CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | hydroquinones |
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Accession: | CHEBI:24646
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browse the term
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Definition: | Benzenediols that have the hydroxy substituents in the 1- and 4-positions. |
Synonyms: | related_synonym: | 1,4-benzoquinols; Formula=C6H2O2R4; SMILES=OC1=C(*)C(*)=C(O)C(*)=C1*; a 1,4-benzoquinol; a quinol; benzene-1,4-diols |
| alt_id: | CHEBI:134188; MESH:D006873 |
| xref_mesh: | MESH:D006873 |
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Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
decreases response to substance |
ISO |
NFE2L2 protein results in decreased susceptibility to Hydroquinones |
CTD |
PMID:20932822 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA |
CTD |
PMID:27837168 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA |
CTD |
PMID:27837168 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of AHR protein] which results in increased expression of CYP1B1 mRNA |
CTD |
PMID:27837168 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Gpr35 |
G protein-coupled receptor 35 |
multiple interactions |
ISO |
1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein |
CTD |
PMID:20826425 |
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NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
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Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
2,5-di-tert-butylhydroquinone results in increased expression of GSTP1 protein |
CTD |
PMID:12680784 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
increases response to substance |
ISO |
NFE2L2 gene mutant form results in increased susceptibility to 2,5-di-tert-butylhydroquinone |
CTD |
PMID:12842875 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of ABCC1 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCC1 protein |
CTD |
PMID:11836020 PMID:16014739 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO EXP |
2-tert-butylhydroquinone results in increased expression of ABCC2 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCC2 protein |
CTD |
PMID:11264000 PMID:11836020 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased expression of ABCG2 mRNA; 2-tert-butylhydroquinone results in increased expression of ABCG2 protein AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of ABCG2 protein] |
CTD |
PMID:17077187 |
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NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Adh7 |
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of ADH7 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO EXP |
AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of ABCG2 protein]; AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA] 2-tert-butylhydroquinone results in increased activity of and results in increased localization of AHR protein |
CTD |
PMID:12948865 PMID:15608132 PMID:17077187 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Akr1b10 |
aldo-keto reductase family 1 member B10 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of AKR1B10 mRNA |
CTD |
PMID:30806763 |
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NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:23112101 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Ar |
androgen receptor |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:18324785 |
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NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Atp5f1a |
ATP synthase F1 subunit alpha |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [thallium nitrate results in decreased expression of ATP5F1A protein] |
CTD |
PMID:31726083 |
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NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
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Bach1 |
BTB domain and CNC homolog 1 |
affects localization multiple interactions |
ISO |
2-tert-butylhydroquinone affects the localization of BACH1 protein 2-tert-butylhydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein]; [ferric chloride results in increased oxidation of 2-tert-butylhydroquinone] promotes the reaction [2-tert-butylhydroquinone analog binds to BACH1 protein] |
CTD |
PMID:28645578 |
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NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
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Bax |
BCL2 associated X, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in decreased expression of BAX protein 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein] 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased expression of BAX protein] [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in decreased expression of BAX protein |
CTD |
PMID:22275372 PMID:26878773 PMID:28583816 PMID:32565124 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2 |
BCL2, apoptosis regulator |
multiple interactions increases expression |
ISO EXP |
2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to BCL2 promoter]; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in increased expression of BCL2 protein; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of BCL2 mRNA] 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein] 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein] 2-tert-butylhydroquinone results in increased expression of BCL2 mRNA; 2-tert-butylhydroquinone results in increased expression of BCL2 protein |
CTD |
PMID:22275372 PMID:26878773 PMID:28583816 PMID:32565124 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Bco2 |
beta-carotene oxygenase 2 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of BCO2 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 8:54,965,577...54,990,604
Ensembl chr 8:54,965,583...54,998,864
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Blvrb |
biliverdin reductase B |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of BLVRB mRNA |
CTD |
PMID:16014739 |
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NCBI chr 1:84,256,063...84,273,726
Ensembl chr 1:84,256,159...84,274,075
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Casp3 |
caspase 3 |
multiple interactions |
ISO EXP |
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of CASP3 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein] 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein] 2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP3 protein]; 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; solanesol promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]] |
CTD |
PMID:22275372 PMID:25341683 PMID:25645596 PMID:26878773 PMID:28583816 PMID:32073640 PMID:32428544 PMID:32565124 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Casp4 |
caspase 4 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased activity of CASP4 protein] |
CTD |
PMID:25341683 |
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NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
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Casp7 |
caspase 7 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased activity of CASP7 protein] |
CTD |
PMID:22275372 |
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NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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Cat |
catalase |
multiple interactions increases activity |
ISO EXP |
2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased activity of CAT protein] 2-tert-butylhydroquinone results in increased activity of CAT protein 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of CAT protein] 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA] |
CTD |
PMID:26878773 PMID:32428544 PMID:32565124 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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Cbr3 |
carbonyl reductase 3 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CBR3 mRNA |
CTD |
PMID:16014739 |
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NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
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Ccl5 |
C-C motif chemokine ligand 5 |
increases secretion |
ISO |
2-tert-butylhydroquinone results in increased secretion of CCL5 protein |
CTD |
PMID:30806763 |
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NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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Ccn2 |
cellular communication network factor 2 |
decreases expression |
ISO |
2-tert-butylhydroquinone results in decreased expression of CCN2 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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Ccnd1 |
cyclin D1 |
increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased expression of CCND1 protein 2-tert-butylhydroquinone promotes the reaction [sodium arsenite results in increased expression of CCND1 protein] |
CTD |
PMID:26878773 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cd5l |
Cd5 molecule-like |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CD5L mRNA |
CTD |
PMID:16014739 |
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NCBI chr 2:186,685,104...186,696,117
Ensembl chr 2:186,685,104...186,696,117
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Cd69 |
Cd69 molecule |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein] |
CTD |
PMID:30171972 |
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NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
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Cd86 |
CD86 molecule |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CD86 protein |
CTD |
PMID:19033392 |
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NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions increases expression |
ISO |
2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased expression of CDK4 protein] 2-tert-butylhydroquinone results in increased expression of CDK4 protein |
CTD |
PMID:26878773 |
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NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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Ces1d |
carboxylesterase 1D |
multiple interactions increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of and results in increased activity of CES1 protein alternative form; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form] |
CTD |
PMID:19715681 |
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NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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Crebbp |
CREB binding protein |
multiple interactions |
ISO |
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; 2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]] |
CTD |
PMID:21443188 |
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NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
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Creg2 |
cellular repressor of E1A-stimulated genes 2 |
affects response to substance |
ISO |
CREG2 gene SNP affects the susceptibility to 2-tert-butylhydroquinone |
CTD |
PMID:25622337 |
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NCBI chr 9:46,328,088...46,402,237
Ensembl chr 9:46,360,061...46,401,911
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Csf1 |
colony stimulating factor 1 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein]; 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein]; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein |
CTD |
PMID:23112101 |
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NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
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Csf1r |
colony stimulating factor 1 receptor |
multiple interactions |
ISO |
[2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CSF1R protein |
CTD |
PMID:23112101 |
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NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
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Ctsk |
cathepsin K |
multiple interactions |
ISO |
[TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein |
CTD |
PMID:23112101 |
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NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
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Cul3 |
cullin 3 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein] |
CTD |
PMID:18417180 PMID:30261176 |
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NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
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Cxcl1 |
C-X-C motif chemokine ligand 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CXCL1 mRNA |
CTD |
PMID:30806763 |
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NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CXCL1 mRNA |
CTD |
PMID:30806763 |
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NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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Cyb5a |
cytochrome b5 type A |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CYB5A mRNA |
CTD |
PMID:16014739 |
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NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
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Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of CYBB protein] |
CTD |
PMID:28844481 |
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NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CYP11A1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of CYP11A1 protein] |
CTD |
PMID:32565124 |
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NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases activity |
ISO |
2-tert-butylhydroquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; 2-tert-butylhydroquinone promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; 2-tert-butylhydroquinone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; FH535 inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased activity of CYP1A1 protein]; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP1A1 mRNA] 2-tert-butylhydroquinone results in increased expression of and results in increased activity of CYP1A1 protein; resveratrol inhibits the reaction [2-tert-butylhydroquinone results in increased activity of CYP1A1 protein] |
CTD |
PMID:9973208 PMID:15608132 PMID:15627257 PMID:16581943 PMID:25174530 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp2a3 |
cytochrome P450, family 2, subfamily a, polypeptide 3 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CYP2A5 mRNA |
CTD |
PMID:29788535 |
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NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
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Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of CYP2C19 mRNA; 2-tert-butylhydroquinone results in increased expression of CYP2C19 protein |
CTD |
PMID:24830941 |
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NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of DDIT3 protein] |
CTD |
PMID:25341683 |
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NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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Dsc3 |
desmocollin 3 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of DSC3 mRNA |
CTD |
PMID:16014739 |
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NCBI chr18:11,753,047...11,789,846
Ensembl chr18:11,753,047...11,789,708
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Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of DUSP1 mRNA |
CTD |
PMID:30806763 |
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NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:25341683 |
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NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
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G |
Ephx1 |
epoxide hydrolase 1 |
increases expression multiple interactions |
EXP ISO |
2-tert-butylhydroquinone results in increased expression of EPHX1 mRNA NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of EPHX1 exon] 2-tert-butylhydroquinone results in increased expression of EPHX1 exon; 2-tert-butylhydroquinone results in increased expression of EPHX1 protein alternative form |
CTD |
PMID:20650352 PMID:24704207 |
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NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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G |
Esd |
esterase D |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of ESD mRNA |
CTD |
PMID:16014739 |
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NCBI chr15:56,756,848...56,776,348
Ensembl chr15:56,756,661...56,776,348
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G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein] |
CTD |
PMID:16524372 |
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NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
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G |
Fgf18 |
fibroblast growth factor 18 |
decreases expression |
ISO |
2-tert-butylhydroquinone results in decreased expression of FGF18 mRNA |
CTD |
PMID:16014739 |
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NCBI chr10:18,047,109...18,082,290
Ensembl chr10:18,047,109...18,063,391
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in increased expression of FOS protein 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of FOS protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FOS protein]; 2-tert-butylhydroquinone promotes the reaction [FOS protein binds to CYP2C9 promoter] |
CTD |
PMID:24830941 PMID:28844481 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of FSHB protein] |
CTD |
PMID:32565124 |
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NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] |
CTD |
PMID:23829535 PMID:25003661 |
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NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
Ftl1 |
ferritin light chain 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of FTL1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Ftmt |
ferritin mitochondrial |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of FTMT mRNA |
CTD |
PMID:15664434 |
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NCBI chr18:47,294,292...47,295,541
Ensembl chr18:47,294,292...47,295,541
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G |
Gabpa |
GA binding protein transcription factor subunit alpha |
affects localization |
ISO |
2-tert-butylhydroquinone affects the localization of GABPA protein |
CTD |
PMID:16308312 |
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NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815
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G |
Gata3 |
GATA binding protein 3 |
increases activity |
ISO |
[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased activity of GATA3 protein |
CTD |
PMID:22250088 |
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NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
affects expression increases expression multiple interactions increases activity |
ISO EXP |
2-tert-butylhydroquinone affects the expression of GCLC mRNA 2-tert-butylhydroquinone results in increased expression of GCLC mRNA 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]; [2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA] |
CTD |
PMID:7955076 PMID:10978506 PMID:12007577 PMID:15946948 PMID:16014739 PMID:17980396 PMID:19183254 PMID:19328227 PMID:22250088 PMID:23906629 PMID:24128855 PMID:27178040 PMID:30547568 PMID:30806763 PMID:32428544 |
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NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
multiple interactions increases expression |
ISO EXP |
NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA] 2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]; [2,2',4,4'-tetrabromodiphenyl ether co-treated with 2-tert-butylhydroquinone] results in increased expression of GCLM mRNA |
CTD |
PMID:10978506 PMID:12007577 PMID:12081989 PMID:16014739 PMID:19183254 PMID:19328227 PMID:24632381 PMID:25003661 PMID:25305463 PMID:30547568 |
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NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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G |
Gpr87 |
G protein-coupled receptor 87 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of GPR87 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212
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G |
Gpx1 |
glutathione peroxidase 1 |
increases expression multiple interactions |
EXP |
2-tert-butylhydroquinone results in increased expression of GPX1 protein 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of GPX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein] |
CTD |
PMID:28583816 PMID:32565124 |
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NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gria1 |
glutamate ionotropic receptor AMPA type subunit 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of GRIA1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
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G |
Gsr |
glutathione-disulfide reductase |
increases activity multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in increased activity of GSR protein 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased activity of GSR protein] 2-tert-butylhydroquinone inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] |
CTD |
PMID:12572858 PMID:24970285 PMID:32565124 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gss |
glutathione synthetase |
increases expression multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in increased expression of GSS mRNA [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of GSS mRNA |
CTD |
PMID:10978506 PMID:19183254 PMID:32428544 |
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NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
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G |
Gsta2 |
glutathione S-transferase alpha 2 |
increases expression increases activity multiple interactions |
EXP ISO |
2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA; 2-tert-butylhydroquinone results in increased expression of GSTA2 protein 2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA 2-tert-butylhydroquinone results in increased activity of GSTA1 protein Tetradecanoylphorbol Acetate promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2]; 2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein; [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of GSTA2 protein]; Dexamethasone promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 mRNA]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2 protein] |
CTD |
PMID:7568053 PMID:7587946 PMID:12242683 PMID:15155840 PMID:15319326 PMID:15357004 PMID:15627257 PMID:15870285 PMID:16014739 |
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NCBI chr 8:85,640,081...85,645,621
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G |
Gsta5 |
glutathione S-transferase alpha 5 |
increases expression |
EXP |
2-tert-butylhydroquinone results in increased expression of GSTA5 mRNA |
CTD |
PMID:20650352 |
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NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
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G |
Gsta6 |
glutathione S-transferase alpha 6 |
increases activity increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased activity of GSTA1 protein 2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA Tetradecanoylphorbol Acetate promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA] |
CTD |
PMID:7568053 PMID:15627257 PMID:16014739 |
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NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176
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G |
Gstm1 |
glutathione S-transferase mu 1 |
increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased expression of GSTM1 protein 2-tert-butylhydroquinone results in increased expression of GSTM1 mRNA [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of GSTM1 mRNA |
CTD |
PMID:21443188 PMID:32428544 |
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NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP ISO |
