PRKACA (protein kinase cAMP-activated catalytic subunit alpha) - Rat Genome Database

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Gene: PRKACA (protein kinase cAMP-activated catalytic subunit alpha) Homo sapiens
Analyze
Symbol: PRKACA
Name: protein kinase cAMP-activated catalytic subunit alpha
RGD ID: 1344608
HGNC Page HGNC
Description: Exhibits enzyme binding activity; protein kinase A regulatory subunit binding activity; and protein kinase activity. Involved in several processes, including cellular response to glucose stimulus; regulation of bicellular tight junction assembly; and regulation of osteoblast differentiation. Localizes to several cellular components, including cAMP-dependent protein kinase complex; nucleotide-activated protein kinase complex; and sperm midpiece. Colocalizes with axoneme. Implicated in adrenal cortical adenoma; congestive heart failure; and primary pigmented nodular adrenocortical disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAFD1; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC102831; MGC48865; PKA C-alpha; PKACA; PPNAD4; protein kinase A catalytic subunit
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
arsenite(3-)  (ISO)
asbestos  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
BAPTA  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bucladesine  (ISO)
buprenorphine  (ISO)
buspirone  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captopril  (ISO)
chaetocin  (ISO)
cisplatin  (EXP)
clenbuterol  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
dexamethasone  (ISO)
dicrotophos  (EXP)
dobutamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fluoranthene  (ISO)
formaldehyde  (EXP)
genistein  (EXP)
genistein 7-O-beta-D-glucoside  (EXP)
glycitein  (EXP)
glycitin  (EXP)
glyphosate  (EXP)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
hydroxysafflor yellow A  (ISO)
KT 5720  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
Licarin A  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
ochratoxin A  (EXP)
oxidopamine  (ISO)
oxycodone  (ISO)
panobinostat  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
pregabalin  (ISO)
prostaglandin E2  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
sulindac  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
taurolithocholic acid  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
theophylline  (EXP)
thioacetamide  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
Tylophorine  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling using intracellular calcium source  (TAS)
cell communication by electrical coupling involved in cardiac conduction  (TAS)
cellular response to cold  (IEA,ISO)
cellular response to epinephrine stimulus  (TAS)
cellular response to glucose stimulus  (IDA)
cellular response to heat  (IDA)
cellular response to parathyroid hormone stimulus  (IEA,ISO)
circadian sleep/wake cycle, REM sleep  (ISO)
cytokine-mediated signaling pathway  (TAS)
high-density lipoprotein particle assembly  (TAS)
mesoderm formation  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
mRNA processing  (IDA)
negative regulation of meiotic cell cycle  (ISO)
negative regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  (IEA,ISO)
neural tube closure  (IEA,ISO)
peptidyl-serine phosphorylation  (IDA,IMP,ISO,TAS)
peptidyl-threonine phosphorylation  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of protein export from nucleus  (IEA,ISO)
protein autophosphorylation  (IEA,ISO)
protein kinase A signaling  (IBA)
protein localization to lipid droplet  (IEA,ISO)
protein phosphorylation  (IDA,IEA,ISO,NAS)
regulation of bicellular tight junction assembly  (IDA)
regulation of cardiac conduction  (TAS)
regulation of cardiac muscle contraction  (TAS)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (TAS)
regulation of cell cycle  (ISS)
regulation of cellular respiration  (ISO)
regulation of cytosolic calcium ion concentration  (TAS)
regulation of heart rate  (TAS)
regulation of macroautophagy  (TAS)
regulation of osteoblast differentiation  (IDA)
regulation of proteasomal protein catabolic process  (IDA)
regulation of protein binding  (TAS)
regulation of protein processing  (IEA,ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (TAS)
