GSTA5 (glutathione S-transferase alpha 5) - Rat Genome Database
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Gene: GSTA5 (glutathione S-transferase alpha 5) Homo sapiens
Analyze
Symbol: GSTA5
Name: glutathione S-transferase alpha 5
RGD ID: 1344623
HGNC Page HGNC
Description: Predicted to have glutathione binding activity and glutathione transferase activity. Predicted to be involved in several processes, including glutathione metabolic process; response to bacterium; and response to stilbenoid. Localizes to cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glutathione S-transferase A5; glutathione S-transferase A5-5; glutathione transferase A5; GST class-alpha member 5
RGD Orthologs
Mouse
Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AC114760.1   GSTA7P   GSTA8P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,831,655 - 52,846,095 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl652,831,655 - 52,840,843 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,831,742 - 52,846,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,696,540 - 52,710,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,804,499 - 52,818,852 (-)NCBINCBI36hg18NCBI36
Build 34652,804,498 - 52,818,852NCBI
Celera654,358,301 - 54,372,656 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,527,978 - 52,542,334 (-)NCBIHuRef
CHM1_1652,698,651 - 52,713,008 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
hypertension  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
1-Cyano-2-hydroxy-3-butene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-imidazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (ISO)
alpha-hexachlorocyclohexane  (ISO)
anthracen-2-amine  (ISO)
Azaspiracid  (EXP)
benzo[a]pyrene  (EXP)
benzotriazole  (ISO)
benzyl isothiocyanate  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
cafestol  (ISO)
cefaloridine  (ISO)
chlorambucil  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
coumarin  (ISO)
curcumin  (ISO)
cyproconazole  (ISO)
decabromodiphenyl ether  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
ethoxyquin  (ISO)
etofenprox  (ISO)
fenofibrate  (ISO)
fipronil  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
glutathione  (ISO)
hydrogen peroxide  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
kahweol  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
L-selenocysteine  (ISO)
melatonin  (ISO)
melphalan  (ISO)
menadione  (EXP,ISO)
methapyrilene  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oxfendazole  (ISO)
oxybenzone  (ISO)
oxycodone  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
pentanal  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chloride  (ISO)
prochloraz  (ISO)
propanal  (EXP)
propiconazole  (ISO)
Propiverine  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
sinigrin  (ISO)
sodium arsenite  (ISO)
stilbene oxide  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
tauroursodeoxycholic acid  (ISO)
tert-butyl ethyl ether  (ISO)
tetrachloromethane  (ISO)
thiazoles  (ISO)
thioacetamide  (ISO)
toluene  (ISO)
triadimefon  (ISO)
triazoles  (ISO)
trichloroethene  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IDA,ISO)
extracellular exosome  (HDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10676639   PMID:12042665   PMID:14574404   PMID:17601350   PMID:18977241   PMID:19664689   PMID:20200426   PMID:20237496   PMID:21873635   PMID:23533145   PMID:26186194   PMID:28514442  
PMID:30639242   PMID:32296183  


Genomics

Comparative Map Data
GSTA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl652,831,655 - 52,846,095 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl652,831,655 - 52,840,843 (-)EnsemblGRCh38hg38GRCh38
GRCh38652,831,742 - 52,846,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37652,696,540 - 52,710,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,804,499 - 52,818,852 (-)NCBINCBI36hg18NCBI36
Build 34652,804,498 - 52,818,852NCBI
Celera654,358,301 - 54,372,656 (-)NCBI
Cytogenetic Map6p12.2NCBI
HuRef652,527,978 - 52,542,334 (-)NCBIHuRef
CHM1_1652,698,651 - 52,713,008 (-)NCBICHM1_1
Gsta1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,137,951 - 78,149,965 (+)NCBIGRCm39mm39
GRCm39 Ensembl978,137,938 - 78,149,966 (+)Ensembl
GRCm38978,230,669 - 78,242,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,230,656 - 78,242,684 (+)EnsemblGRCm38mm10GRCm38
MGSCv37978,078,476 - 78,090,490 (+)NCBIGRCm37mm9NCBIm37
MGSCv36978,016,370 - 78,028,355 (+)NCBImm8
Celera975,462,780 - 75,478,144 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
Gsta5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2879,105,561 - 79,117,472 (+)NCBI
Rnor_6.0 Ensembl885,553,734 - 85,565,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0885,553,659 - 85,564,914 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0885,111,369 - 85,122,622 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,202,554 - 83,211,997 (+)NCBIRGSC3.4rn4RGSC3.4
Celera878,852,562 - 78,862,243 (+)NCBICelera
Cytogenetic Map8q31NCBI