2-tert-butylhydroquinone results in increased expression of GSTP1 protein 2-tert-butylhydroquinone results in increased expression of GSTP1 mRNA |
CTD |
PMID:12680784 PMID:15533597 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Gzmb |
granzyme B |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GZMB protein] |
CTD |
PMID:30171972 |
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NCBI chr15:35,413,862...35,417,293
Ensembl chr15:35,413,793...35,417,316
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] |
CTD |
PMID:28583816 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hbg1 |
hemoglobin subunit gamma 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of HBG1 mRNA |
CTD |
PMID:21464371 |
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NCBI chr 1:168,992,841...168,994,219
Ensembl chr 1:168,992,722...168,994,253
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G |
Hes1 |
hes family bHLH transcription factor 1 |
decreases expression |
EXP |
2-tert-butylhydroquinone results in decreased expression of HES1 protein |
CTD |
PMID:29663635 |
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NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein] |
CTD |
PMID:23112101 |
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NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [sodium arsenite results in increased expression of HMOX1 protein]; [2-tert-butylhydroquinone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Calcium affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA] 2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA; 2-tert-butylhydroquinone results in increased expression of HMOX1 protein 2-tert-butylhydroquinone inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [decamethrin results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in increased expression of HMOX1 protein]; [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride; FGF1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein] 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 protein]; 2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of HMOX1 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of HMOX1 mRNA; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in increased expression of HMOX1 protein; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 protein]; Calcium Chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA] |
CTD |
PMID:8612205 PMID:10473555 PMID:10874044 PMID:10975858 PMID:16014739 PMID:16524372 PMID:17676812 PMID:18227147 PMID:18417180 PMID:18482591 PMID:18512965 PMID:19033392 PMID:19715681 PMID:21107535 PMID:21443188 PMID:22250088 PMID:22493042 PMID:22983789 PMID:23112101 PMID:23906629 PMID:23942037 PMID:23945499 PMID:24128855 PMID:24970285 PMID:25003661 PMID:25305463 PMID:26878773 PMID:26879219 PMID:28264691 PMID:28583816 PMID:28645578 PMID:29663635 PMID:30476502 PMID:30547568 PMID:31726083 PMID:32073640 PMID:32428544 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hsd17b3 |
hydroxysteroid (17-beta) dehydrogenase 3 |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of HSD17B3 mRNA] |
CTD |
PMID:32565124 |
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NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of HSD3B1 mRNA] |
CTD |
PMID:32565124 |
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|
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G |
Hsf1 |
heat shock transcription factor 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of HSF1 mRNA |
CTD |
PMID:30309986 |
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NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [pterostilbene results in increased expression of HSPA5 protein] |
CTD |
PMID:25341683 |
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NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; 2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; 2-tert-butylhydroquinone results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of IFNG mRNA; HMOX1 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] |
CTD |
PMID:22250088 PMID:23942037 PMID:30171972 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of IKBKB protein modified form] |
CTD |
PMID:28844481 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10 |
interleukin 10 |
multiple interactions increases expression |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of IL10 mRNA] 2-tert-butylhydroquinone results in increased expression of IL10 mRNA |
CTD |
PMID:32565124 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]] |
CTD |
PMID:25680285 |
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NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL23A protein binds to IL12B protein]]; 2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]] |
CTD |
PMID:25680285 |
|
NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL13 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL13 mRNA |
CTD |
PMID:22250088 |
|
NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
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G |
Il16 |
interleukin 16 |
increases secretion |
ISO |
2-tert-butylhydroquinone results in increased secretion of IL16 protein |
CTD |
PMID:30806763 |
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NCBI chr 1:145,781,923...145,881,538
Ensembl chr 1:145,781,928...145,870,912
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G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of IL1A mRNA |
CTD |
PMID:30806763 |
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NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of and results in increased secretion of IL1B protein] |
CTD |
PMID:28583816 PMID:28844481 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
decreases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in decreased expression of IL2 mRNA 2-tert-butylhydroquinone results in decreased expression of and results in decreased secretion of IL2 protein |
CTD |
PMID:23945499 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL23A protein binds to IL12B protein]] |
CTD |
PMID:25680285 |
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NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
decreases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in decreased expression of IL2RA mRNA; 2-tert-butylhydroquinone results in decreased expression of IL2RA protein 2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein] |
CTD |
PMID:23945499 PMID:30171972 |
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NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL4 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL4 mRNA |
CTD |
PMID:22250088 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL5 protein |
CTD |
PMID:22250088 |
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NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
2-tert-butylhydroquinone inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased secretion of IL6 protein] 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased expression of and results in increased secretion of IL6 protein] |
CTD |
PMID:25305463 PMID:28844481 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
2-tert-butylhydroquinone promotes the reaction [JUND protein binds to CYP2C9 promoter]; 2-tert-butylhydroquinone promotes the reaction [JUND protein modified form binds to CYP2C9 promoter]; JUND mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of CYP2C9 mRNA]; pyrazolanthrone inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of JUND protein] |
CTD |
PMID:24830941 |
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NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
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G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions increases expression decreases response to substance affects binding |
ISO EXP |
2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein] 2-tert-butylhydroquinone promotes the reaction [thallium nitrate results in decreased expression of KEAP1 protein] 2-tert-butylhydroquinone results in increased expression of KEAP1 protein KEAP1 protein mutant form results in decreased susceptibility to 2-tert-butylhydroquinone 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to CUL3 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]] 2-tert-butylhydroquinone binds to KEAP1 protein |
CTD |
PMID:18417180 PMID:18512965 PMID:19033392 PMID:19808700 PMID:23589329 PMID:30261176 PMID:31368498 PMID:31726083 PMID:32073640 |
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NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of LHB protein] |
CTD |
PMID:32565124 |
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NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases phosphorylation multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:24830941 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:24830941 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mchr1 |
melanin-concentrating hormone receptor 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of MCHR1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 7:122,456,846...122,459,324
Ensembl chr 7:122,456,799...122,459,960
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G |
Mfn2 |
mitofusin 2 |
multiple interactions increases expression |
EXP |
2-tert-butylhydroquinone inhibits the reaction [thallium nitrate results in decreased expression of MFN2 protein] 2-tert-butylhydroquinone results in increased expression of MFN2 protein |
CTD |
PMID:31726083 |
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NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
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G |
Mt1 |
metallothionein 1 |
increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased expression of MT1 mRNA 2-tert-butylhydroquinone promotes the reaction [Cycloheximide results in increased expression of MT1 mRNA]; Cycloheximide promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]]; MTF1 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Zinc deficiency inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA] |
CTD |
PMID:14998373 PMID:19276070 |
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NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mt2A |
metallothionein 2A |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of MT2 mRNA |
CTD |
PMID:14998373 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Mtf1 |
metal-regulatory transcription factor 1 |
multiple interactions |
ISO |
MTF1 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA] |
CTD |
PMID:14998373 |
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NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122
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G |
Mtrf1 |
mitochondrial translation release factor 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of MTRF1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr15:61,662,000...61,689,867
Ensembl chr15:61,662,264...61,689,862
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
[TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein |
CTD |
PMID:23112101 |
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NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions affects localization increases response to substance increases expression increases activity affects response to substance decreases response to substance increases ubiquitination increases stability affects binding |
ISO EXP |
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein]; 2-tert-butylhydroquinone affects the localization of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein results in increased ubiquitination of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]; 2-tert-butylhydroquinone results in increased expression of and affects the localization of NFE2L2 protein; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased susceptibility to arsenite; [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein] which results in decreased susceptibility to Oxidopamine; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; Egtazic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; KEAP1 protein mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; KEAP1 protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NFE2L2 protein]; Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; NFE2L2 affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12A mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B mRNA]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of [IL12B protein binds to IL12A protein]]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of EPHX1 exon]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of CES1 mRNA alternative form] 2-tert-butylhydroquinone affects the localization of NFE2L2 protein NFE2L2 protein mutant form results in increased susceptibility to 2-tert-butylhydroquinone NFE2L2 protein affects the susceptibility to 2-tert-butylhydroquinone 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin affects the expression of and affects the localization of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to BCL2 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone results in increased expression of and affects the localization of NFE2L2 protein; [2-tert-butylhydroquinone co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] promotes the reaction [NFE2L2 protein binds to KEAP1 protein]; [2-tert-butylhydroquinone inhibits the reaction [KEAP1 protein binds to NFE2L2 protein]] which results in increased activity of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased activity of TBX21 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of and results in decreased secretion of IFNG protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased expression of IFNG mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL13 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL4 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of and results in increased secretion of IL5 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL13 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of IL4 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in decreased expression of BAX protein; [2-tert-butylhydroquinone results in increased stability of NFE2L2 protein] which results in increased expression of BCL2 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 2-tert-butylhydroquinone] results in increased expression of NFE2L2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [2-tert-butylhydroquinone results in increased ubiquitination of NFE2L2 protein]; Cadmium Chloride inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to KEAP1 protein]]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of BCL2 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [2-tert-butylhydroquinone inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]] 2-tert-butylhydroquinone results in increased activity of NFE2L2 protein; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased activity of GATA3 protein 2-tert-butylhydroquinone affects the localization of and results in increased activity of NFE2L2 protein; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of NFE2L2 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; [2-tert-butylhydroquinone promotes the reaction [[NFE2L2 protein binds to HMOX1 promoter] which results in increased expression of HMOX1 mRNA]] which results in decreased susceptibility to Magnesium Chloride; [thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of NFE2L2 protein; decamethrin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NFE2L2 protein]; N-acetylsphingosine inhibits the reaction [2-tert-butylhydroquinone results in increased localization of NFE2L2 protein] NFE2L2 protein results in decreased susceptibility to 2-tert-butylhydroquinone 2-tert-butylhydroquinone results in increased expression of NFE2L2 mRNA; 2-tert-butylhydroquinone results in increased expression of NFE2L2 protein 2-tert-butylhydroquinone binds to NFE2L2 protein |
CTD |
PMID:10473555 PMID:10874044 PMID:12446695 PMID:14510636 PMID:14998373 PMID:15319326 PMID:15870285 PMID:16092930 PMID:17676812 PMID:18417180 PMID:18512965 PMID:18852027 PMID:19033392 PMID:19183254 PMID:19276070 PMID:19328227 PMID:19715681 PMID:19786557 PMID:20554019 PMID:20932822 PMID:21107535 PMID:21443188 PMID:21464371 PMID:22250088 PMID:22275372 PMID:22476201 PMID:22684020 PMID:22746536 PMID:22983789 PMID:23589329 PMID:23707609 PMID:23906629 PMID:23942037 PMID:23945499 PMID:24704207 PMID:25003661 PMID:25341683 PMID:25680285 PMID:26878773 PMID:26879219 PMID:26958860 PMID:28583816 PMID:28645578 PMID:28790194 PMID:28844481 PMID:29663635 PMID:29857117 PMID:30476502 PMID:30806763 PMID:31368498 PMID:31726083 PMID:32073640 PMID:32428544 PMID:32565124 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:28583816 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nkd1 |
NKD inhibitor of WNT signaling pathway 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of NKD1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 protein] |
CTD |
PMID:32073640 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Notch1 |
notch receptor 1 |
decreases expression |
EXP |
2-tert-butylhydroquinone results in decreased expression of NOTCH1 protein |
CTD |
PMID:29663635 |
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NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity increases expression multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in increased activity of NQO1 protein 2-tert-butylhydroquinone results in increased expression of NQO1 mRNA; 2-tert-butylhydroquinone results in increased expression of NQO1 protein 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of NQO1 mRNA; [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; AG-879 inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Cycloheximide inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Paraquat inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; Zinc promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA] 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein]; 2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; 2-tert-butylhydroquinone results in increased expression of and results in increased activity of NQO1 protein; [thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 protein; Dexamethasone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of and results in increased activity of NQO1 protein]; Dexamethasone inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA] 2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; 2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of NQO1 mRNA]; [lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA; [sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA; [sodium arsenite co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 protein; Acetylcysteine inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; ferric chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 protein]; NFE2L2 affects the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with 2-tert-butylhydroquinone] results in increased expression of NQO1 mRNA] |
CTD |
PMID:7587946 PMID:9029048 PMID:11163336 PMID:14510636 PMID:14998373 PMID:15627257 PMID:16014739 PMID:16600132 PMID:17980396 PMID:18417180 PMID:18512965 PMID:19033392 PMID:19276070 PMID:20650352 PMID:21464371 PMID:22250088 PMID:22275372 PMID:22493042 PMID:23056183 PMID:23906629 PMID:23945499 PMID:24128855 PMID:24632381 PMID:24646717 PMID:24704207 PMID:24970285 PMID:25003661 PMID:25680285 PMID:26878773 PMID:28264691 PMID:28583816 PMID:28645578 PMID:29663635 PMID:30476502 PMID:30547568 PMID:30806763 PMID:31368498 PMID:31726083 PMID:32428544 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
ISO |
2-tert-butylhydroquinone binds to and results in decreased activity of NR1I3 protein alternative form |
CTD |
PMID:20869355 |
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NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of PCNA protein] |
CTD |
PMID:32565124 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Pgd |
phosphogluconate dehydrogenase |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of PGD mRNA |
CTD |
PMID:16014739 |
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NCBI chr 5:165,966,128...165,982,327
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G |
Prdx1 |
peroxiredoxin 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of PRDX1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
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G |
Prf1 |
perforin 1 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PRF1 protein] |
CTD |
PMID:30171972 |
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NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of PRKACA mRNA |
CTD |
PMID:16014739 |
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NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
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G |
Procr |
protein C receptor |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of PROCR mRNA |
CTD |
PMID:16014739 |
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NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
ISO |
PTEN protein affects the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA] |
CTD |
PMID:23829535 |
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NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
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G |
Ptgr1 |
prostaglandin reductase 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of PTGR1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein] |
CTD |
PMID:28583816 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rel |
REL proto-oncogene, NF-kB subunit |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of REL mRNA |
CTD |
PMID:16014739 |
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NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP ISO |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in increased activity of RELA protein] 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA protein] |
CTD |
PMID:28583816 PMID:28844481 PMID:32073640 PMID:32565124 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rorc |
RAR-related orphan receptor C |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of RORC mRNA |
CTD |
PMID:16014739 |
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NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
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G |
Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of SLC3A2 mRNA |
CTD |
PMID:19183254 |
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NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
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G |
Slc40a1 |
solute carrier family 40 member 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of SLC40A1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of SLC7A11 mRNA |
CTD |
PMID:19183254 |
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NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of SOD1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Sodium Chloride, Dietary results in decreased expression of SOD1 protein] |
CTD |
PMID:28844481 PMID:32565124 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO |
2-tert-butylhydroquinone results in increased expression of SOD2 mRNA [2-tert-butylhydroquinone co-treated with Cisplatin] results in increased expression of SOD2 mRNA |
CTD |
PMID:32428544 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sqor |
sulfide quinone oxidoreductase |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of SQOR mRNA |
CTD |
PMID:16014739 |
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NCBI chr 3:114,894,944...114,939,375
Ensembl chr 3:114,900,343...114,939,370
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G |
Sqstm1 |
sequestosome 1 |
increases expression multiple interactions |
ISO EXP |
2-tert-butylhydroquinone results in increased expression of SQSTM1 protein [thallium nitrate co-treated with 2-tert-butylhydroquinone] results in increased expression of SQSTM1 protein |
CTD |
PMID:23589329 PMID:31726083 |
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NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of SRC protein |
CTD |
PMID:23112101 |
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NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
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G |
Srxn1 |