regulation of synaptic transmission, glutamatergic  (ISO)
renal water homeostasis  (TAS)
sperm capacitation  (ISS)
spontaneous exocytosis of neurotransmitter  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (EXP)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (EXP)
amiodarone pharmacodynamics pathway  (EXP)
amlodipine pharmacodynamics pathway  (EXP)
apoptotic cell death pathway  (IEA)
atenolol pharmacodynamics pathway  (EXP)
betaxolol pharmacodynamics pathway  (EXP)
bile acid transport pathway  (IEA)
bisoprolol pharmacodynamics pathway  (EXP)
bupranolol drug pathway  (EXP)
bupranolol pharmacodynamics pathway  (EXP)
carvedilol pharmacodynamics pathway  (EXP)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (EXP)
disopyramide pharmacodynamics pathway  (EXP)
dobutamine pharmacodynamics pathway  (EXP)
dopamine signaling pathway  (TAS)
eicosanoid signaling pathway  (EXP)
Entamoebiasis pathway  (IEA)
esmolol pharmacodynamics pathway  (EXP)
flecainde pharmacodynamics pathway  (EXP)
fosphenytoin pharmacodynamics pathway  (EXP)
glutamate signaling pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (EXP)
Hedgehog signaling pathway  (EXP,IEA)
ibutilide pharmacodynamics pathway  (EXP)
insulin signaling pathway  (IEA)
interleukin-3 signaling pathway  (EXP)
isoprenaline pharmacodynamics pathway  (EXP)
isradipine pharmacodynamics pathway  (EXP)
levobunolol pharmacodynamics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
long term potentiation  (IEA)
metoprolol pharmacodynamics pathway  (EXP)
mexiletine pharmacodynamics pathway  (EXP)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (EXP)
nebivolol pharmacodynamics pathway  (EXP)
nifedipine pharmacodynamics pathway  (EXP)
nimodipine pharmacodynamics pathway  (EXP)
nisoldipine pharmacodynamics pathway  (EXP)
nitrendipine pharmacodynamics pathway  (EXP)
penbutolol pharmacodynamics pathway  (EXP)
phenytoin pharmacodynamics pathway  (EXP)
phosphatidylinositol 3-kinase-Akt signaling pathway  (EXP)
pindolol pharmacodynamics pathway  (EXP)
prion disease pathway  (IEA)
procainamide pharmacodynamics pathway  (EXP)
propranolol pharmacodynamics pathway  (EXP)
protein kinase A (PKA) signaling pathway  (TAS)
quinidine pharmacodynamics pathway  (EXP)
sotalol pharmacodynamics pathway  (EXP)
syndecan signaling pathway  (EXP)
timolol pharmacodynamics pathway  (EXP)
vascular endothelial growth factor signaling pathway  (EXP)
vasopressin signaling pathway via receptor type 2  (IEA)
verapamil pharmacodynamics pathway  (EXP)
Vibrio cholerae infection pathway  (IEA)
Wnt signaling pathway  (IEA)

References

Additional References at PubMed
PMID:33381   PMID:221492   PMID:1281154   PMID:1322130   PMID:1375229   PMID:1375933   PMID:1377674   PMID:1406653   PMID:1545828   PMID:1650365   PMID:1684878   PMID:1706595  
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PMID:27498007   PMID:27567978   PMID:27606678   PMID:27714810   PMID:27722768   PMID:27813054   PMID:27871112   PMID:27880917   PMID:27911714   PMID:27986643   PMID:28051330   PMID:28100013  
PMID:28119464   PMID:28122154   PMID:28202680   PMID:28202681   PMID:28223151   PMID:28235949   PMID:28250426   PMID:28369983   PMID:28428082   PMID:28514442   PMID:28555617   PMID:28575131  
PMID:28581524   PMID:28583374   PMID:28613156   PMID:28634551   PMID:28759570   PMID:28834963   PMID:28835500   PMID:28934360   PMID:29123182   PMID:29162697   PMID:29229926   PMID:29259079  
PMID:29484758   PMID:29568061   PMID:29576612   PMID:29688805   PMID:29899111   PMID:30021884   PMID:30575818   PMID:30615103   PMID:30773093   PMID:30783609   PMID:30835912   PMID:30948266  
PMID:30992362   PMID:31040297   PMID:31063128   PMID:31091453   PMID:31112131   PMID:31165764   PMID:31189917   PMID:31353306   PMID:31391242   PMID:31477623   PMID:31527615   PMID:31665637  
PMID:31676785   PMID:31678302   PMID:31678420   PMID:31964716   PMID:31980649   PMID:32203420   PMID:32296183   PMID:32353859   PMID:32580140   PMID:32814053   PMID:32877691   PMID:32879366  
PMID:33058759   PMID:33060197   PMID:33167377   PMID:33233484   PMID:33957083  


Genomics

Comparative Map Data
PRKACA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,091,688 - 14,118,084 (-)EnsemblGRCh38hg38GRCh38