Position Markers
RH71356  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p12.2UniSTS
Cytogenetic Map6p12.1UniSTS
GeneMap99-GB4 RH Map6209.44UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:202
Interacting mature miRNAs:208
Transcripts:ENST00000284562, ENST00000370989, ENST00000475052
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 6 114 33 6 32 1 4 118 15 1
Below cutoff 343 72 427 277 172 180 135 47 70 92 477 320 97 11 80

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000284562   ⟹   ENSP00000284562
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,831,742 - 52,846,095 (-)Ensembl
RefSeq Acc Id: ENST00000370989   ⟹   ENSP00000360028
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,831,655 - 52,840,843 (-)Ensembl
RefSeq Acc Id: ENST00000475052
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,831,655 - 52,840,843 (-)Ensembl
RefSeq Acc Id: NM_153699   ⟹   NP_714543
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,831,742 - 52,846,095 (-)NCBI
GRCh37652,696,540 - 52,710,893 (-)RGD
Build 36652,804,499 - 52,818,852 (-)NCBI Archive
Celera654,358,301 - 54,372,656 (-)RGD
HuRef652,527,978 - 52,542,334 (-)ENTREZGENE
CHM1_1652,698,651 - 52,713,008 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_714543 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA00071 (Get FASTA)   NCBI Sequence Viewer  
  EAX04386 (Get FASTA)   NCBI Sequence Viewer  
  EAX04387 (Get FASTA)   NCBI Sequence Viewer  
  Q7RTV2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_714543   ⟸   NM_153699
- UniProtKB: Q7RTV2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000360028   ⟸   ENST00000370989
RefSeq Acc Id: ENSP00000284562   ⟸   ENST00000284562
Protein Domains
GST C-terminal   GST N-terminal


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p12.3-11.2(chr6:50971182-57432788)x1 copy number loss See cases [RCV000134922] Chr6:50971182..57432788 [GRCh38]
Chr6:50938895..57297586 [GRCh37]
Chr6:51046854..57405545 [NCBI36]
Chr6:6p12.3-11.2
pathogenic
GRCh38/hg38 6p12.3-12.1(chr6:51093754-53859634)x4 copy number gain See cases [RCV000137095] Chr6:51093754..53859634 [GRCh38]
Chr6:51061467..53724432 [GRCh37]
Chr6:51169426..53832391 [NCBI36]
Chr6:6p12.3-12.1
pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1
pathogenic|uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1
likely pathogenic
GRCh37/hg19 6p12.2(chr6:52653495-52860229)x3 copy number gain not provided [RCV001258722] Chr6:52653495..52860229 [GRCh37]
Chr6:6p12.2
likely benign
GRCh37/hg19 6p12.2-12.1(chr6:52657712-53622715)x3 copy number gain not provided [RCV001258723] Chr6:52657712..53622715 [GRCh37]
Chr6:6p12.2-12.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19662 AgrOrtholog
COSMIC GSTA5 COSMIC
Ensembl Genes ENSG00000182793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000284562 UniProtKB/Swiss-Prot
  ENSP00000360028 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000284562 UniProtKB/Swiss-Prot
  ENST00000370989 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.30.10 UniProtKB/Swiss-Prot
GTEx ENSG00000182793 GTEx
HGNC ID HGNC:19662 ENTREZGENE
Human Proteome Map GSTA5 Human Proteome Map
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:221357 UniProtKB/Swiss-Prot
NCBI Gene 221357 ENTREZGENE
OMIM 607605 OMIM
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB PA134962856 PharmGKB
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt GSTA5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5SZC2 UniProtKB/Swiss-Prot