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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-tert-butylhydroquinone
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Accession:CHEBI:78886 term browser browse the term
Definition:A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Synonyms:exact_synonym: 2-tert-butylbenzene-1,4-diol
 related_synonym: 2-(1,1-Dimethylethyl)-1,4-benzenediol;   2-Tertiary-butylhydroquinone;   2-t-Butyl-1,4-benzenediol;   2-t-Butylhydroquinone;   2-tert-Butyl(1,4)hydroquinone;   2-tert-Butyl-1,4-benzenediol;   Formula=C10H14O2;   InChI=1S/C10H14O2/c1-10(2,3)8-6-7(11)4-5-9(8)12/h4-6,11-12H,1-3H3;   InChIKey=BGNXCDMCOKJUMV-UHFFFAOYSA-N;   MTBHQ;   Mono-tert-butylhydroquinone;   Mono-tertiarybutylhydroquinone;   SMILES=CC(C)(C)c1cc(O)ccc1O;   TBHQ;   t-Butyl hydroquinone;   t-Butylhydroquinone;   tert-Butyl-1,4-benzenediol;   tert-Butylhydroquinone;   tertiary-Butylhydroquinone
 xref: CAS:1948-33-0;   HMDB:HMDB0032062;   LINCS:LSM-36677
 xref_mesh: MESH:C018855
 xref: Reaxys:637923;   Wikipedia:Tert-Butylhydroquinone


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2-tert-butylhydroquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) increases expression EXP
ISO		 2-tert-butylhydroquinone results in increased expression of ABCC1 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCC1 protein CTD PMID:11836020 PMID:16014739 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression EXP
ISO		 2-tert-butylhydroquinone results in increased expression of ABCC2 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCC2 protein CTD PMID:11264000 PMID:11836020 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) increases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased expression of ABCG2 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCG2 protein
AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of ABCG2 protein]		 CTD PMID:17077187 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression ISO 2-tert-butylhydroquinone results in increased expression of ADH7 mRNA CTD PMID:16014739 NCBI chr 4:99,412,263...99,435,342
Ensembl chr 4:99,412,261...99,435,510 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP
ISO		 AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of ABCG2 protein]; AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA]
2-tert-butylhydroquinone results in increased activity of and results in increased localization of AHR protein		 CTD PMID:12948865 PMID:15608132 PMID:17077187 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP 2-tert-butylhydroquinone results in increased expression of AKR1B10 mRNA CTD PMID:30806763 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of AKR1C1 mRNA CTD PMID:9973208 PMID:30806763 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein] CTD PMID:23112101 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G AR androgen receptor multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; 2-tert-butylhydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 PMID:33049310 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [thallium nitrate results in decreased expression of ATP5F1A protein] CTD PMID:31726083 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334 		JBrowse link
G B4GALT1 beta-1,4-galactosyltransferase 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of B4GALT1 mRNA CTD PMID:35724838 NCBI chr 9:33,104,077...33,185,089
Ensembl chr 9:33,100,493...33,167,336 		JBrowse link
G BACH1 BTB domain and CNC homolog 1 affects localization
multiple interactions		 EXP 2-tert-butylhydroquinone affects the localization of BACH1 protein
2-tert-butylhydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; [ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein]		 CTD PMID:28645578 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 2-tert-butylhydroquinone results in decreased expression of BAX protein
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in increased expression of BAX protein]
2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein]
[2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in decreased expression of BAX protein		 CTD PMID:22275372 PMID:26878773 PMID:28583816 PMID:32565124 PMID:37075934 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression		 ISO
EXP		 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to BCL2 promoter]; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in increased expression of BCL2 protein; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of BCL2 mRNA]
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of BCL2 protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of BCL2 protein]; 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]
2-tert-butylhydroquinone results in increased expression of BCL2 mRNA; 2-tert-butylhydroquinone results in increased expression of BCL2 protein		 CTD PMID:22275372 PMID:26878773 PMID:28583816 PMID:31423616 PMID:32565124 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCO2 beta-carotene oxygenase 2 increases expression ISO 2-tert-butylhydroquinone results in increased expression of BCO2 mRNA CTD PMID:16014739 NCBI chr11:112,175,512...112,218,946
Ensembl chr11:112,175,510...112,224,699 		JBrowse link
G BLVRB biliverdin reductase B increases expression ISO 2-tert-butylhydroquinone results in increased expression of BLVRB mRNA CTD PMID:16014739 NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of CASP3 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein]
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; solanesol promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]]		 CTD PMID:22275372 PMID:25341683 PMID:25645596 PMID:26878773 PMID:28583816 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP4 caspase 4 multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP7 caspase 7 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased activity of CASP7 protein] CTD PMID:22275372 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CAT catalase multiple interactions
increases activity		 EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
2-tert-butylhydroquinone results in increased activity of CAT protein