GRCh381914,091,688 - 14,117,762 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,202,500 - 14,228,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,063,500 - 14,089,559 (-)NCBINCBI36hg18NCBI36
Build 341914,063,508 - 14,085,992NCBI
Celera1914,096,777 - 14,122,833 (-)NCBI
Cytogenetic Map19p13.12NCBI
HuRef1913,774,379 - 13,800,126 (-)NCBIHuRef
CHM1_11914,202,926 - 14,228,985 (-)NCBICHM1_1
Prkaca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,699,607 - 84,723,073 (+)NCBIGRCm39mm39
GRCm39 Ensembl884,699,622 - 84,723,072 (+)Ensembl
GRCm38883,972,978 - 83,996,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,972,993 - 83,996,443 (+)EnsemblGRCm38mm10GRCm38
MGSCv37886,496,877 - 86,520,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv36886,863,093 - 86,886,544 (+)NCBImm8
Celera888,266,474 - 88,289,645 (+)NCBICelera
Cytogenetic Map8C2NCBI
Prkaca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21924,155,081 - 24,178,430 (-)NCBI
Rnor_6.0 Ensembl1925,095,089 - 25,118,860 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01925,095,089 - 25,118,869 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01936,073,104 - 36,096,884 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41925,840,795 - 25,864,786 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11925,845,620 - 25,861,927 (-)NCBI
Celera1923,703,180 - 23,726,723 (-)NCBICelera
Cytogenetic Map19q11NCBI
Prkaca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,793,718 - 32,812,930 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,794,172 - 32,807,944 (-)NCBIChiLan1.0ChiLan1.0
PRKACA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11914,385,183 - 14,406,205 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,385,191 - 14,406,205 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01913,657,344 - 13,683,864 (-)NCBIMhudiblu_PPA_v0panPan3
PRKACA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,416,730 - 48,425,237 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,409,045 - 48,426,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,283,546 - 48,299,768 (+)NCBI
ROS_Cfam_1.02048,926,811 - 48,944,065 (+)NCBI
UMICH_Zoey_3.12048,138,017 - 48,154,228 (+)NCBI
UNSW_CanFamBas_1.02048,564,570 - 48,580,793 (+)NCBI
UU_Cfam_GSD_1.02048,807,387 - 48,823,603 (+)NCBI
Prkaca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,588,938 - 207,605,559 (+)NCBI
SpeTri2.0NW_0049366592,750,015 - 2,765,914 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl265,074,870 - 65,095,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1265,074,876 - 65,095,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,350,544 - 65,371,236 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1612,743,752 - 12,759,155 (-)NCBI
Vero_WHO_p1.0NW_0236660746,888,080 - 6,914,845 (+)NCBI
Prkaca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,319,426 - 1,336,848 (-)NCBI

Position Markers
WI-14108  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,230,336 - 14,230,485UniSTSGRCh37
Build 361914,091,336 - 14,091,485RGDNCBI36
Celera1914,124,611 - 14,124,760RGD
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map19p13.12UniSTS
HuRef1913,801,903 - 13,802,052UniSTS
GeneMap99-GB4 RH Map1975.87UniSTS
Whitehead-RH Map1966.6UniSTS
RH65125  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,207,232 - 14,207,428UniSTSGRCh37
Build 361914,068,232 - 14,068,428RGDNCBI36
Celera1914,101,509 - 14,101,705RGD
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map19p13.12UniSTS
HuRef1913,779,112 - 13,779,308UniSTS
PRKACA__2119  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,202,516 - 14,203,371UniSTSGRCh37
Build 361914,063,516 - 14,064,371RGDNCBI36
Celera1914,096,793 - 14,097,648RGD
HuRef1913,774,395 - 13,775,250UniSTS
RH47780  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,213,691 - 14,213,838UniSTSGRCh37
Build 361914,074,691 - 14,074,838RGDNCBI36
Celera1914,107,968 - 14,108,115RGD
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map19p13.12UniSTS
HuRef1913,785,571 - 13,785,718UniSTS
GeneMap99-GB4 RH Map1975.35UniSTS
D1S3205  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,208,074 - 14,208,214UniSTSGRCh37
Build 361914,069,074 - 14,069,214RGDNCBI36
Celera1914,102,351 - 14,102,491RGD
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map19p13.12UniSTS
HuRef1913,779,954 - 13,780,094UniSTS