sulfiredoxin 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of SRXN1 mRNA |
CTD |
PMID:16014739 PMID:22003191 |
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NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of STAR mRNA]; 2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in decreased expression of STAR protein] |
CTD |
PMID:32565124 |
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NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Tbx21 |
T-box transcription factor 21 |
multiple interactions |
ISO |
[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased activity of TBX21 protein |
CTD |
PMID:22250088 |
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NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein] 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF protein] |
CTD |
PMID:28583816 PMID:32073640 PMID:32565124 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of AKT1 protein]; 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein]; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of CSF1R protein; [2-tert-butylhydroquinone co-treated with CSF1 protein co-treated with TNFSF11 protein] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CSF1R protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of SRC protein; [TNFSF11 protein co-treated with 2-tert-butylhydroquinone] results in increased expression of HMOX1 protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of CTSK protein; [TNFSF11 protein co-treated with CSF1 protein co-treated with 2-tert-butylhydroquinone] results in decreased expression of NFATC1 protein |
CTD |
PMID:23112101 |
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NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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G |
Tob1 |
transducer of ErbB-2.1 |
decreases expression |
ISO |
2-tert-butylhydroquinone results in decreased expression of TOB1 mRNA |
CTD |
PMID:16014739 |
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NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of TXNRD1 mRNA |
CTD |
PMID:12949356 PMID:16014739 PMID:30806763 |
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NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
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G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
EXP |
2-tert-butylhydroquinone results in increased expression of UGT1A1 mRNA |
CTD |
PMID:20650352 |
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NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
increases expression increases activity multiple interactions |
EXP ISO |
2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA 2-tert-butylhydroquinone results in increased activity of UGT1A6 protein AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of UGT1A6 mRNA] |
CTD |
PMID:10220484 PMID:12948865 |
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NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of UGT1A9 mRNA |
CTD |
PMID:10220484 |
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NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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G |
Ugt2b7 |
UDP glucuronosyltransferase family 2 member B7 |
increases expression |
ISO |
2-tert-butylhydroquinone results in increased expression of UGT2B7 mRNA |
CTD |
PMID:10220484 |
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NCBI chr14:22,597,103...22,619,968
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone inhibits the reaction [Diclofenac results in increased activity of CASP3 protein] |
CTD |
PMID:14599462 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
increases metabolic processing multiple interactions |
EXP |
DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone A 771726 inhibits the reaction [DHODH protein results in increased metabolism of 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone] |
CTD |
PMID:9802339 |
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NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
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G |
A4galt |
alpha 1,4-galactosyltransferase (P blood group) |
decreases expression |
ISO |
hydroquinone results in decreased expression of A4GALT mRNA |
CTD |
PMID:31256213 |
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NCBI chr 7:124,085,832...124,110,440
Ensembl chr 7:124,085,834...124,089,385
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
increases expression |
ISO |
hydroquinone results in increased expression of ABCC3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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G |
Ace2 |
angiotensin I converting enzyme 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ACE2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr X:32,050,734...32,095,860
Ensembl chr X:32,049,931...32,096,016
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G |
Adap2 |
ArfGAP with dual PH domains 2 |
increases expression |
ISO |
hydroquinone results in increased expression of ADAP2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:67,494,851...67,527,582
Ensembl chr10:67,494,984...67,526,426
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G |
Adprh |
ADP-ribosylarginine hydrolase |
increases expression |
ISO |
hydroquinone results in increased expression of ADPRH mRNA |
CTD |
PMID:31256213 |
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NCBI chr11:64,861,772...64,868,112
Ensembl chr11:64,861,768...64,868,108
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G |
Adtrp |
androgen-dependent TFPI-regulating protein |
increases expression |
ISO |
hydroquinone results in increased expression of ADTRP mRNA |
CTD |
PMID:31256213 |
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NCBI chr17:22,619,913...22,688,296
Ensembl chr17:22,619,891...22,688,307
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G |
Aen |
apoptosis enhancing nuclease |
increases expression |
ISO |
hydroquinone results in increased expression of AEN mRNA |
CTD |
PMID:23416264 |
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NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
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G |
Afap1 |
actin filament associated protein 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of AFAP1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr14:79,923,132...80,035,096
Ensembl chr14:79,919,717...79,988,110
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G |
Aggf1 |
angiogenic factor with G patch and FHA domains 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of AGGF1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 2:25,068,804...25,095,429
Ensembl chr 2:25,069,620...25,095,106
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G |
Ahr |
aryl hydrocarbon receptor |
affects localization multiple interactions increases expression |
ISO EXP |
hydroquinone affects the localization of AHR protein alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of AHR protein] |
CTD |
PMID:15935814 PMID:29935983 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Aifm2 |
apoptosis inducing factor, mitochondria associated 2 |
increases expression |
ISO |
hydroquinone results in increased expression of AIFM2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
decreases expression |
ISO |
hydroquinone results in decreased expression of AKR1B10 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein] |
CTD |
PMID:17464197 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein binds to and affects the transport of hydroquinone |
CTD |
PMID:8831264 |
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NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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G |
Aldh1l2 |
aldehyde dehydrogenase 1 family, member L2 |
increases expression |
ISO |
hydroquinone results in increased expression of ALDH1L2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 7:26,375,866...26,425,838
Ensembl chr 7:26,375,866...26,425,108
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
increases expression |
ISO |
hydroquinone results in increased expression of ALDH2 mRNA |
CTD |
PMID:15452088 |
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NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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G |
Aldh3a1 |
aldehyde dehydrogenase 3 family, member A1 |
increases expression |
ISO |
hydroquinone results in increased expression of ALDH3A1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
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G |
Alox12 |
arachidonate 12-lipoxygenase, 12S type |
increases expression |
ISO |
hydroquinone results in increased expression of ALOX12 mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
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G |
Alox12b |
arachidonate 12-lipoxygenase, 12R type |
increases expression |
ISO |
hydroquinone results in increased expression of ALOX12B mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:55,744,646...55,756,524
Ensembl chr10:55,744,588...55,756,566
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G |
Aloxe3 |
arachidonate lipoxygenase 3 |
increases expression |
ISO |
hydroquinone results in increased expression of ALOXE3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr10:55,711,996...55,735,915
Ensembl chr10:55,712,043...55,735,911
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G |
Alpk1 |
alpha-kinase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of ALPK1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 2:231,997,360...232,117,471
Ensembl chr 2:231,996,088...232,117,134
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G |
Ankdd1a |
ankyrin repeat and death domain containing 1A |
decreases expression |
ISO |
hydroquinone results in decreased expression of ANKDD1A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:71,034,630...71,057,265
Ensembl chr 8:71,035,309...71,055,969
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|
G |
Anxa1 |
annexin A1 |
increases expression |
ISO |
hydroquinone results in increased expression of ANXA1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
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|
G |
Anxa3 |
annexin A3 |
increases expression |
ISO |
hydroquinone results in increased expression of ANXA3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:14,371,921...14,426,503
Ensembl chr14:14,364,008...14,426,437
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|
G |
Aqp3 |
aquaporin 3 (Gill blood group) |
decreases expression |
ISO |
hydroquinone results in decreased expression of AQP3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
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|
G |
Arg1 |
arginase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of ARG1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
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|
G |
Arg2 |
arginase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of ARG2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
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|
G |
Arhgap27 |
Rho GTPase activating protein 27 |
increases expression |
ISO |
hydroquinone results in increased expression of ARHGAP27 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:91,418,535...91,451,831
Ensembl chr10:91,419,912...91,448,477
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|
G |
Arhgap42 |
Rho GTPase activating protein 42 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ARHGAP42 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:7,210,999...7,446,215
Ensembl chr 8:7,213,822...7,426,611
|
|
G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
affects expression |
ISO |
hydroquinone affects the expression of ARHGDIA protein |
CTD |
PMID:17181942 |
|
NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550
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|
G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of ARHGEF2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
|
|
G |
Arhgef26 |
Rho guanine nucleotide exchange factor 26 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ARHGEF26 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:27,107,263...27,236,336
Ensembl chr 2:27,107,318...27,236,672
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|
G |
Arl3 |
ADP ribosylation factor like GTPase 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ARL3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:266,287,015...266,333,099
Ensembl chr 1:266,287,017...266,333,105
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|
G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
hydroquinone results in increased expression of ASNS mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
|
|
G |
Asprv1 |
aspartic peptidase, retroviral-like 1 |
increases expression |
ISO |
hydroquinone results in increased expression of ASPRV1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:118,431,755...118,433,286
Ensembl chr 4:118,431,755...118,432,775
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|
G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
hydroquinone results in increased expression of ATF3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
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|
G |
Atf4 |
activating transcription factor 4 |
increases expression |
ISO |
hydroquinone results in increased expression of ATF4 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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|
G |
Atg5 |
autophagy related 5 |
multiple interactions increases expression |
ISO |
PARP1 protein promotes the reaction [hydroquinone results in increased expression of ATG5 mRNA]; SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of ATG5 mRNA] |
CTD |
PMID:28263894 |
|
NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
|
|
G |
Atp2c2 |
ATPase secretory pathway Ca2+ transporting 2 |
increases expression |
ISO |
hydroquinone results in increased expression of ATP2C2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:52,347,480...52,404,608
Ensembl chr19:52,347,580...52,404,607
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|
G |
Atp6v1c2 |
ATPase H+ transporting V1 subunit C2 |
increases expression |
ISO |
hydroquinone results in increased expression of ATP6V1C2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:42,585,452...42,632,289
Ensembl chr 6:42,585,934...42,630,983
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|
G |
Azgp1 |
alpha-2-glycoprotein 1, zinc-binding |
increases expression |
ISO |
hydroquinone results in increased expression of AZGP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647
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|
G |
Bach1 |
BTB domain and CNC homolog 1 |
multiple interactions affects localization |
ISO |
[ferric chloride results in increased oxidation of hydroquinone] promotes the reaction [hydroquinone analog binds to BACH1 protein]; hydroquinone promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of BACH1 protein] hydroquinone affects the localization of BACH1 protein |
CTD |
PMID:28645578 |
|
NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
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|
G |
Bad |
BCL2-associated agonist of cell death |
decreases expression |
ISO |
hydroquinone results in decreased expression of BAD mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
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|
G |
Bag1 |
BAG cochaperone 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of BAG1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
|
|
G |
Bambi |
BMP and activin membrane-bound inhibitor |
increases expression |
ISO |
hydroquinone results in increased expression of BAMBI mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
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|
G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
hydroquinone results in increased expression of BBC3 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 1:78,261,491...78,267,802
|
|
G |
Bcl11a |
BAF chromatin remodeling complex subunit BCL11A |
decreases expression |
ISO |
hydroquinone results in decreased expression of BCL11A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:108,826,717...108,921,197
Ensembl chr14:108,826,831...108,921,669
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|
G |
Bcl11b |
BAF chromatin remodeling complex subunit BCL11B |
decreases expression |
ISO |
hydroquinone results in decreased expression of BCL11B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
[PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of BCL2 protein |
CTD |
PMID:28444915 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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|
G |
Bdh2 |
3-hydroxybutyrate dehydrogenase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of BDH2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:240,461,505...240,482,149
Ensembl chr 2:240,461,505...240,482,145
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|
G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of BECN1 mRNA; hydroquinone results in increased expression of BECN1 protein PARP1 protein promotes the reaction [hydroquinone results in increased expression of BECN1 mRNA]; SIRT1 protein inhibits the reaction [hydroquinone results in increased expression of BECN1 mRNA] |
CTD |
PMID:28263894 |
|
NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
increases expression decreases expression |
ISO |
hydroquinone results in increased expression of BIRC3 mRNA hydroquinone results in decreased expression of BIRC3 mRNA |
CTD |
PMID:15452088 PMID:31256213 |
|
NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression multiple interactions |
ISO |
hydroquinone results in decreased expression of BIRC5 protein Lithium Chloride inhibits the reaction [hydroquinone results in decreased expression of BIRC5 protein] |
CTD |
PMID:28886972 |
|
NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
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|
G |
Bnip3 |
BCL2 interacting protein 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of BNIP3 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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|
G |
Bora |
bora, aurora kinase A activator |
decreases expression |
ISO |
hydroquinone results in decreased expression of BORA mRNA |
CTD |
PMID:23416264 |
|
NCBI chr15:83,442,217...83,463,737
Ensembl chr15:83,442,144...83,463,717
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|
G |
Bpifc |
BPI fold containing family C |
increases expression |
ISO |
hydroquinone results in increased expression of BPIFC mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:23,854,846...23,911,953
Ensembl chr 7:23,854,846...23,911,953
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|
G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
ISO |
hydroquinone results in increased expression of BRCA1 protein |
CTD |
PMID:29421518 |
|
NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
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|
G |
Bst2 |
bone marrow stromal cell antigen 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of BST2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
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|
G |
Btg2 |
BTG anti-proliferation factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of BTG2 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
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|
G |
Bub3 |
BUB3 mitotic checkpoint protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of BUB3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
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|
G |
Ca3 |
carbonic anhydrase 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CA3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
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|
G |
Ca9 |
carbonic anhydrase 9 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CA9 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
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|
G |
Calb2 |
calbindin 2 |
increases expression |
ISO |
hydroquinone results in increased expression of CALB2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:41,482,743...41,509,617
Ensembl chr19:41,482,728...41,509,658
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|
G |
Calcb |
calcitonin-related polypeptide, beta |
increases expression |
ISO |
hydroquinone results in increased expression of CALCB mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:184,271,116...184,276,480
Ensembl chr 1:184,271,590...184,276,475
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|
G |
Calhm6 |
calcium homeostasis modulator family member 6 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CALHM6 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:27,681,138...27,683,580
Ensembl chr20:27,681,036...27,682,861
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|
G |
Calml3 |
calmodulin-like 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CALML3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:70,070,458...70,073,697
Ensembl chr17:70,072,156...70,073,530
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|
G |
Capn2 |
calpain 2 |
decreases activity |
ISO |
hydroquinone results in decreased activity of CAPN2 protein |
CTD |
PMID:9118890 |
|
NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases activity increases cleavage decreases activity decreases expression |
ISO |
[PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of and affects the activity of CASP3 protein; Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of CASP3 protein]; IGF1 protein inhibits the reaction [hydroquinone results in increased expression of CASP3 protein modified form]; Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of CASP3 protein modified form] hydroquinone results in increased cleavage of CASP3 protein hydroquinone results in decreased activity of CASP3 protein [hydroquinone results in increased abundance of Reactive Oxygen Species] which results in decreased activity of CASP3 protein hydroquinone results in decreased expression of CASP3 mRNA |
CTD |
PMID:15337166 PMID:15452088 PMID:15777082 PMID:15816534 PMID:20946948 PMID:22302391 PMID:22960397 PMID:23776099 PMID:28444915 PMID:28886972 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CASP6 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
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|
G |
Casp7 |
caspase 7 |
increases cleavage increases expression decreases activity multiple interactions |
ISO |
hydroquinone results in increased cleavage of CASP7 protein hydroquinone results in increased expression of CASP7 protein modified form hydroquinone results in decreased activity of CASP7 protein Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of CASP7 protein modified form]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of CASP7 protein] |
CTD |
PMID:19064679 PMID:22960397 PMID:28886972 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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|
G |
Casp8 |
caspase 8 |
multiple interactions increases activity |
ISO |
MPO protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein] hydroquinone results in increased activity of CASP8 protein |
CTD |
PMID:15777082 PMID:23776099 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
|
|
G |
Casp9 |
caspase 9 |
decreases expression multiple interactions increases expression increases activity increases cleavage |
ISO |
hydroquinone results in decreased expression of CASP9 mRNA Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of CASP9 protein modified form] hydroquinone results in increased activity of CASP9 protein hydroquinone results in increased cleavage of CASP9 protein |
CTD |
PMID:15452088 PMID:15777082 PMID:15816534 PMID:20946948 PMID:22302391 PMID:23776099 PMID:28886972 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Cat |
catalase |
decreases response to substance |
ISO |
CAT protein results in decreased susceptibility to hydroquinone |
CTD |
PMID:10193577 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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|
G |
Cavin2 |
caveolae associated protein 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CAVIN2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:55,244,136...55,256,153
Ensembl chr 9:55,243,255...55,256,340