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA]		 CTD PMID:26878773 PMID:32428544 PMID:32565124 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBR3 carbonyl reductase 3 increases expression ISO 2-tert-butylhydroquinone results in increased expression of CBR3 mRNA CTD PMID:16014739 NCBI chr21:36,135,079...36,146,562
Ensembl chr21:36,135,079...36,146,562 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CCL2 mRNA CTD PMID:35724838 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CCL20 mRNA CTD PMID:35724838 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 increases secretion EXP 2-tert-butylhydroquinone results in increased secretion of CCL5 protein CTD PMID:30806763 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CCN2 cellular communication network factor 2 decreases expression ISO 2-tert-butylhydroquinone results in decreased expression of CCN2 mRNA CTD PMID:16014739 NCBI chr 6:131,948,176...131,951,372
Ensembl chr 6:131,948,176...131,951,372 		JBrowse link
G CCND1 cyclin D1 increases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased expression of CCND1 protein
2-tert-butylhydroquinone promotes the reaction [sodium arsenite results in increased expression of CCND1 protein]		 CTD PMID:26878773 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD5L CD5 molecule like increases expression ISO 2-tert-butylhydroquinone results in increased expression of CD5L mRNA CTD PMID:16014739 NCBI chr 1:157,827,068...157,841,808
Ensembl chr 1:157,830,911...157,898,256 		JBrowse link
G CD69 CD69 molecule multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein] CTD PMID:30171972 NCBI chr12:9,752,486...9,760,901
Ensembl chr12:9,752,486...9,760,901 		JBrowse link
G CD86 CD86 molecule increases expression EXP 2-tert-butylhydroquinone results in increased expression of CD86 protein CTD PMID:19033392 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CDK4 cyclin dependent kinase 4 multiple interactions
increases expression		 EXP 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein]
2-tert-butylhydroquinone results in increased expression of CDK4 protein		 CTD PMID:26878773 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CES1 carboxylesterase 1 multiple interactions
increases expression		 EXP 2-tert-butylhydroquinone results in increased expression of and results in increased activity of CES1 protein alternative form; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form] CTD PMID:19715681 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CREBBP CREB binding protein multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; 2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]] CTD PMID:21443188 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G CREG2 cellular repressor of E1A stimulated genes 2 affects response to substance EXP CREG2 gene SNP affects the susceptibility to 2-tert-butylhydroquinone CTD PMID:25622337 NCBI chr 2:101,345,550...101,387,503
Ensembl chr 2:101,345,550...101,387,503 		JBrowse link
G CSF1 colony stimulating factor 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein]; 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein]; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein CTD PMID:23112101 NCBI chr 1:109,910,506...109,930,992
Ensembl chr 1:109,910,242...109,930,992 		JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CSF1R protein CTD PMID:23112101 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372 		JBrowse link
G CTSK cathepsin K multiple interactions ISO [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein CTD PMID:23112101 NCBI chr 1:150,796,208...150,808,260
Ensembl chr 1:150,794,880...150,809,577 		JBrowse link
G CUL3 cullin 3 multiple interactions EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] CTD PMID:18417180 PMID:30261176 NCBI chr 2:224,470,150...224,585,363
Ensembl chr 2:224,470,150...224,585,397 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CXCL1 mRNA CTD PMID:30806763 PMID:35724838 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CXCL2 mRNA CTD PMID:35724838 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CXCL8 mRNA CTD PMID:30806763 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYB5A cytochrome b5 type A increases expression ISO 2-tert-butylhydroquinone results in increased expression of CYB5A mRNA CTD PMID:16014739 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] CTD PMID:28844481 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYCS cytochrome c, somatic increases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased expression of CYCS protein
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the localization of CYCS protein]; 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of CYCS protein]		 CTD PMID:31423616 PMID:35123993 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CYP11A1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CYP11A1 protein] CTD PMID:32565124 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
increases expression
increases activity		 EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; 2-tert-butylhydroquinone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2-tert-butylhydroquinone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; FH535 inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased activity of CYP1A1 protein]; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP1A1 mRNA]
2-tert-butylhydroquinone results in increased expression of and results in increased activity of CYP1A1 protein; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased activity of CYP1A1 protein]		 CTD PMID:9973208 PMID:15608132 PMID:15627257 PMID:16581943 PMID:25174530 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases expression EXP
ISO		 2-tert-butylhydroquinone results in increased expression of CYP2A6 mRNA
