3-methylcholanthrene - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	3-methylcholanthrene	go back to main search page
Accession:	CHEBI:34342	browse the term
Definition:	A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Synonyms:	exact_synonym:	3-methyl-1,2-dihydrocyclopenta[ij]tetraphene
	related_synonym:	1,2-Dihydro-3-methylbenz(j)aceanthrylene; 20-MC; 20-Methylcholanthrene; 3-MC; 3-MCA; 3-methyl-1,2-dihydrobenzo[j]aceanthrylene; Formula=C21H16; InChI=1S/C21H16/c1-13-6-7-15-12-20-17-5-3-2-4-14(17)8-9-18(20)19-11-10-16(13)21(15)19/h2-9,12H,10-11H2,1H3; InChIKey=PPQNQXQZIWHJRB-UHFFFAOYSA-N; MC; MCA; Methylcholanthrene; SMILES=Cc1ccc2cc3c(ccc4ccccc34)c3CCc1c23
	xref:	Beilstein:1913890; CAS:56-49-5; KEGG:C14470; LINCS:LSM-5711
	xref_mesh:	MESH:D008748
	xref:	PMID:11922910; PMID:16359657; PMID:24658119; PMID:26076008; PMID:7561049; Reaxys:1913890; Wikipedia:Methylcholanthrene

show annotations for term's descendants Sort by:
Rat (949) Mouse (999) Human (973) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (949)

3-methylcholanthrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression

Methylcholanthrene results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

increases expression

Methylcholanthrene results in increased expression of ABCB1 mRNA; Methylcholanthrene results in increased expression of ABCB1A mRNA

PMID:11096091 PMID:27160211

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

increases expression
multiple interactions

Methylcholanthrene results in increased expression of ABCB1B mRNA
Methylcholanthrene promotes the reaction [TRP53 protein binds to ABCB1B promoter]

PMID:11096091 PMID:20713471

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily B member 4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily B member 6

increases expression

Methylcholanthrene results in increased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 3

increases expression

Methylcholanthrene results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

increases expression

Methylcholanthrene results in increased expression of ABCC4 mRNA; Methylcholanthrene results in increased expression of ABCC4 protein

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily G member 2

multiple interactions
affects response to substance
increases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of ABCG2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ABCG2 5' UTR]
ABCG2 5' UTR affects the susceptibility to Methylcholanthrene
Methylcholanthrene results in increased expression of ABCG2; Methylcholanthrene results in increased expression of ABCG2 mRNA; Methylcholanthrene results in increased expression of ABCG2 mRNA alternative form; Methylcholanthrene results in increased expression of ABCG2 protein

PMID:20804740 PMID:23081912

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ABI family member 3 binding protein

decreases expression

Methylcholanthrene results in decreased expression of ABI3BP mRNA

NCBI chr11:43,912,187...44,128,888
Ensembl chr11:43,913,043...44,128,929

G

acyl-CoA oxidase 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ACOX2 promoter]

NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160

G

acyl-CoA synthetase long-chain family member 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ACSL4 promoter]

NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427

G

actin, alpha 1, skeletal muscle

decreases expression

Methylcholanthrene results in decreased expression of ACTA1 mRNA

NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742

G

actin alpha 2, smooth muscle

decreases expression

Methylcholanthrene results in decreased expression of ACTA2 mRNA

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase domain 8

increases expression

Methylcholanthrene results in increased expression of ADAM8 mRNA

NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

decreases acetylation
increases expression
multiple interactions
increases methylation

Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter
Methylcholanthrene results in increased expression of ADAMTS1 mRNA
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of ADAMTS1 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ADAMTS1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of ADAMTS1 promoter]

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

decreases expression

Methylcholanthrene results in decreased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

ADAM metallopeptidase with thrombospondin type 1 motif, 2

decreases expression

Methylcholanthrene results in decreased expression of ADAMTS2 mRNA

NCBI chr10:34,920,992...35,126,465
Ensembl chr10:34,921,049...35,123,821

G

ADAM metallopeptidase with thrombospondin type 1 motif, 4

increases expression

Methylcholanthrene results in increased expression of ADAMTS4 mRNA

NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065

G

adenylate cyclase 7

increases expression

Methylcholanthrene results in increased expression of ADCY7 mRNA

PMID:20713471 PMID:29554273

NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311

G

adhesion G protein-coupled receptor F1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ADGRF1 promoter]

NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704

G

adhesion G protein-coupled receptor G5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of ADGRG5 mRNA; [Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of ADGRG5 mRNA

NCBI chr19:10,074,787...10,098,640
Ensembl chr19:10,079,375...10,097,214

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Methylcholanthrene results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase 6 (class V)

decreases expression

Methylcholanthrene results in decreased expression of ADH6 mRNA

NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases expression

Methylcholanthrene results in increased expression of ADH7 mRNA

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

adenosine A2a receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A3 receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADORA3 mRNA

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adrenoceptor alpha 2A

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ADRA2A promoter]
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ADRA2A mRNA

PMID:20348232 PMID:23519560

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

anterior gradient 2, protein disulphide isomerase family member

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to AGR2 promoter]

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

aryl hydrocarbon receptor

increases response to substance
affects localization
multiple interactions
increases expression
increases degradation
decreases expression
increases activity
increases localization
affects response to substance
affects binding

AHR protein results in increased susceptibility to Methylcholanthrene; AHR results in increased susceptibility to Methylcholanthrene
Methylcholanthrene affects the localization of AHR protein
[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene; [chrysin co-treated with Methylcholanthrene] affects the activity of AHR protein; [Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; [Methylcholanthrene co-treated with Oxygen deficiency] results in increased expression of AHR mRNA; [Methylcholanthrene co-treated with pirinixic acid] results in increased expression of AHR protein; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; [Quercetin co-treated with Methylcholanthrene] affects the activity of AHR protein; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of ABCG2 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP3A5 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Methylcholanthrene binds to and results in increased activity of AHR protein; Methylcholanthrene binds to and results in increased activity of AHR protein polymorphism; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ABCG2 5' UTR]; Methylcholanthrene promotes the reaction [AHR protein binds to ACOX2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ACSL4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ADGRF1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ADRA2A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to AGR2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to AKAP13 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANGPTL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD13C promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD30B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP22 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP35 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP44 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARL3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ARMC12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BAMBI promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BPIFA2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]; Methylcholanthrene promotes the reaction [AHR protein binds to BRWD1-AS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C16ORF74 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF19 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF36 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CA12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CA8 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CACNA1B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CALB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CAST promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC144NL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC57 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCN5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CD55 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CEACAM3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CENPL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CEP70 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CFAP61 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CHPT1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CHRDL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CILK1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CISD1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLDN17 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLK3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CLPSL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to COLCA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CRKL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CTNNA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CUEDC1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYB5B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP2A7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DEGS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DIAPH1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DTNA promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DUSP14 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EHD3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EPS15 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ERCC6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to EXOSC9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FOXN1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to FREM2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GDPD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GPHB5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GREB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GRIK4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to GSDMC promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to H2BC1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to H2BC21 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HCRTR2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HDAC11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HOXC11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HSBP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IER3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGFBPL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to INHBC promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IRF2BPL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ISOC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ITPR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JPH1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KATNAL2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KCTD16 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KCTD3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KIR2DL4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KLF9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to KRT75 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LGALS8 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LGI1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LIF promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LIMA1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LINC00173 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LRP11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LSM5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to LY6E promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MAPKAP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MBNL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MED13L promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MESP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MGST2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MIDEAS promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MLLT6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MLPH promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MRTFB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MS4A7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MSMB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MTCL3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MYOF promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to MYOM2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NBPF10 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NBPF3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NDST1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NELFCD promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NFE2L2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NMRAL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to NXT2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to OSBPL10 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to OTUB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PAXBP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PCOLCE2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PDCD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PHACTR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PIGP promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to POGZ promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to POTEB promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PPIAL4A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PSG5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PSG9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to PWWP3A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RABL2A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RALGAPA2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RANBP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBM24 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBMS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RBSN promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RERG promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RFFL promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGPD5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGPD6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RGS3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RHOBTB1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RHOH promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RPL11 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RTN3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to S100P promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SAMD12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SCN3B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SIK3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC16A6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC22A23 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLC44A1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SLU7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SMAP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SMARCE1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SNAPIN promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SOCS7 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SOS1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPON2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPRED1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SPTLC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SS18 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to STARD13 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SWSAP1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SYCP2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SYT12 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TBL1XR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TEAD4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to THBS2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to THEM5 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TIPARP promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM116 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM30A promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM45B promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMEM97 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TMTC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TNK2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRERF1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM39 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM55 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRIM72 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to TTC3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to UBE2E1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to UMODL1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VEZT promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VIPR1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VSTM1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to VWCE promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WBP1L promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WDR26 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to WEE1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZBTB4 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZCCHC2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZMAT3 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZMIZ1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF281 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF552 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF587 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF695 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ZNF710 promoter]; Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of AHR protein]; Methylcholanthrene results in increased activity of and results in increased degradation of AHR protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of AHR protein]; omeprazole sulfide inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Resveratrol inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]
Methylcholanthrene results in increased expression of AHR protein
Methylcholanthrene results in increased degradation of AHR protein
Methylcholanthrene results in decreased expression of AHR protein
Methylcholanthrene results in increased localization of AHR protein
AHR affects the susceptibility to Methylcholanthrene
[Methylcholanthrene binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [Methylcholanthrene binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR affects the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of CYP3A11 mRNA]; AHR protein affects the reaction [Methylcholanthrene affects the expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene results in increased expression of FMO3 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of XDH protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased activity of and results in increased localization of AHR protein]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; Curcumin inhibits the reaction [Methylcholanthrene binds to AHR protein]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Methylcholanthrene binds to and affects the localization of AHR protein; Methylcholanthrene binds to and results in increased activity of AHR protein; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene results in increased activity of and results in increased localization of AHR protein; omeprazole sulfide inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; Raloxifene Hydrochloride inhibits the reaction [Methylcholanthrene binds to AHR protein]
[Genistein co-treated with Methylcholanthrene] affects the activity of AHR protein; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]
Methylcholanthrene results in increased expression of AHR mRNA

PMID:1650214 PMID:1654865 PMID:1658612 PMID:1846074 PMID:2154949 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Tetradecanoylphorbol Acetate co-treated with Methylcholanthrene] results in increased expression of AHRR mRNA
Methylcholanthrene results in increased expression of AHRR mRNA

PMID:9887096 PMID:11423533 PMID:12655030 PMID:14672759

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

A-kinase anchoring protein 13

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of AKAP13 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to AKAP13 promoter]

PMID:20348232 PMID:20713471

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1 member A1

increases expression

Methylcholanthrene results in increased expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1, member C1

increases expression

Methylcholanthrene results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

AKT serine/threonine kinase 1

multiple interactions
increases expression
decreases acetylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

increases expression

Methylcholanthrene results in increased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

aldehyde dehydrogenase 3 family, member A1

increases expression

Methylcholanthrene results in increased expression of ALDH3A1 mRNA

PMID:1416978 PMID:20713471 PMID:28601433

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

angiopoietin-like 2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of ANGPTL2 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to ANGPTL2 promoter]

PMID:20348232 PMID:20713471

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

ankyrin 2

decreases expression

Methylcholanthrene results in decreased expression of ANK2 mRNA

NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923

G

ANKH inorganic pyrophosphate transport regulator

increases expression

Methylcholanthrene results in increased expression of ANK mRNA

NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187

G

ankyrin repeat domain 13C

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ANKRD13C promoter]

NCBI chr 2:247,023,040...247,070,433
Ensembl chr 2:247,022,286...247,070,433

G

anillin, actin binding protein

increases expression

Methylcholanthrene results in increased expression of ANLN mRNA

NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538

G

annexin A8

increases expression

Methylcholanthrene results in increased expression of ANXA8 mRNA

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

apoptotic peptidase activating factor 1

increases expression

Methylcholanthrene results in increased expression of APAF1 mRNA

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

APC down-regulated 1

increases expression

Methylcholanthrene results in increased expression of APCDD1 mRNA

NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070

G

apolipoprotein A4

decreases expression

Methylcholanthrene results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein C1

decreases expression

Methylcholanthrene results in decreased expression of APOC1 mRNA

NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375

G

apolipoprotein D

decreases expression

Methylcholanthrene results in decreased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

aquaporin 5

increases expression

Methylcholanthrene results in increased expression of AQP5 mRNA

PMID:20713471 PMID:26372666

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

amphiregulin

increases expression

Methylcholanthrene results in increased expression of AREG mRNA

PMID:16257430 PMID:26372666

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho GTPase activating protein 11A

increases expression

Methylcholanthrene results in increased expression of ARHGAP11A mRNA

NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559

G

Rho GTPase activating protein 22

increases expression
multiple interactions

Methylcholanthrene results in increased expression of ARHGAP22 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP22 promoter]

PMID:20348232 PMID:20713471

NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548

G

Rho GTPase activating protein 35

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP35 promoter]

NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298

G

Rho GTPase activating protein 44

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARHGAP44 promoter]

NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297

G

ADP ribosylation factor like GTPase 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARL3 promoter]

NCBI chr 1:245,400,659...245,446,673
Ensembl chr 1:245,400,550...245,446,820

G

ADP-ribosylation factor like GTPase 6 interacting protein 5

increases expression

Methylcholanthrene results in increased expression of ARL6IP5 mRNA

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

armadillo repeat containing 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ARMC12 promoter]

NCBI chr20:6,587,859...6,598,355
Ensembl chr20:6,587,859...6,598,352

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions
increases localization
increases expression

[AHR gene mutant form binds to ARNT protein] which results in decreased susceptibility to Methylcholanthrene; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]
Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]
Methylcholanthrene results in increased localization of ARNT protein
Methylcholanthrene results in increased expression of ARNT mRNA

PMID:11768231 PMID:19951702 PMID:20348232 PMID:20570689 PMID:21756928 More...

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin, beta 1

increases expression

Methylcholanthrene results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

ADP-ribosyltransferase 3

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ART3 mRNA

NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407

G

achaete-scute family bHLH transcription factor 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of ASCL1 mRNA

NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993

G

anti-silencing function 1B histone chaperone

increases expression

Methylcholanthrene results in increased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

acid sensing ion channel subunit 1

increases expression

Methylcholanthrene results in increased expression of ASIC1 mRNA

NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541

G

assembly factor for spindle microtubules

increases expression

Methylcholanthrene results in increased expression of ASPM mRNA

NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755

G

asporin

decreases expression

Methylcholanthrene results in decreased expression of ASPN mRNA

NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041

G

ATPase family, AAA domain containing 2

increases expression

Methylcholanthrene results in increased expression of ATAD2 mRNA

NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738

G

antioxidant 1 copper chaperone

increases expression

Methylcholanthrene results in increased expression of ATOX1 mRNA

NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950

G

ATPase H+ transporting V1 subunit C2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of ATP6V1C2 mRNA

NCBI chr 6:40,080,545...40,144,199
Ensembl chr 6:40,080,547...40,120,028

G

aurora kinase A

increases expression

Methylcholanthrene results in increased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

aurora kinase B

increases expression

Methylcholanthrene results in increased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

BCL2-associated agonist of cell death

increases expression

Methylcholanthrene results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BAR/IMD domain containing adaptor protein 2

increases expression

Methylcholanthrene results in increased expression of BAIAP2 mRNA

NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134

G

BMP and activin membrane-bound inhibitor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BAMBI promoter]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
increases methylation

Methylcholanthrene results in increased expression of BAX mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of BAX mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of BAX promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]

PMID:23273579 PMID:29094188

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BBX high mobility group box domain containing

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BBX promoter]

NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251

G

BCAS3, microtubule associated cell migration factor

decreases expression

Methylcholanthrene results in decreased expression of BCAS3 mRNA

NCBI chr10:70,213,710...70,673,080
Ensembl chr10:70,214,098...70,673,080

G

BCL10, immune signaling adaptor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of BCL10 mRNA

NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523

G

BCL2, apoptosis regulator

increases expression
decreases expression

Methylcholanthrene results in increased expression of BCL2 mRNA
Methylcholanthrene results in decreased expression of BCL2 mRNA

PMID:23273579 PMID:35487396

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL6, transcription repressor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of BCL6 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter]

PMID:20348232 PMID:20713471 PMID:25926378

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

3-hydroxybutyrate dehydrogenase 2

decreases expression

Methylcholanthrene results in decreased expression of BDH2 mRNA

NCBI chr 2:223,702,410...223,723,076
Ensembl chr 2:223,702,412...223,723,072

G

baculoviral IAP repeat-containing 3

increases expression

Methylcholanthrene results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

increases expression

Methylcholanthrene results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Bcl2 modifying factor

increases expression

Methylcholanthrene results in increased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

bone morphogenetic protein 15

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of BMP15 mRNA

NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187

G

bone morphogenetic protein 4

decreases expression

Methylcholanthrene results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

bisphosphoglycerate mutase

increases expression

Methylcholanthrene results in increased expression of BPGM mRNA

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

BPI fold containing family A, member 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to BPIFA2 promoter]