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|
G |
Cbs |
cystathionine beta synthase |
increases expression |
ISO |
hydroquinone results in increased expression of CBS mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
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|
G |
Ccdc127 |
coiled-coil domain containing 127 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCDC127 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:31,538,088...31,545,573
Ensembl chr 1:31,539,215...31,545,559
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|
G |
Ccdc163 |
coiled-coil domain containing 163 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCDC163 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:135,562,034...135,568,067
Ensembl chr 5:135,562,034...135,568,062
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|
G |
Ccdc8 |
coiled-coil domain containing 8 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCDC8 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:78,933,372...78,936,700
Ensembl chr 1:78,933,372...78,936,700
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|
G |
Ccdc88c |
coiled-coil domain containing 88C |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCDC88C mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:124,905,811...125,028,011
Ensembl chr 6:124,905,808...125,027,553
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|
G |
Ccl11 |
C-C motif chemokine ligand 11 |
increases expression |
ISO |
hydroquinone results in increased expression of CCL11 protein |
CTD |
PMID:17572062 |
|
NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases secretion decreases expression multiple interactions increases secretion increases expression |
ISO |
hydroquinone results in decreased secretion of CCL2 protein hydroquinone results in decreased expression of CCL2 mRNA hydroquinone inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E. coli O26-B6] results in increased secretion of CCL2 protein]; hydroquinone inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of CCL2 protein] hydroquinone results in increased secretion of CCL2 protein hydroquinone results in increased expression of CCL2 protein |
CTD |
PMID:17572062 PMID:20946948 PMID:22302391 PMID:22465845 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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|
G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression |
ISO |
hydroquinone results in increased expression of CCL3 protein |
CTD |
PMID:17572062 |
|
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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|
G |
Ccl4 |
C-C motif chemokine ligand 4 |
increases expression |
ISO |
hydroquinone results in increased expression of CCL4 protein |
CTD |
PMID:17572062 PMID:18353026 |
|
NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
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|
G |
Ccl5 |
C-C motif chemokine ligand 5 |
increases expression |
ISO |
hydroquinone results in increased expression of CCL5 protein |
CTD |
PMID:17572062 |
|
NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
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|
G |
Ccn1 |
cellular communication network factor 1 |
affects expression |
ISO |
hydroquinone affects the expression of CCN1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
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|
G |
Ccn2 |
cellular communication network factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of CCN2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
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|
G |
Ccna1 |
cyclin A1 |
increases expression |
ISO |
hydroquinone results in increased expression of CCNA1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
Lithium Chloride inhibits the reaction [hydroquinone results in decreased expression of CCND1 protein] |
CTD |
PMID:28886972 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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|
G |
Ccne2 |
cyclin E2 |
increases expression |
ISO |
hydroquinone results in increased expression of CCNE2 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
|
|
G |
Ccnf |
cyclin F |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCNF mRNA |
CTD |
PMID:23416264 |
|
NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
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|
G |
Ccsap |
centriole, cilia and spindle-associated protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of CCSAP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:56,615,326...56,634,031
Ensembl chr19:56,617,399...56,633,633
|
|
G |
Cd69 |
Cd69 molecule |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 protein] |
CTD |
PMID:20054000 |
|
NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
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G |
Cd80 |
Cd80 molecule |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein] |
CTD |
PMID:19148301 |
|
NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
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|
G |
Cd86 |
CD86 molecule |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of CD86 protein hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] |
CTD |
PMID:19148301 PMID:19665512 |
|
NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
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|
G |
Cdca2 |
cell division cycle associated 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CDCA2 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr15:44,365,396...44,411,601
Ensembl chr15:44,365,405...44,411,004
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|
G |
Cdca7 |
cell division cycle associated 7 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CDCA7 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:59,153,281...59,163,916
Ensembl chr 3:59,153,280...59,163,913
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|
G |
Cdh26 |
cadherin 26 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CDH26 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:173,969,004...174,020,867
Ensembl chr 3:173,969,273...174,019,766
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
hydroquinone results in increased expression of CDKN1A mRNA |
CTD |
PMID:23416264 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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|
G |
Cdkn1c |
cyclin-dependent kinase inhibitor 1C |
decreases expression |
ISO |
hydroquinone results in decreased expression of CDKN1C mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
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|
G |
Cdsn |
corneodesmosin |
increases expression |
ISO |
hydroquinone results in increased expression of CDSN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:3,704,626...3,707,266
|
|
G |
Cemip |
cell migration inducing hyaluronidase |
increases expression |
ISO |
hydroquinone results in increased expression of CEMIP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:146,069,774...146,226,320
Ensembl chr 1:146,069,771...146,226,462
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|
G |
Cenpa |
centromere protein A |
decreases expression |
ISO |
hydroquinone results in decreased expression of CENPA mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856
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G |
Ces1d |
carboxylesterase 1D |
increases expression |
ISO |
hydroquinone results in increased expression of CES1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
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G |
Cfap44 |
cilia and flagella associated protein 44 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CFAP44 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:61,160,793...61,237,056
Ensembl chr11:61,162,628...61,234,944
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression |
ISO |
hydroquinone results in increased expression of CFLAR mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
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|
G |
Ch25h |
cholesterol 25-hydroxylase |
increases expression |
ISO |
hydroquinone results in increased expression of CH25H mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:252,807,062...252,811,409
Ensembl chr 1:252,807,065...252,808,380
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|
G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of CHAC1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:111,160,205...111,163,425
Ensembl chr 3:111,160,205...111,163,425
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G |
Chp2 |
calcineurin-like EF hand protein 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CHP2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:192,169,634...192,173,228
Ensembl chr 1:192,169,841...192,173,253
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G |
Chst2 |
carbohydrate sulfotransferase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of CHST2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:103,186,759...103,190,612
Ensembl chr 8:103,188,651...103,190,243
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G |
Clca4 |
chloride channel accessory 4 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CLCA4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:250,842,939...250,864,060
Ensembl chr 2:250,843,165...250,862,419
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G |
Cldn8 |
claudin 8 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CLDN8 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:28,525,641...28,527,890
Ensembl chr11:28,525,643...28,527,890
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G |
Clic3 |
chloride intracellular channel 3 |
increases expression |
ISO |
hydroquinone results in increased expression of CLIC3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:2,675,732...2,678,248
Ensembl chr 3:2,676,296...2,680,565
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G |
Clmp |
CXADR-like membrane protein |
increases expression |
ISO |
hydroquinone results in increased expression of CLMP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:44,846,685...44,975,460
Ensembl chr 8:44,847,157...44,975,457
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G |
Cmpk2 |
cytidine/uridine monophosphate kinase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CMPK2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:45,683,242...45,694,824
Ensembl chr 6:45,683,234...45,694,822
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G |
Cnfn |
cornifelin |
increases expression |
ISO |
hydroquinone results in increased expression of CNFN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:82,234,032...82,236,602
Ensembl chr 1:82,234,032...82,236,179
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G |
Cnmd |
chondromodulin |
increases response to substance increases expression multiple interactions |
ISO |
CNMD protein results in increased susceptibility to hydroquinone hydroquinone results in increased expression of CNMD mRNA Dactinomycin inhibits the reaction [hydroquinone results in increased expression of CNMD protein]; hydroquinone results in increased expression of and results in increased secretion of CNMD protein; NQO1 protein inhibits the reaction [CNMD protein results in increased susceptibility to hydroquinone]; NQO1 protein inhibits the reaction [hydroquinone results in increased expression of CNMD protein] |
CTD |
PMID:19525446 |
|
NCBI chr15:61,923,291...61,947,840
Ensembl chr15:61,923,299...61,947,764
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G |
Col1a1 |
collagen type I alpha 1 chain |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of COL1A1 protein [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]; TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein] |
CTD |
PMID:18055817 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Col2a1 |
collagen type II alpha 1 chain |
multiple interactions |
EXP |
[COL2A1 protein co-treated with Freund's Adjuvant co-treated with hydroquinone] results in increased expression of and results in increased secretion of TNF protein; [COL2A1 protein co-treated with Freund's Adjuvant co-treated with hydroquinone] results in increased secretion of IL1B protein; [COL2A1 protein co-treated with hydroquinone] results in increased expression of IL6 protein |
CTD |
PMID:29908986 PMID:29935983 |
|
NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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G |
Col4a1 |
collagen type IV alpha 1 chain |
decreases expression increases expression multiple interactions |
ISO |
hydroquinone results in decreased expression of COL4A1 mRNA hydroquinone results in increased expression of COL4A1 protein [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]; TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein] |
CTD |
PMID:18055817 |
|
NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
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G |
Col5a2 |
collagen type V alpha 2 chain |
decreases expression |
ISO |
hydroquinone results in decreased expression of COL5A2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:52,091,088...52,238,735
Ensembl chr 9:52,092,511...52,238,564
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G |
Crct1 |
cysteine-rich C-terminal 1 |
increases expression |
ISO |
hydroquinone results in increased expression of CRCT1 mRNA |
CTD |
PMID:31256213 |
|
Ensembl chr 2:193,330,397...193,330,699
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|
G |
Crispld2 |
cysteine-rich secretory protein LCCL domain containing 2 |
increases expression |
ISO |
hydroquinone results in increased expression of CRISPLD2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:52,647,038...52,705,118
Ensembl chr19:52,647,070...52,705,131
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G |
Csf1r |
colony stimulating factor 1 receptor |
multiple interactions |
ISO |
hydroquinone promotes the reaction [[CSF1R protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
CTD |
PMID:7884313 |
|
NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
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|
G |
Csf2 |
colony stimulating factor 2 |
multiple interactions |
ISO |
[CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK1 protein; [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK3 protein hydroquinone promotes the reaction [[CSF2 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] |
CTD |
PMID:7884313 PMID:15129224 |
|
NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
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|
G |
Csgalnact1 |
chondroitin sulfate N-acetylgalactosaminyltransferase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of CSGALNACT1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr16:22,704,318...23,075,071
Ensembl chr16:22,979,444...23,074,798
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G |
Csrnp3 |
cysteine and serine rich nuclear protein 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CSRNP3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:51,883,559...52,120,290
Ensembl chr 3:51,883,559...52,120,290
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|
G |
Csrp2 |
cysteine and glycine-rich protein 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CSRP2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
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|
G |
Cst6 |
cystatin E/M |
increases expression |
ISO |
hydroquinone results in increased expression of CST6 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:220,727,292...220,729,000
Ensembl chr 1:220,727,292...220,729,000
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G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
hydroquinone results in increased expression of CTH mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions affects localization decreases expression |
ISO |
hydroquinone inhibits the reaction [CTNNB1 protein binds to LEF1 protein]; hydroquinone results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; IGF1 protein inhibits the reaction [hydroquinone results in decreased expression of CTNNB1 protein]; Lithium Chloride inhibits the reaction [hydroquinone results in decreased expression of CTNNB1 protein]; PPP2CA protein affects the reaction [hydroquinone affects the localization of CTNNB1 protein]; PPP2CA protein affects the reaction [hydroquinone results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2R5A protein affects the reaction [hydroquinone affects the localization of CTNNB1 protein]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of and results in decreased phosphorylation of CTNNB1 protein] |
CTD |
PMID:28886972 PMID:30567741 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
decreases expression |
ISO |
hydroquinone results in decreased expression of CXCL12 mRNA |
CTD |
PMID:22960397 |
|
NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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G |
Cycs |
cytochrome c, somatic |
affects localization |
ISO |
hydroquinone affects the localization of CYCS protein |
CTD |
PMID:15777082 PMID:15816534 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
affects response to substance increases expression |
ISO |
CYP1A1 protein affects the susceptibility to hydroquinone hydroquinone results in increased expression of CYP1A1 mRNA |
CTD |
PMID:8242868 PMID:23416264 PMID:31256213 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
hydroquinone results in increased expression of CYP1B1 mRNA |
CTD |
PMID:23416264 PMID:31256213 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
multiple interactions |
EXP |
[CYP2B1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone |
CTD |
PMID:8211999 |
|
NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
affects response to substance |
ISO |
CYP2B1 protein affects the susceptibility to hydroquinone |
CTD |
PMID:8242868 |
|
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions |
ISO |
[CYP2D6 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
CTD |
PMID:21402134 |
|
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions increases expression |
EXP ISO |
[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone; [CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone] hydroquinone results in increased expression of CYP2E1 mRNA; hydroquinone results in increased expression of CYP2E1 protein [CYP2E1 protein affects the metabolism of Benzene] which affects the chemical synthesis of hydroquinone; PPP2CA protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 mRNA]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein] |
CTD |
PMID:8211999 PMID:15051535 PMID:30567741 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
[CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
CTD |
PMID:21402134 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
[CYP3A5 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone |
CTD |
PMID:21402134 |
|
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Cyp4f18 |
cytochrome P450, family 4, subfamily f, polypeptide 18 |
increases expression |
ISO |
hydroquinone results in increased expression of CYP4F18 mRNA |
CTD |
PMID:23940708 |
|
NCBI chr16:19,501,680...19,528,935
Ensembl chr16:19,410,810...19,528,999
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G |
Cysrt1 |
cysteine rich tail 1 |
increases expression |
ISO |
hydroquinone results in increased expression of CYSRT1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:2,458,295...2,462,037
Ensembl chr 3:2,458,295...2,459,385
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|
G |
Dap |
death-associated protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of DAP mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
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G |
Dapl1 |
death associated protein-like 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DAPL1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:45,538,408...45,559,281
Ensembl chr 3:45,538,797...45,559,331
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G |
Dapp1 |
dual adaptor of phosphotyrosine and 3-phosphoinositides 1 |
increases expression |
ISO |
hydroquinone results in increased expression of DAPP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:243,175,346...243,224,883
Ensembl chr 2:243,175,346...243,224,883
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|
G |
Dbt |
dihydrolipoamide branched chain transacylase E2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DBT mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:219,563,783...219,592,651
Ensembl chr 2:219,563,783...219,592,650
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|
G |
Dcun1d3 |
defective in cullin neddylation 1 domain containing 3 |
increases expression |
ISO |
hydroquinone results in increased expression of DCUN1D3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:189,626,442...189,666,440
Ensembl chr 1:189,627,972...189,666,440
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DDAH1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:251,634,368...251,766,009
Ensembl chr 2:251,634,431...251,766,014
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|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
hydroquinone results in increased expression of DDIT3 mRNA |
CTD |
PMID:23416264 PMID:31256213 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
|
|
G |
Ddit4 |
DNA-damage-inducible transcript 4 |
increases expression |
ISO |
hydroquinone results in increased expression of DDIT4 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
|
|
G |
Depdc7 |
DEP domain containing 7 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DEPDC7 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:94,665,714...94,687,013
Ensembl chr 3:94,665,717...94,686,989
|
|
G |
Dffb |
DNA fragmentation factor subunit beta |
decreases expression |
ISO |
hydroquinone results in decreased expression of DFFB mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:171,250,559...171,261,875
Ensembl chr 5:171,249,633...171,262,119
|
|
G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
affects expression |
ISO |
hydroquinone affects the expression of DKK1 mRNA |
CTD |
PMID:22960397 |
|
NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
|
|
G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
increases expression |
ISO |
hydroquinone results in increased expression of DNAJA1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
|
|
G |
Dnajb1 |
DnaJ heat shock protein family (Hsp40) member B1 |
increases expression |
ISO |
hydroquinone results in increased expression of DNAJB1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
|
|
G |
Dner |
delta/notch-like EGF repeat containing |
decreases expression |
ISO |
hydroquinone results in decreased expression of DNER mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
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|
G |
Dnmt1 |
DNA methyltransferase 1 |
decreases expression affects expression |
ISO |
hydroquinone results in decreased expression of DNMT1 mRNA; hydroquinone results in decreased expression of DNMT1 protein hydroquinone affects the expression of DNMT1 mRNA |
CTD |
PMID:22245671 PMID:27979589 PMID:31899212 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
|
|
G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression increases expression |
ISO |
hydroquinone results in decreased expression of DNMT3A mRNA; hydroquinone results in decreased expression of DNMT3A protein hydroquinone results in increased expression of DNMT3A mRNA |
CTD |
PMID:22245671 PMID:27979589 PMID:31899212 |
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NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
decreases expression multiple interactions affects expression |
ISO |
hydroquinone results in decreased expression of DNMT3B mRNA Decitabine affects the reaction [hydroquinone affects the expression of DNMT3B mRNA]; trichostatin A affects the reaction [hydroquinone affects the expression of DNMT3B mRNA] |
CTD |
PMID:22245671 PMID:31899212 |
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NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
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G |
Dtx3l |
deltex E3 ubiquitin ligase 3L |
decreases expression |
ISO |
hydroquinone results in decreased expression of DTX3L mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:67,758,093...67,767,623 NCBI chr11:67,768,542...67,772,428