2-tert-butylhydroquinone results in increased expression of CYP2A5 mRNA		 CTD PMID:24830941 PMID:29788535 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases expression EXP 2-tert-butylhydroquinone results in increased expression of CYP2C19 mRNA; 2-tert-butylhydroquinone results in increased expression of CYP2C19 protein CTD PMID:24830941 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]; 2-tert-butylhydroquinone promotes the reaction [FOS protein binds to CYP2C9 promoter]; 2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]; 2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]; JUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]; pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]
2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA; 2-tert-butylhydroquinone results in increased expression of CYP2C9 protein		 CTD PMID:24830941 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions
increases expression		 EXP 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein]
2-tert-butylhydroquinone results in increased expression of DDIT3 protein		 CTD PMID:25341683 PMID:35724838 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DSC3 desmocollin 3 increases expression ISO 2-tert-butylhydroquinone results in increased expression of DSC3 mRNA CTD PMID:16014739 NCBI chr18:30,989,365...31,042,742
Ensembl chr18:30,989,365...31,042,815 		JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of DUSP1 mRNA CTD PMID:30806763 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195 		JBrowse link
G EDN1 endothelin 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of EDN1 mRNA CTD PMID:35724838 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGF epidermal growth factor multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein] CTD PMID:36343453 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression
multiple interactions		 ISO
EXP		 2-tert-butylhydroquinone results in increased expression of EPHX1 mRNA
NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of EPHX1 exon]
2-tert-butylhydroquinone results in increased expression of EPHX1 exon; 2-tert-butylhydroquinone results in increased expression of EPHX1 protein alternative form		 CTD PMID:20650352 PMID:24704207 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G ESD esterase D increases expression ISO 2-tert-butylhydroquinone results in increased expression of ESD mRNA CTD PMID:16014739 NCBI chr13:46,771,256...46,797,700
Ensembl chr13:46,771,256...46,797,420 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP 2-tert-butylhydroquinone binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G ESR2 estrogen receptor 2 multiple interactions EXP 2-tert-butylhydroquinone binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FGF1 fibroblast growth factor 1 multiple interactions ISO 2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein] CTD PMID:16524372 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070 		JBrowse link
G FGF18 fibroblast growth factor 18 decreases expression ISO 2-tert-butylhydroquinone results in decreased expression of FGF18 mRNA CTD PMID:16014739 NCBI chr 5:171,419,647...171,457,626
Ensembl chr 5:171,419,647...171,457,626 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of FOS protein
2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of FOS protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FOS protein]; 2-tert-butylhydroquinone promotes the reaction [FOS protein binds to CYP2C9 promoter]		 CTD PMID:24830941 PMID:28844481 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of FSHB protein] CTD PMID:32565124 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions
increases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 PMID:25003661 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634 		JBrowse link
G FTL ferritin light chain increases expression ISO 2-tert-butylhydroquinone results in increased expression of FTL1 mRNA CTD PMID:16014739 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,967,896 		JBrowse link
G FTMT ferritin mitochondrial increases expression ISO 2-tert-butylhydroquinone results in increased expression of FTMT mRNA CTD PMID:15664434 NCBI chr 5:121,851,882...121,852,833
Ensembl chr 5:121,851,882...121,852,833 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of G6PD mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of G6PD protein] CTD PMID:35478295 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GABPA GA binding protein transcription factor subunit alpha affects localization EXP 2-tert-butylhydroquinone affects the localization of GABPA protein CTD PMID:16308312 NCBI chr21:25,734,972...25,772,460
Ensembl chr21:25,734,570...25,772,460 		JBrowse link
G GATA3 GATA binding protein 3 increases activity ISO [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased activity of GATA3 protein CTD PMID:22250088 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit affects expression
decreases expression
increases expression
multiple interactions
increases activity		 EXP
ISO		 2-tert-butylhydroquinone affects the expression of GCLC mRNA
2-tert-butylhydroquinone results in decreased expression of GCLC mRNA
2-tert-butylhydroquinone results in increased expression of GCLC mRNA
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]; [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]		 CTD PMID:7955076 PMID:10978506 PMID:12007577 PMID:15946948 PMID:16014739 More... NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
decreases expression
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA]
2-tert-butylhydroquinone results in decreased expression of GCLM mRNA
2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]; [2,2',4,4'-tetrabromodiphenyl ether co-treated with 2-tert-butylhydroquinone] results in increased expression of GCLM mRNA		 CTD PMID:10978506 PMID:12007577 PMID:12081989 PMID:16014739 PMID:19183254 More... NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456 		JBrowse link
G GPR87 G protein-coupled receptor 87 increases expression ISO 2-tert-butylhydroquinone results in increased expression of GPR87 mRNA CTD PMID:16014739 NCBI chr 3:151,294,086...151,316,820
Ensembl chr 3:151,294,086...151,316,820 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Matrines results in increased expression of GPT protein] CTD PMID:37716422 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX1 glutathione peroxidase 1 increases expression
multiple interactions		 ISO 2-tert-butylhydroquinone results in increased expression of GPX1 protein