NCBI chr 3:142,493,379...142,501,343
Ensembl chr 3:142,493,379...142,501,337

G

BRCA1, DNA repair associated

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to BRCA1 protein]
Methylcholanthrene results in increased expression of BRCA1 mRNA

PMID:18259752 PMID:20713471

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

Bri3 binding protein

increases expression

Methylcholanthrene results in increased expression of BRI3BP mRNA

NCBI chr12:31,176,742...31,188,563
Ensembl chr12:31,173,971...31,188,572

G

BRCA1 interacting helicase 1

increases expression

Methylcholanthrene results in increased expression of BRIP1 mRNA

NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324

G

bone marrow stromal cell antigen 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of BST1 mRNA

NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180

G

BTG anti-proliferation factor 2

increases expression

Methylcholanthrene results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

BUB1 mitotic checkpoint serine/threonine kinase

increases expression

Methylcholanthrene results in increased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

G

BUB1 mitotic checkpoint serine/threonine kinase B

increases expression

Methylcholanthrene results in increased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

G

similar to human chromosome 4 open reading frame 19

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF19 promoter]

NCBI chr14:44,387,386...44,478,344
Ensembl chr14:44,387,393...44,478,041

G

similar to human chromosome 4 open reading frame 36

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C4ORF36 promoter]

NCBI chr14:6,058,581...6,065,848
Ensembl chr14:6,058,581...6,065,847

G

similar to human chromosome 16 open reading frame 74

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to C16ORF74 promoter]

NCBI chr19:48,660,288...48,686,287
Ensembl chr19:48,660,288...48,686,349

G

complement C1q binding protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of C1QBP mRNA

NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649

G

complement C3

increases expression

Methylcholanthrene results in increased expression of C3 mRNA

PMID:16257430 PMID:29554273

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

complement C4A

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4A mRNA

NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080

G

complement C4B

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of C4B mRNA

NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681

G

complement C6

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of C6 mRNA

NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275

G

calcium voltage-gated channel subunit alpha1 B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CACNA1B promoter]

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CACNA1G mRNA

NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752

G

cell adhesion molecule 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of CADM1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CADM1 gene

NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833

G

calbindin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CALB2 promoter]

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

calcitonin receptor like receptor

decreases expression

Methylcholanthrene results in decreased expression of CALCRL mRNA

NCBI chr 3:69,428,348...69,525,910
Ensembl chr 3:69,430,120...69,525,910

G

calmodulin 1

increases expression

Methylcholanthrene results in increased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

calreticulin

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CALR mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CALR mRNA]

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

calcium/calmodulin-dependent protein kinase II beta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CAMK2B mRNA

NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994

G

capping actin protein, gelsolin like

increases expression

Methylcholanthrene results in increased expression of CAPG mRNA

NCBI chr 4:104,594,743...104,611,856
Ensembl chr 4:104,594,753...104,611,856

G

calcyphosine

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TNFRSF23 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of TNFRSF23 mRNA

PMID:20713471 PMID:25926378

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CA12 promoter]

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 8

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CA8 promoter]

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

G

calcium/calmodulin dependent serine protein kinase

decreases expression

Methylcholanthrene results in decreased expression of CASK mRNA

NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694

G

caspase 3

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CASP3 mRNA
Methylcholanthrene inhibits the reaction [3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased cleavage of and results in increased activity of CASP3 protein]

PMID:11323195 PMID:11999409 PMID:20713471

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression
multiple interactions
increases methylation

Methylcholanthrene results in increased expression of CASP9 mRNA
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of CASP9 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CASP9 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CASP9 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]

PMID:23273579 PMID:29094188

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

calpastatin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CAST promoter]

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

coiled-coil domain containing 57

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CCDC57 promoter]

NCBI chr10:106,092,784...106,196,405
Ensembl chr10:106,092,947...106,196,077

G

coiled-coil domain containing 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CCDC6 promoter]

NCBI chr20:18,432,177...18,528,186
Ensembl chr20:18,433,695...18,528,658

G

C-C motif chemokine ligand 17

decreases expression

Methylcholanthrene results in decreased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 2

increases expression

Methylcholanthrene results in increased expression of CCL2 mRNA

PMID:20713471 PMID:23397585

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

decreases expression

Methylcholanthrene results in decreased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

increases expression

Methylcholanthrene results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cellular communication network factor 1

increases expression

Methylcholanthrene results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 3

increases expression

Methylcholanthrene results in increased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cellular communication network factor 4

decreases expression

Methylcholanthrene results in decreased expression of CCN4 mRNA

NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248

G

cellular communication network factor 5

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CCN5 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to CCN5 promoter]

PMID:20348232 PMID:20713471

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

cyclin A2

increases expression

Methylcholanthrene results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression

Methylcholanthrene results in increased expression of CCNB1 mRNA

PMID:20713471 PMID:26372666

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CCNB2 mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of CCNB2 mRNA]

PMID:20713471 PMID:26372666

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

increases expression

Methylcholanthrene results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

increases expression

Methylcholanthrene results in increased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

increases expression

Methylcholanthrene results in increased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

cyclin G2

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CCNG2 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CCNG2 mRNA]

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

Cd300e molecule

increases expression

Methylcholanthrene results in increased expression of CD300E mRNA

NCBI chr10:100,289,729...100,309,996
Ensembl chr10:100,291,437...100,299,311

G

CD300 molecule-like family member b

increases expression

Methylcholanthrene results in increased expression of CD300LB mRNA

NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790

G

CD3 delta subunit of T-cell receptor complex

decreases expression

Methylcholanthrene results in decreased expression of CD3D mRNA

NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809

G

CD44 molecule

multiple interactions
increases expression

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form
Methylcholanthrene results in increased expression of CD44 mRNA

PMID:15390079 PMID:20713471

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

Cd48 molecule

increases expression

Methylcholanthrene results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

Cd5 molecule

increases expression

Methylcholanthrene results in increased expression of CD5 mRNA

NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313

G

CD55 molecule (Cromer blood group)

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CD55 promoter]

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

CD59b molecule

increases mutagenesis

Methylcholanthrene results in increased mutagenesis of CD59 protein

NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847

G

CD9 molecule

multiple interactions
decreases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA]

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

CD96 molecule

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CD96 mRNA

NCBI chr11:54,702,290...54,776,618
Ensembl chr11:54,702,290...54,776,621

G

cytidine deaminase

increases expression

Methylcholanthrene results in increased expression of CDA mRNA

NCBI chr 5:150,556,615...150,583,231
Ensembl chr 5:150,556,615...150,583,231

G

cell division cycle 20

increases expression

Methylcholanthrene results in increased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

cell division cycle 25C

increases expression

Methylcholanthrene results in increased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 45

increases expression

Methylcholanthrene results in increased expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cell division cycle 6

increases expression

Methylcholanthrene results in increased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle associated 2

increases expression

Methylcholanthrene results in increased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 3

increases expression

Methylcholanthrene results in increased expression of CDCA3 mRNA

NCBI chr 4:157,634,775...157,638,799
Ensembl chr 4:157,634,928...157,638,799

G

cell division cycle associated 5

increases expression

Methylcholanthrene results in increased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 8

increases expression

Methylcholanthrene results in increased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 1

decreases expression

Methylcholanthrene results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 13

decreases expression

Methylcholanthrene results in decreased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin 2

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of CDH2 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased expression of CDH2 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of CDH2 gene

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CDH5 mRNA

NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368

G

cyclin dependent kinase 2

decreases expression
increases acetylation
increases expression
decreases methylation
multiple interactions

Methylcholanthrene results in decreased expression of CDK2 protein
Methylcholanthrene results in increased acetylation of CDK2 promoter
Methylcholanthrene results in increased expression of CDK2 mRNA
Methylcholanthrene results in decreased methylation of CDK2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]

PMID:18022818 PMID:29094188

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions
increases response to substance

Methylcholanthrene results in increased expression of CDKN1A mRNA
SB 203580 inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A mRNA]
Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]; resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1A protein]
CDKN1A protein results in increased susceptibility to Methylcholanthrene

PMID:15882963 PMID:18022818

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression
increases response to substance

Acetylcysteine inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]; resveratrol inhibits the reaction [Methylcholanthrene results in increased expression of CDKN1B protein]
CDKN1B protein results in increased susceptibility to Methylcholanthrene

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein N-terminal like

increases expression

Methylcholanthrene results in increased expression of CDKN2AIPNL mRNA

NCBI chr10:36,231,134...36,240,569
Ensembl chr10:36,231,087...36,240,564

G

cyclin-dependent kinase inhibitor 3

increases expression

Methylcholanthrene results in increased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

chromatin licensing and DNA replication factor 1

increases expression

Methylcholanthrene results in increased expression of CDT1 mRNA

NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659

G

CEA cell adhesion molecule 19

increases expression

Methylcholanthrene results in increased expression of CEACAM19 mRNA

NCBI chr 1:79,542,107...79,550,927
Ensembl chr 1:79,542,107...79,550,927

G

CCAAT/enhancer binding protein alpha

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

multiple interactions

[Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein A

increases expression

Methylcholanthrene results in increased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein E

increases expression

Methylcholanthrene results in increased expression of CENPE mRNA

NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669

G

centromere protein F

increases expression

Methylcholanthrene results in increased expression of CENPF mRNA

NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669

G

centromere protein H

increases expression

Methylcholanthrene results in increased expression of CENPH mRNA

NCBI chr 2:31,896,675...31,910,179
Ensembl chr 2:31,894,667...31,910,154

G

centromere protein I

increases expression

Methylcholanthrene results in increased expression of CENPI mRNA

NCBI chr X:97,515,919...97,567,671
Ensembl chr X:97,515,972...97,567,657

G

centromere protein K

increases expression

Methylcholanthrene results in increased expression of CENPK mRNA

NCBI chr 2:35,360,390...35,421,372
Ensembl chr 2:35,360,132...35,385,706

G

centromere protein L

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CENPL promoter]

NCBI chr13:73,337,235...73,352,115
Ensembl chr13:73,337,257...73,352,114

G

centromere protein U

increases expression

Methylcholanthrene results in increased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

centrosomal protein 55

increases expression

Methylcholanthrene results in increased expression of CEP55 mRNA

NCBI chr 1:235,832,823...235,848,401
Ensembl chr 1:235,832,878...235,848,394

G

centrosomal protein 70

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CEP70 promoter]

NCBI chr 8:99,810,270...99,863,279
Ensembl chr 8:99,810,367...99,862,855

G

carboxylesterase 1D

decreases expression

Methylcholanthrene results in decreased expression of CES1 protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

decreases expression

Methylcholanthrene results in decreased expression of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

carboxylesterase 3a

increases expression

Methylcholanthrene results in increased expression of CES3 mRNA

NCBI chr19:32,992,386...33,000,562

G

cilia and flagella associated protein 61

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CFAP61 promoter]

NCBI chr 3:133,354,400...133,633,310
Ensembl chr 3:133,354,197...133,633,320

G

chromodomain helicase DNA binding protein 1-like

increases expression

Methylcholanthrene results in increased expression of CHD1L mRNA

NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595

G

chromodomain helicase DNA binding protein 8

increases expression

Methylcholanthrene results in increased expression of CHD8 mRNA

NCBI chr15:24,905,789...24,965,461
Ensembl chr15:24,905,789...24,951,285

G

checkpoint with forkhead and ring finger domains

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHFR mRNA

NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014

G

chitinase 3 like 1

increases expression

Methylcholanthrene results in increased expression of CHI3L1 mRNA

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cysteine-rich hydrophobic domain 1

increases expression

Methylcholanthrene results in increased expression of CHIC1 mRNA

NCBI chr X:68,362,014...68,406,155
Ensembl chr X:68,361,969...68,437,887

G

cysteine-rich hydrophobic domain 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CHIC2 mRNA

NCBI chr14:33,157,669...33,192,015
Ensembl chr14:33,157,537...33,191,895

G

choline kinase alpha

increases expression

Methylcholanthrene results in increased expression of CHKA mRNA

NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516

G

choline phosphotransferase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CHPT1 promoter]

NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103

G

chordin-like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CHRDL2 promoter]

NCBI chr 1:154,343,201...154,370,651
Ensembl chr 1:154,343,201...154,370,640

G

cholinergic receptor nicotinic beta 1 subunit

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

ciliogenesis associated kinase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CILK1 promoter]

NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691

G

CDGSH iron sulfur domain 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CISD1 promoter]

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

cytokine inducible SH2-containing protein

decreases expression

Methylcholanthrene results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

cytoskeleton associated protein 2

increases expression

Methylcholanthrene results in increased expression of CKAP2 mRNA

NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913

G

cytoskeleton associated protein 2-like

increases expression

Methylcholanthrene results in increased expression of CKAP2L mRNA

NCBI chr 3:116,497,186...116,524,302
Ensembl chr 3:116,498,022...116,524,366

G

CDC28 protein kinase regulatory subunit 2

increases expression

Methylcholanthrene results in increased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

G

claudin 17

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLDN17 promoter]

NCBI chr11:27,827,454...27,828,630
Ensembl chr11:27,827,454...27,828,630

G

CDC-like kinase 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLK3 promoter]

NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181

G

colipase-like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CLPSL2 promoter]

NCBI chr20:6,608,128...6,610,951
Ensembl chr20:6,608,128...6,610,951

G

claspin

increases expression

Methylcholanthrene results in increased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

c-Maf-inducing protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of CMIP mRNA

NCBI chr19:45,304,597...45,510,653
Ensembl chr19:45,304,031...45,508,709

G

consortin, connexin sorting protein

increases expression

Methylcholanthrene results in increased expression of CNST mRNA

NCBI chr13:91,296,740...91,373,531
Ensembl chr13:91,296,142...91,373,531

G

contactin 1

increases expression

Methylcholanthrene results in increased expression of CNTN1 mRNA

NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541

G

collagen type XI alpha 1 chain

decreases expression

Methylcholanthrene results in decreased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type III alpha 1 chain

decreases expression

Methylcholanthrene results in decreased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type V alpha 1 chain

decreases expression

Methylcholanthrene results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

decreases expression

Methylcholanthrene results in decreased expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

collagen type VIII alpha 1 chain

decreases expression

Methylcholanthrene results in decreased expression of COL8A1 mRNA

NCBI chr11:42,776,851...42,906,432
Ensembl chr11:42,777,628...42,906,424

G

coactosin-like F-actin binding protein 1

decreases expression

Methylcholanthrene results in decreased expression of COTL1 mRNA

NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689

G

cytochrome c oxidase subunit 4i1

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to COX4I1 promoter]
Methylcholanthrene results in increased expression of COX4I1 mRNA

PMID:20348232 PMID:23273579

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

coproporphyrinogen oxidase

increases expression

Methylcholanthrene results in increased expression of CPOX mRNA

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

G

carnitine palmitoyltransferase 1A

increases expression

Methylcholanthrene results in increased expression of CPT1A protein

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 1

increases expression

Methylcholanthrene results in increased expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element modulator

decreases expression

Methylcholanthrene results in decreased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

CRK like proto-oncogene, adaptor protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CRKL promoter]

NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238

G

crystallin zeta

multiple interactions
increases activity
increases expression

AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]; Lead promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased activity of CRYZ protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CRYZ mRNA]
sanguinarine inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]

PMID:15297030 PMID:19788401

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

CUB and Sushi multiple domains 3

decreases expression

Methylcholanthrene results in decreased expression of CSMD3 mRNA

NCBI chr 7:78,747,322...80,066,466
Ensembl chr 7:78,748,480...80,066,369

G

casein beta

multiple interactions

Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of CSN2 mRNA]

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

cysteine and glycine-rich protein 2

increases expression

Methylcholanthrene results in increased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

catenin alpha 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CTNNA1 promoter]

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

G

catenin beta 1

affects response to substance
multiple interactions
increases response to substance

CTNNB1 protein affects the susceptibility to Methylcholanthrene
CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]
CTNNB1 protein results in increased susceptibility to Methylcholanthrene

PMID:21498875 PMID:25174530

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin D

increases expression

Methylcholanthrene results in increased expression of CTSD mRNA

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

CUE domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CUEDC1 promoter]

NCBI chr10:72,892,637...72,986,546
Ensembl chr10:72,892,637...72,986,542

G

C-X3-C motif chemokine ligand 1

increases expression

Methylcholanthrene results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 10

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome b5 type B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to CYB5B promoter]