Ensembl chr11:67,757,928...67,767,622
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G |
Dusp19 |
dual specificity phosphatase 19 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DUSP19 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 3:67,849,966...67,862,475
Ensembl chr 3:67,849,966...67,862,475
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G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
ISO |
hydroquinone results in increased expression of DUSP5 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
ISO |
hydroquinone results in increased expression of DUSP6 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
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G |
Dzip1 |
DAZ interacting zinc finger protein 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of DZIP1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr15:104,117,551...104,168,574
Ensembl chr15:104,117,556...104,170,958
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G |
E4f1 |
E4F transcription factor 1 |
increases expression affects response to substance multiple interactions |
ISO |
hydroquinone results in increased expression of E4F1 mRNA; hydroquinone results in increased expression of E4F1 protein E4F1 protein affects the susceptibility to hydroquinone [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of H2AX protein modified form; [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of RB1 protein; [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of RB1 protein modified form |
CTD |
PMID:30448557 PMID:30506647 |
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NCBI chr10:13,812,335...13,835,847
Ensembl chr10:13,815,293...13,826,945
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G |
Ecm2 |
extracellular matrix protein 2 |
increases expression |
ISO |
hydroquinone results in increased expression of ECM2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:15,533,760...15,566,403
Ensembl chr17:15,533,972...15,566,332
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G |
Edn1 |
endothelin 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of EDN1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Edn2 |
endothelin 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of EDN2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
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G |
Eef2k |
eukaryotic elongation factor-2 kinase |
decreases expression |
ISO |
hydroquinone results in decreased expression of EEF2K mRNA |
CTD |
PMID:31256213 |
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NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324
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G |
Efna1 |
ephrin A1 |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of EFNA1 mRNA |
CTD |
PMID:32198055 |
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NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
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G |
Egr3 |
early growth response 3 |
increases expression |
ISO |
hydroquinone results in increased expression of EGR3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
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G |
Ehmt2 |
euchromatic histone lysine methyltransferase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of EHMT2 protein |
CTD |
PMID:27979589 |
|
NCBI chr20:4,576,033...4,592,980
Ensembl chr20:4,576,057...4,592,980
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G |
Eid3 |
EP300 interacting inhibitor of differentiation 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of EID3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:26,976,154...26,977,479
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|
G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression |
ISO |
hydroquinone results in increased expression of EIF4EBP1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
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G |
Elf3 |
E74 like ETS transcription factor 3 |
increases expression |
ISO |
hydroquinone results in increased expression of ELF3 mRNA |
CTD |
PMID:23416264 |
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NCBI chr13:52,083,873...52,088,798
Ensembl chr13:52,083,859...52,088,780
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G |
Elf5 |
E74 like ETS transcription factor 5 |
increases expression |
ISO |
hydroquinone results in increased expression of ELF5 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 3:93,333,514...93,374,454
Ensembl chr 3:93,351,619...93,371,656
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G |
Elmod1 |
ELMO domain containing 1 |
increases expression |
ISO |
hydroquinone results in increased expression of ELMOD1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:58,486,078...58,542,884
Ensembl chr 8:58,486,078...58,542,844
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G |
Elovl4 |
ELOVL fatty acid elongase 4 |
increases expression |
ISO |
hydroquinone results in increased expression of ELOVL4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:91,310,690...91,338,625
Ensembl chr 8:91,310,630...91,338,843
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G |
Elovl5 |
ELOVL fatty acid elongase 5 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
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G |
Elp2 |
elongator acetyltransferase complex subunit 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ELP2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr18:16,544,515...16,581,086
Ensembl chr18:16,544,508...16,581,116
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|
G |
Epb41l3 |
erythrocyte membrane protein band 4.1-like 3 |
increases expression |
ISO |
hydroquinone results in increased expression of EPB41L3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 9:117,314,935...117,666,408
Ensembl chr 9:117,538,009...117,666,410
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G |
Ephx1 |
epoxide hydrolase 1 |
multiple interactions |
EXP |
EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Benzene] which results in increased chemical synthesis of hydroquinone]; EPHX1 protein promotes the reaction [[CYP2E1 protein results in increased metabolism of Phenol] which results in increased chemical synthesis of hydroquinone] |
CTD |
PMID:8211999 |
|
NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
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G |
Eps8l1 |
EPS8-like 1 |
increases expression |
ISO |
hydroquinone results in increased expression of EPS8L1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:72,926,106...72,942,433
Ensembl chr 1:72,927,151...72,941,869
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G |
Ereg |
epiregulin |
increases expression |
ISO |
hydroquinone results in increased expression of EREG mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
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G |
Erich5 |
glutamate-rich 5 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ERICH5 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:73,222,331...73,243,684
Ensembl chr 7:73,222,730...73,242,899
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G |
Esr1 |
estrogen receptor 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ESR1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Etv4 |
ETS variant transcription factor 4 |
increases expression |
ISO |
hydroquinone results in increased expression of ETV4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:89,685,058...89,700,300
Ensembl chr10:89,685,058...89,700,283
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|
G |
Exosc3 |
exosome component 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of EXOSC3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705
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G |
Exosc6 |
exosome component 6 |
increases expression |
ISO |
hydroquinone results in increased expression of EXOSC6 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:43,190,879...43,193,164
Ensembl chr19:43,191,390...43,192,208
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|
G |
Ezh2 |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
decreases expression |
ISO |
hydroquinone results in decreased expression of EZH2 protein |
CTD |
PMID:27979589 |
|
NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
|
|
G |
F2r |
coagulation factor II (thrombin) receptor |
decreases expression |
ISO |
hydroquinone results in decreased expression of F2R mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
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|
G |
Fadd |
Fas associated via death domain |
decreases expression |
ISO |
hydroquinone results in decreased expression of FADD mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
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G |
Fam117b |
family with sequence similarity 117, member B |
decreases expression |
ISO |
hydroquinone results in decreased expression of FAM117B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:66,716,969...66,784,487
Ensembl chr 9:66,716,969...66,784,487
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G |
Fam13a |
family with sequence similarity 13, member A |
decreases expression |
ISO |
hydroquinone results in decreased expression of FAM13A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:89,183,180...89,281,282
Ensembl chr 4:89,183,768...89,281,222
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G |
Fam43a |
family with sequence similarity 43, member A |
increases expression |
ISO |
hydroquinone results in increased expression of FAM43A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984
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G |
Fam83d |
family with sequence similarity 83, member D |
decreases expression |
ISO |
hydroquinone results in decreased expression of FAM83D mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 3:155,269,344...155,288,612
Ensembl chr 3:155,269,347...155,288,533
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G |
Fas |
Fas cell surface death receptor |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of FAS protein [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of FAS protein |
CTD |
PMID:23776099 PMID:28444915 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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|
G |
Faslg |
Fas ligand |
increases expression |
ISO |
hydroquinone results in increased expression of FASLG protein |
CTD |
PMID:23776099 |
|
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fbxo5 |
F-box protein 5 |
decreases expression |
ISO |
hydroquinone results in decreased expression of FBXO5 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
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G |
Fgfr3 |
fibroblast growth factor receptor 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of FGFR3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
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|
G |
Fibin |
fin bud initiation factor homolog |
increases expression |
ISO |
hydroquinone results in increased expression of FIBIN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:101,545,207...101,547,478
Ensembl chr 3:101,545,208...101,547,478
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|
G |
Fn1 |
fibronectin 1 |
affects expression |
ISO |
hydroquinone affects the expression of FN1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
hydroquinone results in decreased expression of FOS mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
|
|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
increases expression |
ISO |
hydroquinone results in increased expression of FOSL1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
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|
G |
Fry |
FRY microtubule binding protein |
increases expression |
ISO |
hydroquinone results in increased expression of FRY mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:5,573,729...5,822,874
Ensembl chr12:5,573,729...5,822,874
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G |
Fsip1 |
fibrous sheath interacting protein 1 |
increases expression |
ISO |
hydroquinone results in increased expression of FSIP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:109,877,943...110,021,186
Ensembl chr 3:109,969,152...110,021,149
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G |
Fth1 |
ferritin heavy chain 1 |
increases expression |
ISO |
hydroquinone results in increased expression of FTH1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
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G |
Fzd2 |
frizzled class receptor 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of FZD2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:90,550,147...90,552,057
Ensembl chr10:90,550,147...90,552,057
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G |
G0s2 |
G0/G1switch 2 |
increases expression |
ISO |
hydroquinone results in increased expression of G0S2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
|
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
hydroquinone results in increased expression of GADD45A mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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G |
Gas1 |
growth arrest-specific 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of GAS1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
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G |
Gask1b |
golgi associated kinase 1B |
decreases expression |
ISO |
hydroquinone results in decreased expression of GASK1B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:178,678,946...178,751,459
Ensembl chr 2:178,679,041...178,750,668
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G |
Gata1 |
GATA binding protein 1 |
decreases expression multiple interactions |
ISO |
hydroquinone results in decreased expression of GATA1 mRNA decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA]]; hydroquinone inhibits the reaction [Hemin results in increased expression of GATA1 mRNA] |
CTD |
PMID:21414390 PMID:23973255 |
|
NCBI chr X:15,273,937...15,281,759
Ensembl chr X:15,378,789...15,382,066
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G |
Gata2 |
GATA binding protein 2 |
multiple interactions decreases expression |
ISO |
hydroquinone promotes the reaction [Hemin results in decreased expression of GATA2 mRNA] hydroquinone results in decreased expression of GATA2 mRNA |
CTD |
PMID:21414390 |
|
NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488
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|
G |
Gbp2 |
guanylate binding protein 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of GBP2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
ISO |
hydroquinone results in increased expression of GCLC mRNA; hydroquinone results in increased expression of GCLC protein |
CTD |
PMID:30547568 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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|
G |
Gclm |
glutamate cysteine ligase, modifier subunit |
increases expression |
ISO |
hydroquinone results in increased expression of GCLM mRNA; hydroquinone results in increased expression of GCLM protein |
CTD |
PMID:21059386 PMID:30547568 PMID:31256213 |
|
NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
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|
G |
Gda |
guanine deaminase |
increases expression |
ISO |
hydroquinone results in increased expression of GDA mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:238,982,542...239,057,663
Ensembl chr 1:238,982,392...239,057,732
|
|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
hydroquinone results in increased expression of GDF15 mRNA |
CTD |
PMID:23416264 PMID:31256213 |
|
NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
|
|
G |
Gdpd3 |
glycerophosphodiester phosphodiesterase domain containing 3 |
increases expression |
ISO |
hydroquinone results in increased expression of GDPD3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
|
|
G |
Gfpt1 |
glutamine fructose-6-phosphate transaminase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of GFPT1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:118,852,046...118,901,583
Ensembl chr 4:118,852,062...118,901,591
|
|
G |
Gk |
glycerol kinase |
increases expression |
ISO |
hydroquinone results in increased expression of GK mRNA |
CTD |
PMID:31256213 |
|
NCBI chr X:54,227,291...54,303,897
Ensembl chr X:54,227,397...54,303,864
|
|
G |
Glmp |
glycosylated lysosomal membrane protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of GLMP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:187,697,528...187,701,118
Ensembl chr 2:187,697,523...187,701,118
|
|
G |
Glrx |
glutaredoxin |
increases expression |
ISO |
hydroquinone results in increased expression of GLRX mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
|
|
G |
Glul |
glutamate-ammonia ligase |
decreases expression |
ISO |
hydroquinone results in decreased expression of GLUL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
|
|
G |
Gmpr |
guanosine monophosphate reductase |
decreases expression |
ISO |
hydroquinone results in decreased expression of GMPR mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:19,543,274...19,580,929
Ensembl chr17:19,543,275...19,580,929
|
|
G |
Gosr2 |
golgi SNAP receptor complex member 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of GOSR2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:91,735,772...91,756,123
Ensembl chr10:91,736,780...91,756,081
|
|
G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of GOT1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
|
|
G |
Gpat3 |
glycerol-3-phosphate acyltransferase 3 |
increases expression |
ISO |
hydroquinone results in increased expression of GPAT3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
|
|
G |
Gpr155 |
G protein-coupled receptor 155 |
decreases expression |
ISO |
hydroquinone results in decreased expression of GPR155 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:60,051,545...60,105,567
Ensembl chr 3:60,051,535...60,105,242
|
|
G |
Gprc5a |
G protein-coupled receptor, class C, group 5, member A |
decreases expression |
ISO |
hydroquinone results in decreased expression of GPRC5A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
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G |
Gpx2 |
glutathione peroxidase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of GPX2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
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G |
Grb10 |
growth factor receptor bound protein 10 |
increases expression |
ISO |
hydroquinone results in increased expression of GRB10 mRNA |
CTD |
PMID:31256213 |
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NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
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G |
Grb2 |
growth factor receptor bound protein 2 |
affects expression |
ISO |
hydroquinone affects the expression of GRB2 protein |
CTD |
PMID:20021034 |
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NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
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G |
Grhl1 |
grainyhead-like transcription factor 1 |
increases expression |
ISO |
hydroquinone results in increased expression of GRHL1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 6:43,734,837...43,795,757
Ensembl chr 6:43,743,702...43,794,342
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
hydroquinone results in increased expression of and results in decreased phosphorylation of and results in increased activity of GSK3B protein; IGF1 protein inhibits the reaction [hydroquinone results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [hydroquinone results in increased expression of GSK3B protein] |
CTD |
PMID:28886972 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Peroxynitrous Acid results in decreased activity of GSR protein] |
CTD |
PMID:15831208 |
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NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gss |
glutathione synthetase |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of GSS protein NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of GSS protein] |
CTD |
PMID:21059386 |
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NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
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G |
Gstm1 |
glutathione S-transferase mu 1 |
affects response to substance |
ISO |
GSTM1 gene polymorphism affects the susceptibility to hydroquinone |
CTD |
PMID:15141365 |
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NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
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G |
Gtpbp2 |
GTP binding protein 2 |
increases expression |
ISO |
hydroquinone results in increased expression of GTPBP2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 9:17,198,957...17,208,456
Ensembl chr 9:17,198,957...17,209,220
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
increases expression |
ISO |
hydroquinone results in increased expression of GUCY1B1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
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G |
Gvin1 |
GTPase, very large interferon inducible 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of GVINP1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 1:173,233,675...173,259,901
Ensembl chr 1:173,252,058...173,259,702
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G |
Gypa |
glycophorin A |
decreases expression |
ISO |
hydroquinone results in decreased expression of GYPA protein |
CTD |
PMID:21414390 |
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NCBI chr19:31,115,545...31,131,079
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G |
H1f4 |
H1.4 linker histone, cluster member |
decreases expression |
ISO |
hydroquinone results in decreased expression of H1-4 mRNA |
CTD |
PMID:23416264 |
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NCBI chr17:43,734,461...43,735,120
Ensembl chr17:43,734,461...43,735,120
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G |
H1f5 |
H1.5 linker histone, cluster member |
decreases expression |
ISO |
hydroquinone results in decreased expression of H1-5 mRNA |
CTD |
PMID:23416264 |
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NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
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G |
H2ac12 |
H2A clustered histone 12 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H2AC12 mRNA |
CTD |
PMID:23416264 |
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NCBI chr17:44,527,990...44,528,557
Ensembl chr17:44,528,125...44,528,511
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G |
H2ac20 |
H2A clustered histone 20 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H2AC20 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 2:198,360,271...198,360,735
Ensembl chr 2:198,360,301...198,360,678
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G |
H2ac21 |
H2A clustered histone 21 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H2AC21 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 2:198,359,754...198,360,146
Ensembl chr 2:198,359,754...198,360,146
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G |
H2ax |
H2A.X variant histone |
multiple interactions increases phosphorylation affects localization increases expression |
ISO |
[E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of H2AX protein modified form; [POLH mutant form results in increased susceptibility to hydroquinone] which results in increased expression of H2AX protein; WRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AX protein alternative form]; WRN protein affects the reaction [hydroquinone results in increased expression of H2AX protein] hydroquinone results in increased phosphorylation of H2AX protein hydroquinone affects the localization of H2AX protein modified form |
CTD |
PMID:17875398 PMID:18835433 PMID:20036648 PMID:21267443 PMID:22981619 PMID:30506647 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
H4c3 |
H4 clustered histone 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C3 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262
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G |
H4f3 |
H1.3 linker histone, cluster member |
decreases expression |
ISO |
hydroquinone results in decreased expression of H1-3 mRNA |
CTD |