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]		 CTD PMID:28583816 PMID:32565124 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of GPX4 mRNA; 2-tert-butylhydroquinone results in increased expression of GPX4 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of GPX4 protein]
2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of GPX4 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of GPX4 protein]		 CTD PMID:37393915 PMID:37716422 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of GRIA1 mRNA CTD PMID:16014739 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GSR glutathione-disulfide reductase increases activity
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased activity of GSR protein
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of GSR protein]
2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]		 CTD PMID:12572858 PMID:24970285 PMID:32565124 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSS glutathione synthetase increases expression
multiple interactions		 ISO 2-tert-butylhydroquinone results in increased expression of GSS mRNA
[2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of GSS mRNA		 CTD PMID:10978506 PMID:19183254 PMID:32428544 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression
multiple interactions		 ISO 2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA; 2-tert-butylhydroquinone results in increased expression of GSTA2 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2]; 2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein]		 CTD PMID:7587946 PMID:12242683 PMID:15155840 PMID:15319326 PMID:15357004 More... NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression
increases activity
multiple interactions		 ISO 2-tert-butylhydroquinone results in increased expression of GSTA5 mRNA
2-tert-butylhydroquinone results in increased activity of GSTA1 protein
Tetradecanoylphorbol Acetate promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA]		 CTD PMID:7568053 PMID:15627257 PMID:16014739 PMID:20650352 NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of GSTM1 protein
2-tert-butylhydroquinone results in increased expression of GSTM1 mRNA
[2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of GSTM1 mRNA		 CTD PMID:21443188 PMID:32428544 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 increases expression ISO
EXP		 2-tert-butylhydroquinone results in increased expression of GSTP1 protein
2-tert-butylhydroquinone results in increased expression of GSTP1 mRNA		 CTD PMID:12680784 PMID:15533597 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G GZMB granzyme B multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GZMB protein] CTD PMID:30171972 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267 		JBrowse link
G H2AX H2A.X variant histone multiple interactions
increases expression		 ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein]
2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of H2AX protein]
2-tert-butylhydroquinone results in increased expression of H2AX protein		 CTD PMID:28583816 PMID:35123993 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HBG1 hemoglobin subunit gamma 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of HBG1 mRNA CTD PMID:21464371 NCBI chr11:5,248,269...5,249,857
Ensembl chr11:5,248,269...5,249,857 		JBrowse link
G HES1 hes family bHLH transcription factor 1 decreases expression ISO 2-tert-butylhydroquinone results in decreased expression of HES1 protein CTD PMID:29663635 NCBI chr 3:194,136,148...194,138,732
Ensembl chr 3:194,136,148...194,138,732 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein] CTD PMID:23112101 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP
ISO		 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; [2-tert-butylhydroquinone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; Calcium affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]
2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA; 2-tert-butylhydroquinone results in increased expression of HMOX1 protein
2-tert-butylhydroquinone inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [decamethrin results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in increased expression of HMOX1 protein]; [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride; FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of HMOX1 mRNA; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]		 CTD PMID:8612205 PMID:10473555 PMID:10874044 PMID:10975858 PMID:16014739 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSD17B3 hydroxysteroid 17-beta dehydrogenase 3 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of HSD17B3 mRNA] CTD PMID:32565124 NCBI chr 9:96,235,306...96,302,176
Ensembl chr 9:96,235,306...96,302,176 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of HSD3B1 mRNA] CTD PMID:32565124 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G HSF1 heat shock transcription factor 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of HSF1 mRNA CTD PMID:30309986 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein] CTD PMID:25341683 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:35724838 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of IFNG mRNA; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:22250088 PMID:23942037 PMID:30171972 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IKBKB protein modified form] CTD PMID:28844481 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression		 ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of IL10 mRNA]
2-tert-butylhydroquinone results in increased expression of IL10 mRNA		 CTD PMID:32565124 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]] CTD PMID:25680285 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL23A protein binds to IL12B protein]]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]] CTD PMID:25680285 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL13 interleukin 13 multiple interactions ISO [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL13 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL13 mRNA CTD PMID:22250088 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL16 interleukin 16 increases secretion EXP 2-tert-butylhydroquinone results in increased secretion of IL16 protein CTD PMID:30806763 NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058 		JBrowse link