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Methylcholanthrene results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects expression

Methylcholanthrene affects the expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases activity
increases metabolic processing
increases expression
increases methylation
increases acetylation
decreases response to substance
increases expression

[Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A1 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; [Methylcholanthrene co-treated with Oxygen deficiency] results in increased expression of CYP1A1 mRNA; [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP1A1 mRNA; [Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [NR3C1 protein co-treated with Dexamethasone] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [pirinixic acid co-treated with Methylcholanthrene] results in increased activity of CYP1A1 protein; [pirinixic acid co-treated with Methylcholanthrene] results in increased expression of CYP1A1 mRNA; AHR gene mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; Arsenic Trioxide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Glyburide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of and results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A1 mRNA]; Methylcholanthrene promotes the reaction [pirinixic acid results in increased activity of CYP1A1 protein]; Methylcholanthrene promotes the reaction [pirinixic acid results in increased expression of CYP1A1 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Oxygen deficiency affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; tyrphostin AG 1024 inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; tyrphostin AG 1024 inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]
Methylcholanthrene results in decreased activity of CYP1A1 protein
Methylcholanthrene results in increased activity of CYP1A1 promoter; Methylcholanthrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of Methylcholanthrene
[[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA; AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CYP1A1 promoter]; Buthionine Sulfoximine inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Ethoxyquin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; isoimperatorin promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [CYP1A1 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sodium arsenite inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
Methylcholanthrene results in increased expression of CYP1A1 mRNA; Methylcholanthrene results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [Capsaicin results in increased activity of CEBPB protein] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; [Methylcholanthrene binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [Methylcholanthrene binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR affects the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [Methylcholanthrene affects the expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Arsenic inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Cadmium inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Capsaicin inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Chromium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Chromium promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CTNNB1 protein affects the reaction [[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Cycloheximide promotes the reaction [Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]]; Cycloheximide promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Lead inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Lead inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 enhancer]; Methylcholanthrene promotes the reaction [AHR protein binds to CYP1A1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1A1 enhancer]; Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein; POR gene mutant form inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
CYP1A1 gene mutant form results in decreased susceptibility to Methylcholanthrene
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:1316759 PMID:1617633 PMID:1994898 PMID:2154949 PMID:3785172 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
affects response to substance
increases activity
increases expression
increases response to substance

[Celsior co-treated with Methylcholanthrene] results in increased expression of CYP1A2 mRNA; [Dexamethasone co-treated with Mifepristone] promotes the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; AHR protein affects the susceptibility to [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dehydroepiandrosterone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Dexamethasone inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]
CYP1A2 affects the susceptibility to Methylcholanthrene
[[Methylcholanthrene results in increased expression of CYP1A1 protein] co-treated with [Methylcholanthrene results in increased expression of CYP1A2 protein]] results in decreased susceptibility to 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole; [Methylcholanthrene results in increased activity of CYP1A2 protein] which results in increased oxidation of Uroporphyrinogens; lead nitrate inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; Methylcholanthrene promotes the reaction [CYP1A2 protein results in increased oxidation of Toluene]; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein; protocatechuic acid inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A2 protein]; sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]
Methylcholanthrene results in increased expression of CYP1A2 mRNA; Methylcholanthrene results in increased expression of CYP1A2 protein
[Methylcholanthrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A2 mRNA; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 protein]; CTNNB1 gene mutant form affects the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A1 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]; CYP1A2 gene mutant form promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
CYP1A2 gene mutant form results in increased susceptibility to Methylcholanthrene

PMID:1617633 PMID:1994898 PMID:3785172 PMID:4054433 PMID:6749129 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases chemical synthesis
increases metabolic processing
increases expression
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of CYP1B1 protein; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased chemical synthesis of Methylcholanthrene metabolite
CYP1B1 protein results in increased metabolism of Methylcholanthrene
Methylcholanthrene results in increased expression of CYP1B1 mRNA; Methylcholanthrene results in increased expression of CYP1B1 protein
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:9783729 PMID:10402558 PMID:11323195 PMID:11328961 PMID:11502733 More...

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP2A1 mRNA

PMID:11323195 PMID:19118567 PMID:22934830

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 2

decreases expression
increases expression

Methylcholanthrene results in decreased expression of CYP2A2 mRNA
Methylcholanthrene results in increased expression of CYP2A2 mRNA

PMID:11328961 PMID:22934830 PMID:23273579

NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487

G

cytochrome P450, family 2, subfamily a, polypeptide 3

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to CYP2A7 promoter]
Methylcholanthrene results in increased expression of CYP2A3 mRNA
Methylcholanthrene results in increased expression of CYP2A4 mRNA

PMID:12845369 PMID:20348232 PMID:22934830 PMID:30503582

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
affects expression

Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]
Methylcholanthrene affects the expression of CYP2B1 mRNA

PMID:18486174 PMID:23273579

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
affects expression

Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]
Methylcholanthrene affects the expression of CYP2B2 mRNA

PMID:18486174 PMID:23273579

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

Methylcholanthrene results in decreased expression of CYP2B3 mRNA
Methylcholanthrene results in decreased expression of CYP2B10 mRNA

PMID:11328961 PMID:30503582

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression
increases expression

Methylcholanthrene promotes the reaction [CYP2C11 protein results in increased oxidation of Toluene]
Methylcholanthrene results in decreased expression of CYP2C11 mRNA
Methylcholanthrene results in increased expression of CYP2C11 mRNA

PMID:1994898 PMID:10476907 PMID:22978700 PMID:23273579

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily c, polypeptide 13

increases expression

Methylcholanthrene results in increased expression of CYP2C13 protein

NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

Methylcholanthrene results in increased expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases expression

Methylcholanthrene results in increased expression of CYP2D4 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity
decreases expression
increases expression
increases expression

[Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [Acetone co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [Acetone co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; [Methylcholanthrene results in decreased expression of CYP2E1 protein] which affects the metabolism of Benzene; [protocatechuic acid co-treated with Methylcholanthrene] results in decreased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Methylcholanthrene promotes the reaction [CYP2E1 protein results in increased oxidation of Toluene]
Methylcholanthrene results in decreased activity of CYP2E1 protein
Methylcholanthrene results in decreased expression of CYP2E1 mRNA; Methylcholanthrene results in decreased expression of CYP2E1 protein
Methylcholanthrene results in increased expression of CYP2E1 mRNA; Methylcholanthrene results in increased expression of CYP2E1 protein
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:1994898 PMID:3113478 PMID:7493548 PMID:8734847 PMID:9118891 More...

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP2S1 mRNA

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases expression
decreases expression

Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA]
Methylcholanthrene results in decreased expression of CYP3A4 protein
[Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA; Methylcholanthrene results in decreased expression of and results in decreased activity of CYP3A4 protein

PMID:10640517 PMID:11181506 PMID:23846873 PMID:24999631

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases expression
multiple interactions

Methylcholanthrene results in increased expression of CYP3A5 mRNA
AHR protein affects the reaction [Methylcholanthrene results in increased expression of CYP3A5 mRNA]

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 3

increases expression
increases expression

Methylcholanthrene results in increased expression of CYP4A3 mRNA
3-methylcholanthrene increases expression of mRNA in rat heart

CTD
RGD

PMID:19889059 PMID:19889059

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

Methylcholanthrene results in increased expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases expression
increases expression

Methylcholanthrene results in increased expression of CYP4F4 mRNA
3-methylcholanthrene increases expression of mRNA in rat heart

CTD
RGD

PMID:19889059 PMID:19889059

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 4, subfamily f, polypeptide 5

increases expression
increases expression

Methylcholanthrene results in increased expression of CYP4F5 mRNA
3-methylcholanthrene increases expression of mRNA in rat heart

CTD
RGD

PMID:19889059 PMID:19889059

NCBI chr 7:11,544,040...11,558,982
Ensembl chr 7:11,544,082...11,558,978

G

cytochrome P450, family 4, subfamily f, polypeptide 6

decreases expression

Methylcholanthrene results in decreased expression of CYP4F6 mRNA

NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782

G

DAB adaptor protein 2

increases expression

Methylcholanthrene results in increased expression of DAB2 mRNA

NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476

G

dishevelled-binding antagonist of beta-catenin 1

decreases expression

Methylcholanthrene results in decreased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

death associated protein kinase 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of DAPK1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of DAPK1 promoter
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of DAPK1 mRNA

PMID:20970405 PMID:23519560

NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991

G

death-associated protein kinase 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DAPK2 mRNA

NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567

G

deleted in azoospermia-like

decreases expression

Methylcholanthrene results in decreased expression of DAZL mRNA

NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323

G

drebrin 1

decreases expression

Methylcholanthrene results in decreased expression of DBN1 mRNA

NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984

G

deoxycytidine kinase

increases expression

Methylcholanthrene results in increased expression of DCK mRNA

NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247

G

doublecortin-like kinase 1

decreases expression

Methylcholanthrene results in decreased expression of DCLK1 mRNA

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

discoidin domain receptor tyrosine kinase 2

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA]

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DEAD-box helicase 17

increases expression

Methylcholanthrene results in increased expression of DDX17 mRNA

NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193

G

DEAD-box helicase 4

decreases expression

Methylcholanthrene results in decreased expression of DDX4 mRNA

NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723

G

DEAD-box helicase 5

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

delta(4)-desaturase, sphingolipid 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DEGS1 promoter]

NCBI chr13:93,946,154...93,953,677
Ensembl chr13:93,946,157...93,953,664

G

DEP domain containing 1

increases expression

Methylcholanthrene results in increased expression of DEPDC1A mRNA

NCBI chr 2:248,684,508...248,717,951
Ensembl chr 2:248,684,523...248,717,951

G

DEP domain containing 1B

increases expression

Methylcholanthrene results in increased expression of DEPDC1B mRNA

NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779

G

DEP domain containing MTOR-interacting protein

decreases expression

Methylcholanthrene results in decreased expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

dihydrofolate reductase

increases expression

Methylcholanthrene results in increased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

diaphanous-related formin 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DIAPH1 promoter]

NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172

G

DLG associated protein 5

increases expression

Methylcholanthrene results in increased expression of DLGAP5 mRNA

NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518

G

delta like canonical Notch ligand 1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of DLL1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DLL1 mRNA]

NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179

G

dentin matrix acidic phosphoprotein 1

increases expression

Methylcholanthrene results in increased expression of DMP1 mRNA

NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323

G

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions
increases expression
increases methylation
increases acetylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of DNAJB6 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DNAJB6 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of DNAJB6 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C9

increases expression

Methylcholanthrene results in increased expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

DNA methyltransferase 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] affects the expression of and affects the localization of DNMT3A protein

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

denticleless E3 ubiquitin protein ligase homolog

increases expression

Methylcholanthrene results in increased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dystrobrevin, alpha

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DTNA promoter]

NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261

G

dual specificity phosphatase 14

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to DUSP14 promoter]

NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329

G

dual specificity phosphatase 4

increases expression

Methylcholanthrene results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 6

increases expression

Methylcholanthrene results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

deoxyuridine triphosphatase

increases expression

Methylcholanthrene results in increased expression of DUT mRNA

NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771

G

dual specificity tyrosine phosphorylation regulated kinase 2

decreases expression

Methylcholanthrene results in decreased expression of DYRK2 mRNA

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

G

E2F transcription factor 7

increases expression

Methylcholanthrene results in increased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

increases expression

Methylcholanthrene results in increased expression of E2F8 mRNA

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

extracellular matrix protein 1

increases expression

Methylcholanthrene results in increased expression of ECM1 mRNA

NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671

G

epithelial cell transforming 2

increases expression

Methylcholanthrene results in increased expression of ECT2 mRNA

NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911

G

ephrin A5

decreases expression

Methylcholanthrene results in decreased expression of EFNA5 mRNA

NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413

G

ephrin B1

increases expression

Methylcholanthrene results in increased expression of EFNB1 mRNA

NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157

G

epidermal growth factor receptor

decreases expression

Methylcholanthrene results in decreased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 2

increases expression

Methylcholanthrene results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

increases expression

Methylcholanthrene results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

EH-domain containing 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EHD3 promoter]

NCBI chr 6:21,640,861...21,665,601
Ensembl chr 6:21,639,290...21,665,236

G

eukaryotic translation initiation factor 1A

increases expression

Methylcholanthrene results in increased expression of EIF1AY mRNA

NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696

G

eukaryotic translation initiation factor 2B subunit beta

increases expression

Methylcholanthrene results in increased expression of EIF2B2 mRNA

NCBI chr 6:104,866,926...104,873,351
Ensembl chr 6:104,866,753...104,873,353

G

eukaryotic translation initiation factor 4E family member 1B

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EIF4E1B mRNA

NCBI chr17:9,831,338...9,856,250
Ensembl chr17:9,832,230...9,835,137

G

eukaryotic translation initiation factor 4E binding protein 2

increases expression

Methylcholanthrene results in increased expression of EIF4EBP2 mRNA

NCBI chr20:29,379,444...29,400,110
Ensembl chr20:29,382,668...29,399,946

G

engulfment and cell motility 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ELMO1 mRNA

NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788

G

ELOVL fatty acid elongase 3

increases expression

Methylcholanthrene results in increased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

essential meiotic structure-specific endonuclease 1

increases expression

Methylcholanthrene results in increased expression of EME1 mRNA

NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435

G

epithelial membrane protein 1

increases expression

Methylcholanthrene results in increased expression of EMP1 mRNA

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

glutamyl aminopeptidase

decreases expression

Methylcholanthrene results in decreased expression of ENPEP mRNA

NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Methylcholanthrene results in decreased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

endothelial PAS domain protein 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of EPAS1 mRNA

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor B6

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of EPHB6 mRNA

NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230

G

epoxide hydrolase 1

increases activity
increases expression

Methylcholanthrene results in increased activity of EPHX1 protein
Methylcholanthrene results in increased expression of EPHX1 mRNA

PMID:3621371 PMID:23273579

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

epoxide hydrolase 2

increases activity
increases expression
decreases activity
increases expression

Methylcholanthrene results in increased activity of EPHX2 protein
Methylcholanthrene results in increased expression of EPHX2 mRNA; Methylcholanthrene results in increased expression of EPHX2 protein
Methylcholanthrene results in decreased activity of EPHX2 protein
3-methylcholanthrene increases expression of mRNA, protein in rat heart

CTD
RGD

PMID:3621371 PMID:19889059 PMID:19889059

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

epidermal growth factor receptor pathway substrate 15

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EPS15 promoter]

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

EGFR pathway substrate 8, signaling adaptor

increases expression

Methylcholanthrene results in increased expression of EPS8 mRNA

NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873

G

ERCC excision repair 6, chromatin remodeling factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ERCC6 promoter]

NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587

G

ERCC excision repair 6 like, spindle assembly checkpoint helicase

increases expression

Methylcholanthrene results in increased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

G

epiregulin

increases expression

Methylcholanthrene results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

Methylcholanthrene results in increased expression of ESCO2 mRNA

NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306

G

extra spindle pole bodies like 1, separase

increases expression

Methylcholanthrene results in increased expression of ESPL1 mRNA

NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984

G

estrogen receptor 1

multiple interactions
affects binding
increases activity
increases expression
decreases expression

Fulvestrant inhibits the reaction [Methylcholanthrene results in increased expression of ESR1 mRNA]; Methylcholanthrene binds to and results in increased activity of ESR1 protein; Methylcholanthrene promotes the reaction [AHR protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to ESR1 promoter]; Methylcholanthrene promotes the reaction [ESR1 protein binds to CYP1A1 promoter]
Methylcholanthrene binds to ESR1 protein
Methylcholanthrene results in increased activity of ESR1 protein
Methylcholanthrene results in decreased expression of ESR1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]

PMID:16257430 PMID:16489053 PMID:16972788 PMID:20348232 PMID:23273579 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

ETS variant transcription factor 1

increases expression

Methylcholanthrene results in increased expression of ETV1 mRNA

NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775

G

ETS variant transcription factor 5

increases expression

Methylcholanthrene results in increased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

exonuclease 1

increases expression

Methylcholanthrene results in increased expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

exosome component 9

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to EXOSC9 promoter]

NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051

G

F11 receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of F11R mRNA

NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402

G

fatty acid binding protein 4

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of FABP4 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas cell surface death receptor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fc alpha receptor

increases expression

Methylcholanthrene results in increased expression of FCAR mRNA

NCBI chr 1:69,626,458...69,660,558

G

FCH and double SH3 domains 2

increases expression

Methylcholanthrene results in increased expression of FCHSD2 mRNA

NCBI chr 1:155,444,471...155,685,350
Ensembl chr 1:155,444,460...155,685,539

G

Fc receptor-like 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of FCRL5 mRNA

