MIR380 (microRNA 380) - Rat Genome Database

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Gene: MIR380 (microRNA 380) Homo sapiens
Analyze
Symbol: MIR380
Name: microRNA 380
RGD ID: 1350037
HGNC Page HGNC:31873
Description: Predicted to be involved in energy homeostasis. Predicted to act upstream of or within cellular response to leukemia inhibitory factor.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-380; mir-380; MIR380-3p; MIRN380
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,025,017 - 101,025,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,025,017 - 101,025,077 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,491,354 - 101,491,414 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,561,106 - 100,561,166 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,547,386 - 81,547,446 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,674,837 - 81,674,897 (+)NCBIHuRef
CHM1_114101,429,490 - 101,429,550 (+)NCBICHM1_1
T2T-CHM13v2.01495,260,461 - 95,260,521 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR380HumanKagami-Ogata syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Paternal uniparental disomy 14ClinVarPMID:18176563
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR380Humanadult respiratory distress syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
MIR380HumanCocaine-Related Disorders  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:20643829
MIR380Humanpapillary thyroid carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28030816

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR380Human1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOMir380 (Mus musculus)6480464NFE2L2 protein affects the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:29071302
MIR380Human1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOMir380 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:29071302
MIR380Human17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of MIR380 mRNACTDPMID:22113133
MIR380Human2-tert-butylhydroquinone increases expressionISOMir380 (Mus musculus)64804642-tert-butylhydroquinone results in increased expression of MIR380CTDPMID:31368498
MIR380Human2-tert-butylhydroquinone multiple interactionsISOMir380 (Mus musculus)6480464Paraquat inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MIR380]CTDPMID:31368498
MIR380Humanbenzene increases expressionISOMir380 (Mus musculus)6480464Benzene results in increased expression of MIR380 mRNACTDPMID:32105654
MIR380Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of MIR380 promoterCTDPMID:27901495
MIR380Humancadmium atom multiple interactionsISOMir380 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR380 mRNACTDPMID:28892167
MIR380Humancadmium dichloride multiple interactionsISOMir380 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR380 mRNACTDPMID:28892167
MIR380Humancocaine increases expressionISOMir380 (Mus musculus)6480464Cocaine results in increased expression of MIR380 mRNACTDPMID:20643829
MIR380Humancocaine multiple interactionsISOMir380 (Mus musculus)6480464AGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]CTDPMID:20643829
MIR380HumanDiosbulbin B increases expressionISOMir380 (Mus musculus)6480464diosbulbin B results in increased expression of MIR380 mRNACTDPMID:28844483
MIR380Humanmethylisothiazolinone increases expressionEXP 64804642-methyl-4-isothiazolin-3-one results in increased expression of MIR380 mRNACTDPMID:31629900
MIR380Humanmonocrotaline decreases expressionISOMir380 (Mus musculus)6480464Monocrotaline results in decreased expression of MIR380 mRNACTDPMID:28818515
MIR380Humanp-cresol increases expressionISOMir380 (Mus musculus)64804644-cresol results in increased expression of MIR380 mRNACTDPMID:32105654
MIR380Humanparaquat multiple interactionsISOMir380 (Mus musculus)6480464NFE2L2 protein affects the reaction [Paraquat affects the expression of MIR380 mRNA] more ...CTDPMID:29071302 and PMID:31368498
MIR380Humanparaquat affects expressionISOMir380 (Mus musculus)6480464Paraquat affects the expression of MIR380 mRNACTDPMID:29071302
MIR380Humanparaquat decreases expressionISOMir380 (Mus musculus)6480464Paraquat results in decreased expression of MIR380CTDPMID:31368498
MIR380Humanparaquat increases response to substanceISOMir380 (Mus musculus)6480464MIR380 results in increased susceptibility to ParaquatCTDPMID:31368498
MIR380Humanphenobarbital affects expressionISOMir380 (Mus musculus)6480464Phenobarbital affects the expression of MIR380 mRNACTDPMID:23091169

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR380Humancellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOMir380 (Mus musculus)9068941 PMID:20439489MGIPMID:20439489
MIR380Humanenergy homeostasis involved_inISOMir380 (Mus musculus)9068941 PMID:25124681MGIPMID:25124681


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:15310658   PMID:15538371   PMID:16381832   PMID:17604727   PMID:20871609   PMID:21037258   PMID:27835701   PMID:29743236   PMID:31821848   PMID:35758158   PMID:38220171  



MIR380
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,025,017 - 101,025,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,025,017 - 101,025,077 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,491,354 - 101,491,414 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,561,106 - 100,561,166 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,547,386 - 81,547,446 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,674,837 - 81,674,897 (+)NCBIHuRef
CHM1_114101,429,490 - 101,429,550 (+)NCBICHM1_1
T2T-CHM13v2.01495,260,461 - 95,260,521 (+)NCBIT2T-CHM13v2.0
Mir380
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,678,237 - 109,678,297 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,678,237 - 109,678,297 (+)EnsemblGRCm39 Ensembl
GRCm3812109,711,803 - 109,711,863 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,711,803 - 109,711,863 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,950,013 - 110,950,073 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,909,029 - 110,909,089 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI

.