G IL17D interleukin 17D multiple interactions EXP 2-tert-butylhydroquinone promotes the reaction [Oxygen deficiency results in increased expression of IL17D protein] CTD PMID:34023435 NCBI chr13:20,701,513...20,723,098
Ensembl chr13:20,702,127...20,723,098 		JBrowse link
G IL1A interleukin 1 alpha increases expression EXP 2-tert-butylhydroquinone results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of and results in increased secretion of IL1B protein]
2-tert-butylhydroquinone inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [IL1B protein affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; 2-tert-butylhydroquinone inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]		 CTD PMID:28583816 PMID:28844481 PMID:35724838 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 decreases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in decreased expression of IL2 mRNA
2-tert-butylhydroquinone results in decreased expression of and results in decreased secretion of IL2 protein		 CTD PMID:23945499 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL23A protein binds to IL12B protein]] CTD PMID:25680285 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha decreases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in decreased expression of IL2RA mRNA; 2-tert-butylhydroquinone results in decreased expression of IL2RA protein
2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]		 CTD PMID:23945499 PMID:30171972 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370 		JBrowse link
G IL4 interleukin 4 multiple interactions ISO
EXP		 [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL4 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL4 mRNA
2-tert-butylhydroquinone promotes the reaction [Oxygen deficiency results in increased expression of IL4 protein]		 CTD PMID:22250088 PMID:34023435 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL5 interleukin 5 multiple interactions ISO [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL5 protein CTD PMID:22250088 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased secretion of IL6 protein]; 2-tert-butylhydroquinone promotes the reaction [Oxygen deficiency results in increased expression of IL6 protein]
2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of and results in increased secretion of IL6 protein]		 CTD PMID:25305463 PMID:28844481 PMID:34023435 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 EXP 2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]; 2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]; JUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]; pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein] CTD PMID:24830941 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KDR kinase insert domain receptor increases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased expression of KDR protein
[cyanoginosin LR co-treated with 2-tert-butylhydroquinone] results in increased expression of KDR protein		 CTD PMID:36206955 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions
increases expression
affects binding
decreases response to substance		 EXP
ISO		 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]
2-tert-butylhydroquinone results in increased expression of KEAP1 protein
2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein]
2-tert-butylhydroquinone binds to KEAP1 protein
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]
KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone		 CTD PMID:18417180 PMID:18512965 PMID:19033392 PMID:19808700 PMID:23589329 More... NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of LHB protein] CTD PMID:32565124 NCBI chr19:49,015,980...49,019,498
Ensembl chr19:49,015,980...49,017,091 		JBrowse link
G MAFG MAF bZIP transcription factor G decreases expression EXP 2-tert-butylhydroquinone results in decreased expression of MAFG mRNA CTD PMID:35724838 NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of MAPK1 protein]; 2-tert-butylhydroquinone inhibits the reaction [arsenite results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24830941 PMID:36343453 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of MAPK3 protein]; 2-tert-butylhydroquinone inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:24830941 PMID:36343453 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCHR1 melanin concentrating hormone receptor 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of MCHR1 mRNA CTD PMID:16014739 NCBI chr22:40,679,484...40,682,812
Ensembl chr22:40,679,273...40,682,812 		JBrowse link
G MFN2 mitofusin 2 increases expression
multiple interactions		 ISO 2-tert-butylhydroquinone results in increased expression of MFN2 protein
2-tert-butylhydroquinone inhibits the reaction [thallium nitrate results in decreased expression of MFN2 protein]		 CTD PMID:31726083 NCBI chr 1:11,980,444...12,013,508
Ensembl chr 1:11,980,181...12,015,211 		JBrowse link
G MIR380 microRNA 380 multiple interactions
increases expression		 ISO Paraquat inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MIR380] CTD PMID:31368498 NCBI chr14:101,025,017...101,025,077
Ensembl chr14:101,025,017...101,025,077 		JBrowse link
G MT1X metallothionein 1X multiple interactions
increases expression		 ISO 2-tert-butylhydroquinone promotes the reaction [Cycloheximide results in increased expression of MT1 mRNA]; Cycloheximide promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]]; MTF1 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Zinc deficiency inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA] CTD PMID:14998373 PMID:19276070 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G MT2A metallothionein 2A increases expression ISO 2-tert-butylhydroquinone results in increased expression of MT2 mRNA CTD PMID:14998373 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MTF1 metal regulatory transcription factor 1 multiple interactions ISO MTF1 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA] CTD PMID:14998373 NCBI chr 1:37,809,574...37,859,592