NCBI chr 2:172,881,763...172,912,912
Ensembl chr 2:172,881,448...172,913,148

G

farnesyl diphosphate synthase

decreases expression

Methylcholanthrene results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin reductase

increases expression

Methylcholanthrene results in increased expression of FDXR mRNA

NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658

G

fibroblast growth factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF1 mRNA

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 10

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF10 mRNA

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 18

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FGF18 mRNA

NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818

G

fibroblast growth factor 7

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF7 mRNA

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

Fibroblast growth factor receptor 1

increases expression

Methylcholanthrene results in increased expression of FGFR1 mRNA

PMID:20713471 PMID:29554273

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fibroblast growth factor receptor 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

fragile histidine triad diadenosine triphosphatase

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter
Methylcholanthrene results in decreased expression of FHIT mRNA

PMID:20970405 PMID:22100608

NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340

G

fidgetin-like 1

increases expression

Methylcholanthrene results in increased expression of FIGNL1 mRNA

NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455

G

flavin containing dimethylaniline monoxygenase 2

increases expression

Methylcholanthrene results in increased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 3

multiple interactions
increases expression
decreases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of FMO3 mRNA]; Methylcholanthrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]
Methylcholanthrene results in decreased expression of FMO3 mRNA

PMID:20570689 PMID:23273579 PMID:23846873 PMID:25926378

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

fibromodulin

decreases expression

Methylcholanthrene results in decreased expression of FMOD mRNA

NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Methylcholanthrene results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box M1

affects response to substance

FOXM1 protein affects the susceptibility to Methylcholanthrene

PMID:18345025 PMID:19672312

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box N1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to FOXN1 promoter]

NCBI chr10:63,251,400...63,273,710
Ensembl chr10:63,251,400...63,273,710

G

forkhead box N3

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of FOXN3 mRNA]

NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401

G

forkhead box N4

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to FOXN4 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of FOXN4 mRNA]

NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921

G

forkhead box O3

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

FRAS1 related extracellular matrix 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to FREM2 promoter]

NCBI chr 2:137,602,784...137,740,785
Ensembl chr 2:137,602,784...137,740,785

G

FRY like transcription coactivator

increases expression

Methylcholanthrene results in increased expression of FRYL mRNA

NCBI chr14:34,956,623...35,189,738
Ensembl chr14:34,956,620...35,190,222

G

follistatin

decreases expression

Methylcholanthrene results in decreased expression of FST mRNA

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

follistatin-like 1

decreases expression

Methylcholanthrene results in decreased expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

fucosyltransferase 8

increases expression

Methylcholanthrene results in increased expression of FUT8 mRNA

NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677

G

FXYD domain-containing ion transport regulator 5

increases expression

Methylcholanthrene results in increased expression of FXYD5 mRNA

NCBI chr 1:86,267,937...86,277,329
Ensembl chr 1:86,267,406...86,277,519

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of FYN mRNA

NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911

G

GRB2-associated binding protein 2

decreases expression

Methylcholanthrene results in decreased expression of GAB2 mRNA

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

gamma-aminobutyric acid type A receptor subunit alpha 3

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GABRA3 mRNA

NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559

G

growth arrest and DNA-damage-inducible, alpha

decreases expression

Methylcholanthrene results in decreased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

polypeptide N-acetylgalactosaminyltransferase 15

increases expression

Methylcholanthrene results in increased expression of GALNT15 mRNA

NCBI chr16:7,227,232...7,267,002
Ensembl chr16:7,227,271...7,267,014

G

polypeptide N-acetylgalactosaminyltransferase 18

decreases expression

Methylcholanthrene results in decreased expression of GALNT18 mRNA

NCBI chr 1:165,593,180...165,904,268
Ensembl chr 1:165,593,187...165,904,268

G

polypeptide N-acetylgalactosaminyltransferase 7

increases expression

Methylcholanthrene results in increased expression of GALNT7 mRNA

NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690

G

growth arrest-specific 2 like 3

increases expression

Methylcholanthrene results in increased expression of GAS2L3 mRNA

NCBI chr 7:23,803,578...23,836,816
Ensembl chr 7:23,806,310...23,836,411

G

GATA binding protein 6

multiple interactions
increases activity

Methylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon]
Methylcholanthrene results in increased activity of GATA6 protein

NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532

G

glycine C-acetyltransferase

increases expression

Methylcholanthrene results in increased expression of GCAT mRNA

NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473

G

GTP cyclohydrolase 1

increases expression

Methylcholanthrene results in increased expression of GCH1 mRNA

NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698

G

GTP cyclohydrolase I feedback regulator

increases expression

Methylcholanthrene results in increased expression of GCHFR mRNA

NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080

G

growth differentiation factor 9

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

glial cell derived neurotrophic factor

decreases expression

Methylcholanthrene results in decreased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glycerophosphodiester phosphodiesterase domain containing 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GDPD4 promoter]

NCBI chr 1:152,233,516...152,342,329
Ensembl chr 1:152,233,499...152,342,158

G

growth hormone 1

decreases activity

Methylcholanthrene results in decreased activity of GH1 protein

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone receptor

decreases expression
increases expression

Methylcholanthrene results in decreased expression of GHR mRNA
Methylcholanthrene results in increased expression of GHR protein

PMID:22978700 PMID:23169610

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

GINS complex subunit 3

increases expression

Methylcholanthrene results in increased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

GINS complex subunit 4

increases expression

Methylcholanthrene results in increased expression of GINS4 mRNA

NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273

G

gap junction protein, alpha 1

increases expression

Methylcholanthrene results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

geminin, DNA replication inhibitor

increases expression

Methylcholanthrene results in increased expression of GMNN mRNA

NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054

G

G protein subunit beta 4

increases expression

Methylcholanthrene results in increased expression of GNB4 mRNA

NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579

G

glycine N-methyltransferase

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of GNMT mRNA
[Methylcholanthrene co-treated with GNMT protein] results in increased expression of CYP1A1 mRNA

PMID:9261130 PMID:22100608

NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434

G

glypican 1

increases expression

Methylcholanthrene results in increased expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

glycerophosphocholine phosphodiesterase 1

decreases expression

Methylcholanthrene results in decreased expression of GPCPD1 mRNA

NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517

G

glycoprotein hormone subunit beta 5

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GPHB5 promoter]

NCBI chr 6:94,129,968...94,134,585
Ensembl chr 6:94,131,021...94,133,570

G

glycoprotein nmb

increases expression

Methylcholanthrene results in increased expression of GPNMB mRNA

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

glutathione peroxidase 1

increases expression

Methylcholanthrene results in increased expression of GPX1 mRNA

PMID:23273579 PMID:23712962

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

growth regulating estrogen receptor binding 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GREB1 promoter]

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

glutamate ionotropic receptor AMPA type subunit 3

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor kainate type subunit 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GRIK4 promoter]

NCBI chr 8:42,903,043...43,331,990
Ensembl chr 8:42,905,056...43,193,751

G

glutamate ionotropic receptor kainate type subunit 5

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

gasdermin C

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to GSDMC promoter]

NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344

G

gasdermin D

increases expression

Methylcholanthrene results in increased expression of GSDMD mRNA

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

gasdermin E

increases expression

Methylcholanthrene results in increased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

glutathione-disulfide reductase

increases activity
increases expression

Methylcholanthrene results in increased activity of GSR protein
Methylcholanthrene results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

increases activity
increases expression

Methylcholanthrene results in increased activity of GSS protein
Methylcholanthrene results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 2

increases expression
decreases expression

Methylcholanthrene results in increased expression of GSTA2 mRNA
Methylcholanthrene results in decreased expression of GSTA2 mRNA

PMID:10476907 PMID:11328961 PMID:23273579

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase kappa 1

increases expression

Methylcholanthrene results in increased expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 1

increases expression

Methylcholanthrene results in increased expression of GSTM1 mRNA

PMID:11328961 PMID:23273579

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

increases expression

Methylcholanthrene results in increased expression of GSTP1 mRNA

PMID:19118567 PMID:23273579

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

G-2 and S-phase expressed 1

increases expression

Methylcholanthrene results in increased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

GULP PTB domain containing engulfment adaptor 1

increases expression

Methylcholanthrene results in increased expression of GULP1 mRNA

NCBI chr 9:46,622,699...46,899,005
Ensembl chr 9:46,622,669...46,899,005

G

H2B clustered histone 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to H2BC1 promoter]

NCBI chr17:41,172,041...41,172,510
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782

G

H3.3 histone B

decreases expression

Methylcholanthrene results in decreased expression of H3F3B mRNA

NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709

G

3-hydroxyacyl-CoA dehydratase 4

increases expression

Methylcholanthrene results in increased expression of HACD4 mRNA

NCBI chr 5:102,887,597...102,915,376
Ensembl chr 5:102,887,588...102,915,338

G

histone H3 associated protein kinase

increases expression

Methylcholanthrene results in increased expression of HASPIN mRNA

NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512

G

hemoglobin alpha, adult chain 1

increases expression

Methylcholanthrene results in increased expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

HCK proto-oncogene, Src family tyrosine kinase

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of HCK mRNA

NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693

G

hypocretin receptor 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HCRTR2 promoter]

NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893

G

histone deacetylase 11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HDAC11 promoter]

NCBI chr 4:123,645,873...123,667,407
Ensembl chr 4:123,650,157...123,667,405

G

histone deacetylase 5

increases expression

Methylcholanthrene results in increased expression of HDAC5 mRNA

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

hephaestin

increases expression

Methylcholanthrene results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

G

hes family bHLH transcription factor 1

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HES1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hepatocyte growth factor

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

Hedgehog-interacting protein

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HHIP mRNA

NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528

G

hypoxia inducible factor 1 subunit alpha

increases expression

Methylcholanthrene results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

homeodomain interacting protein kinase 2

decreases expression

Methylcholanthrene results in decreased expression of HIPK2 mRNA

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

G

histone cluster 1, H2bc

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to H2BC21 promoter]

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

high mobility group AT-hook 1

increases expression

Methylcholanthrene results in increased expression of HMGA1 mRNA

NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752

G

high mobility group AT-hook 2

increases expression

Methylcholanthrene results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

3-hydroxy-3-methylglutaryl-CoA reductase

decreases expression

Methylcholanthrene results in decreased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Methylcholanthrene results in decreased expression of HMGCS1 mRNA

PMID:20713471 PMID:35487396

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hyaluronan-mediated motility receptor

increases expression

Methylcholanthrene results in increased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

heme oxygenase 1

multiple interactions
increases expression

[Methylcholanthrene co-treated with Copper] results in increased expression of HMOX1 mRNA; [Methylcholanthrene co-treated with Lead] results in increased expression of HMOX1 mRNA; [Methylcholanthrene co-treated with Mercury] results in increased expression of HMOX1 mRNA
Methylcholanthrene results in increased expression of HMOX1 mRNA

PMID:15297030 PMID:19889059 PMID:22100608

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein A1

multiple interactions

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

heterogeneous nuclear ribonucleoprotein A2/B1

multiple interactions

[Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

homeo box C10

increases expression

Methylcholanthrene results in increased expression of HOXC10 mRNA

NCBI chr 7:134,103,741...134,108,966
Ensembl chr 7:134,103,643...134,108,966

G

homeobox C11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HOXC11 promoter]

NCBI chr 7:134,091,224...134,094,738
Ensembl chr 7:134,091,552...134,094,738

G

hippocalcin-like 4

increases expression

Methylcholanthrene results in increased expression of HPCAL4 mRNA

NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416

G

15-hydroxyprostaglandin dehydrogenase

increases expression

Methylcholanthrene results in increased expression of HPGD mRNA

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

heat shock factor binding protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to HSBP1 promoter]

NCBI chr19:47,401,039...47,405,373
Ensembl chr19:47,400,966...47,435,821

G

HscB mitochondrial iron-sulfur cluster co-chaperone

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of HSCB mRNA

NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909

G

heat shock protein 90 alpha family class A member 1

increases expression

Methylcholanthrene results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 8

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HSPA8 mRNA]

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

intercellular adhesion molecule 1

increases acetylation
increases expression
multiple interactions

Methylcholanthrene results in increased acetylation of ICAM1 promoter
Methylcholanthrene results in increased expression of ICAM1 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

increases expression

Methylcholanthrene results in increased expression of ID2 mRNA

PMID:20713471 PMID:23397585

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 3

increases expression

Methylcholanthrene results in increased expression of ID3 mRNA

NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter]

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

isopentenyl-diphosphate delta isomerase 1

decreases expression

Methylcholanthrene results in decreased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

immediate early response 3

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IER3 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to IER3 promoter]

PMID:20348232 PMID:20713471 PMID:22579512

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon, alpha-inducible protein 27

decreases expression

Methylcholanthrene results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 44

decreases expression

Methylcholanthrene results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein with tetratricopeptide repeats 1

decreases expression

Methylcholanthrene results in decreased expression of IFIT1 mRNA

NCBI chr 1:232,152,038...232,154,103
Ensembl chr 1:232,127,170...232,154,435

G

interferon-induced protein with tetratricopeptide repeats 2

increases expression

Methylcholanthrene results in increased expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Methylcholanthrene results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon beta 1

increases expression

Methylcholanthrene results in increased expression of IFNB1 mRNA

NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523

G

insulin-like growth factor 2

increases acetylation
increases methylation
increases expression
multiple interactions

Methylcholanthrene results in increased acetylation of IGF2 promoter
Methylcholanthrene results in increased methylation of IGF2 promoter
Methylcholanthrene results in increased expression of IGF2 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 6

increases expression

Methylcholanthrene results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

insulin-like growth factor binding protein-like 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IGFBPL1 promoter]

NCBI chr 5:60,076,428...60,091,833
Ensembl chr 5:60,076,429...60,091,833

G

interleukin 12A

increases expression

Methylcholanthrene results in increased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12 receptor subunit beta 1

increases expression

Methylcholanthrene results in increased expression of IL12RB1 mRNA

NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769

G

interleukin 18

increases expression

Methylcholanthrene results in increased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 18 receptor 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL18R1 mRNA

NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715

G

interleukin 18 receptor accessory protein

increases expression

Methylcholanthrene results in increased expression of IL18RAP mRNA

NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959

G

interleukin 1 alpha

increases expression

Methylcholanthrene results in increased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IL1B mRNA
[Methylcholanthrene results in increased activity of AHR protein] which results in increased expression of IL1B mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IL1B mRNA]

PMID:14993811 PMID:35487396

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

Methylcholanthrene results in increased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 6

increases expression
multiple interactions

Methylcholanthrene results in increased expression of IL6 mRNA
[Methylcholanthrene co-treated with TNF protein] results in increased expression of IL6 mRNA

PMID:14993811 PMID:23396138 PMID:29554273

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL6ST mRNA

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin 7 receptor

multiple interactions
increases expression

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL7R mRNA
Methylcholanthrene results in increased expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

G

inner mitochondrial membrane peptidase subunit 2

decreases expression

Methylcholanthrene results in decreased expression of IMMP2L mRNA

NCBI chr 6:58,070,035...58,970,165
Ensembl chr 6:58,070,283...58,969,840

G

inhibin subunit beta C

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to INHBC promoter]

NCBI chr 7:63,184,141...63,197,630
Ensembl chr 7:63,184,142...63,197,630

G

insulin 2

multiple interactions

Methylcholanthrene promotes the reaction [Glucose results in increased secretion of INS protein alternative form]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

IQ motif containing GTPase activating protein 3

increases expression

Methylcholanthrene results in increased expression of IQGAP3 mRNA

NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956

G

interferon regulatory factor 2 binding protein-like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to IRF2BPL promoter]

NCBI chr 6:106,527,179...106,531,294
Ensembl chr 6:106,528,053...106,530,401

G

insulin receptor substrate 1

decreases expression

Methylcholanthrene results in decreased expression of IRS1 mRNA

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

isochorismatase domain containing 2b

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ISOC2 promoter]

NCBI chr 1:68,972,960...68,993,760
Ensembl chr 1:68,972,960...68,993,757

G

integrin subunit alpha 10

increases expression

Methylcholanthrene results in increased expression of ITGA10 mRNA

NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172

G

integrin subunit alpha 7

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGA7 mRNA

NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450

G

integrin subunit beta 5

decreases expression

Methylcholanthrene results in decreased expression of ITGB5 mRNA

NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472

G

integrin subunit beta 8

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of ITGB8 mRNA
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA]

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

integrin subunit beta like 1

increases expression

Methylcholanthrene results in increased expression of ITGBL1 mRNA

NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733

G

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to ITPR1 promoter]
Methylcholanthrene results in increased expression of ITPR1 mRNA

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

G

jagged canonical Notch ligand 1

decreases expression
increases methylation
increases acetylation
multiple interactions
increases expression

Methylcholanthrene results in decreased expression of JAG1 mRNA
Methylcholanthrene results in increased methylation of JAG1 promoter
Methylcholanthrene results in increased acetylation of JAG1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]; Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]