1 to 10 of 44 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q32.2-32.33(chr14:100309382-106855263)x1 copy number loss See cases [RCV000050938] Chr14:100309382..106855263 [GRCh38]
Chr14:100775719..107263478 [GRCh37]
Chr14:99845472..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:97938637-106855263)x1 copy number loss See cases [RCV000050696] Chr14:97938637..106855263 [GRCh38]
Chr14:98404974..107263478 [GRCh37]
Chr14:97474727..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100590353-106855264)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051553]|See cases [RCV000051553] Chr14:100590353..106855264 [GRCh38]
Chr14:101056690..107263479 [GRCh37]
Chr14:100126443..106334524 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:100808300-106855263)x1 copy number loss See cases [RCV000051113] Chr14:100808300..106855263 [GRCh38]
Chr14:101274637..107263478 [GRCh37]
Chr14:100344390..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q31.2-32.33(chr14:83912345-106855405)x3 copy number gain See cases [RCV000052294] Chr14:83912345..106855405 [GRCh38]
Chr14:84378689..107263620 [GRCh37]
Chr14:83448442..106334665 [NCBI36]
Chr14:14q31.2-32.33
pathogenic
GRCh38/hg38 14q31.3-32.33(chr14:86094030-106832642)x3 copy number gain See cases [RCV000052295] Chr14:86094030..106832642 [GRCh38]
Chr14:86560374..107240869 [GRCh37]
Chr14:85630127..106311914 [NCBI36]
Chr14:14q31.3-32.33
pathogenic
GRCh38/hg38 14q32.13-32.33(chr14:94628219-106451054)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052298]|See cases [RCV000052298] Chr14:94628219..106451054 [GRCh38]
Chr14:95094556..106906960 [GRCh37]
Chr14:94164309..105978005 [NCBI36]
Chr14:14q32.13-32.33
pathogenic
GRCh38/hg38 14q32.12-32.33(chr14:91455861-106832642)x3 copy number gain See cases [RCV000052296] Chr14:91455861..106832642 [GRCh38]
Chr14:91922205..107240869 [GRCh37]
Chr14:90991958..106311914 [NCBI36]
Chr14:14q32.12-32.33
pathogenic
GRCh38/hg38 14q32.2-32.33(chr14:99831655-106855263)x1 copy number loss See cases [RCV000133831] Chr14:99831655..106855263 [GRCh38]
Chr14:100297992..107263478 [GRCh37]
Chr14:99367745..106334523 [NCBI36]
Chr14:14q32.2-32.33
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
1 to 10 of 44 rows

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TP53hsa-miR-380-5pOncomiRDBexternal_infoNANA20871609

Predicted Targets
Summary Value
Count of predictions:20260
Count of gene targets:8295
Count of transcripts:15228
Interacting mature miRNAs:hsa-miR-380-3p, hsa-miR-380-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
1 3 4 4 36 11 14 1 1 16 1 7 30 25 5 38 4 15 12



Ensembl Acc Id: ENST00000362112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl14101,025,017 - 101,025,077 (+)Ensembl
RefSeq Acc Id: NR_029872
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3814101,025,017 - 101,025,077 (+)NCBI
GRCh3714101,491,354 - 101,491,414 (+)RGD
Celera1481,547,386 - 81,547,446 (+)RGD
HuRef1481,674,837 - 81,674,897 (+)ENTREZGENE
CHM1_114101,429,490 - 101,429,550 (+)NCBI
T2T-CHM13v2.01495,260,461 - 95,260,521 (+)NCBI
Sequence:


1 to 13 of 13 rows
Database
Acc Id
Source(s)
COSMIC MIR380 COSMIC
Ensembl Genes ENSG00000198982 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362112 ENTREZGENE
GTEx ENSG00000198982 GTEx
HGNC ID HGNC:31873 ENTREZGENE
Human Proteome Map MIR380 Human Proteome Map
miRBase MI0000788 ENTREZGENE
NCBI Gene 494329 ENTREZGENE
OMIM 613654 OMIM
PharmGKB PA164722699 PharmGKB
RNAcentral URS00002CAE0C RNACentral
  URS000075BE5F RNACentral
  URS000075D37E RNACentral
1 to 13 of 13 rows