Ensembl chr 1:37,809,574...37,859,592 		JBrowse link
G MTRF1 mitochondrial translation release factor 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of MTRF1 mRNA CTD PMID:16014739 NCBI chr13:41,216,369...41,312,038
Ensembl chr13:41,216,369...41,263,577 		JBrowse link
G NFATC1 nuclear factor of activated T cells 1 multiple interactions ISO [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein CTD PMID:23112101 NCBI chr18:79,395,930...79,529,323
Ensembl chr18:79,395,856...79,529,325 		JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of NFE2L1 protein CTD PMID:33838154 NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
affects localization
increases response to substance
increases expression
increases activity
affects response to substance
decreases response to substance
increases ubiquitination
increases stability
affects binding		 EXP
ISO		 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein]; 2-tert-butylhydroquinone affects the localization of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [arsenite results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone promotes the reaction [Oxygen deficiency results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; 2-tert-butylhydroquinone results in increased expression of and affects the localization of NFE2L2 protein; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased susceptibility to arsenite; [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine; brusatol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; NFE2L2 affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of EPHX1 exon]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form]
2-tert-butylhydroquinone affects the localization of NFE2L2 protein
NFE2L2 protein mutant form results in increased susceptibility to 2-tert-butylhydroquinone
2-tert-butylhydroquinone results in increased expression of NFE2L2 mRNA; 2-tert-butylhydroquinone results in increased expression of NFE2L2 protein
NFE2L2 protein affects the susceptibility to 2-tert-butylhydroquinone
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin affects the expression of and affects the localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to BCL2 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone results in increased expression of and affects the localization of NFE2L2 protein; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased activity of TBX21 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of IFNG mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL13 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL4 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL5 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL13 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL4 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in decreased expression of BAX protein; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in increased expression of BCL2 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 2-tert-butylhydroquinone] results in increased expression of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [2-tert-butylhydroquinone results in increased ubiquitination of NFE2L2 protein]; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of BCL2 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
2-tert-butylhydroquinone results in increased activity of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased activity of GATA3 protein
2-tert-butylhydroquinone affects the localization of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of and results in decreased localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone results in increased expression of and results in increased localization of NFE2L2 protein; [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride; [thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of NFE2L2 protein; decamethrin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein]; NFE2L2 gene mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]
NFE2L2 protein results in decreased susceptibility to 2-tert-butylhydroquinone
2-tert-butylhydroquinone binds to NFE2L2 protein		 CTD PMID:10473555 PMID:10874044 PMID:12446695 PMID:14510636 PMID:14998373 More... NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]
2-tert-butylhydroquinone inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of NFKBIA protein]		 CTD PMID:28583816 PMID:35724838 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NKD1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of NKD1 mRNA CTD PMID:16014739 NCBI chr16:50,548,396...50,649,249
Ensembl chr16:50,548,396...50,649,249 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 protein] CTD PMID:32073640 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOTCH1 notch receptor 1 decreases expression ISO 2-tert-butylhydroquinone results in decreased expression of NOTCH1 protein CTD PMID:29663635 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases activity
decreases expression
increases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased activity of NQO1 protein
2-tert-butylhydroquinone results in decreased expression of NQO1 mRNA
2-tert-butylhydroquinone results in increased expression of NQO1 mRNA; 2-tert-butylhydroquinone results in increased expression of NQO1 protein
2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of NQO1 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; AG-879 inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Cycloheximide inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Paraquat inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Zinc promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]
2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Emodin results in decreased expression of NQO1 protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of NQO1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of NQO1 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of NQO1 protein; [thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 protein; Dexamethasone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NQO1 protein]; Dexamethasone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]