Stanford-G3 RH Map19410.0UniSTS
NCBI RH Map1991.5UniSTS
GeneMap99-G3 RH Map19410.0UniSTS
STS-N57750  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,207,403 - 14,207,532UniSTSGRCh37
Build 361914,068,403 - 14,068,532RGDNCBI36
Celera1914,101,680 - 14,101,809RGD
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map19p13.12UniSTS
HuRef1913,779,283 - 13,779,412UniSTS
GeneMap99-GB4 RH Map1973.1UniSTS
RH69574  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371914,202,582 - 14,202,704UniSTSGRCh37
GRCh37884,883,126 - 84,883,248UniSTSGRCh37
Build 36885,045,681 - 85,045,803RGDNCBI36
Celera880,887,179 - 80,887,301RGD
Celera1914,096,859 - 14,096,981UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map19p13.1UniSTS
HuRef1913,774,461 - 13,774,583UniSTS
HuRef880,374,724 - 80,374,846UniSTS
GeneMap99-GB4 RH Map8400.81UniSTS
NCBI RH Map8878.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4452
Count of miRNA genes:1003
Interacting mature miRNAs:1267
Transcripts:ENST00000308677, ENST00000350356, ENST00000536649, ENST00000587372, ENST00000587533, ENST00000588209, ENST00000589284, ENST00000589994, ENST00000590853, ENST00000593092
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2430 2951 1715 618 1900 460 4355 2178 3643 407 1446 1607 171 1204 2788 3
Low 2 34 9 5 47 4 15 69 11 6 1 1 1
Below cutoff 2 1 2 7 1 4 2 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_207518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC022098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF208004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF224718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF239744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC108259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU543573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ667173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC604549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC604551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000308677   ⟹   ENSP00000309591
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,091,688 - 14,117,762 (-)Ensembl
RefSeq Acc Id: ENST00000350356
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,091,697 - 14,108,390 (-)Ensembl
RefSeq Acc Id: ENST00000536649
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,096,971 - 14,112,647 (-)Ensembl
RefSeq Acc Id: ENST00000587372   ⟹   ENSP00000468352
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,093,043 - 14,106,860 (-)Ensembl
RefSeq Acc Id: ENST00000587533
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,096,371 - 14,098,465 (-)Ensembl
RefSeq Acc Id: ENST00000588209
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,093,650 - 14,101,278 (-)Ensembl
RefSeq Acc Id: ENST00000589284   ⟹   ENSP00000466660
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,102,901 - 14,118,084 (-)Ensembl
RefSeq Acc Id: ENST00000589994   ⟹   ENSP00000466651
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,093,050 - 14,114,188 (-)Ensembl
RefSeq Acc Id: ENST00000590853   ⟹   ENSP00000466976
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,092,036 - 14,117,732 (-)Ensembl
RefSeq Acc Id: ENST00000593092   ⟹   ENSP00000466289
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,097,248 - 14,107,404 (-)Ensembl
RefSeq Acc Id: ENST00000677951   ⟹   ENSP00000504551
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,091,688 - 14,116,230 (-)Ensembl
RefSeq Acc Id: ENST00000677971   ⟹   ENSP00000502958
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,091,688 - 14,108,814 (-)Ensembl
RefSeq Acc Id: ENST00000678736
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,112,455 - 14,113,081 (-)Ensembl
RefSeq Acc Id: ENST00000679067
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,096,251 - 14,098,510 (-)Ensembl
RefSeq Acc Id: NM_001304349   ⟹   NP_001291278
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,091,688 - 14,108,390 (-)NCBI
CHM1_11914,202,926 - 14,219,622 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002730   ⟹   NP_002721
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,091,688 - 14,117,762 (-)NCBI
GRCh371914,202,500 - 14,228,559 (-)ENTREZGENE
Build 361914,063,500 - 14,089,559 (-)NCBI Archive
HuRef1913,774,379 - 13,800,126 (-)ENTREZGENE
