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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-tert-butyl-4-hydroxyanisole
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Accession:CHEBI:76357 term browser browse the term
Definition:An aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho- to the methoxy group is replaced by a tert-butyl group.
Synonyms:exact_synonym: 3-tert-butyl-4-methoxyphenol
 related_synonym: 2-(1,1-dimethylethyl)-4-hydroxyanisole;   2-BHA;   2-tert-butyl-p-hydroxyanisole;   3-(1,1-dimethylethyl)-4-methoxyphenol;   4-hydroxy-2-tert-butylanisole;   4-methoxy-3-tert-butylphenol;   4-methoxy-5-tert-butylphenol;   Formula=C11H16O2;   InChI=1S/C11H16O2/c1-11(2,3)9-7-8(12)5-6-10(9)13-4/h5-7,12H,1-4H3;   InChIKey=IMOYOUMVYICGCA-UHFFFAOYSA-N;   SMILES=COc1ccc(O)cc1C(C)(C)C;   m-tert-butyl-p-methoxyphenol;   p-methoxy-m-tert-butylphenol
 xref: CAS:88-32-4;   HMDB:HMDB0031848;   PMID:3201475;   PMID:458807;   PMID:7059997;   PMID:7285002;   PMID:7388831;   Reaxys:2209222


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butylated hydroxyanisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA
Butylated Hydroxyanisole results in increased expression of ABCC2 mRNA
Butylated Hydroxyanisole results in increased expression of ABCC2 mRNA; Butylated Hydroxyanisole results in increased expression of ABCC2 protein		 CTD PMID:15833929 PMID:16426233 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression		 ISO [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA
Butylated Hydroxyanisole results in increased expression of ABCC3 mRNA		 CTD PMID:15833929 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression
multiple interactions		 ISO Butylated Hydroxyanisole results in increased expression of ABCC4 mRNA
[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA		 CTD PMID:15833929 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression		 ISO [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
Butylated Hydroxyanisole results in increased expression of ABCC5 mRNA		 CTD PMID:15833929 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases expression		 ISO [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA
Butylated Hydroxyanisole results in increased expression of ABCC6 mRNA		 CTD PMID:15833929 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Aco1 aconitase 1 multiple interactions EXP Butylated Hydroxyanisole inhibits the reaction [Cadmium Chloride affects the localization of ACO1 protein] CTD PMID:25106854 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Butylated Hydroxyanisole results in increased expression of AHR mRNA CTD PMID:17627975 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression EXP Butylated Hydroxyanisole results in increased expression of AKR7A3 protein CTD PMID:8198522 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of ALDH1A2 mRNA CTD PMID:28927898 NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107 		JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH1B1 mRNA CTD PMID:17998271 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH3A1 mRNA CTD PMID:17998271 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH4A1 mRNA CTD PMID:17998271 NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345 		JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH7A1 mRNA CTD PMID:17998271 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193 		JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of ALDH8A1 mRNA CTD PMID:17998271 NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 ISO Butylated Hydroxyanisole binds to AR protein
Butylated Hydroxyanisole inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Butylated Hydroxyanisole inhibits the reaction [Dihydrotestosterone binds to AR protein]		 CTD PMID:10696776 PMID:14579009 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]
Butylated Hydroxyanisole inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein]		 CTD PMID:12470298 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Aurkb aurora kinase B increases expression EXP Butylated Hydroxyanisole results in increased expression of AURKB protein CTD PMID:23535288 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO Butylated Hydroxyanisole results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208 		JBrowse link
G Car13 carbonic anhydrase 13 increases expression ISO Butylated Hydroxyanisole results in increased expression of CAR13 mRNA CTD PMID:19000923 NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Butylated Hydroxyanisole results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity		 ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein; Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased activity of CASP3 protein]
Butylated Hydroxyanisole results in decreased activity of CASP3 protein		 CTD PMID:14981915 PMID:16407847 PMID:21843585 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] CTD PMID:21843585 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase multiple interactions EXP Butylated Hydroxyanisole inhibits the reaction [Estradiol results in increased activity of CAT protein]; Butylated Hydroxyanisole inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] CTD PMID:19526586 PMID:27718046 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of CBR1 mRNA; Butylated Hydroxyanisole results in increased expression of CBR1 protein CTD PMID:23247010 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Cbx5 chromobox 5 increases expression EXP Butylated Hydroxyanisole results in increased expression of CBX5 protein CTD PMID:23535288 NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO Butylated Hydroxyanisole results in increased expression of CCNB1 mRNA CTD PMID:19000923 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Butylated Hydroxyanisole results in increased expression of CDK1 protein CTD PMID:23535288 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Butylated Hydroxyanisole results in increased expression of CDKN1A mRNA