2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA]; [lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA; [sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA; [sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 protein; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; NFE2L2 affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA]		 CTD PMID:7587946 PMID:9029048 PMID:11163336 PMID:14510636 PMID:14998373 More... NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP 2-tert-butylhydroquinone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP 2-tert-butylhydroquinone binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G OLR1 oxidized low density lipoprotein receptor 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of OLR1 mRNA CTD PMID:35724838 NCBI chr12:10,158,301...10,176,266
Ensembl chr12:10,158,301...10,172,138 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [Atorvastatin results in increased cleavage of PARP1 protein] CTD PMID:31423616 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of PCNA protein] CTD PMID:32565124 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PDGFB platelet derived growth factor subunit B increases expression EXP 2-tert-butylhydroquinone results in increased expression of PDGFB mRNA CTD PMID:35724838 NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982 		JBrowse link
G PGD phosphogluconate dehydrogenase increases expression ISO 2-tert-butylhydroquinone results in increased expression of PGD mRNA CTD PMID:16014739 NCBI chr 1:10,399,064...10,420,511
Ensembl chr 1:10,398,592...10,420,511 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO
EXP		 2-tert-butylhydroquinone binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRDX1 peroxiredoxin 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of PRDX1 mRNA CTD PMID:16014739 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732 		JBrowse link
G PRF1 perforin 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein] CTD PMID:30171972 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha increases expression ISO 2-tert-butylhydroquinone results in increased expression of PRKACA mRNA CTD PMID:16014739 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 decreases expression EXP 2-tert-butylhydroquinone results in decreased expression of PRKAG2 mRNA CTD PMID:35724838 NCBI chr 7:151,556,127...151,877,115
Ensembl chr 7:151,556,124...151,877,214 		JBrowse link
G PROCR protein C receptor increases expression ISO 2-tert-butylhydroquinone results in increased expression of PROCR mRNA CTD PMID:16014739 NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240 		JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions EXP PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] CTD PMID:23829535 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G PTGR1 prostaglandin reductase 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of PTGR1 mRNA CTD PMID:16014739 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of PTGS2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein]
2-tert-butylhydroquinone inhibits the reaction [Matrines results in increased expression of PTGS2 mRNA]		 CTD PMID:28583816 PMID:37393915 PMID:37716422 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit increases expression ISO 2-tert-butylhydroquinone results in increased expression of REL mRNA CTD PMID:16014739 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation		 ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased activity of RELA protein]
2-tert-butylhydroquinone results in decreased phosphorylation of RELA protein
2-tert-butylhydroquinone inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [IL1B protein affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of RELA protein]
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA protein]; 2-tert-butylhydroquinone promotes the reaction [Particulate Matter results in decreased phosphorylation of RELA protein]		 CTD PMID:28583816 PMID:28844481 PMID:32073640 PMID:32565124 PMID:35724838 More... NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RORC RAR related orphan receptor C increases expression ISO 2-tert-butylhydroquinone results in increased expression of RORC mRNA CTD PMID:16014739 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 increases expression ISO 2-tert-butylhydroquinone results in increased expression of SLC3A2 mRNA CTD PMID:19183254 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC40A1 solute carrier family 40 member 1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of SLC40A1 mRNA CTD PMID:16014739 NCBI chr 2:189,560,590...189,580,786
Ensembl chr 2:189,560,590...189,583,758 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases expression
multiple interactions		 ISO
EXP		 2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNA
2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNA; 2-tert-butylhydroquinone results in increased expression of SLC7A11 protein
2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of SLC7A11 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Matrines results in decreased expression of SLC7A11 protein]		 CTD PMID:19183254 PMID:37716422 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of SOD1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1 protein] CTD PMID:28844481 PMID:32565124 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression
multiple interactions		 ISO
EXP		 2-tert-butylhydroquinone results in increased expression of SOD2 mRNA
2-tert-butylhydroquinone inhibits the reaction [Atorvastatin affects the expression of SOD2 protein]
2-tert-butylhydroquinone results in increased expression of SOD2 protein
[2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of SOD2 mRNA		 CTD PMID:31423616 PMID:32428544 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SP1 Sp1 transcription factor increases expression EXP 2-tert-butylhydroquinone results in increased expression of SP1 protein CTD PMID:36206955 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SQOR sulfide quinone oxidoreductase increases expression ISO 2-tert-butylhydroquinone results in increased expression of SQOR mRNA CTD PMID:16014739 NCBI chr15:45,631,148...45,691,281
