOX5AP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl117,411,644 - 7,438,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1117,371,328 - 7,438,111 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,222,771 - 7,287,566 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5AP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,618,030 - 9,642,990 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl39,617,949 - 9,643,184 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605734,722,809 - 34,747,583 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5ap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,475,200 - 7,506,283 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247767,475,269 - 7,646,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000010916   ⟹   ENSSTOP00000009791
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647225,477,010 - 25,502,840 (+)Ensembl
RefSeq Acc Id: XM_005317070   ⟹   XP_005317127
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945170,449,329 - 170,475,090 (-)NCBI
SpeTri2.0NW_00493647225,477,094 - 25,502,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013360520   ⟹   XP_013215974
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945170,449,661 - 170,475,151 (-)NCBI
SpeTri2.0NW_00493647225,477,095 - 25,502,494 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040281626   ⟹   XP_040137560
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404945170,449,329 - 170,475,090 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005317127 (Get FASTA)   NCBI Sequence Viewer  
  XP_013215974 (Get FASTA)   NCBI Sequence Viewer  
  XP_040137560 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000009791.2
GenBank Protein KAG3293228 (Get FASTA)   NCBI Sequence Viewer  
  KAG3293229 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005317127   ⟸   XM_005317070
- Peptide Label: isoform X2
- UniProtKB: I3MGC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013215974   ⟸   XM_013360520
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040137560   ⟸   XM_040281626
- Peptide Label: isoform X1
RefSeq Acc Id: ENSSTOP00000009791   ⟸   ENSSTOT00000010916


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010915 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000010916.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/TrEMBL
InterPro 5_LipOase_AP UniProtKB/TrEMBL
  FLAP/GST2/LTC4S_CS UniProtKB/TrEMBL
  MAPEG-like_dom_sf UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/TrEMBL
NCBI Gene Alox5ap ENTREZGENE
PANTHER ARACHIDONATE 5-LIPOXYGENASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/TrEMBL
PRINTS 5LPOXGNASEAP UniProtKB/TrEMBL
PROSITE FLAP_GST2_LTC4S UniProtKB/TrEMBL
Superfamily-SCOP SSF161084 UniProtKB/TrEMBL
UniProt I3MGC6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-09 Alox5ap  arachidonate 5-lipoxygenase activating protein  LOC101963472  arachidonate 5-lipoxygenase activating protein  Symbol and/or name change 5135510 APPROVED
2021-03-26 LOC101963472  arachidonate 5-lipoxygenase activating protein  Alox5ap  arachidonate 5-lipoxygenase activating protein  Symbol and/or name change 5135510 APPROVED