Hydrogen Peroxide promotes the reaction [Butylated Hydroxyanisole results in increased expression of CDKN1A mRNA]		 CTD PMID:29486183 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdx1 caudal type homeo box 1 affects expression ISO Butylated Hydroxyanisole affects the expression of CDX1 mRNA CTD PMID:28927898 NCBI chr18:54,472,587...54,490,913
Ensembl chr18:54,473,444...54,490,814 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] CTD PMID:21220312 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces1d carboxylesterase 1D increases expression
decreases expression		 ISO Butylated Hydroxyanisole results in increased expression of CES1 mRNA
Butylated Hydroxyanisole results in decreased expression of CES1D protein		 CTD PMID:18227147 PMID:26179144 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2c carboxylesterase 2C decreases expression ISO Butylated Hydroxyanisole results in decreased expression of CES2C protein CTD PMID:26179144 NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790 		JBrowse link
G Ces2e carboxylesterase 2E decreases expression ISO Butylated Hydroxyanisole results in decreased expression of CES2E mRNA CTD PMID:26179144 NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO CTNNB1 gene mutant form inhibits the reaction [Butylated Hydroxyanisole results in increased expression of CYP1A1 mRNA]; CTNNB1 gene mutant form inhibits the reaction [Butylated Hydroxyanisole results in increased expression of CYP1A2 mRNA] CTD PMID:25174530 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity EXP Butylated Hydroxyanisole results in decreased activity of CYP17A1 protein CTD PMID:27388148 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO Butylated Hydroxyanisole results in increased expression of CYP1A1 mRNA
CTNNB1 gene mutant form inhibits the reaction [Butylated Hydroxyanisole results in increased expression of CYP1A1 mRNA]		 CTD PMID:25174530 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO Butylated Hydroxyanisole results in increased expression of CYP1A2 mRNA
CTNNB1 gene mutant form inhibits the reaction [Butylated Hydroxyanisole results in increased expression of CYP1A2 mRNA]		 CTD PMID:25174530 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Butylated Hydroxyanisole results in increased expression of CYP2B10 mRNA CTD PMID:17627975 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Butylated Hydroxyanisole results in increased expression of CYP2J2 mRNA CTD PMID:24021950 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DDIT3 mRNA]] CTD PMID:18691550 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dmp1 dentin matrix acidic phosphoprotein 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of DMP1 mRNA CTD PMID:19000923 NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323 		JBrowse link
G Dusp1 dual specificity phosphatase 1 affects response to substance
multiple interactions		 ISO DUSP1 protein affects the susceptibility to Butylated Hydroxyanisole
DUSP1 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]		 CTD PMID:30844440 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Butylated Hydroxyanisole inhibits the reaction [Particulate Matter results in increased phosphorylation of EGFR protein]; Butylated Hydroxyanisole inhibits the reaction [Vehicle Emissions results in increased phosphorylation of EGFR protein]		 CTD PMID:17028263 PMID:21220312 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases activity ISO Butylated Hydroxyanisole results in increased activity of EPHX1 protein CTD PMID:3621371 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression
increases activity		 ISO Butylated Hydroxyanisole results in decreased expression of EPHX2 protein
Butylated Hydroxyanisole results in increased activity of EPHX2 protein		 CTD PMID:3621371 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Esr1 estrogen receptor 1 affects binding
increases activity
decreases expression
multiple interactions		 ISO Butylated Hydroxyanisole binds to ESR1 protein
Butylated Hydroxyanisole results in increased activity of ESR1 protein
Butylated Hydroxyanisole results in decreased expression of ESR1 mRNA
Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR1 protein]		 CTD PMID:12822488 PMID:14579009 PMID:16756374 PMID:19063592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding
increases activity
multiple interactions		 ISO Butylated Hydroxyanisole binds to ESR2 protein
Butylated Hydroxyanisole results in increased activity of ESR2 protein
Butylated Hydroxyanisole inhibits the reaction [Estradiol binds to ESR2 protein]		 CTD PMID:12822488 PMID:16756374 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Butylated Hydroxyanisole promotes the reaction [FOS protein binds to NQO1 promoter] CTD PMID:8375015 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxyanisole results in increased expression of FOSL1 mRNA CTD PMID:19000923 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of FTH1 protein CTD PMID:38657941 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Butylated Hydroxyanisole results in increased expression of GCLC mRNA