Ensembl chr15:45,631,148...45,691,281 		JBrowse link
G SQSTM1 sequestosome 1 increases expression
decreases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of SQSTM1 protein
2-tert-butylhydroquinone results in decreased expression of SQSTM1 mRNA
[thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of SQSTM1 protein		 CTD PMID:23589329 PMID:31726083 PMID:35724838 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of SRC protein CTD PMID:23112101 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SRXN1 sulfiredoxin 1 increases expression
decreases expression		 ISO
EXP		 2-tert-butylhydroquinone results in increased expression of SRXN1 mRNA
2-tert-butylhydroquinone results in increased expression of SRXN1 protein
2-tert-butylhydroquinone results in decreased expression of SRXN1 mRNA		 CTD PMID:16014739 PMID:22003191 PMID:35724838 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of STAR mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of STAR protein] CTD PMID:32565124 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression EXP 2-tert-butylhydroquinone results in increased expression of TAP1 mRNA CTD PMID:35724838 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions ISO [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased activity of TBX21 protein CTD PMID:22250088 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TGFA transforming growth factor alpha multiple interactions EXP 2-tert-butylhydroquinone inhibits the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein] CTD PMID:36343453 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193 		JBrowse link
G THRB thyroid hormone receptor beta multiple interactions EXP 2-tert-butylhydroquinone binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP		 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]
2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF protein]		 CTD PMID:28583816 PMID:32073640 PMID:32565124 PMID:35724838 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 increases expression
multiple interactions		 EXP 2-tert-butylhydroquinone results in increased expression of TNFAIP3 mRNA; 2-tert-butylhydroquinone results in increased expression of TNFAIP3 protein
2-tert-butylhydroquinone inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]		 CTD PMID:35724838 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TNFRSF9 TNF receptor superfamily member 9 increases expression EXP 2-tert-butylhydroquinone results in increased expression of TNFRSF9 mRNA CTD PMID:35724838 NCBI chr 1:7,915,871...7,940,839
Ensembl chr 1:7,915,871...7,943,165 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions ISO 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein]; 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein]; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CSF1R protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of SRC protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein CTD PMID:23112101 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TOB1 transducer of ERBB2, 1 decreases expression ISO 2-tert-butylhydroquinone results in decreased expression of TOB1 mRNA CTD PMID:16014739 NCBI chr17:50,862,223...50,867,978
Ensembl chr17:50,862,223...50,867,978 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of TP53 protein
2-tert-butylhydroquinone inhibits the reaction [Emodin results in increased expression of TP53 protein]
2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of TP53 protein]		 CTD PMID:35123993 PMID:37393915 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRIB3 tribbles pseudokinase 3 decreases expression EXP 2-tert-butylhydroquinone results in decreased expression of TRIB3 mRNA CTD PMID:35724838 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression
decreases expression		 EXP
ISO		 2-tert-butylhydroquinone results in increased expression of TXNRD1 mRNA
2-tert-butylhydroquinone results in decreased expression of TXNRD1 mRNA		 CTD PMID:12949356 PMID:16014739 PMID:30806763 PMID:35724838 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO 2-tert-butylhydroquinone results in increased expression of UGT1A1 mRNA CTD PMID:20650352 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression
increases activity		 EXP
ISO		 AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA]
2-tert-butylhydroquinone results in increased activity of UGT1A6 protein		 CTD PMID:10220484 PMID:12948865 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases expression EXP 2-tert-butylhydroquinone results in increased expression of UGT1A9 mRNA CTD PMID:10220484 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 increases expression EXP 2-tert-butylhydroquinone results in increased expression of UGT2B7 mRNA CTD PMID:10220484 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 increases expression EXP 2-tert-butylhydroquinone results in increased expression of VCAM1 mRNA CTD PMID:35724838 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP 2-tert-butylhydroquinone results in decreased expression of VEGFA mRNA CTD PMID:35724838 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    role 26325
      chemical role 24361
        antioxidant 17555
          food antioxidant 1135
            2-tert-butylhydroquinone 178
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    p-block element atom 26216
                      carbon group element atom 25661
                        carbon atom 25623
                          organic molecular entity 25623
                            organic molecule 25366
                              organic cyclic compound 24419
                                organic aromatic compound 24014
                                  phenols 21235
                                    benzenediols 9925
                                      hydroquinones 1207
                                        2-tert-butylhydroquinone 178
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