PMID:20713471 PMID:29094188

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 2

decreases expression

Methylcholanthrene results in decreased expression of JAK2 mRNA

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

junctophilin 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to JPH1 promoter]

NCBI chr 5:2,030,227...2,137,171
Ensembl chr 5:2,030,281...2,125,284

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Methylcholanthrene results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

katanin catalytic subunit A1 like 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KATNAL2 promoter]

NCBI chr18:70,531,759...70,607,886
Ensembl chr18:70,531,754...70,608,082

G

potassium two pore domain channel subfamily K member 2

increases expression

Methylcholanthrene results in increased expression of KCNK2 mRNA

NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435

G

potassium calcium-activated channel subfamily N member 4

increases expression

Methylcholanthrene results in increased expression of KCNN4 mRNA

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

G

potassium channel tetramerization domain containing 1

increases expression

Methylcholanthrene results in increased expression of KCTD1 mRNA

NCBI chr18:6,122,390...6,316,434
Ensembl chr18:6,122,390...6,317,393

G

potassium channel tetramerization domain containing 16

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KCTD16 promoter]

NCBI chr18:32,166,236...32,473,067
Ensembl chr18:32,166,861...32,491,749

G

potassium channel tetramerization domain containing 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KCTD3 promoter]

NCBI chr13:100,510,193...100,548,765
Ensembl chr13:100,510,195...100,548,718

G

potassium channel tetramerization domain containing 5

decreases expression

Methylcholanthrene results in decreased expression of KCTD5 mRNA

NCBI chr10:13,079,216...13,105,197
Ensembl chr10:13,079,214...13,105,209

G

kinase insert domain receptor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of KDR mRNA

NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018

G

Kelch-like ECH-associated protein 1

increases expression

Methylcholanthrene results in increased expression of KEAP1 mRNA

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

kinesin family member 11

increases expression
multiple interactions

Methylcholanthrene results in increased expression of KIF11 mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]

PMID:20713471 PMID:26372666

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 18A

increases expression
multiple interactions

Methylcholanthrene results in increased expression of KIF18A mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF18A mRNA]

PMID:20713471 PMID:26372666

NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582

G

kinesin family member 20A

increases expression

Methylcholanthrene results in increased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member 22

increases expression

Methylcholanthrene results in increased expression of KIF22 mRNA

NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401

G

kinesin family member 23

increases expression

Methylcholanthrene results in increased expression of KIF23 mRNA

NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072

G

kinesin family member 2C

increases expression

Methylcholanthrene results in increased expression of KIF2C mRNA

PMID:20713471 PMID:26372666

NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637

G

KIT proto-oncogene receptor tyrosine kinase

affects expression

Methylcholanthrene affects the expression of KIT mRNA

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

KIT ligand

increases expression

Methylcholanthrene results in increased expression of KITL mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 2

increases expression

Methylcholanthrene results in increased expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

KLF transcription factor 5

increases expression

Methylcholanthrene results in increased expression of KLF5 mRNA

NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445

G

KLF transcription factor 9

multiple interactions
decreases expression

Methylcholanthrene promotes the reaction [AHR protein binds to KLF9 promoter]
Methylcholanthrene results in decreased expression of KLF9 mRNA

PMID:20348232 PMID:23397585

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

lysine methyltransferase 2E

increases expression

Methylcholanthrene results in increased expression of KMT2E mRNA

NCBI chr 4:11,658,218...11,727,373
Ensembl chr 4:11,658,979...11,727,373

G

kininogen 1

multiple interactions
decreases expression

AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 mRNA]; AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 protein]
Methylcholanthrene results in decreased expression of KNG1 mRNA; Methylcholanthrene results in decreased expression of KNG1 protein

NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555

G

kinetochore-localized astrin/SPAG5 binding protein

increases expression

Methylcholanthrene results in increased expression of KNSTRN mRNA

NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715

G

kinetochore associated 1

increases expression

Methylcholanthrene results in increased expression of KNTC1 mRNA

NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561

G

karyopherin subunit alpha 2

increases expression

Methylcholanthrene results in increased expression of KPNA2 mRNA

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

G

KRAS proto-oncogene, GTPase

multiple interactions
increases mutagenesis

Methylcholanthrene promotes the reaction [GATA6 protein binds to KRAS exon]; Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]
Methylcholanthrene results in increased mutagenesis of KRAS gene

PMID:11195466 PMID:16271038 PMID:20101149

NCBI chr 4:178,185,418...178,218,484

G

keratin 75

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to KRT75 promoter]

NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345

G

laminin subunit alpha 4

decreases expression

Methylcholanthrene results in decreased expression of LAMA4 mRNA

NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347

G

laminin subunit alpha 5

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMA5 mRNA

NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451

G

laminin subunit gamma 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lecithin cholesterol acyltransferase

decreases expression

Methylcholanthrene results in decreased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

low density lipoprotein receptor

decreases expression

Methylcholanthrene results in decreased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

lymphoid enhancer binding factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of LEF1 mRNA

NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794

G

galectin 1

increases expression

Methylcholanthrene results in increased expression of LGALS1 mRNA

NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345

G

galectin 2

increases expression

Methylcholanthrene results in increased expression of LGALS2 mRNA

NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802

G

galectin 3

increases expression

Methylcholanthrene results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

galectin 8

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LGALS8 promoter]

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

leucine-rich, glioma inactivated 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LGI1 promoter]

NCBI chr 1:236,043,269...236,084,617
Ensembl chr 1:236,042,954...236,084,616

G

LIF, interleukin 6 family cytokine

increases expression
multiple interactions

Methylcholanthrene results in increased expression of LIF mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to LIF promoter]

PMID:20348232 PMID:20713471

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

LIM domain and actin binding 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LIMA1 promoter]

NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473

G

lamin B1

increases expression

Methylcholanthrene results in increased expression of LMNB1 mRNA

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lemur tyrosine kinase 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of LMTK2 mRNA

NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750

G

lysyl oxidase

decreases expression

Methylcholanthrene results in decreased expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

G

LDL receptor related protein 11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LRP11 promoter]

NCBI chr 1:2,048,307...2,108,115
Ensembl chr 1:2,079,438...2,108,110

G

leucine rich repeat protein 1

increases expression

Methylcholanthrene results in increased expression of LRR1 mRNA

NCBI chr 6:87,643,195...87,651,894
Ensembl chr 6:87,643,217...87,651,894

G

leucine rich repeat containing 8 VRAC subunit D

increases expression

Methylcholanthrene results in increased expression of LRRC8D mRNA

NCBI chr14:4,029,971...4,134,922
Ensembl chr14:4,029,473...4,135,877

G

LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Methylcholanthrene results in increased expression of LSM4 mRNA

NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LSM5 promoter]

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

increases expression

Methylcholanthrene results in increased expression of LSM6 mRNA

NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484

G

latent transforming growth factor beta binding protein 1

increases expression

Methylcholanthrene results in increased expression of LTBP1 mRNA

NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349

G

lumican

decreases expression

Methylcholanthrene results in decreased expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

G

lymphocyte antigen 6 family member A

increases expression

Methylcholanthrene results in increased expression of LY6A mRNA

NCBI chr 7:107,177,191...107,189,436
Ensembl chr 7:107,183,469...107,189,981

G

lymphocyte antigen 6 family member E

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to LY6E promoter]

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

mitotic arrest deficient 1 like 1

increases expression

Methylcholanthrene results in increased expression of MAD1L1 mRNA

NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703

G

membrane associated guanylate kinase, WW and PDZ domain containing 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of MAGI1 mRNA

NCBI chr 4:126,205,663...126,811,354
Ensembl chr 4:126,206,816...126,811,691

G

mitogen activated protein kinase kinase 1

increases expression

Methylcholanthrene results in increased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 3

increases expression

Methylcholanthrene results in increased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase 1

increases expression

Methylcholanthrene results in increased expression of MAPK1 mRNA

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen-activated protein kinase 8

multiple interactions

Methylcholanthrene results in increased phosphorylation of and results in increased activity of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MAPK associated protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MAPKAP1 promoter]

NCBI chr 3:17,715,813...17,918,387
Ensembl chr 3:17,715,834...17,918,384

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Methylcholanthrene results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

microtubule associated serine/threonine kinase-like

increases expression

Methylcholanthrene results in increased expression of MASTL mRNA

NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353

G

methionine adenosyltransferase 1A

decreases expression

Methylcholanthrene results in decreased expression of MAT1A mRNA

NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274

G

matrilin 2

decreases expression

Methylcholanthrene results in decreased expression of MATN2 mRNA

NCBI chr 7:65,494,996...65,644,613
Ensembl chr 7:65,494,834...65,645,113

G

muscleblind-like splicing regulator 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MBNL1 promoter]

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

G

minichromosome maintenance 10 replication initiation factor

increases expression

Methylcholanthrene results in increased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 3

increases expression

Methylcholanthrene results in increased expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 4

increases expression

Methylcholanthrene results in increased expression of MCM4 mRNA

NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144

G

minichromosome maintenance complex component 5

increases expression

Methylcholanthrene results in increased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

increases expression

Methylcholanthrene results in increased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

mediator complex subunit 13L

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MED13L promoter]

NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473

G

maternal embryonic leucine zipper kinase

increases expression

Methylcholanthrene results in increased expression of MELK mRNA

NCBI chr 5:58,540,393...58,600,562
Ensembl chr 5:58,540,449...58,600,937

G

mesoderm posterior bHLH transcription factor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MESP1 promoter]

NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875

G

microfibril associated protein 3 like

increases expression

Methylcholanthrene results in increased expression of MFAP3L mRNA

NCBI chr16:29,411,643...29,454,665
Ensembl chr16:29,415,849...29,430,863

G

microsomal glutathione S-transferase 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MGST2 promoter]

NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828

G

midline 1

decreases expression

Methylcholanthrene results in decreased expression of MID1 mRNA

NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353

G

mitotic deacetylase associated SANT domain protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MIDEAS promoter]

NCBI chr 6:103,784,779...103,854,470
Ensembl chr 6:103,787,873...103,829,178

G

microRNA 101-2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR101B mRNA

NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467

G

microRNA 122

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

microRNA 130a

affects expression

Methylcholanthrene affects the expression of MIR130A mRNA

NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629

G

microRNA 130b

decreases expression

Methylcholanthrene results in decreased expression of MIR130B mRNA

NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244

G

microRNA 144

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR144 mRNA

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

G

microRNA 145

decreases expression

Methylcholanthrene results in decreased expression of MIR145A mRNA

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

microRNA 191

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR191 mRNA

NCBI chr 8:109,264,098...109,264,188

G

microRNA 19a

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR19A mRNA

NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993

G

microRNA 206

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR206 mRNA

NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332

G

microRNA 210

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR210 mRNA

NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454

G

microRNA 211

decreases expression

Methylcholanthrene results in decreased expression of MIR211 mRNA

NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644

G

microRNA 32

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of MIR32 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR32 mRNA

NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152

G

microRNA 340-1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR340 mRNA

NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665

G

microRNA 345

affects expression
multiple interactions

Methylcholanthrene affects the expression of MIR345 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MIR345 mRNA

NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122

G

microRNA 3545

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR203 mRNA

NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656

G

microRNA 425

decreases expression

Methylcholanthrene results in decreased expression of MIR425 mRNA

NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637

G

microRNA 449a

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MIR449A mRNA

NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804

G

microRNA 497

increases expression

Methylcholanthrene results in increased expression of MIR497 mRNA

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 92a-2

decreases expression

Methylcholanthrene results in decreased expression of MIR92-2 mRNA

NCBI chr X:132,421,942...132,422,033
Ensembl chr X:132,421,942...132,422,033

G

marker of proliferation Ki-67

increases expression
multiple interactions

Methylcholanthrene results in increased expression of MKI67 mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of MKI67 mRNA]; Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of MKI67 protein]

PMID:20713471 PMID:26372666

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MLLT6, PHD finger containing

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MLLT6 promoter]

NCBI chr10:82,657,258...82,678,899
Ensembl chr10:82,656,872...82,676,073

G

melanophilin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MLPH promoter]

NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983

G

matrix metallopeptidase 1

increases expression

Methylcholanthrene results in increased expression of MMP1 mRNA

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 13

increases expression
decreases expression

Methylcholanthrene results in increased expression of MMP13 mRNA
Methylcholanthrene results in decreased expression of MMP13 mRNA

PMID:20713471 PMID:29554273

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

multiple interactions

[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of MMP2 mRNA; [Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

increases expression

Methylcholanthrene results in increased expression of MMP3 mRNA

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions
decreases expression

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MMP9 mRNA
Methylcholanthrene results in decreased expression of MMP9 mRNA

PMID:23519560 PMID:29554273

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose phosphate isomerase

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]

NCBI chr 8:57,947,883...57,956,205
Ensembl chr 8:57,947,893...57,956,150

G

MPL proto-oncogene, thrombopoietin receptor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MPL mRNA

NCBI chr 5:131,973,895...131,987,472
Ensembl chr 5:131,973,895...131,986,797

G

myocardin related transcription factor B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MRTFB promoter]

NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897

G

membrane spanning 4-domains A7

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MS4A7 promoter]

NCBI chr 1:207,969,117...207,984,743
Ensembl chr 1:207,968,761...207,983,260

G

mutS homolog 4

decreases expression

Methylcholanthrene results in decreased expression of MSH4 mRNA

NCBI chr 2:242,785,392...242,844,609
Ensembl chr 2:242,792,661...242,843,487

G

mutS homolog 5

decreases expression

Methylcholanthrene results in decreased expression of MSH5 mRNA

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

mesothelin

increases expression

Methylcholanthrene results in increased expression of MSLN mRNA

NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643

G

microseminoprotein, beta

multiple interactions
increases expression
affects binding

Methylcholanthrene promotes the reaction [AHR protein binds to MSMB promoter]
Methylcholanthrene results in increased expression of MSMB mRNA
Methylcholanthrene binds to MSMB protein

PMID:3940634 PMID:20348232

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

G

methylsterol monooxygenase 1

decreases expression

Methylcholanthrene results in decreased expression of MSMO1 mRNA

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

metallothionein 2A

multiple interactions
increases expression

AHR protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]; Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]; NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MTCL family member 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MTCL3 promoter]

NCBI chr 1:28,629,036...28,701,416
Ensembl chr 1:28,620,293...28,701,796

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MTHFD2 mRNA

NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608

G

MYB proto-oncogene like 1

affects expression

Methylcholanthrene affects the expression of MYBL1 mRNA

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYB proto-oncogene like 2

decreases expression

Methylcholanthrene results in decreased expression of MYBL2 mRNA

NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708

G

myosin heavy chain 7

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of MYH7 mRNA

NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217

G

myosin light chain 9

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of MYL9 mRNA
[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MYL9 mRNA

PMID:20713471 PMID:25926378

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MYLK mRNA

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

myosin ID

decreases expression

Methylcholanthrene results in decreased expression of MYO1D mRNA

NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349

G

myosin VIIA

decreases expression

Methylcholanthrene results in decreased expression of MYO7A mRNA

NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157

G

myoferlin

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MYOF promoter]

NCBI chr 1:235,673,666...235,822,413
Ensembl chr 1:235,673,666...235,822,334

G

myomesin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to MYOM2 promoter]

NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772

G

nuclear autoantigenic sperm protein

increases expression

Methylcholanthrene results in increased expression of NASP mRNA

NCBI chr 5:130,057,363...130,083,003
Ensembl chr 5:130,057,363...130,082,928

G

neural cell adhesion molecule 1

decreases expression

Methylcholanthrene results in decreased expression of NCAM1 mRNA

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

non-SMC condensin II complex, subunit G2

increases expression

Methylcholanthrene results in increased expression of NCAPG2 mRNA

NCBI chr 6:137,342,449...137,418,083
Ensembl chr 6:137,342,943...137,415,159

G

non-SMC condensin I complex, subunit H

increases expression

Methylcholanthrene results in increased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

neutrophil cytosolic factor 1

increases expression

Methylcholanthrene results in increased expression of NCF1 mRNA

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NCK adaptor protein 2

decreases expression

Methylcholanthrene results in decreased expression of NCK2 mRNA

NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307

G

NDC80 kinetochore complex component

decreases expression
increases expression

Methylcholanthrene results in decreased expression of NDC80 mRNA
Methylcholanthrene results in increased expression of NDC80 mRNA

PMID:20713471 PMID:22579512

NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924

G

NDRG family member 4

increases expression

Methylcholanthrene results in increased expression of NDRG4 mRNA

NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914

G

N-deacetylase and N-sulfotransferase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NDST1 promoter]

NCBI chr18:54,136,887...54,199,545
Ensembl chr18:54,140,779...54,178,191

G

neural precursor cell expressed, developmentally down-regulated 9

increases expression

Methylcholanthrene results in increased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

