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Gene: CTSK (cathepsin K) Homo sapiens
Symbol: CTSK
Name: cathepsin K
RGD ID: 734172
Description: Exhibits several functions, including collagen binding activity; cysteine-type endopeptidase activity; and fibronectin binding activity. Involved in collagen catabolic process; proteolysis involved in cellular protein catabolic process; and thyroid hormone generation. Localizes to extracellular space; lysosome; and nucleoplasm. Implicated in pycnodysostosis. Biomarker of intracranial aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cathepsin O; cathepsin O1; cathepsin O2; cathepsin X; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD
Mus musculus (house mouse) : Ctsk (cathepsin K)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctsk (cathepsin K)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctsk (cathepsin K)
Pan paniscus (bonobo/pygmy chimpanzee) : CTSK (cathepsin K)
Canis lupus familiaris (dog) : CTSK (cathepsin K)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctsk (cathepsin K)
Chlorocebus sabaeus (African green monkey) : CTSK (cathepsin K)
Heterocephalus glaber (naked mole-rat) : Ctsk (cathepsin K)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1150,796,208 - 150,808,260 (-)EnsemblGRCh38hg38GRCh38
GRCh381150,796,208 - 150,808,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,768,684 - 150,780,917 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,035,311 - 149,047,436 (-)NCBINCBI36hg18NCBI36
Build 341147,581,759 - 147,593,885NCBI
Celera1123,884,715 - 123,896,850 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,146,309 - 122,158,545 (-)NCBIHuRef
CHM1_11152,164,010 - 152,176,259 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CTSK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 734172
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.