Butylated Hydroxyanisole results in increased expression of GCLC mRNA; Butylated Hydroxyanisole results in increased expression of GCLC protein		 CTD PMID:16426233 PMID:25922074 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of GPX4 protein CTD PMID:38657941 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Butylated Hydroxyanisole results in increased expression of GSTA3 protein CTD PMID:9794803 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases expression		 EXP Butylated Hydroxyanisole promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxyanisole results in increased expression of and results in increased activity of GSTA5 protein
Butylated Hydroxyanisole results in increased expression of GSTA5 protein		 CTD PMID:8198522 PMID:9794803 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases activity
increases expression		 ISO NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTM1 protein]
Butylated Hydroxyanisole results in increased expression of GSTM1 mRNA; Butylated Hydroxyanisole results in increased expression of GSTM1 protein		 CTD PMID:2597111 PMID:11309284 PMID:11895860 PMID:11991805 PMID:18723825 More... NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Butylated Hydroxyanisole results in increased expression of GSTM2 mRNA; Butylated Hydroxyanisole results in increased expression of GSTM2 protein; Butylated Hydroxyanisole results in increased expression of GSTM5 protein CTD PMID:1859377 PMID:11309284 PMID:11991805 PMID:18723825 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 increases expression ISO Butylated Hydroxyanisole results in increased expression of GSTM4 mRNA; Butylated Hydroxyanisole results in increased expression of GSTM4 protein CTD PMID:1859377 PMID:11991805 PMID:18723825 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO
EXP		 Butylated Hydroxyanisole results in increased expression of GSTM3 mRNA; Butylated Hydroxyanisole results in increased expression of GSTM3 protein CTD PMID:6822548 PMID:9794803 PMID:11991805 PMID:18723825 NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of GSTO1 mRNA CTD PMID:18723825 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases activity
increases expression
multiple interactions		 ISO
EXP		 Butylated Hydroxyanisole results in increased activity of GSTP1 protein
Butylated Hydroxyanisole results in increased expression of GSTP1 protein
NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTP1 protein]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased expression of GSTP1 protein]		 CTD PMID:2597111 PMID:9794803 PMID:11895860 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Butylated Hydroxyanisole results in increased expression of GSTT1 mRNA; Butylated Hydroxyanisole results in increased expression of GSTT1 protein CTD PMID:9794803 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] CTD PMID:21220312 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Butylated Hydroxyanisole results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [Butylated Hydroxyanisole results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; [Hydrogen Peroxide co-treated with Butylated Hydroxyanisole] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA]
Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA; Butylated Hydroxyanisole results in increased expression of HMOX1 protein		 CTD PMID:18227147 PMID:25922074 PMID:29086419 PMID:29486183 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hoxa1 homeobox A1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of HOXA1 mRNA CTD PMID:28927898 NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of HOXB9 mRNA CTD PMID:28927898 NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Butylated Hydroxyanisole results in decreased expression of HSD17B3 mRNA; Butylated Hydroxyanisole results in decreased expression of HSD17B3 protein CTD PMID:27388148 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity EXP Butylated Hydroxyanisole results in decreased activity of HSD3B1 protein CTD PMID:27388148 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP		 Butylated Hydroxyanisole results in decreased expression of and results in decreased secretion of IFNG protein
[Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of IFNG mRNA		 CTD PMID:22250088 PMID:32179172 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]; Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]; Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]] CTD PMID:18691550 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of IL10 mRNA CTD PMID:32179172 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]] CTD PMID:18691550 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Butylated Hydroxyanisole inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
Butylated Hydroxyanisole inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]
[Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of IL1B mRNA		 CTD PMID:1515551 PMID:8186192 PMID:32179172 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]; Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]]; Butylated Hydroxyanisole inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]
[Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of IL6 mRNA		 CTD PMID:8186192 PMID:18691550 PMID:30844440 PMID:32179172 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Butylated Hydroxyanisole results in increased expression of JUN mRNA
Butylated Hydroxyanisole promotes the reaction [JUN protein binds to NQO1 promoter]		 CTD PMID:8375015 PMID:19000923 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase decreases expression ISO Butylated Hydroxyanisole results in decreased expression of LFNG mRNA CTD PMID:28927898 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:21220312 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor increases expression EXP Butylated Hydroxyanisole results in increased expression of LHCGR mRNA CTD PMID:27388148 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Lhx1 LIM homeobox 1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of LHX1 mRNA CTD PMID:28927898 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAP2K4 protein] CTD PMID:16407847 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]
Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]		 CTD PMID:16407847 PMID:21220312 PMID:21843585 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of DDIT3 mRNA]]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL1A protein]]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IL6 protein]] CTD PMID:18691550 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK3 protein]
Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:16407847 PMID:21220312 PMID:21843585 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO
EXP		 Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK8 protein]
Butylated Hydroxyanisole inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]; Butylated Hydroxyanisole inhibits the reaction [IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]; Butylated Hydroxyanisole inhibits the reaction [MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased activity of MAPK8 protein]]; Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased activity of MAPK8 protein]		 CTD PMID:15989949 PMID:16407847 PMID:18593901 PMID:18691550 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of MEOX1 mRNA CTD PMID:28927898 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 increases expression ISO Butylated Hydroxyanisole results in increased expression of MGST3 mRNA CTD PMID:18723825 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of MIXL1 mRNA CTD PMID:28927898 NCBI chr13:92,422,031...92,426,065
Ensembl chr13:92,422,031...92,426,065 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression
decreases expression		 EXP Butylated Hydroxyanisole results in increased expression of MKI67 protein
Butylated Hydroxyanisole results in decreased expression of MKI67 protein		 CTD PMID:23535288 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]
Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of COX2 protein]		 CTD PMID:12470298 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects activity
multiple interactions
increases expression
affects response to substance		 ISO
EXP		 Butylated Hydroxyanisole affects the activity of NFE2L2 protein
[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Butylated Hydroxyanisole binds to and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTM1 protein]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTP1 protein]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased expression of GSTP1 protein]
Butylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]
Butylated Hydroxyanisole results in increased expression of NFE2L2 protein
Butylated Hydroxyanisole results in increased stability of and results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to Butylated Hydroxyanisole		 CTD PMID:11309284 PMID:11895860 PMID:15833929 PMID:15919853 PMID:22530035 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions		 ISO
EXP		 Butylated Hydroxyanisole results in increased activity of NQO1 protein
Butylated Hydroxyanisole results in increased expression of NQO1 mRNA
Butylated Hydroxyanisole results in increased expression of NQO1 mRNA; Butylated Hydroxyanisole results in increased expression of NQO1 protein
Butylated Hydroxyanisole promotes the reaction [FOS protein binds to NQO1 promoter]; Butylated Hydroxyanisole promotes the reaction [JUN protein binds to NQO1 promoter]		 CTD PMID:8375015 PMID:10092053 PMID:11309284 PMID:15919853 PMID:16045903 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Butylated Hydroxyanisole results in increased expression of NR1I2 mRNA CTD PMID:17627975 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression ISO Butylated Hydroxyanisole results in increased expression of NR1I3 mRNA CTD PMID:17627975 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] CTD PMID:16407847 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions
increases expression		 ISO Butylated Hydroxyanisole binds to PGR protein
Butylated Hydroxyanisole inhibits the reaction [Progesterone binds to PGR protein]
Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]
Butylated Hydroxyanisole results in increased expression of PGR mRNA		 CTD PMID:12822488 PMID:14579009 PMID:21220312 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO Butylated Hydroxyanisole results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Butylated Hydroxyanisole results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein] CTD PMID:21362627 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA]
Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]		 CTD PMID:12470298 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]] CTD PMID:21220312 PMID:30844440 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [erastin results in increased expression of SESN2 protein] CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of SLC3A2 protein CTD PMID:38657941 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of SLC7A11 protein CTD PMID:38657941 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO Butylated Hydroxyanisole results in increased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA; Butylated Hydroxyanisole inhibits the reaction [Particulate Matter results in decreased activity of SOD2 protein] CTD PMID:14981915 PMID:36007723 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions
increases expression
increases activity		 EXP Butylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]; Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased activity of SOD3 protein]; Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 mRNA]; Butylated Hydroxyanisole inhibits the reaction [Estradiol results in decreased expression of SOD3 protein]
Butylated Hydroxyanisole results in increased expression of SOD3 mRNA; Butylated Hydroxyanisole results in increased expression of SOD3 protein
Butylated Hydroxyanisole results in increased activity of SOD3 protein		 CTD PMID:23027624 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Butylated Hydroxyanisole results in decreased expression of SP5 mRNA CTD PMID:28927898 NCBI chr 3:55,274,931...55,277,733
Ensembl chr 3:55,274,931...55,277,733 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression EXP Butylated Hydroxyanisole results in decreased expression of SRD5A1 mRNA; Butylated Hydroxyanisole results in decreased expression of SRD5A1 protein CTD PMID:27388148 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [Particulate Matter results in increased phosphorylation of STAT3 protein]; Butylated Hydroxyanisole inhibits the reaction [Vanadates results in increased phosphorylation of STAT3 protein]; Butylated Hydroxyanisole inhibits the reaction [Vehicle Emissions results in increased phosphorylation of STAT3 protein] CTD PMID:17028263 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 increases expression ISO Butylated Hydroxyanisole results in increased expression of SULT1E1 mRNA CTD PMID:25922074 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tbx6 T-box transcription factor 6 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of TBX6 mRNA CTD PMID:28927898 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593 		JBrowse link
G Tbxt T-box transcription factor T decreases expression ISO Butylated Hydroxyanisole results in decreased expression of T mRNA CTD PMID:28927898 NCBI chr 1:52,298,104...52,309,813
Ensembl chr 1:52,298,099...52,305,864 		JBrowse link
G Tfeb transcription factor EB increases expression ISO Butylated Hydroxyanisole results in increased expression of TFEB protein CTD PMID:38657941 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects response to substance
decreases response to substance		 ISO
EXP		 Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid]
Butylated Hydroxyanisole affects the susceptibility to TNF protein
Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]; Butylated Hydroxyanisole inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]
Butylated Hydroxyanisole results in decreased susceptibility to TNF protein
[Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of TNF mRNA		 CTD PMID:1515551 PMID:8186192 PMID:8740460 PMID:10588948 PMID:12470298 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] CTD PMID:21220312 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]] CTD PMID:10588948 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO		 Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TP53 protein]
Butylated Hydroxyanisole inhibits the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]		 CTD PMID:18593901 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO Butylated Hydroxyanisole results in increased expression of UGT1A1 mRNA CTD PMID:18227147 PMID:19144771 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Butylated Hydroxyanisole results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 decreases expression ISO Butylated Hydroxyanisole results in decreased expression of UGT2B1 mRNA CTD PMID:19144771 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Butylated Hydroxyanisole results in increased expression of VEGFA mRNA CTD PMID:19000923 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    chemical entity 19896
      molecular entity 19896
        polyatomic entity 19848
          heteroatomic molecular entity 19806
            hydroxides 19365
              organic hydroxy compound 18978
                phenols 18676
                  2-tert-butyl-4-hydroxyanisole 127
                    butylated hydroxyanisole 127
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  ether 17326
                                    aromatic ether 16608
                                      2-tert-butyl-4-hydroxyanisole 127
                                        butylated hydroxyanisole 127
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