PMID:23416264 |
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NCBI chr17:43,797,711...43,798,450
Ensembl chr17:43,797,721...43,798,383
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G |
Hbb |
hemoglobin subunit beta |
multiple interactions |
ISO |
decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA]]; hydroquinone inhibits the reaction [Hemin results in increased expression of HBB mRNA] |
CTD |
PMID:21414390 PMID:23973255 |
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NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
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G |
Hbegf |
heparin-binding EGF-like growth factor |
increases expression |
ISO |
hydroquinone results in increased expression of HBEGF mRNA |
CTD |
PMID:31256213 |
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NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
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G |
Hdac1 |
histone deacetylase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of HDAC1 protein |
CTD |
PMID:30448557 |
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NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of HDAC2 protein |
CTD |
PMID:30448557 |
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NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
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G |
Hdac9 |
histone deacetylase 9 |
increases expression |
ISO |
hydroquinone results in increased expression of HDAC9 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
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G |
Hfe |
homeostatic iron regulator |
decreases expression |
ISO |
hydroquinone results in decreased expression of HFE mRNA |
CTD |
PMID:31256213 |
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NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
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G |
Hist1h4m |
histone cluster 1, H4m |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C1 mRNA |
CTD |
PMID:23416264 |
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Ensembl chr17:44,815,684...44,815,995
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G |
Hist2h2aa3 |
histone cluster 2 H2A family member A3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H2AC18 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 2:198,388,766...198,389,293
Ensembl chr 2:198,388,809...198,389,201 Ensembl chr 2:198,388,809...198,389,201
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G |
Hist2h4 |
histone cluster 2, H4 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C2 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350
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G |
Hjurp |
Holliday junction recognition protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of HJURP mRNA |
CTD |
PMID:23416264 |
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NCBI chr 9:95,347,739...95,362,228
Ensembl chr 9:95,349,086...95,362,014
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G |
Hmbs |
hydroxymethylbilane synthase |
multiple interactions |
ISO |
decitabine inhibits the reaction [hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA]]; hydroquinone inhibits the reaction [Hemin results in increased expression of HMBS mRNA] |
CTD |
PMID:21414390 PMID:23973255 |
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NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748
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G |
Hmgb2 |
high mobility group box 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of HMGB2 mRNA |
CTD |
PMID:23416264 |
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NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191 Ensembl chr11:36,077,617...36,080,191
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of HMOX1 mRNA ferric chloride promotes the reaction [hydroquinone results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of HMOX1 protein] hydroquinone results in increased expression of HMOX1 mRNA; hydroquinone results in increased expression of HMOX1 protein |
CTD |
PMID:17464197 PMID:21059386 PMID:28645578 PMID:29508652 PMID:30547568 PMID:31256213 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Hotairm1 |
Hoxa transcript antisense RNA, myeloid-specific 1 |
multiple interactions affects expression affects methylation |
ISO |
Decitabine affects the reaction [hydroquinone affects the expression of HOTAIRM1 mRNA]; Decitabine affects the reaction [hydroquinone affects the methylation of HOTAIRM1 promoter]; trichostatin A affects the reaction [hydroquinone affects the expression of HOTAIRM1 mRNA]; trichostatin A affects the reaction [hydroquinone affects the methylation of HOTAIRM1 promoter] |
CTD |
PMID:31899212 |
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NCBI chr 4:82,127,355...82,130,853
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions affects expression |
ISO |
3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of HRAS protein]; Doxorubicin inhibits the reaction [hydroquinone results in decreased expression of HRAS protein]; hydroquinone promotes the reaction [PARP1 protein binds to and results in increased ADP-ribosylation of and results in increased expression of HRAS protein]; PARP1 protein promotes the reaction [hydroquinone results in increased expression of HRAS protein] hydroquinone affects the expression of HRAS mRNA; hydroquinone affects the expression of HRAS protein |
CTD |
PMID:26047893 |
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NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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G |
Hsd17b2 |
hydroxysteroid (17-beta) dehydrogenase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of HSD17B2 mRNA |
CTD |
PMID:31256213 |
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NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
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G |
Hspa13 |
heat shock protein family A (Hsp70) member 13 |
increases expression |
ISO |
hydroquinone results in increased expression of HSPA13 mRNA |
CTD |
PMID:31256213 |
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NCBI chr11:14,146,515...14,160,697
Ensembl chr11:14,144,130...14,160,892
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G |
Hspa2 |
heat shock protein family A (Hsp70) member 2 |
increases expression |
ISO |
hydroquinone results in increased expression of HSPA2 mRNA |
CTD |
PMID:15452088 |
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NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
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G |
Hyls1 |
HYLS1, centriolar and ciliogenesis associated |
decreases expression |
ISO |
hydroquinone results in decreased expression of HYLS1 mRNA |
CTD |
PMID:23416264 |
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NCBI chr 8:36,763,470...36,772,199
Ensembl chr 8:36,763,481...36,764,422
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G |
Id1 |
inhibitor of DNA binding 1, HLH protein |
increases expression |
ISO |
hydroquinone results in increased expression of ID1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
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G |
Id3 |
inhibitor of DNA binding 3, HLH protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of ID3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
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G |
Id4 |
inhibitor of DNA binding 4, HLH protein |
increases expression |
ISO |
hydroquinone results in increased expression of ID4 mRNA |
CTD |
PMID:31256213 |
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NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
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G |
Ier3 |
immediate early response 3 |
increases expression |
ISO |
hydroquinone results in increased expression of IER3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
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G |
Ifi44 |
interferon-induced protein 44 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IFI44 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
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G |
Ifi44l |
interferon-induced protein 44-like |
decreases expression |
ISO |
hydroquinone results in decreased expression of IFI44L mRNA |
CTD |
PMID:31256213 |
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NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
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G |
Ifih1 |
interferon induced with helicase C domain 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IFIH1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
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G |
Ifit3 |
interferon-induced protein with tetratricopeptide repeats 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IFIT3 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [[IFNG protein co-treated with lipopolysaccharide, E. coli O26-B6] results in increased secretion of CCL2 protein]; hydroquinone inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of IFNG protein]; IFNG protein promotes the reaction [[Lipopolysaccharides co-treated with hydroquinone] results in increased abundance of Nitric Oxide] |
CTD |
PMID:3137358 PMID:7884313 PMID:22465845 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Ifrd1 |
interferon-related developmental regulator 1 |
increases expression |
ISO |
hydroquinone results in increased expression of IFRD1 mRNA |
CTD |
PMID:31256213 |
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NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO |
IGF1 protein inhibits the reaction [hydroquinone results in decreased expression of CTNNB1 protein]; IGF1 protein inhibits the reaction [hydroquinone results in decreased phosphorylation of GSK3B protein]; IGF1 protein inhibits the reaction [hydroquinone results in increased expression of CASP3 protein modified form] |
CTD |
PMID:28886972 |
|
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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G |
Igfbp3 |
insulin-like growth factor binding protein 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IGFBP3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:20054000 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] hydroquinone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL10 protein] |
CTD |
PMID:17464197 PMID:17572062 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12b |
interleukin 12B |
multiple interactions increases expression |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA] hydroquinone results in increased expression of IL12B mRNA |
CTD |
PMID:15894107 PMID:17464197 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il17a |
interleukin 17A |
increases secretion |
EXP |
hydroquinone results in increased secretion of IL17A protein |
CTD |
PMID:29935983 |
|
NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression decreases cleavage |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased cleavage of IL1A protein] Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of IL1A protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]; PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein] hydroquinone results in increased expression of IL1A mRNA; hydroquinone results in increased expression of IL1A protein hydroquinone results in decreased cleavage of IL1A protein |
CTD |
PMID:1868253 PMID:8548860 PMID:9118901 PMID:28836394 PMID:31256213 |
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NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
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G |
Il1b |
interleukin 1 beta |
decreases cleavage increases expression decreases secretion multiple interactions |
ISO EXP |
hydroquinone results in decreased cleavage of IL1B protein hydroquinone results in increased expression of IL1B mRNA hydroquinone results in decreased secretion of IL1B protein hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] [COL2A1 protein co-treated with Freund's Adjuvant co-treated with hydroquinone] results in increased secretion of IL1B protein; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] |
CTD |
PMID:8548860 PMID:9118901 PMID:17464197 PMID:19148301 PMID:22717997 PMID:29908986 PMID:31256213 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il1f10 |
interleukin 1 family member 10 |
increases expression |
ISO |
hydroquinone results in increased expression of IL1F10 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:1,408,560...1,416,601
Ensembl chr 3:1,413,671...1,416,599
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 protein] |
CTD |
PMID:9571986 |
|
NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il23a |
interleukin 23 subunit alpha |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA] |
CTD |
PMID:17464197 |
|
NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
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G |
Il33 |
interleukin 33 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IL33 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
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G |
Il36g |
interleukin 36, gamma |
increases expression |
ISO |
hydroquinone results in increased expression of IL36G mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:1,285,658...1,291,836
Ensembl chr 3:1,285,664...1,291,865
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G |
Il36rn |
interleukin 36 receptor antagonist |
increases expression |
ISO |
hydroquinone results in increased expression of IL36RN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
hydroquinone promotes the reaction [keyhole-limpet hemocyanin results in increased expression of IL4 mRNA]; hydroquinone promotes the reaction [keyhole-limpet hemocyanin results in increased expression of IL4 protein] |
CTD |
PMID:12153512 |
|
NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il6 |
interleukin 6 |
multiple interactions decreases secretion |
EXP ISO |
[COL2A1 protein co-treated with hydroquinone] results in increased expression of IL6 protein; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] hydroquinone results in decreased secretion of IL6 protein |
CTD |
PMID:17464197 PMID:19148301 PMID:20054000 PMID:22302391 PMID:22717997 PMID:29935983 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Inhba |
inhibin subunit beta A |
increases expression |
ISO |
hydroquinone results in increased expression of INHBA mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
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|
G |
Inpp4b |
inositol polyphosphate-4-phosphatase type II B |
increases expression |
ISO |
hydroquinone results in increased expression of INPP4B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:29,592,889...30,341,528
Ensembl chr19:29,597,905...29,968,424
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|
G |
Irs1 |
insulin receptor substrate 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of IRS1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
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|
G |
Isg15 |
ISG15 ubiquitin-like modifier |
decreases expression |
ISO |
hydroquinone results in decreased expression of ISG15 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
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|
G |
Itgb1 |
integrin subunit beta 1 |
decreases activity decreases expression |
ISO |
hydroquinone results in decreased activity of ITGB1 protein hydroquinone results in decreased expression of ITGB1 mRNA hydroquinone results in decreased expression of ITGB1 protein |
CTD |
PMID:17464197 PMID:19148301 |
|
NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
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G |
Itgb2 |
integrin subunit beta 2 |
decreases expression increases expression |
ISO |
hydroquinone results in decreased expression of ITGB2 protein hydroquinone results in decreased expression of ITGB2 mRNA hydroquinone results in increased expression of ITGB2 protein |
CTD |
PMID:17464197 PMID:19148301 PMID:21664406 |
|
NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
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G |
Itgb3 |
integrin subunit beta 3 |
increases expression |
ISO |
hydroquinone results in increased expression of ITGB3 protein |
CTD |
PMID:21664406 |
|
NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
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G |
Ivl |
involucrin |
increases expression |
ISO |
hydroquinone results in increased expression of IVL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
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|
G |
Jag1 |
jagged canonical Notch ligand 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of JAG1 mRNA |
CTD |
PMID:22960397 |
|
NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
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|
G |
Jrk |
Jrk helix-turn-helix protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of JRK mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:115,941,788...115,946,471
Ensembl chr 7:115,942,743...115,946,425
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|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
affects localization |
ISO |
hydroquinone affects the localization of JUN protein |
CTD |
PMID:26807887 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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|
G |
Kbtbd6 |
kelch repeat and BTB domain containing 6 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KBTBD6 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:61,731,574...61,733,331
Ensembl chr15:61,731,735...61,733,742
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|
G |
Kbtbd7 |
kelch repeat and BTB domain containing 7 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KBTBD7 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:61,692,041...61,696,506
|
|
G |
Kcnj15 |
potassium inwardly-rectifying channel, subfamily J, member 15 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KCNJ15 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:35,545,185...35,588,517
Ensembl chr11:35,568,182...35,585,390
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G |
Kdm6a |
lysine demethylase 6A |
decreases expression |
ISO |
hydroquinone results in decreased expression of KDM6A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr X:4,805,493...4,945,788
Ensembl chr X:4,806,277...4,945,944
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|
G |
Kics2 |
KICSTOR subunit 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of C12ORF66 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:63,922,871...63,937,721
Ensembl chr 7:63,922,879...63,936,385
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|
G |
Kif18a |
kinesin family member 18A |
decreases expression |
ISO |
hydroquinone results in decreased expression of KIF18A mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 3:100,366,168...100,426,867
Ensembl chr 3:100,366,168...100,427,030
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|
G |
Kitlg |
KIT ligand |
increases expression |
ISO |
hydroquinone results in increased expression of KITLG mRNA |
CTD |
PMID:22960397 |
|
NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
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|
G |
Klf2 |
Kruppel-like factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of KLF2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr16:19,223,087...19,225,037
Ensembl chr16:19,223,087...19,225,037
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|
G |
Klf7 |
Kruppel like factor 7 |
increases expression |
ISO |
hydroquinone results in increased expression of KLF7 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:70,740,480...70,787,913
Ensembl chr 9:70,740,480...70,787,913
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G |
Klhl31 |
kelch-like family member 31 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KLHL31 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:84,945,444...84,968,811
Ensembl chr 8:84,945,444...84,968,811
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G |
Klk6 |
kallikrein related-peptidase 6 |
increases expression |
ISO |
hydroquinone results in increased expression of KLK6 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:99,762,195...99,769,486
Ensembl chr 1:99,762,253...99,769,488
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|
G |
Klrg2 |
killer cell lectin like receptor G2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KLRG2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:66,370,674...66,381,351
Ensembl chr 4:66,371,511...66,380,734
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|
G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
[PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of KRAS protein |
CTD |
PMID:28444915 |
|
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
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|
G |
Krt13 |
keratin 13 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KRT13 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:88,032,130...88,036,040
Ensembl chr10:88,032,130...88,036,040
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|
G |
Krt19 |
keratin 19 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KRT19 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
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|
G |
Krt23 |
keratin 23 |
increases expression |
ISO |
hydroquinone results in increased expression of KRT23 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:87,391,623...87,407,634
Ensembl chr10:87,391,623...87,407,634
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|
G |
Krt24 |
keratin 24 |
decreases expression |
ISO |
hydroquinone results in decreased expression of KRT24 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:87,190,184...87,195,075
Ensembl chr10:87,189,934...87,195,075
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|
G |
Krt78 |
keratin 78 |
increases expression |
ISO |
hydroquinone results in increased expression of KRT78 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:143,545,245...143,553,063
Ensembl chr 7:143,545,411...143,552,588
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|
G |
Krt80 |
keratin 80 |
increases expression |
ISO |
hydroquinone results in increased expression of KRT80 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:142,995,715...143,015,932
Ensembl chr 7:142,994,119...143,016,040
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|
G |
Lama4 |
laminin subunit alpha 4 |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of LAMA4 protein [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]; TIMP2 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
CTD |
PMID:18055817 |
|
NCBI chr20:44,060,715...44,201,966
Ensembl chr20:44,060,731...44,209,614
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G |
Lasp1 |
LIM and SH3 protein 1 |
affects expression |
ISO |
hydroquinone affects the expression of LASP1 protein |
CTD |
PMID:20021034 |
|
NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
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|
G |
Lcn2 |
lipocalin 2 |
increases expression |
ISO |
hydroquinone results in increased expression of LCN2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
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|
G |
Lef1 |
lymphoid enhancer binding factor 1 |
multiple interactions decreases expression |
ISO |
hydroquinone inhibits the reaction [CTNNB1 protein binds to LEF1 protein] hydroquinone results in decreased expression of LEF1 protein |
CTD |
PMID:28886972 |
|
NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
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|
G |
Lgalsl |
galectin-like |
increases expression |
ISO |
hydroquinone results in increased expression of LGALSL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:105,047,915...105,055,421
Ensembl chr14:105,047,919...105,055,421
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|
G |
Lgr4 |
leucine-rich repeat-containing G protein-coupled receptor 4 |
decreases expression |
ISO |
hydroquinone results in decreased expression of LGR4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:101,051,960...101,152,119
Ensembl chr 3:101,051,955...101,152,119
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|
G |
Lipg |
lipase G, endothelial type |
increases expression |
ISO |
hydroquinone results in increased expression of LIPG mRNA |