NIMA-related kinase 2

increases expression

Methylcholanthrene results in increased expression of NEK2 mRNA

NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051

G

negative elongation factor complex member C/D

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NELFCD promoter]

NCBI chr 3:163,213,765...163,224,886
Ensembl chr 3:163,213,762...163,224,884

G

nuclear factor of activated T-cells 2

decreases expression

Methylcholanthrene results in decreased expression of NFATC2 mRNA

NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions

Methylcholanthrene results in increased expression of NFE2L2 mRNA; Methylcholanthrene results in increased expression of NFE2L2 protein
NFE2L2 protein affects the reaction [Methylcholanthrene results in increased expression of PSMB5 mRNA]
Methylcholanthrene promotes the reaction [AHR protein binds to NFE2L2 promoter]

PMID:16723119 PMID:20348232 PMID:20713471 PMID:23712962

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

increases expression

Methylcholanthrene results in increased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor zeta

increases expression

Methylcholanthrene results in increased expression of NFKBIZ mRNA

NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723

G

nuclear transcription factor Y subunit alpha

multiple interactions
increases activity

Methylcholanthrene promotes the reaction [NFYA protein binds to KRAS exon]
Methylcholanthrene results in increased activity of NFYA protein

NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898

G

nerve growth factor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of NGF mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NGF mRNA

PMID:20713471 PMID:23519560

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

NHERF family PDZ scaffold protein 2

decreases expression

Methylcholanthrene results in decreased expression of NHERF2 mRNA

NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049

G

niban apoptosis regulator 1

increases expression

Methylcholanthrene results in increased expression of NIBAN1 mRNA

NCBI chr13:63,674,240...63,827,748
Ensembl chr13:63,674,171...63,827,729

G

NKD inhibitor of WNT signaling pathway 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NKD2 mRNA

NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821

G

NmrA like redox sensor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NMRAL1 promoter]

NCBI chr10:10,841,693...10,850,199
Ensembl chr10:10,841,799...10,850,192

G

NOP58 ribonucleoprotein

increases expression

Methylcholanthrene results in increased expression of NOL5 mRNA

NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810

G

notch receptor 2

decreases acetylation
multiple interactions
increases expression
increases methylation

Methylcholanthrene results in decreased acetylation of NOTCH2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

natriuretic peptide A

increases expression

3-methylcholanthrene increases expression of mRNA in rat heart

RGD

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

natriuretic peptide B

increases expression

3-methylcholanthrene increases expression of mRNA in rat heart

RGD

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases activity
increases expression

Arsenic promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Cadmium promotes the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]; Chromium inhibits the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Chromium inhibits the reaction [Methylcholanthrene results in increased expression of NQO1 mRNA]
[protocatechuic acid co-treated with Methylcholanthrene] results in increased activity of NQO1 protein; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Ethoxyquin promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Ethoxyquin results in increased activity of NQO1 protein]; Methylcholanthrene results in increased expression of and results in increased activity of NQO1 protein
Methylcholanthrene results in increased expression of NQO1 mRNA; Methylcholanthrene results in increased expression of NQO1 protein

PMID:4005852 PMID:11323195 PMID:12206817 PMID:15302093 PMID:15337587 More...

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

increases expression

Methylcholanthrene results in increased expression of NQO2 mRNA

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

nuclear receptor subfamily 0, group B, member 2

increases expression

Methylcholanthrene results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 1, group H, member 3

increases expression

Methylcholanthrene results in increased expression of NR1H3 mRNA

NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722

G

nuclear receptor subfamily 1, group I, member 3

increases expression
affects expression

Methylcholanthrene results in increased expression of NR1I3 mRNA
Methylcholanthrene affects the expression of NR1I3 mRNA

PMID:19118567 PMID:23273579

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 3, group C, member 1

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of NR3C1 protein
[NR3C1 protein co-treated with Dexamethasone] inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; [NR3C1 protein co-treated with Dexamethasone] results in decreased susceptibility to Methylcholanthrene; NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]; NR3C1 protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]

PMID:1638671 PMID:23994556 PMID:24091107

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

decreases expression

Methylcholanthrene results in decreased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

neuronal regeneration related protein

decreases expression

Methylcholanthrene results in decreased expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

neuritin 1

increases expression

Methylcholanthrene results in increased expression of NRN1 mRNA

NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896

G

neurexin 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of NRXN2 mRNA

NCBI chr 1:203,726,420...203,842,301
Ensembl chr 1:203,735,753...203,842,297

G

NAD(P) dependent steroid dehydrogenase-like

decreases expression

Methylcholanthrene results in decreased expression of NSDHL mRNA

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

nudix hydrolase 21

increases expression

Methylcholanthrene results in increased expression of NUDT21 mRNA

NCBI chr19:10,974,800...10,993,841
Ensembl chr19:10,974,241...10,991,682

G

nucleolar and spindle associated protein 1

increases expression

Methylcholanthrene results in increased expression of NUSAP1 mRNA

NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624

G

nucleoredoxin

decreases expression

Methylcholanthrene results in decreased expression of NXN mRNA

NCBI chr10:61,109,322...61,247,578
Ensembl chr10:61,110,020...61,248,251

G

nuclear transport factor 2-like export factor 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to NXT2 promoter]

NCBI chr X:105,855,616...105,862,902
Ensembl chr X:105,855,608...105,862,899

G

osteoglycin

decreases expression

Methylcholanthrene results in decreased expression of OGN mRNA

NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739

G

Opa interacting protein 5

increases expression

Methylcholanthrene results in increased expression of OIP5 mRNA

NCBI chr 3:106,593,746...106,603,281
Ensembl chr 3:106,593,760...106,603,250

G

olfactomedin 1

increases expression

Methylcholanthrene results in increased expression of OLFM1 mRNA

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

olfactory receptor family 11 subfamily H member 4

decreases expression

Methylcholanthrene results in decreased expression of OR11H4 mRNA

NCBI chr15:23,946,991...23,947,977
Ensembl chr15:23,946,943...23,953,404

G

olfactory receptor family 4 subfamily D member 5

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of OR4D5 mRNA

NCBI chr 8:40,423,865...40,424,809
Ensembl chr 8:40,423,865...40,424,809

G

olfactory receptor family 6 subfamily S member 1

decreases expression

Methylcholanthrene results in decreased expression of OR6S1 mRNA

NCBI chr15:24,291,540...24,292,535
Ensembl chr15:24,291,243...24,295,559

G

olfactory receptor family 8 subfamily J member 3B

increases expression

Methylcholanthrene results in increased expression of OR8J3C mRNA

NCBI chr 3:71,382,854...71,383,801
Ensembl chr 3:71,382,854...71,383,801

G

oxysterol binding protein-like 10

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to OSBPL10 promoter]

NCBI chr 8:114,661,050...114,918,664
Ensembl chr 8:114,660,743...114,918,625

G

odd-skipped related transciption factor 2

decreases expression

Methylcholanthrene results in decreased expression of OSR2 mRNA

NCBI chr 7:66,487,841...66,495,003
Ensembl chr 7:66,487,839...66,495,224

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to OTUB2 promoter]

NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644

G

OTU deubiquitinase with linear linkage specificity like

increases expression

Methylcholanthrene results in increased expression of OTULINL mRNA

NCBI chr 2:78,405,994...78,433,860
Ensembl chr 2:78,408,593...78,433,838

G

purinergic receptor P2X 7

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of P2RX7 mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of P2RX7 mRNA

PMID:20713471 PMID:23519560

NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619

G

purinergic receptor P2Y1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of P2RY1 mRNA

NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457

G

phenylalanine hydroxylase

decreases expression

Methylcholanthrene results in decreased expression of PAH mRNA

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

p21 (RAC1) activated kinase 6

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PAK6 mRNA

NCBI chr 3:105,638,248...105,674,399
Ensembl chr 3:105,638,653...105,672,975

G

protein associated with LIN7 2, MAGUK p55 family member

increases expression

Methylcholanthrene results in increased expression of PALS2 mRNA

NCBI chr 4:79,173,488...79,257,542
Ensembl chr 4:79,124,806...79,254,140

G

par-6 family cell polarity regulator beta

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of PARD6B mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PARD6B mRNA

PMID:20713471 PMID:23519560

NCBI chr 3:156,790,540...156,811,620
Ensembl chr 3:156,790,540...156,811,622

G

poly (ADP-ribose) polymerase 1

multiple interactions

Methylcholanthrene inhibits the reaction [3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

PAX3 and PAX7 binding protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PAXBP1 promoter]

NCBI chr11:30,272,037...30,301,504
Ensembl chr11:30,272,037...30,301,648

G

PDZ binding kinase

increases expression

Methylcholanthrene results in increased expression of PBK mRNA

NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014

G

protocadherin 18

decreases expression

Methylcholanthrene results in decreased expression of PCDH18 mRNA

NCBI chr 2:133,831,996...133,845,992
Ensembl chr 2:133,832,001...133,845,883

G

protocadherin 7

decreases expression

Methylcholanthrene results in decreased expression of PCDH7 mRNA

NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051

G

phosphoenolpyruvate carboxykinase 1

decreases expression

Methylcholanthrene results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

procollagen C-endopeptidase enhancer 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PCOLCE2 promoter]

NCBI chr 8:96,193,461...96,251,116
Ensembl chr 8:96,193,461...96,251,114

G

programmed cell death 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PDCD4 promoter]

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phosphodiesterase 1B

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDE1B mRNA

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

G

PDZ and LIM domain 5

decreases expression

Methylcholanthrene results in decreased expression of PDLIM5 mRNA

NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275

G

PDZ domain containing 8

increases expression

Methylcholanthrene results in increased expression of PDZD8 mRNA

NCBI chr 1:258,449,218...258,506,828
Ensembl chr 1:258,449,218...258,506,828

G

pellino E3 ubiquitin protein ligase family member 2

increases expression

Methylcholanthrene results in increased expression of PELI2 mRNA

NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106

G

platelet factor 4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

phosphoglycerate kinase 2

decreases expression

Methylcholanthrene results in decreased expression of PGK2 mRNA

NCBI chr 9:20,480,367...20,481,933
Ensembl chr 9:20,480,203...20,571,481

G

progesterone receptor

increases expression
multiple interactions

Methylcholanthrene results in increased expression of PGR mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR protein]

PMID:16257430 PMID:26372666

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatase and actin regulator 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PHACTR1 promoter]

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

G

phosphate regulating endopeptidase X-linked

increases expression

Methylcholanthrene results in increased expression of PHEX mRNA

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

phosphorylase kinase regulatory subunit alpha 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PHKA2 mRNA

NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466

G

phosphatidylinositol glycan anchor biosynthesis, class P

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PIGP promoter]

NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PIK3CB mRNA

NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PIK3CD mRNA

NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

phosphoinositide-3-kinase, regulatory subunit 5

increases expression

Methylcholanthrene results in increased expression of PIK3R5 mRNA

NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374

G

Pim-2 proto-oncogene, serine/threonine kinase

increases expression

Methylcholanthrene results in increased expression of PIM2 mRNA

NCBI chr X:14,617,582...14,622,851
Ensembl chr X:14,617,582...14,622,851

G

PBX/knotted 1 homeobox 2

decreases expression

Methylcholanthrene results in decreased expression of PKNOX2 mRNA

NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940

G

phospholipase A2 group VII

increases expression

Methylcholanthrene results in increased expression of PLA2G7 mRNA

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

G

plasminogen activator, urokinase

increases expression

Methylcholanthrene results in increased expression of PLAU mRNA

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

phospholipase C, gamma 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PLCG2 mRNA

NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930

G

pleckstrin homology domain containing A6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PLEKHA6 promoter]

NCBI chr13:44,614,740...44,754,951
Ensembl chr13:44,615,011...44,754,673

G

pleckstrin homology and RhoGEF domain containing G2

decreases expression

Methylcholanthrene results in decreased expression of PLEKHG2 mRNA

NCBI chr 1:83,651,902...83,665,063
Ensembl chr 1:83,647,748...83,665,063

G

polo-like kinase 3

increases expression

Methylcholanthrene results in increased expression of PLK3 mRNA

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

polo-like kinase 4

increases expression

Methylcholanthrene results in increased expression of PLK4 mRNA

NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942

G

phospholipid phosphatase 3

decreases expression

Methylcholanthrene results in decreased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

pogo transposable element derived with ZNF domain

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to POGZ promoter]

NCBI chr 2:182,394,269...182,440,711
Ensembl chr 2:182,380,768...182,440,707

G

DNA polymerase alpha 1, catalytic subunit

increases expression

Methylcholanthrene results in increased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

DNA polymerase epsilon 2, accessory subunit

increases expression

Methylcholanthrene results in increased expression of POLE2 mRNA

NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305

G

DNA polymerase kappa

increases expression

Methylcholanthrene results in increased expression of POLK mRNA; Methylcholanthrene results in increased expression of POLK protein

NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313

G

paraoxonase 1

multiple interactions
increases activity
increases expression

7-ketocholesterol inhibits the reaction [Methylcholanthrene results in increased expression of PON1 mRNA]
Methylcholanthrene results in increased activity of PON1 protein
Methylcholanthrene results in increased expression of PON1 protein

PMID:11551529 PMID:15169886 PMID:26006071

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

paraoxonase 3

increases expression

Methylcholanthrene results in increased expression of PON3 mRNA

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

cytochrome p450 oxidoreductase

increases activity
multiple interactions
increases expression
decreases activity

Methylcholanthrene results in increased activity of POR protein
Methylcholanthrene inhibits the reaction [POR gene mutant form results in decreased expression of CYP3A11 mRNA]; Methylcholanthrene results in increased expression of and results in increased activity of POR protein; POR gene mutant form inhibits the reaction [Methylcholanthrene affects the expression of CYP2D9 protein]; POR gene mutant form inhibits the reaction [Methylcholanthrene results in decreased expression of MUP2 mRNA]; POR gene mutant form inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]
Methylcholanthrene results in increased expression of POR mRNA
sanguinarine promotes the reaction [Methylcholanthrene results in decreased activity of POR protein]

PMID:19788401 PMID:22978700 PMID:23169610 PMID:23846873

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

periostin

decreases expression

Methylcholanthrene results in decreased expression of POSTN mRNA

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator activated receptor alpha

increases expression

Methylcholanthrene results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

pro-platelet basic protein

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PPBP mRNA

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

peptidylprolyl isomerase H

increases expression

Methylcholanthrene results in increased expression of PPIH mRNA

NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

increases expression

Methylcholanthrene results in increased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase 4, regulatory subunit 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

protein regulator of cytokinesis 1

increases expression

Methylcholanthrene results in increased expression of PRC1 mRNA

NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765

G

PR/SET domain 9

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PRDM9 mRNA

NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PREX1 mRNA

NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688

G

prickle planar cell polarity protein 2

decreases expression

Methylcholanthrene results in decreased expression of PRICKLE2 mRNA

NCBI chr 4:124,869,655...125,214,862
Ensembl chr 4:124,869,552...125,214,824

G

protein kinase AMP-activated non-catalytic subunit beta 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB1 promoter]

NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661

G

protein kinase AMP-activated non-catalytic subunit beta 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRKAB2 promoter]

NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872

G

protein kinase D3

decreases expression

Methylcholanthrene results in decreased expression of PRKD3 mRNA

NCBI chr 6:16,032,507...16,108,444
Ensembl chr 6:16,032,585...16,108,443

G

phosphoribosyl pyrophosphate synthetase 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PRPS1 promoter]

NCBI chr X:104,132,139...104,154,191
Ensembl chr X:104,132,141...104,154,187

G

proteasome 20S subunit beta 5

increases activity
increases expression
multiple interactions

Methylcholanthrene results in increased activity of PSMB5 protein
Methylcholanthrene results in increased expression of PSMB5 mRNA; Methylcholanthrene results in increased expression of PSMB5 protein
NFE2L2 protein affects the reaction [Methylcholanthrene results in increased expression of PSMB5 mRNA]

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 6

increases expression

Methylcholanthrene results in increased expression of PSMB6 protein

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 7

increases expression

Methylcholanthrene results in increased expression of PSMB7 protein

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

proteasome 20S subunit beta 8

increases expression

Methylcholanthrene results in increased expression of PSMB8 mRNA

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

proteasome activator subunit 2

increases expression

Methylcholanthrene results in increased expression of PSME2 mRNA

NCBI chr15:29,078,495...29,082,794
Ensembl chr15:29,078,500...29,082,946

G

proline and serine rich coiled-coil 1

increases expression

Methylcholanthrene results in increased expression of PSRC1 mRNA

NCBI chr 2:196,022,361...196,026,874
Ensembl chr 2:196,022,361...196,026,874

G

phosphotriesterase related

increases expression

Methylcholanthrene results in increased expression of PTER mRNA

NCBI chr17:76,058,388...76,119,633
Ensembl chr17:76,058,503...76,119,627

G

prostaglandin E receptor 4

increases expression

Methylcholanthrene results in increased expression of PTGER4 mRNA

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

increases expression

Methylcholanthrene results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin F receptor

