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Gene: CASP7 (caspase 7) Homo sapiens
Symbol: CASP7
Name: caspase 7
Description: Exhibits cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in apoptotic process; cellular response to staurosporine; and proteolysis. Localizes to the cytosol and nucleus. Implicated in Alzheimer's disease; breast cancer; colon cancer; hereditary ataxia; and lung non-small cell carcinoma. Biomarker of Alzheimer's disease and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptotic protease MCH-3; CASP-7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; caspase-7; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; LICE2; Lice2 alpha/beta/gamma; MCH3
Mus musculus (house mouse) : Casp7 (caspase 7)  MGI  Alliance
Rattus norvegicus (Norway rat) : Casp7 (caspase 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Casp7 (caspase 7)
Pan paniscus (bonobo/pygmy chimpanzee) : CASP7 (caspase 7)
Canis lupus familiaris (dog) : CASP7 (caspase 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Casp7 (caspase 7)
Sus scrofa (pig) : CASP7 (caspase 7)
Chlorocebus sabaeus (green monkey) : CASP7 (caspase 7)
Heterocephalus glaber (naked mole-rat) : Casp7 (caspase 7)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl10113,679,162 - 113,730,907 (+)Ensembl
GRCh3810113,679,162 - 113,730,909 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710115,438,921 - 115,490,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,428,925 - 115,480,654 (+)NCBINCBI36hg18NCBI36
Build 3410115,428,952 - 115,480,652NCBI
Celera10109,166,297 - 109,218,022 (+)NCBI
Cytogenetic Map10q25.3NCBI
HuRef10109,065,803 - 109,118,487 (+)NCBIHuRef
CHM1_110115,720,952 - 115,772,694 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CASP7
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1298347
Created: 2004-05-11
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.