CHM1_11914,202,926 - 14,228,985 (-)NCBI
Sequence:
RefSeq Acc Id: NM_207518   ⟹   NP_997401
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,091,688 - 14,114,191 (-)NCBI
GRCh371914,202,500 - 14,228,559 (-)ENTREZGENE
Build 361914,063,500 - 14,085,992 (-)NCBI Archive
HuRef1913,774,379 - 13,800,126 (-)ENTREZGENE
CHM1_11914,202,926 - 14,225,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017026948   ⟹   XP_016882437
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,091,688 - 14,117,603 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002721   ⟸   NM_002730
- Peptide Label: isoform Calpha1
- UniProtKB: P17612 (UniProtKB/Swiss-Prot),   A0A024R7J0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_997401   ⟸   NM_207518
- Peptide Label: isoform Calpha2
- UniProtKB: P17612 (UniProtKB/Swiss-Prot),   A8K8B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291278   ⟸   NM_001304349
- Peptide Label: isoform 3
- UniProtKB: P17612 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016882437   ⟸   XM_017026948
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000309591   ⟸   ENST00000308677
RefSeq Acc Id: ENSP00000468352   ⟸   ENST00000587372
RefSeq Acc Id: ENSP00000466660   ⟸   ENST00000589284
RefSeq Acc Id: ENSP00000466651   ⟸   ENST00000589994
RefSeq Acc Id: ENSP00000466976   ⟸   ENST00000590853
RefSeq Acc Id: ENSP00000466289   ⟸   ENST00000593092
RefSeq Acc Id: ENSP00000502958   ⟸   ENST00000677971
RefSeq Acc Id: ENSP00000504551   ⟸   ENST00000677951
Promoters
RGD ID:6795936
Promoter ID:HG_KWN:29098
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_002730
Position:
Human AssemblyChrPosition (strand)Source
Build 361914,089,246 - 14,090,532 (-)MPROMDB
RGD ID:7238823
Promoter ID:EPDNEW_H25157
Type:initiation region
Name:PRKACA_1
Description:protein kinase cAMP-activated catalytic subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,117,762 - 14,117,822EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.13-13.12(chr19:13533925-14258833)x1 copy number loss See cases [RCV000051051] Chr19:13533925..14258833 [GRCh38]
Chr19:13644739..14369645 [GRCh37]
Chr19:13505739..14230645 [NCBI36]
Chr19:19p13.13-13.12
uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
NM_002730.3(PRKACA):c.617T>G (p.Leu206Arg) single nucleotide variant Pigmented nodular adrenocortical disease, primary, 4 [RCV000119834]|not provided [RCV000122662] Chr19:14097604 [GRCh38]
Chr19:14208416 [GRCh37]
Chr19:19p13.12
pathogenic|likely pathogenic|other
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
NM_002730.4(PRKACA):c.597_599dup (p.Cys200_Gly201insTrp) duplication Pigmented nodular adrenocortical disease, primary, 4 [RCV000149856] Chr19:14097621..14097622 [GRCh38]
Chr19:14208434..14208436 [GRCh37]
Chr19:19p13.12
pathogenic
GRCh37/hg19 19p13.12(chr19:14194074-14239226)x1 copy number loss not provided [RCV000752568] Chr19:14194074..14239226 [GRCh37]
Chr19:19p13.12
benign
GRCh37/hg19 19p13.2-13.12(chr19:9678768-14853426) copy number gain See cases [RCV000446985] Chr19:9678768..14853426 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.12-13.11(chr19:14124666-16431349)x1 copy number loss See cases [RCV000448818] Chr19:14124666..16431349 [GRCh37]
Chr19:19p13.12-13.11
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:13592592-14717528)x1 copy number loss See cases [RCV000511445] Chr19:13592592..14717528 [GRCh37]
Chr19:19p13.2-13.12
likely pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:12574343-14726197)x1 copy number loss See cases [RCV000511130] Chr19:12574343..14726197 [GRCh37]
Chr19:19p13.2-13.12
pathogenic
GRCh37/hg19 19p13.2-13.12(chr19:11608072-14543046)x3 copy number gain See cases [RCV000511013] Chr19:11608072..14543046 [GRCh37]
Chr19:19p13.2-13.12
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
GRCh37/hg19 19p13.12(chr19:14221642-14276711)x3 copy number gain not provided [RCV000752570] Chr19:14221642..14276711 [GRCh37]
Chr19:19p13.12
benign
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_002730.4(PRKACA):c.870C>T (p.Asn290=) single nucleotide variant not provided [RCV000917835] Chr19:14093688 [GRCh38]
Chr19:14204500 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.843C>G (p.Arg281=) single nucleotide variant not provided [RCV000947925] Chr19:14093715 [GRCh38]
Chr19:14204527 [GRCh37]