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of PTGFR mRNA
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PTGFR mRNA

PMID:20713471 PMID:23519560

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

prostaglandin-endoperoxide synthase 1

increases expression

Methylcholanthrene results in increased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

increases expression

Methylcholanthrene results in increased expression of PTGS2 mRNA

PMID:20713471 PMID:28601433

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions
decreases phosphorylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

pleiotrophin

decreases expression

Methylcholanthrene results in decreased expression of PTN mRNA

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

PTTG1 regulator of sister chromatid separation, securin

increases expression

Methylcholanthrene results in increased expression of PTTG1 mRNA

NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837

G

pentraxin 3

increases expression

Methylcholanthrene results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

PWWP domain containing 3A, DNA repair factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to PWWP3A promoter]

NCBI chr 7:9,465,180...9,482,053
Ensembl chr 7:9,465,195...9,481,966

G

2-phosphoxylose phosphatase 1

increases expression

Methylcholanthrene results in increased expression of PXYLP1 mRNA

NCBI chr 8:97,419,766...97,485,163
Ensembl chr 8:97,419,776...97,485,064

G

Rac family small GTPase 1

increases expression

Methylcholanthrene results in increased expression of RAC1 mRNA

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

Rac GTPase-activating protein 1

increases expression

Methylcholanthrene results in increased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

RAD51 recombinase

increases expression

Methylcholanthrene results in increased expression of RAD51 mRNA

NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035

G

RAD51 associated protein 1

increases expression

Methylcholanthrene results in increased expression of RAD51AP1 mRNA

NCBI chr 4:159,759,454...159,772,473
Ensembl chr 4:159,759,459...159,772,524

G

RAD54 like

increases expression

Methylcholanthrene results in increased expression of RAD54L mRNA

NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070

G

Ral GTPase activating protein catalytic subunit alpha 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RALGAPA2 promoter]

NCBI chr 3:133,658,725...133,938,821
Ensembl chr 3:133,659,761...133,938,916

G

RAN binding protein 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RANBP2 promoter]

NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481

G

RAS protein activator like 3

increases expression

Methylcholanthrene results in increased expression of RASAL3 mRNA

NCBI chr 7:11,396,554...11,411,347
Ensembl chr 7:11,396,090...11,411,465

G

Ras association domain family member 1

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of RASSF1 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of RASSF1 promoter

NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164

G

RB binding protein 7, chromatin remodeling factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBBP7 promoter]

NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226

G

RNA binding motif protein 24

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBM24 promoter]

NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102

G

RNA binding motif, single stranded interacting protein 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBMS2 promoter]

NCBI chr 7:560,787...603,881
Ensembl chr 7:560,648...600,232

G

RNA binding motif, single stranded interacting protein 3

decreases expression

Methylcholanthrene results in decreased expression of RBMS3 mRNA

NCBI chr 8:116,305,227...117,625,730
Ensembl chr 8:116,309,882...117,625,423

G

recombination signal binding protein for immunoglobulin kappa J region

increases expression

Methylcholanthrene results in increased expression of RBPJ mRNA

NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353

G

rabenosyn, RAB effector

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RBSN promoter]

NCBI chr 4:124,682,228...124,712,578
Ensembl chr 4:124,683,969...124,712,578

G

RAS-like, estrogen-regulated, growth-inhibitor

multiple interactions
decreases expression

Methylcholanthrene promotes the reaction [AHR protein binds to RERG promoter]
Methylcholanthrene results in decreased expression of RERG mRNA

NCBI chr 4:169,981,634...170,089,777
Ensembl chr 4:169,982,279...170,089,715

G

replication factor C subunit 3

increases expression

Methylcholanthrene results in increased expression of RFC3 mRNA

NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778

G

replication factor C subunit 4

increases expression

Methylcholanthrene results in increased expression of RFC4 mRNA

NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122

G

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RFFL promoter]

NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434

G

regulator of G-protein signaling 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RGS3 promoter]

NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894

G

Rho-related BTB domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RHOBTB1 promoter]

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

ras homolog family member C

increases expression

Methylcholanthrene results in increased expression of RHOC mRNA

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

G

ras homolog family member H

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RHOH promoter]

NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369

G

Ras and Rab interactor 3

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RIN3 mRNA

NCBI chr 6:121,431,776...121,540,956
Ensembl chr 6:121,431,339...121,540,957

G

Rho family GTPase 3

decreases expression

Methylcholanthrene results in decreased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 157

decreases expression

Methylcholanthrene results in decreased expression of RNF157 mRNA

NCBI chr10:101,571,972...101,639,874
Ensembl chr10:101,566,295...101,639,942

G

roundabout guidance receptor 1

decreases expression

Methylcholanthrene results in decreased expression of ROBO1 mRNA

NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203

G

receptor tyrosine kinase-like orphan receptor 1

decreases expression

Methylcholanthrene results in decreased expression of ROR1 mRNA

NCBI chr 5:114,744,311...115,088,155
Ensembl chr 5:114,744,304...115,088,155

G

replication protein A2

increases expression

Methylcholanthrene results in increased expression of RPA2 mRNA

NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350

G

ribosomal protein L11

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RPL11 promoter]

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribonucleotide reductase catalytic subunit M1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

ribonucleotide reductase regulatory subunit M2

increases expression

Methylcholanthrene results in increased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

radical S-adenosyl methionine domain containing 2

decreases expression

Methylcholanthrene results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

RT1 class II, locus DMb

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of H2-DMB1 mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

reticulon 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RTN3 promoter]

NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275

G

receptor (chemosensory) transporter protein 4

decreases expression

Methylcholanthrene results in decreased expression of RTP4 mRNA

NCBI chr11:77,237,341...77,249,194
Ensembl chr11:77,238,216...77,335,437

G

retinoid X receptor alpha

increases expression

Methylcholanthrene results in increased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

ryanodine receptor 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to RYR3 promoter]

NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961

G

sterile alpha motif domain containing 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SAMD12 promoter]

NCBI chr 7:84,768,850...85,064,057
Ensembl chr 7:84,768,254...85,271,766

G

SAP30 binding protein

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SAP30BP mRNA

NCBI chr10:101,165,777...101,198,503
Ensembl chr10:101,165,856...101,198,502

G

strawberry notch homolog 1

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SBNO1 mRNA

NCBI chr12:32,175,176...32,234,200
Ensembl chr12:32,185,485...32,230,158

G

suppressor of cancer cell invasion

decreases expression

Methylcholanthrene results in decreased expression of SCAI mRNA

NCBI chr 3:22,813,283...22,925,337
Ensembl chr 3:22,819,574...22,925,363

G

secretory carrier membrane protein 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SCAMP2 mRNA

NCBI chr 8:57,965,612...57,992,248
Ensembl chr 8:57,965,631...57,992,646

G

sodium voltage-gated channel beta subunit 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SCN3B promoter]

NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868

G

selectin P

increases expression

Methylcholanthrene results in increased expression of SELP mRNA

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

semaphorin 5A

increases expression

Methylcholanthrene results in increased expression of SEMA5A mRNA

NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084

G

semaphorin 6D

increases expression

Methylcholanthrene results in increased expression of SEMA6D mRNA

NCBI chr 3:111,883,415...111,941,100
Ensembl chr 3:111,883,872...111,941,094

G

semaphorin 7A (John Milton Hagen blood group)

increases expression

Methylcholanthrene results in increased expression of SEMA7A mRNA

NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536

G

serpin family E member 1

increases expression

Methylcholanthrene results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

secreted frizzled-related protein 1

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP1 mRNA

NCBI chr16:68,575,763...68,614,180
Ensembl chr16:68,575,763...68,614,286

G

secreted frizzled-related protein 2

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFRP2 mRNA

NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063

G

surfactant protein D

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SFTPD mRNA

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

shugoshin 1

increases expression

Methylcholanthrene results in increased expression of SGO1 mRNA

NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805

G

SHC adaptor protein 4

increases expression

Methylcholanthrene results in increased expression of SHC4 mRNA

NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366

G

SHC binding and spindle associated 1

increases expression

Methylcholanthrene results in increased expression of SHCBP1 mRNA

NCBI chr16:84,672,277...84,703,843
Ensembl chr16:84,672,321...84,703,844

G

SIK family kinase 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SIK3 promoter]

NCBI chr 8:46,312,253...46,522,444
Ensembl chr 8:46,311,989...46,522,444

G

sirtuin 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SIRT2 mRNA

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

G

SIVA1, apoptosis-inducing factor

increases expression

Methylcholanthrene results in increased expression of SIVA1 mRNA

NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690

G

SKI8 subunit of superkiller complex

increases expression

Methylcholanthrene results in increased expression of SKIC8 mRNA

NCBI chr 8:55,103,542...55,120,837
Ensembl chr 8:55,103,545...55,120,813

G

solute carrier family 13 member 5

increases expression

Methylcholanthrene results in increased expression of SLC13A5 mRNA

NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945

G

solute carrier family 15 member 2

increases expression

Methylcholanthrene results in increased expression of SLC15A2 mRNA

NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225

G

solute carrier family 16, member 6

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC16A6 promoter]

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 22, member 23

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC22A23 promoter]

NCBI chr17:30,544,106...30,709,790
Ensembl chr17:30,544,106...30,709,790

G

solute carrier family 23 member 1

increases expression

Methylcholanthrene results in increased expression of SLC23A1 mRNA

NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697

G

solute carrier family 27 member 1

increases expression

Methylcholanthrene results in increased expression of SLC27A1 mRNA

NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063

G

solute carrier family 2 member 1

increases expression

Methylcholanthrene results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 44 member 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLC44A1 promoter]

NCBI chr 5:68,061,941...68,241,912
Ensembl chr 5:68,063,618...68,241,909

G

solute carrier family 9 member A9

decreases expression

Methylcholanthrene results in decreased expression of SLC9A9 mRNA

NCBI chr 8:95,232,889...95,797,262
Ensembl chr 8:95,232,905...95,796,318

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

increases expression

Methylcholanthrene results in increased expression of SLCO1B2 mRNA

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

SMC5-SMC6 complex localization factor 2

decreases expression

Methylcholanthrene results in decreased expression of SLF2 mRNA

NCBI chr 1:243,782,786...243,845,418
Ensembl chr 1:243,782,246...243,845,250

G

schlafen family member 2

decreases expression

Methylcholanthrene results in decreased expression of SLFN2 mRNA

NCBI chr10:67,953,322...67,959,659
Ensembl chr10:67,953,171...67,959,458

G

schlafen family member 9

increases expression

Methylcholanthrene results in increased expression of SLFN9 mRNA

NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383

G

slit guidance ligand 2

decreases expression

Methylcholanthrene results in decreased expression of SLIT2 mRNA

NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948

G

SLU7 homolog, splicing factor

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SLU7 promoter]

NCBI chr10:27,908,325...27,923,784
Ensembl chr10:27,908,396...27,923,349

G

small ArfGAP2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SMAP2 promoter]

NCBI chr 5:134,530,542...134,576,938
Ensembl chr 5:134,530,543...134,576,938

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SMARCE1 promoter]

NCBI chr10:84,159,270...84,180,547
Ensembl chr10:84,159,275...84,179,989

G

SET and MYND domain containing 3

decreases expression

Methylcholanthrene results in decreased expression of SMYD3 mRNA

NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253

G

SNAP-associated protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SNAPIN promoter]

NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231

G

suppressor of cytokine signaling 2

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in increased expression of SOCS2 mRNA

NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548

G

suppressor of cytokine signaling 3

multiple interactions
increases expression

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of SOCS3 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of SOCS3 promoter
Methylcholanthrene results in increased expression of SOCS3 mRNA

PMID:20970405 PMID:23169610

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

suppressor of cytokine signaling 7

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SOCS7 promoter]

NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830

G

superoxide dismutase 1

increases expression

Methylcholanthrene results in increased expression of SOD1 mRNA

PMID:23273579 PMID:23712962

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
decreases expression

Methylcholanthrene results in increased expression of SOD2 mRNA
Methylcholanthrene results in decreased expression of SOD2 mRNA

PMID:23712962 PMID:35487396

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sortilin related receptor 1

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [ARNT protein binds to SORL1 promoter]; Methylcholanthrene promotes the reaction [Methylcholanthrene results in increased expression of SORL1 mRNA]

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

SOS Ras/Rac guanine nucleotide exchange factor 1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of SOS1 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to SOS1 promoter]

PMID:16619036 PMID:20348232

NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107

G

SRY-box transcription factor 17

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOX17 mRNA

NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228

G

SRY-box transcription factor 4

decreases expression

Methylcholanthrene results in decreased expression of SOX4 mRNA

NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665

G

Sp1 transcription factor

multiple interactions
increases expression
increases acetylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA]; Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

sperm associated antigen 5

increases expression

Methylcholanthrene results in increased expression of SPAG5 mRNA

NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745

G

SPARC like 1

decreases expression

Methylcholanthrene results in decreased expression of SPARCL1 mRNA

NCBI chr14:5,632,816...5,663,866
Ensembl chr14:5,632,569...5,663,865

G

SPC24 component of NDC80 kinetochore complex

increases expression

Methylcholanthrene results in increased expression of SPC24 mRNA

NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310

G

SPC25 component of NDC80 kinetochore complex

increases expression

Methylcholanthrene results in increased expression of SPC25 mRNA

NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959

G

spindle apparatus coiled-coil protein 1

increases expression

Methylcholanthrene results in increased expression of SPDL1 mRNA

NCBI chr10:19,269,125...19,294,213
Ensembl chr10:19,269,127...19,294,127

G

Spi-B transcription factor

increases expression

Methylcholanthrene results in increased expression of SPIB mRNA

NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780

G

spondin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SPON2 promoter]

NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996

G

sprouty-related, EVH1 domain containing 1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of SPRED1 mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to SPRED1 promoter]

PMID:20348232 PMID:20713471

NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718

G

sprouty-related, EVH1 domain containing 2

increases expression

Methylcholanthrene results in increased expression of SPRED2 mRNA

NCBI chr14:94,149,210...94,250,787
Ensembl chr14:94,148,837...94,249,162

G

sprouty RTK signaling antagonist 2

increases expression

Methylcholanthrene results in increased expression of SPRY2 mRNA

NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009

G

serine palmitoyltransferase, long chain base subunit 1

affects localization
multiple interactions
decreases response to substance

Methylcholanthrene affects the localization of SPTLC1 protein
SPTLC1 protein inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; SPTLC1 protein mutant form inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]
SPTLC1 protein mutant form results in decreased susceptibility to Methylcholanthrene; SPTLC1 protein results in decreased susceptibility to Methylcholanthrene

NCBI chr17:11,877,249...11,916,295
Ensembl chr17:11,877,249...11,916,295

G

serine palmitoyltransferase, long chain base subunit 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SPTLC2 promoter]

NCBI chr 6:106,948,682...107,031,532
Ensembl chr 6:106,950,949...107,031,542

G

serine palmitoyltransferase, small subunit A

decreases expression

Methylcholanthrene results in decreased expression of SPTSSA mRNA

NCBI chr 6:72,144,714...72,156,130
Ensembl chr 6:72,144,714...72,156,214

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
affects expression

Methylcholanthrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [SRC protein binds to AHR protein]]
Methylcholanthrene affects the expression of SRC mRNA

PMID:8937476 PMID:23273579

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

serine and arginine rich splicing factor 1

multiple interactions

[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

SS18 subunit of BAF chromatin remodeling complex

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SS18 promoter]

NCBI chr18:5,773,042...5,835,696
Ensembl chr18:5,773,042...5,835,333

G

steroidogenic acute regulatory protein

increases expression

Methylcholanthrene results in increased expression of STAR mRNA

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

StAR-related lipid transfer domain containing 13

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to STARD13 promoter]

NCBI chr12:566,282...959,372
Ensembl chr12:566,310...959,421

G

signal transducer and activator of transcription 2

increases expression

Methylcholanthrene results in increased expression of STAT2 mRNA

NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967

G

signal transducer and activator of transcription 3

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of STAT3 mRNA

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5B

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to STAT5B promoter]

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

staufen double-stranded RNA binding protein 2

decreases expression

Methylcholanthrene results in decreased expression of STAU2 mRNA

NCBI chr 5:2,840,741...3,084,935
Ensembl chr 5:2,840,765...3,084,929

G

stathmin 1

increases expression

Methylcholanthrene results in increased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

serine/threonine/tyrosine kinase 1

increases expression

Methylcholanthrene results in increased expression of STYK1 mRNA

NCBI chr 4:165,047,613...165,097,890
Ensembl chr 4:165,048,440...165,096,440

G

sulfotransferase family 1A member 1

decreases expression
multiple interactions

Methylcholanthrene results in decreased expression of SULT1A1 mRNA
[Methylcholanthrene co-treated with Oxygen deficiency] results in decreased expression of SULT1A1 mRNA