CTD |
PMID:31256213 |
|
NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
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|
G |
Lmna |
lamin A/C |
affects expression |
ISO |
hydroquinone affects the expression of LMNA protein |
CTD |
PMID:17181942 |
|
NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
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|
G |
LOC102548682 |
histone H4-like |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C6 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr17:43,616,218...43,673,659
Ensembl chr17:43,791,657...43,792,067 Ensembl chr17:43,791,657...43,792,067 Ensembl chr17:43,791,657...43,792,067 Ensembl chr 2:43,791,657...43,792,067 Ensembl chr17:43,791,657...43,792,067 Ensembl chr17:43,791,657...43,792,067 Ensembl chr 2:43,791,657...43,792,067 Ensembl chr 2:43,791,657...43,792,067
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|
G |
LOC102550598 |
small proline-rich protein 2I-like |
increases expression |
ISO |
hydroquinone results in increased expression of SPRR2G mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:192,520,019...192,521,188
Ensembl chr 2:192,520,733...192,520,960
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|
G |
LOC102551184 |
histone H4-like |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C12 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr17:43,770,198...43,821,579
|
|
G |
LOC290595 |
hypothetical gene supported by AF152002 |
decreases expression |
ISO |
hydroquinone results in decreased expression of C10ORF99 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr16:14,352,998...14,360,604
Ensembl chr16:14,353,459...14,360,555
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|
G |
Loricrin |
loricrin cornified envelope precursor protein |
increases expression |
ISO |
hydroquinone results in increased expression of LORICRIN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:191,984,455...191,990,713
Ensembl chr 2:191,984,773...191,986,170
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|
G |
Lrrc27 |
leucine rich repeat containing 27 |
decreases expression |
ISO |
hydroquinone results in decreased expression of LRRC27 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:211,543,751...211,575,823
Ensembl chr 1:211,543,751...211,575,820
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|
G |
Lrriq3 |
leucine-rich repeats and IQ motif containing 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of LRRIQ3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:261,403,040...261,499,893
Ensembl chr 2:261,402,980...261,499,891
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|
G |
Lss |
lanosterol synthase |
decreases expression |
ISO |
hydroquinone results in decreased expression of LSS mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
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|
G |
Ly6e |
lymphocyte antigen 6 family member E |
decreases expression |
ISO |
hydroquinone results in decreased expression of LY6E mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
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|
G |
Ly96 |
lymphocyte antigen 96 |
increases expression |
ISO |
hydroquinone results in increased expression of LY96 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:1,972,212...1,989,448
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|
G |
Lypd5 |
Ly6/Plaur domain containing 5 |
increases expression |
ISO |
hydroquinone results in increased expression of LYPD5 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:81,202,832...81,213,928
Ensembl chr 1:81,208,212...81,213,937
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|
G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
hydroquinone results in increased expression of MAFF mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
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G |
Magi1 |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of MAGI1 mRNA; [hydroquinone co-treated with Hemin] affects the expression of MAGI1 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] |
CTD |
PMID:32198055 |
|
NCBI chr 4:125,684,816...126,300,013
Ensembl chr 4:125,687,307...125,958,112
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G |
Map1b |
microtubule-associated protein 1B |
increases expression |
ISO |
hydroquinone results in increased expression of MAP1B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
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G |
Map7d2 |
MAP7 domain containing 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MAP7D2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr X:38,400,578...38,467,825
Ensembl chr X:38,397,261...38,468,360
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK1 protein; hydroquinone results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:15129224 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [CSF2 protein co-treated with hydroquinone] results in increased phosphorylation of and results in increased activity of MAPK3 protein; hydroquinone results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:15129224 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Marchf3 |
membrane associated ring-CH-type finger 3 |
increases expression |
ISO |
hydroquinone results in increased expression of MARCHF3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr18:51,844,980...51,998,017
Ensembl chr18:51,844,976...52,017,734
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G |
Mbd2 |
methyl-CpG binding domain protein 2 |
decreases expression multiple interactions increases expression |
ISO |
hydroquinone results in decreased expression of MBD2 mRNA PARP1 protein affects the reaction [hydroquinone results in increased expression of MBD2 protein] |
CTD |
PMID:22245671 PMID:30448557 |
|
NCBI chr18:65,814,026...65,885,115
Ensembl chr18:65,814,026...65,885,114
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G |
Mbnl3 |
muscleblind-like splicing regulator 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MBNL3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr X:138,378,674...138,473,365
Ensembl chr X:138,384,912...138,435,391
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G |
Mboat2 |
membrane bound O-acyltransferase domain containing 2 |
increases expression |
ISO |
hydroquinone results in increased expression of MBOAT2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:44,009,872...44,135,501
Ensembl chr 6:44,009,872...44,131,387
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G |
Mctp1 |
multiple C2 and transmembrane domain containing 1 |
increases expression |
ISO |
hydroquinone results in increased expression of MCTP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:3,400,883...4,089,949
Ensembl chr 2:3,400,977...4,088,989
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G |
Mctp2 |
multiple C2 and transmembrane domain containing 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MCTP2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:133,324,881...133,559,644
Ensembl chr 1:133,324,301...133,559,975
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G |
Mettl21a |
methyltransferase like 21A |
decreases expression |
ISO |
hydroquinone results in decreased expression of METTL21A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:71,304,138...71,314,015
Ensembl chr 9:71,304,427...71,313,940
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G |
Mettl7a |
methyltransferase like 7A |
decreases expression |
ISO |
hydroquinone results in decreased expression of METTL7A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:141,973,447...142,021,344
Ensembl chr 7:141,973,553...141,981,432
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|
G |
MGC105649 |
hypothetical LOC302884 |
increases expression |
ISO |
hydroquinone results in increased expression of C15ORF48 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:114,772,603...114,776,156
Ensembl chr 3:114,772,603...114,776,155
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of MGST1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Mid1 |
midline 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MID1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr X:25,458,782...25,839,941
Ensembl chr X:25,458,771...25,628,272
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|
G |
Mir155 |
microRNA 155 |
multiple interactions increases expression |
ISO |
Doxorubicin promotes the reaction [hydroquinone results in increased expression of MIR155 mRNA]; PARP1 protein affects the reaction [hydroquinone results in increased expression of MIR155 mRNA]; trichostatin A promotes the reaction [hydroquinone results in increased expression of MIR155 mRNA] |
CTD |
PMID:30448557 |
|
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
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|
G |
Mir486 |
microRNA 486 |
multiple interactions |
ISO |
hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; hydroquinone inhibits the reaction [Hemin results in increased expression of MIR486-1 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] |
CTD |
PMID:32198055 |
|
Ensembl chr16:73,680,363...73,680,490
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|
G |
Mmp1 |
matrix metallopeptidase 1 |
increases expression |
ISO |
hydroquinone results in increased expression of MMP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
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G |
Mmp14 |
matrix metallopeptidase 14 |
multiple interactions |
ISO |
[MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]; [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]; [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]; [TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]; MMP14 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]; MMP14 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein] |
CTD |
PMID:18055817 |
|
NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
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G |
Mmp15 |
matrix metallopeptidase 15 |
affects expression |
ISO |
hydroquinone affects the expression of MMP15 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr19:10,079,881...10,101,380
Ensembl chr19:10,079,765...10,101,451
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases activity multiple interactions |
ISO |
hydroquinone results in decreased activity of MMP2 protein [MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]; MMP14 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]; TIMP2 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein] |
CTD |
PMID:16936130 PMID:18055817 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp3 |
matrix metallopeptidase 3 |
affects expression increases expression |
ISO |
hydroquinone affects the expression of MMP3 mRNA hydroquinone results in increased expression of MMP3 mRNA |
CTD |
PMID:15452088 PMID:31256213 |
|
NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions increases expression increases secretion |
ISO |
hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]]; hydroquinone promotes the reaction [TNF protein results in increased secretion of MMP9 protein]; pyrazolanthrone inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein]; SB 203580 inhibits the reaction [hydroquinone results in increased secretion of MMP9 protein] hydroquinone results in increased expression of MMP9 mRNA |
CTD |
PMID:17669387 PMID:26807887 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Mob3b |
MOB kinase activator 3B |
decreases expression |
ISO |
hydroquinone results in decreased expression of MOB3B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:50,437,444...50,638,136
Ensembl chr 5:50,438,576...50,638,136
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G |
Mpl |
MPL proto-oncogene, thrombopoietin receptor |
multiple interactions decreases methylation increases expression |
ISO |
decitabine promotes the reaction [hydroquinone results in increased expression of MPL mRNA] hydroquinone results in decreased methylation of MPL gene |
CTD |
PMID:22245671 |
|
NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
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G |
Mpo |
myeloperoxidase |
multiple interactions increases chemical synthesis increases oxidation |
ISO |
[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein; [[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone; [MPO protein co-treated with Hydrogen Peroxide] promotes the reaction [hydroquinone results in decreased activity of TOP2A protein]; [MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone; [MPO protein results in increased hydroxylation of Phenol] which results in increased chemical synthesis of hydroquinone; MPO protein affects the reaction [hydroquinone results in increased cleavage of CASP8 protein] MPO protein results in increased chemical synthesis of hydroquinone MPO protein results in increased oxidation of hydroquinone |
CTD |
PMID:1666626 PMID:10994872 PMID:15777082 PMID:15935818 PMID:31248982 |
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NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
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G |
Mpzl3 |
myelin protein zero-like 3 |
increases expression |
ISO |
hydroquinone results in increased expression of MPZL3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:49,354,257...49,374,444
Ensembl chr 8:49,354,115...49,376,687
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G |
Mt1 |
metallothionein 1 |
increases expression |
ISO |
hydroquinone results in increased expression of MT1 mRNA |
CTD |
PMID:14998373 |
|
NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
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G |
Mthfd1 |
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MTHFD1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
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G |
Mtus1 |
microtubule associated scaffold protein 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MTUS1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr16:54,240,892...54,386,131
Ensembl chr16:54,291,251...54,386,129
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G |
Mx2 |
MX dynamin like GTPase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of MX1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MYC protein] |
CTD |
PMID:12749906 |
|
NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Mycl |
MYCL proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
hydroquinone results in decreased expression of MYCL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:140,691,947...140,698,837
Ensembl chr 5:140,692,779...140,698,609
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G |
Mylip |
myosin regulatory light chain interacting protein |
decreases expression |
ISO |
hydroquinone results in decreased expression of MYLIP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:19,682,040...19,703,681
Ensembl chr17:19,682,040...19,703,681
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G |
Myo1f |
myosin IF |
decreases expression |
ISO |
hydroquinone results in decreased expression of MYO1F mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:18,440,742...18,491,448
Ensembl chr 7:18,440,742...18,491,448
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G |
N4bp2l1 |
NEDD4 binding protein 2-like 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of N4BP2L1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:546,759...576,744
Ensembl chr12:546,760...576,746
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G |
Ncf2 |
neutrophil cytosolic factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of NCF2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
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G |
Nedd4l |
NEDD4 like E3 ubiquitin protein ligase |
decreases expression |
ISO |
hydroquinone results in decreased expression of NEDD4L mRNA |
CTD |
PMID:31256213 |
|
NCBI chr18:60,392,376...60,719,720
Ensembl chr18:60,392,376...60,719,720
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G |
Nefh |
neurofilament heavy |
decreases expression |
ISO |
hydroquinone results in decreased expression of NEFH mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
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G |
Neu3 |
neuraminidase 3 |
increases expression |
ISO |
hydroquinone results in increased expression of NEU3 mRNA |
CTD |
PMID:23776099 |
|
NCBI chr 1:164,803,574...164,814,777
Ensembl chr 1:164,803,574...164,814,651
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G |
Nfatc2 |
nuclear factor of activated T-cells 2 |
increases expression |
ISO |
hydroquinone results in increased expression of NFATC2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292
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G |
Nfe2 |
nuclear factor, erythroid 2 |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Hemin results in increased expression of NFE2 mRNA] |
CTD |
PMID:21414390 |
|
NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions increases expression increases activity |
ISO |
Acetylcysteine inhibits the reaction [hydroquinone results in increased activity of NFE2L2 promoter]; ferric chloride promotes the reaction [hydroquinone results in increased expression of NFE2L2 protein]; hydroquinone affects the localization of and results in increased degradation of NFE2L2 protein; hydroquinone inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; hydroquinone results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of GSS protein]; NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of HMOX1 protein] |
CTD |
PMID:21059386 PMID:21643505 PMID:28645578 |
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NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions increases expression |
ISO |
hydroquinone results in decreased activity of [NFKB1 protein binds to RELA protein] hydroquinone results in increased expression of NFKB1 protein |
CTD |
PMID:15894107 PMID:30448557 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:20054000 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nfkbib |
NFKB inhibitor beta |
decreases degradation |
ISO |
hydroquinone results in decreased degradation of NFKBIB protein |
CTD |
PMID:15894107 |
|
NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
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G |
Niban1 |
niban apoptosis regulator 1 |
increases expression |
ISO |
hydroquinone results in increased expression of NIBAN1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:68,949,665...69,101,600
Ensembl chr13:68,949,665...69,101,588
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G |
Nid1 |
nidogen 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of NID1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:90,553,161...90,627,133
Ensembl chr17:90,553,394...90,627,101
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G |
Nipal3 |
NIPA-like domain containing 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of NIPAL3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:153,808,169...153,843,961
Ensembl chr 5:153,807,955...153,840,178
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression |
ISO |
hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] hydroquinone results in decreased expression of NOS2 mRNA; hydroquinone results in decreased expression of NOS2 protein |
CTD |
PMID:15831208 PMID:17464197 PMID:19148301 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression decreases response to substance multiple interactions |
ISO |
hydroquinone results in increased expression of NQO1 mRNA; hydroquinone results in increased expression of NQO1 protein NQO1 protein results in decreased susceptibility to hydroquinone ferric chloride promotes the reaction [hydroquinone results in increased expression of NQO1 protein]; hydroquinone results in increased expression of and results in increased activity of NQO1 protein; NQO1 protein inhibits the reaction [CNMD protein results in increased susceptibility to hydroquinone]; NQO1 protein inhibits the reaction [hydroquinone results in increased expression of CNMD protein] |
CTD |
PMID:8652659 PMID:10368308 PMID:10393963 PMID:19525446 PMID:21059386 PMID:28645578 PMID:29508652 PMID:30547568 PMID:31256213 |
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NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of NR4A2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
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G |
Nras |
NRAS proto-oncogene, GTPase |
decreases expression |
ISO |
hydroquinone results in decreased expression of NRAS mRNA |
CTD |
PMID:26047893 |
|
NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
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G |
Nudt16 |
nudix hydrolase 16 |
decreases expression |
ISO |
hydroquinone results in decreased expression of NUDT16 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 8:113,673,069...113,675,124
Ensembl chr 8:113,672,758...113,675,128
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G |
Nwd2 |
NACHT and WD repeat domain containing 2 |
increases expression |
ISO |
hydroquinone results in increased expression of NWD2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:46,136,780...46,153,320
Ensembl chr14:46,136,786...46,153,212
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
decreases expression |
ISO |
hydroquinone results in decreased expression of OAS1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
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G |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of OAS2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
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G |
Oasl |
2'-5'-oligoadenylate synthetase-like |
increases expression |
ISO |
hydroquinone results in increased expression of OASL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
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G |
Ocln |
occludin |
multiple interactions |
EXP |
hydroquinone results in decreased degradation of and results in increased expression of OCLN protein |
CTD |
PMID:27587462 |
|
NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
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G |
Olah |
oleoyl-ACP hydrolase |
increases expression |
ISO |
hydroquinone results in increased expression of OLAH mRNA |
CTD |
PMID:31256213 |
|
NCBI chr17:78,878,673...78,903,919
Ensembl chr17:78,879,058...78,903,967
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G |
Olr1356 |
olfactory receptor 1356 |
decreases expression |
ISO |
hydroquinone results in decreased expression of OR2C1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr10:11,941,947...11,942,885
Ensembl chr10:11,941,947...11,942,885
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G |
Ovol1 |
ovo like transcriptional repressor 1 |
increases expression |
ISO |
hydroquinone results in increased expression of OVOL1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:220,927,309...220,938,814
Ensembl chr 1:220,925,605...220,938,814
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G |
P2rx4 |
purinergic receptor P2X 4 |
increases expression |
ISO |
hydroquinone results in increased expression of P2RX4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:39,308,022...39,325,673
Ensembl chr12:39,308,025...39,325,673
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G |
Pa2g4 |
proliferation-associated 2G4 |
affects expression |
ISO |
hydroquinone affects the expression of PA2G4 protein |
CTD |
PMID:17181942 |
|
NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
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G |
Pabpc4l |
poly(A) binding protein, cytoplasmic 4-like |
decreases expression |
ISO |
hydroquinone results in decreased expression of PABPC4L mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:130,656,212...130,658,202
Ensembl chr 2:130,656,212...130,658,202
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G |
Paics |
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase |
decreases expression |
ISO |
hydroquinone results in decreased expression of PAICS mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:33,563,884...33,580,944
Ensembl chr14:33,563,886...33,580,566
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G |
Paip2b |
poly(A) binding protein interacting protein 2B |
decreases expression |
ISO |
hydroquinone results in decreased expression of PAIP2B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:115,484,676...115,516,307