Chr19:19p13.12
benign
NM_002730.4(PRKACA):c.102C>T (p.Pro34=) single nucleotide variant not provided [RCV000879733] Chr19:14107354 [GRCh38]
Chr19:14218166 [GRCh37]
Chr19:19p13.12
benign
NM_002730.4(PRKACA):c.337-9T>C single nucleotide variant not provided [RCV000915580] Chr19:14100917 [GRCh38]
Chr19:14211729 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.381G>A (p.Gly127=) single nucleotide variant not provided [RCV000906190] Chr19:14100864 [GRCh38]
Chr19:14211676 [GRCh37]
Chr19:19p13.12
benign
NM_002730.4(PRKACA):c.540C>T (p.Tyr180=) single nucleotide variant not provided [RCV000981172] Chr19:14097770 [GRCh38]
Chr19:14208582 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.109-6C>T single nucleotide variant not provided [RCV000909096] Chr19:14106894 [GRCh38]
Chr19:14217706 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.711G>A (p.Pro237=) single nucleotide variant not provided [RCV000932530] Chr19:14097415 [GRCh38]
Chr19:14208227 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.165C>T (p.Phe55=) single nucleotide variant not provided [RCV000919602] Chr19:14106832 [GRCh38]
Chr19:14217644 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.624T>G (p.Pro208=) single nucleotide variant not provided [RCV000913532] Chr19:14097597 [GRCh38]
Chr19:14208409 [GRCh37]
Chr19:19p13.12
likely benign
NM_002730.4(PRKACA):c.409G>A (p.Gly137Arg) single nucleotide variant Cardioacrofacial dysplasia 1 [RCV001271119] Chr19:14100836 [GRCh38]
Chr19:14211648 [GRCh37]
Chr19:19p13.12
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9380 AgrOrtholog
COSMIC PRKACA COSMIC
Ensembl Genes ENSG00000072062 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000288516 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000309591 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000466289 UniProtKB/TrEMBL
  ENSP00000466651 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000466660 UniProtKB/TrEMBL
  ENSP00000466976 UniProtKB/TrEMBL
  ENSP00000468352 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000499940 UniProtKB/Swiss-Prot
  ENSP00000500293 UniProtKB/Swiss-Prot
  ENSP00000502958 UniProtKB/TrEMBL
  ENSP00000503953 UniProtKB/TrEMBL
  ENSP00000504551 UniProtKB/TrEMBL
Ensembl Transcript ENST00000308677 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000350356 ENTREZGENE
  ENST00000536649 UniProtKB/TrEMBL
  ENST00000587372 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000589284 UniProtKB/TrEMBL
  ENST00000589994 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000590853 UniProtKB/TrEMBL
  ENST00000593092 UniProtKB/TrEMBL
  ENST00000672938 UniProtKB/Swiss-Prot
  ENST00000673550 UniProtKB/Swiss-Prot
  ENST00000677951 UniProtKB/TrEMBL
  ENST00000677971 UniProtKB/TrEMBL
GTEx ENSG00000072062 GTEx
  ENSG00000288516 GTEx
HGNC ID HGNC:9380 ENTREZGENE
Human Proteome Map PRKACA Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STKc_PKA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5566 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5566 ENTREZGENE
OMIM 601639 OMIM
  615830 OMIM
  619142 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33748 PharmGKB
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R7J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A7I2V5J4_HUMAN UniProtKB/TrEMBL
  A0A7I2YQ82_HUMAN UniProtKB/TrEMBL
  A8K8B9 ENTREZGENE, UniProtKB/TrEMBL
  B7Z708_HUMAN UniProtKB/TrEMBL
  K7EMV1_HUMAN UniProtKB/TrEMBL
  K7ENJ5_HUMAN UniProtKB/TrEMBL
  K7ERP6_HUMAN UniProtKB/TrEMBL
  KAPCA_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q15136_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q32P54 UniProtKB/Swiss-Prot
  Q9H2Y0 UniProtKB/Swiss-Prot
  Q9NRB4 UniProtKB/Swiss-Prot
  Q9NRH9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PRKACA  protein kinase cAMP-activated catalytic subunit alpha    protein kinase, cAMP-dependent, alpha catalytic subunit  Symbol and/or name change 5135510 APPROVED
2015-11-24 PRKACA  protein kinase, cAMP-dependent, alpha catalytic subunit    protein kinase, cAMP-dependent, catalytic, alpha  Symbol and/or name change 5135510 APPROVED
2011-08-16 PRKACA  protein kinase, cAMP-dependent, catalytic, alpha  PRKACA  protein kinase, cAMP-dependent, catalytic, alpha  Symbol and/or name change 5135510 APPROVED