Ensembl chr 4:115,487,313...115,516,296
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G |
Palmd |
palmdelphin |
decreases expression |
ISO |
hydroquinone results in decreased expression of PALMD mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:220,481,292...220,536,004
Ensembl chr 2:220,481,616...220,535,751
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage affects response to substance increases expression increases response to substance affects expression multiple interactions |
ISO |
hydroquinone results in increased cleavage of PARP1 protein PARP1 protein affects the susceptibility to hydroquinone hydroquinone results in increased expression of PARP1 protein PARP1 protein results in increased susceptibility to hydroquinone hydroquinone affects the expression of PARP1 protein 3-aminobenzamide inhibits the reaction [hydroquinone results in increased expression of PARP1 protein]; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of and affects the activity of CASP3 protein; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of BCL2 protein; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of FAS protein; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of KRAS protein; [PARP1 protein affects the susceptibility to hydroquinone] which affects the expression of TP53 protein; Doxorubicin inhibits the reaction [hydroquinone results in decreased expression of PARP1 protein]; hydroquinone promotes the reaction [PARP1 protein binds to and results in increased ADP-ribosylation of and results in increased expression of HRAS protein]; hydroquinone results in increased expression of and results in increased cleavage of PARP1 protein; Lithium Chloride inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [hydroquinone results in increased expression of MBD2 protein]; PARP1 protein affects the reaction [hydroquinone results in increased expression of MIR155 mRNA]; PARP1 protein promotes the reaction [hydroquinone results in increased expression of ATG5 mRNA]; PARP1 protein promotes the reaction [hydroquinone results in increased expression of BECN1 mRNA]; PARP1 protein promotes the reaction [hydroquinone results in increased expression of HRAS protein]; WRN protein inhibits the reaction [hydroquinone results in increased cleavage of PARP1 protein] |
CTD |
PMID:19064679 PMID:26047893 PMID:28263894 PMID:28444915 PMID:28886972 PMID:29421518 PMID:30448557 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Parp9 |
poly (ADP-ribose) polymerase family, member 9 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PARP9 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:67,724,071...67,758,027
Ensembl chr11:67,724,076...67,756,799
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G |
Pbx1 |
PBX homeobox 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PBX1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:86,390,741...86,671,460
Ensembl chr13:86,390,741...86,451,002
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|
G |
Pck2 |
phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
increases expression |
ISO |
hydroquinone results in increased expression of PCK2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
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|
G |
Pdcd4 |
programmed cell death 4 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PDCD4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
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|
G |
Pde11a |
phosphodiesterase 11A |
decreases expression |
ISO |
hydroquinone results in decreased expression of PDE11A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
|
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G |
Pde4b |
phosphodiesterase 4B |
decreases expression |
ISO |
hydroquinone results in decreased expression of PDE4B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
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|
G |
Pdgfrb |
platelet derived growth factor receptor beta |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of PDGFRB mRNA |
CTD |
PMID:32198055 |
|
NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
|
|
G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
decreases activity |
ISO |
hydroquinone metabolite results in decreased activity of PDPK1 protein; hydroquinone results in decreased activity of PDPK1 protein |
CTD |
PMID:20054000 |
|
NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
|
|
G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PECAM1 protein |
CTD |
PMID:21664406 |
|
NCBI chr10:94,850,971...94,913,202
|
|
G |
Peg3 |
paternally expressed 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PEG3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:70,210,810...70,237,450
Ensembl chr 1:70,222,964...70,237,443
|
|
G |
Pgls |
6-phosphogluconolactonase |
affects expression |
ISO |
hydroquinone affects the expression of PGLS protein |
CTD |
PMID:17181942 |
|
NCBI chr16:20,020,444...20,025,930
Ensembl chr16:20,020,444...20,025,930
|
|
G |
Pglyrp4 |
peptidoglycan recognition protein 4 |
increases expression |
ISO |
hydroquinone results in increased expression of PGLYRP4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:190,125,655...190,204,230
Ensembl chr 2:190,125,693...190,148,265
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G |
Phlda1 |
pleckstrin homology-like domain, family A, member 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PHLDA1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
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G |
Pik3c3 |
phosphatidylinositol 3-kinase, catalytic subunit type 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PIK3C3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
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G |
Pik3ip1 |
phosphoinositide-3-kinase interacting protein 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PIK3IP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:83,559,397...83,572,481
Ensembl chr14:83,560,541...83,572,473
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased abundance of Reactive Oxygen Species]; PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of IL1A protein]; PIK3R1 protein modified form inhibits the reaction [hydroquinone results in increased expression of TNF protein] |
CTD |
PMID:28836394 |
|
NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
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G |
Pim1 |
Pim-1 proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
hydroquinone results in increased expression of PIM1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
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G |
Pitx2 |
paired-like homeodomain 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PITX2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
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G |
Pkia |
cAMP-dependent protein kinase inhibitor alpha |
decreases expression |
ISO |
hydroquinone results in decreased expression of PKIA mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:96,593,185...96,668,222
Ensembl chr 2:96,595,088...96,668,222
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G |
Pkp2 |
plakophilin 2 |
increases expression |
ISO |
hydroquinone results in increased expression of PKP2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr11:88,912,163...88,972,213
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|
G |
Plcxd1 |
phosphatidylinositol-specific phospholipase C, X domain containing 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PLCXD1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:52,640,939...52,645,153
Ensembl chr12:52,641,222...52,676,608
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G |
Pld1 |
phospholipase D1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PLD1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
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G |
Pllp |
plasmolipin |
decreases expression |
ISO |
hydroquinone results in decreased expression of PLLP mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:10,731,855...10,752,641
Ensembl chr19:10,731,855...10,752,641
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G |
Pmfbp1 |
polyamine modulated factor 1 binding protein 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PMFBP1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:42,132,551...42,196,990
Ensembl chr19:42,132,527...42,180,981
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G |
Polh |
DNA polymerase eta |
increases response to substance multiple interactions |
ISO |
POLH mutant form results in increased susceptibility to hydroquinone [POLH mutant form results in increased susceptibility to hydroquinone] which results in increased expression of H2AX protein |
CTD |
PMID:22981619 |
|
NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132
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G |
Polr1b |
RNA polymerase I subunit B |
decreases expression |
ISO |
hydroquinone results in decreased expression of POLR1B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:121,632,043...121,656,506
Ensembl chr 3:121,632,043...121,656,506
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases expression |
ISO |
hydroquinone results in increased expression of PPARD mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
increases expression |
ISO |
hydroquinone results in increased expression of PPM1D mRNA |
CTD |
PMID:23416264 |
|
NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
ISO |
hydroquinone results in increased expression of PPP1R15A mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
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G |
Ppp2ca |
protein phosphatase 2 catalytic subunit alpha |
multiple interactions |
ISO |
PPP2CA protein affects the reaction [hydroquinone affects the localization of CTNNB1 protein]; PPP2CA protein affects the reaction [hydroquinone results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2CA protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein] |
CTD |
PMID:30567741 |
|
NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
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G |
Ppp2r5a |
protein phosphatase 2, regulatory subunit B', alpha |
multiple interactions |
ISO |
PPP2R5A protein affects the reaction [hydroquinone affects the localization of CTNNB1 protein]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 mRNA]; PPP2R5A protein affects the reaction [hydroquinone results in increased expression of CYP2E1 protein] |
CTD |
PMID:30567741 |
|
NCBI chr13:110,033,550...110,077,946
Ensembl chr13:110,033,550...110,077,946
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G |
Pptc7 |
protein phosphatase targeting COQ7 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PPTC7 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr12:39,731,107...39,769,480
Ensembl chr12:39,731,121...39,769,480
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G |
Prdm1 |
PR/SET domain 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PRDM1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
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G |
Prdx1 |
peroxiredoxin 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PRDX1 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
increases expression |
ISO |
hydroquinone results in increased expression of PRKDC mRNA; hydroquinone results in increased expression of PRKDC protein |
CTD |
PMID:20036648 PMID:23940708 |
|
NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
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G |
Prr9 |
proline rich 9 |
increases expression |
ISO |
hydroquinone results in increased expression of PRR9 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:192,025,457...192,036,073
Ensembl chr 2:192,025,875...192,027,225
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G |
Prss3 |
serine protease 3 |
increases expression |
ISO |
hydroquinone results in increased expression of PRSS3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 4:70,614,524...70,617,998
Ensembl chr 4:70,614,524...70,617,998
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G |
Psapl1 |
prosaposin-like 1 |
increases expression |
ISO |
hydroquinone results in increased expression of PSAPL1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:79,711,694...79,714,254
Ensembl chr14:79,711,694...79,714,254
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G |
Psrc1 |
proline and serine rich coiled-coil 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PSRC1 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 2:211,176,437...211,181,078
Ensembl chr 2:211,176,556...211,181,123
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G |
Ptgr2 |
prostaglandin reductase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of PTGR2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:107,999,832...108,031,645
Ensembl chr 6:107,999,846...108,031,643
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases expression |
ISO |
hydroquinone results in increased expression of PTGS2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
multiple interactions |
ISO |
[[[MPO protein co-treated with Hydrogen Peroxide] results in increased metabolism of hydroquinone] which results in increased chemical synthesis of quinone] which results in decreased activity of PTPN2 protein |
CTD |
PMID:31248982 |
|
NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
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G |
Pygb |
glycogen phosphorylase B |
increases expression |
ISO |
hydroquinone results in increased expression of PYGB mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
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G |
Qpct |
glutaminyl-peptide cyclotransferase |
increases expression |
ISO |
hydroquinone results in increased expression of QPCT mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:1,657,110...1,689,575
Ensembl chr 6:1,657,331...1,689,559
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G |
Rab30 |
RAB30, member RAS oncogene family |
decreases expression |
ISO |
hydroquinone results in decreased expression of RAB30 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:157,573,344...157,667,973
Ensembl chr 1:157,573,324...157,660,008
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G |
Rab3b |
RAB3B, member RAS oncogene family |
increases expression |
ISO |
hydroquinone results in increased expression of RAB3B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
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G |
Rab7b |
Rab7b, member RAS oncogene family |
decreases expression |
ISO |
hydroquinone results in decreased expression of RAB7B mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:48,456,143...48,483,714
Ensembl chr13:48,455,923...48,482,138
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G |
Rabgap1l |
RAB GTPase activating protein 1-like |
decreases expression |
ISO |
hydroquinone results in decreased expression of RABGAP1L mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:77,975,392...78,609,009
Ensembl chr13:78,011,047...78,609,045
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G |
Rap1a |
RAP1A, member of RAS oncogene family |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAP1A protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAP1A protein] |
CTD |
PMID:32198055 |
|
NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
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G |
Rapgef2 |
Rap guanine nucleotide exchange factor 2 |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 mRNA]; MIR486-1 mRNA affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RAPGEF2 protein] |
CTD |
PMID:32198055 |
|
NCBI chr 2:177,836,191...178,057,378
Ensembl chr 2:177,836,202...178,057,157
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G |
Rassf5 |
Ras association domain family member 5 |
multiple interactions |
ISO |
[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA; [hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein; hydroquinone affects the reaction [[Hemin co-treated with MIR486-1 mRNA] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 mRNA]; MAGI1 protein affects the reaction [[hydroquinone co-treated with Hemin] affects the expression of RASSF5 protein] |
CTD |
PMID:32198055 |
|
NCBI chr13:47,956,754...48,022,333
Ensembl chr13:47,956,790...48,022,333
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G |
Rb1 |
RB transcriptional corepressor 1 |
increases expression multiple interactions |
ISO |
hydroquinone results in increased expression of RB protein [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of RB1 protein; [E4F1 protein affects the susceptibility to hydroquinone] which results in decreased expression of RB1 protein modified form |
CTD |
PMID:26047893 PMID:30506647 |
|
NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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G |
Rbck1 |
RANBP2-type and C3HC4-type zinc finger containing 1 |
increases expression |
ISO |
hydroquinone results in increased expression of RBCK1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 3:147,793,014...147,809,941
Ensembl chr 3:147,793,017...147,809,919
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G |
Rdh12 |
retinol dehydrogenase 12 |
increases expression |
ISO |
hydroquinone results in increased expression of RDH12 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 6:102,392,828...102,405,750
Ensembl chr 6:102,392,828...102,405,750
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G |
Reck |
reversion-inducing-cysteine-rich protein with kazal motifs |
decreases expression |
ISO |
hydroquinone results in decreased expression of RECK mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
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G |
Recql4 |
RecQ like helicase 4 |
increases expression |
ISO |
hydroquinone results in increased expression of RECQL4 mRNA |
CTD |
PMID:15452088 |
|
NCBI chr 7:117,765,892...117,773,128
Ensembl chr 7:117,763,783...117,773,134
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
hydroquinone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and affects the localization of RELA protein] hydroquinone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; hydroquinone results in decreased activity of [NFKB1 protein binds to RELA protein] |
CTD |
PMID:15894107 PMID:16928326 PMID:20054000 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Reps1 |
RALBP1 associated Eps domain containing 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of REPS1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:13,262,049...13,298,347
Ensembl chr 1:13,212,324...13,298,347
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G |
Rftn1 |
raftlin lipid raft linker 1 |
increases expression |
ISO |
hydroquinone results in increased expression of RFTN1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:12,740,885...12,942,358
Ensembl chr 9:12,740,885...12,942,358
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G |
Rfx5 |
regulatory factor X5 |
decreases expression |
ISO |
hydroquinone results in decreased expression of RFX5 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:196,119,054...196,128,109
Ensembl chr 2:196,120,580...196,128,095
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G |
RGD1306063 |
similar to HT021 |
decreases expression |
ISO |
hydroquinone results in decreased expression of C3ORF14 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:12,869,217...12,889,144
Ensembl chr15:12,872,408...12,889,108
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G |
RGD1309651 |
similar to 1190005I06Rik protein |
increases expression |
ISO |
hydroquinone results in increased expression of C16ORF74 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:54,184,554...54,210,872
Ensembl chr19:54,184,946...54,210,515
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G |
RGD1562378 |
histone H4 variant H4-v.1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of H4C14 mRNA |
CTD |
PMID:23416264 |
|
NCBI chr 4:170,762,862...170,763,962
Ensembl chr 4:170,763,605...170,763,916
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G |
Rgs17 |
regulator of G-protein signaling 17 |
increases expression |
ISO |
hydroquinone results in increased expression of RGS17 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:42,491,566...42,587,735
Ensembl chr 1:42,492,761...42,587,721
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G |
Rhcg |
Rh family, C glycoprotein |
increases expression |
ISO |
hydroquinone results in increased expression of RHCG mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:141,325,854...141,349,881
Ensembl chr 1:141,325,856...141,349,881
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G |
Riok2 |
RIO kinase 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of RIOK2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:59,130,008...59,146,457
Ensembl chr 1:59,129,951...59,146,776
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G |
Rnase4 |
ribonuclease A family member 4 |
decreases expression |
ISO |
hydroquinone results in decreased expression of RNASE4 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:28,018,040...28,035,395
Ensembl chr15:28,018,040...28,035,389 Ensembl chr15:28,018,040...28,035,389
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G |
Rnasel |
ribonuclease L |
decreases expression |
ISO |
hydroquinone results in decreased expression of RNASEL mRNA |
CTD |
PMID:31256213 |
|
NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
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G |
Ror1 |
receptor tyrosine kinase-like orphan receptor 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of ROR1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 5:118,892,874...119,239,528
Ensembl chr 5:119,097,715...119,241,733
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G |
Rps6ka2 |
ribosomal protein S6 kinase A2 |
increases expression |
ISO |
hydroquinone results in increased expression of RPS6KA2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
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G |
Rptn |
repetin |
increases expression |
ISO |
hydroquinone results in increased expression of RPTN mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 2:193,722,394...193,729,040
Ensembl chr 2:193,724,248...193,728,302
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G |
Rrad |
RRAD, Ras related glycolysis inhibitor and calcium channel regulator |
increases expression |
ISO |
hydroquinone results in increased expression of RRAD mRNA |
CTD |
PMID:31256213 |
|
NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
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|
G |
Rrp12 |
ribosomal RNA processing 12 homolog |
decreases expression |
ISO |
hydroquinone results in decreased expression of RRP12 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:261,106,768...261,140,416
Ensembl chr 1:261,106,760...261,140,389
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G |
Runx2 |
RUNX family transcription factor 2 |
increases expression |
ISO |
hydroquinone results in increased expression of RUNX2 mRNA |
CTD |
PMID:22960397 |
|
NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
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G |
Satb1 |
SATB homeobox 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of SATB1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 9:2,181,135...2,277,949
Ensembl chr 9:2,190,915...2,274,629
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G |
Sbk1 |
SH3 domain binding kinase 1 |
decreases expression |
ISO |
hydroquinone results in decreased expression of SBK1 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr 1:197,636,230...197,681,031
Ensembl chr 1:67,368,384...67,390,141 Ensembl chr 1:67,368,384...67,390,141
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G |
Scara3 |
scavenger receptor class A, member 3 |
decreases expression |
ISO |
hydroquinone results in decreased expression of SCARA3 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr15:42,605,505...42,638,409
Ensembl chr15:42,605,473...42,638,392
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G |
Scfd2 |
sec1 family domain containing 2 |
decreases expression |
ISO |
hydroquinone results in decreased expression of SCFD2 mRNA |
CTD |
PMID:31256213 |
|
NCBI chr14:36,216,002...36,543,661
Ensembl chr14:36,216,002...36,543,658
| |