PMID:11323195 PMID:33811995

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

sulfotransferase family 1E member 1

decreases expression

Methylcholanthrene results in decreased expression of SULT1E1 mRNA

NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275

G

sulfotransferase family 2A member 1

decreases expression

Methylcholanthrene results in decreased expression of SULT2A1 mRNA

NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134

G

SWIM-type zinc finger 7 associated protein 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SWSAP1 promoter]

NCBI chr 8:20,486,680...20,489,213
Ensembl chr 8:20,486,678...20,489,211

G

synaptonemal complex protein 2

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to SYCP2 promoter]
Methylcholanthrene results in increased expression of SYCP2 mRNA

NCBI chr 3:165,431,715...165,502,134
Ensembl chr 3:165,436,331...165,498,789

G

synaptonemal complex protein 3

decreases expression

Methylcholanthrene results in decreased expression of SYCP3 mRNA

NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511

G

synemin

decreases expression

Methylcholanthrene results in decreased expression of SYNM mRNA

NCBI chr 1:121,333,712...121,363,652
Ensembl chr 1:121,333,720...121,363,652

G

synaptotagmin 12

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to SYT12 promoter]

NCBI chr 1:201,729,307...201,760,192
Ensembl chr 1:201,730,371...201,759,609

G

TRAF family member-associated NFKB activator

increases expression

Methylcholanthrene results in increased expression of TANK mRNA

NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264

G

transporter 1, ATP binding cassette subfamily B member

increases expression

Methylcholanthrene results in increased expression of TAP1 mRNA

NCBI chr20:4,656,262...4,666,634
Ensembl chr20:4,656,263...4,666,901

G

transporter 2, ATP binding cassette subfamily B member

increases expression

Methylcholanthrene results in increased expression of TAP2 mRNA

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

TBL1X/Y related 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TBL1XR1 promoter]

NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055

G

T-box transcription factor 3

increases expression

Methylcholanthrene results in increased expression of TBX3 mRNA

NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708

G

transcription factor 19

increases expression

Methylcholanthrene results in increased expression of TCF19 mRNA

NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271

G

TEA domain transcription factor 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TEAD4 promoter]

NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323

G

trefoil factor 1

increases expression

Methylcholanthrene results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

trefoil factor 3

decreases expression

Methylcholanthrene results in decreased expression of TFF3 mRNA

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

thrombomodulin

increases expression

Methylcholanthrene results in increased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

thrombospondin 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to THBS2 promoter]
[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of THBS2 mRNA

PMID:20348232 PMID:23519560

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

thioesterase superfamily member 5

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to THEM5 promoter]

NCBI chr 2:181,980,783...181,986,002
Ensembl chr 2:181,980,783...181,986,002

G

TIMP metallopeptidase inhibitor 1

increases expression

Methylcholanthrene results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

[Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 mRNA; [Methylcholanthrene co-treated with Diethylnitrosamine] results in increased expression of TIMP2 protein

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TIMP metallopeptidase inhibitor 3

multiple interactions

[Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of TIMP3 protein; [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of TIMP3 gene

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TIPARP mRNA
Methylcholanthrene promotes the reaction [AHR protein binds to TIPARP promoter]

PMID:20348232 PMID:20713471

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

timeless interacting protein

increases expression

Methylcholanthrene results in increased expression of TIPIN mRNA

NCBI chr 8:64,780,813...64,801,358
Ensembl chr 8:64,780,828...64,801,352

G

thymidine kinase 1

increases expression

Methylcholanthrene results in increased expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

transmembrane 4 L six family member 1

increases expression

Methylcholanthrene results in increased expression of TM4SF1 mRNA

NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146

G

transmembrane protein 116

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM116 promoter]

NCBI chr12:35,021,912...35,089,409
Ensembl chr12:35,041,572...35,089,430

G

transmembrane protein 119

increases expression

Methylcholanthrene results in increased expression of TMEM119 mRNA

NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689

G

transmembrane protein 184B

increases expression

Methylcholanthrene results in increased expression of TMEM184B mRNA

NCBI chr 7:110,925,092...110,967,975
Ensembl chr 7:110,925,092...110,967,943

G

transmembrane protein 30A

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM30A promoter]
Methylcholanthrene results in increased expression of TMEM30A mRNA

NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248

G

transmembrane protein 45b

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM45B promoter]

NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453

G

transmembrane protein 97

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMEM97 promoter]

NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730

G

transmembrane O-mannosyltransferase targeting cadherins 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TMTC2 promoter]

NCBI chr 7:40,392,377...40,806,685
Ensembl chr 7:40,394,220...40,807,298

G

tenascin C

decreases expression

Methylcholanthrene results in decreased expression of TNC mRNA

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions
increases expression

[Methylcholanthrene co-treated with TNF protein] results in increased expression of IL6 mRNA
Methylcholanthrene results in increased expression of TNF mRNA

PMID:23273579 PMID:23396138 PMID:35487396

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 21

decreases expression

Methylcholanthrene results in decreased expression of TNFRSF21 mRNA

NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085

G

tumor necrosis factor receptor superfamily, member 22

increases expression

Methylcholanthrene results in increased expression of TNFRSF22 mRNA

NCBI chr 1:198,840,452...198,860,713
Ensembl chr 1:198,840,453...198,856,309

G

TNF receptor superfamily member 9

increases expression

Methylcholanthrene results in increased expression of TNFRSF9 mRNA

NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000

G

tyrosine kinase, non-receptor, 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TNK2 promoter]

NCBI chr11:68,114,725...68,154,254
Ensembl chr11:68,114,726...68,154,009

G

DNA topoisomerase II alpha

increases expression
multiple interactions

Methylcholanthrene results in increased expression of TOP2A mRNA
Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of TOP2A mRNA]

PMID:20713471 PMID:26372666

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

multiple interactions
increases expression

Methylcholanthrene promotes the reaction [TRP53 protein binds to ABCB1B promoter]; Methylcholanthrene promotes the reaction [TRP53 protein binds to FMO3 5' UTR]; Methylcholanthrene results in increased expression of and results in increased activity of TRP53 protein
Methylcholanthrene results in increased expression of TP53 mRNA

PMID:11096091 PMID:20570689 PMID:23273579

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 inducible nuclear protein 2

decreases expression

Methylcholanthrene results in decreased expression of TRP53INP2 mRNA

NCBI chr 3:143,881,427...143,890,104
Ensembl chr 3:143,882,021...143,890,097

G

tumor protein D52

increases expression

Methylcholanthrene results in increased expression of TPD52 mRNA

NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622

G

tyrosylprotein sulfotransferase 1

increases expression

Methylcholanthrene results in increased expression of TPST1 mRNA

NCBI chr12:26,544,536...26,605,706
Ensembl chr12:26,544,536...26,605,704

G

TPX2, microtubule nucleation factor

increases expression

Methylcholanthrene results in increased expression of TPX2 mRNA

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

TNF receptor-associated factor 1

increases expression

Methylcholanthrene results in increased expression of TRAF1 mRNA

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

trafficking protein particle complex subunit 9

decreases expression

Methylcholanthrene results in decreased expression of TRAPPC9 mRNA

NCBI chr 7:104,521,593...104,998,352
Ensembl chr 7:104,521,593...104,998,352

G

transcriptional regulating factor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRERF1 promoter]

NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029

G

tribbles pseudokinase 2

increases expression

Methylcholanthrene results in increased expression of TRIB2 mRNA

NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370

G

tripartite motif-containing 39

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM39 promoter]

NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117

G

tripartite motif-containing 55

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM55 promoter]

NCBI chr 2:102,100,229...102,142,173
Ensembl chr 2:102,088,443...102,142,168

G

tripartite motif containing 63

decreases expression

Methylcholanthrene results in decreased expression of TRIM63 mRNA

NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322

G

tripartite motif containing 72

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRIM72 promoter]

NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606

G

thyroid hormone receptor interactor 13

increases expression

Methylcholanthrene results in increased expression of TRIP13 mRNA

NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074

G

trophinin associated protein

increases expression

Methylcholanthrene results in increased expression of TROAP mRNA

NCBI chr 7:130,233,534...130,242,369
Ensembl chr 7:130,234,544...130,242,365

G

transient receptor potential cation channel, subfamily V, member 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter]

NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517

G

thymic stromal lymphopoietin

increases expression

Methylcholanthrene results in increased expression of TSLP mRNA

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

tetraspanin 8

increases expression

Methylcholanthrene results in increased expression of TSPAN8 mRNA

NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356

G

tetratricopeptide repeat domain 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to TTC3 promoter]

NCBI chr11:33,689,119...33,788,976
Ensembl chr11:33,688,952...33,788,975

G

Ttk protein kinase

increases expression

Methylcholanthrene results in increased expression of TTK mRNA

NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651

G

tubulin, beta 4B class IVb

increases expression

Methylcholanthrene results in increased expression of TUBB4B mRNA

NCBI chr 3:8,037,838...8,040,294
Ensembl chr 3:8,037,799...8,040,296

G

thymidylate synthetase

increases expression

Methylcholanthrene results in increased expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

ubiquitin-conjugating enzyme E2C

increases expression

Methylcholanthrene results in increased expression of UBE2C mRNA

NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339

G

ubiquitin-conjugating enzyme E2E 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to UBE2E1 promoter]

NCBI chr15:7,439,751...7,493,410
Ensembl chr15:7,439,759...7,493,400

G

ubiquitin-conjugating enzyme E2T

increases expression

Methylcholanthrene results in increased expression of UBE2T mRNA

NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835

G

ubiquitin domain containing 1

increases expression

Methylcholanthrene results in increased expression of UBTD1 mRNA

NCBI chr 1:240,794,570...240,845,795
Ensembl chr 1:240,794,570...240,845,788

G

uridine-cytidine kinase 2

decreases expression

Methylcholanthrene results in decreased expression of UCK2 mRNA

NCBI chr13:79,380,807...79,438,121
Ensembl chr13:79,383,846...79,438,352

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

Methylcholanthrene results in increased expression of UGT1A1 mRNA
Methylcholanthrene results in increased expression of UGT1A1 mRNA; Methylcholanthrene results in increased expression of UGT1A1 protein
[Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 3,6-dihydroxychrysene; [Methylcholanthrene results in increased expression of UGT1A1 protein] which results in increased glucuronidation of 6-hydroxychrysene
Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of UGT1A1 mRNA]

PMID:1435739 PMID:18203689 PMID:19118567 PMID:33811995

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

Methylcholanthrene results in increased expression of UGT1A2 mRNA; Methylcholanthrene results in increased expression of UGT1A3 mRNA

PMID:19118567 PMID:28601433

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glycosyltransferase 1 family, polypeptide A3

increases expression

Methylcholanthrene results in increased expression of UGT1A5 mRNA

PMID:19118567 PMID:28601433

NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A5

increases expression

Methylcholanthrene results in increased expression of UGT1A4 mRNA

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions
increases expression
increases activity

[Methylcholanthrene results in increased activity of UGT1A6 protein] which affects the metabolism of Benzene; Methylcholanthrene promotes the reaction [UGT1A6 protein results in increased glucuronidation of 1-naphthol]; UGT1A6 protein affects the reaction [Methylcholanthrene results in increased abundance of Ascorbic Acid]
Methylcholanthrene results in increased expression of UGT1A6 mRNA
[Methylcholanthrene co-treated with Oxygen deficiency] results in decreased expression of UGT1A6 mRNA; Oxygen deficiency inhibits the reaction [Methylcholanthrene results in increased expression of UGT1A6 mRNA]

PMID:1981726 PMID:8263600 PMID:11328961 PMID:19023562 PMID:19118567 More...

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases expression

Methylcholanthrene results in increased expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B7

increases expression

Methylcholanthrene results in increased expression of UGT2B7 mRNA

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

G

uromodulin-like 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to UMODL1 promoter]

NCBI chr20:9,027,751...9,087,133
Ensembl chr20:9,025,724...9,087,146

G

uridine phosphorylase 1

increases expression

Methylcholanthrene results in increased expression of UPP1 mRNA

NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462

G

ubiquitin specific peptidase 17-like A

affects expression

Methylcholanthrene affects the expression of USP17LA mRNA

NCBI chr 1:159,165,961...159,169,738

G

ubiquitin specific peptidase 18

decreases expression
increases expression

Methylcholanthrene results in decreased expression of USP18 mRNA
Methylcholanthrene results in increased expression of USP18 mRNA

PMID:20713471 PMID:29554273

NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144

G

ubiquitin specific peptidase 9, X-linked

increases expression

Methylcholanthrene results in increased expression of USP9X mRNA

NCBI chr X:9,588,825...9,726,993
Ensembl chr X:9,588,825...9,696,711

G

vav guanine nucleotide exchange factor 3

increases expression

Methylcholanthrene results in increased expression of VAV3 mRNA

NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321

G

vascular cell adhesion molecule 1

affects expression

Methylcholanthrene affects the expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

increases expression

Methylcholanthrene results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vezatin, adherens junctions transmembrane protein

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VEZT promoter]

NCBI chr 7:28,512,214...28,597,429
Ensembl chr 7:28,534,249...28,597,356

G

vasoactive intestinal peptide receptor 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VIPR1 promoter]

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

vitrin

multiple interactions

[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of VIT mRNA

NCBI chr 6:16,445,966...16,565,644
Ensembl chr 6:16,445,955...16,565,665

G

V-set and transmembrane domain containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VSTM1 promoter]

NCBI chr 1:65,686,989...65,704,073
Ensembl chr 1:65,687,375...65,701,188

G

von Willebrand factor C and EGF domains

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to VWCE promoter]

NCBI chr 1:207,280,714...207,327,215
Ensembl chr 1:207,282,356...207,312,986

G

von Willebrand factor

multiple interactions

[Methylcholanthrene co-treated with Nanotubes, Carbon] affects the expression of VWF mRNA

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

WW domain binding protein 1-like

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WBP1L promoter]

NCBI chr 1:245,472,292...245,528,627
Ensembl chr 1:245,472,296...245,528,627

G

WDFY family member 4

increases expression

Methylcholanthrene results in increased expression of WDFY4 mRNA

NCBI chr16:8,221,853...8,450,494
Ensembl chr16:8,221,719...8,450,491

G

WD repeat domain 26

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WDR26 promoter]

NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295

G

WEE1 G2 checkpoint kinase

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to WEE1 promoter]

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

WW domain-containing oxidoreductase

decreases expression

Methylcholanthrene results in decreased expression of WWOX mRNA

NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391

G

WW domain containing transcription regulator 1

increases expression

Methylcholanthrene results in increased expression of WWTR1 mRNA

NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968

G

xanthine dehydrogenase

multiple interactions
increases activity
increases expression

AHR protein promotes the reaction [Methylcholanthrene results in increased activity of XDH protein]
Methylcholanthrene results in increased expression of XDH mRNA

PMID:11243847 PMID:20713471 PMID:23273579 PMID:29554273

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

zinc finger and BTB domain containing 4

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZBTB4 promoter]

NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492

G

zinc finger CCCH type containing 8

decreases expression

Methylcholanthrene results in decreased expression of ZC3H8 mRNA

NCBI chr 3:116,176,779...116,193,752
Ensembl chr 3:116,176,798...116,193,787

G

zinc finger CCHC-type containing 2

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZCCHC2 promoter]

NCBI chr13:22,118,677...22,193,626
Ensembl chr13:22,119,568...22,166,373

G

zinc finger CCHC-type containing 9

decreases expression

Methylcholanthrene results in decreased expression of ZCCHC9 mRNA

NCBI chr 2:23,038,156...23,048,249
Ensembl chr 2:23,038,317...23,048,217

G

zinc finger DHHC-type palmitoyltransferase 2

increases expression

Methylcholanthrene results in increased expression of ZDHHC2 mRNA

NCBI chr16:51,808,465...51,878,060
Ensembl chr16:51,808,468...51,878,060

G

zinc finger protein 281

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZNF281 promoter]

NCBI chr13:48,096,103...48,104,265
Ensembl chr13:48,037,286...48,104,888

G

zinc finger protein 37

decreases expression

Methylcholanthrene results in decreased expression of ZFP37 mRNA

NCBI chr 5:75,598,732...75,638,896
Ensembl chr 5:75,598,732...75,638,942

G

zinc finger protein 467

increases expression

Methylcholanthrene results in increased expression of ZFP467 mRNA

NCBI chr 4:77,385,752...77,394,709
Ensembl chr 4:77,385,758...77,392,229

G

zinc finger protein 521

decreases expression

Methylcholanthrene results in decreased expression of ZFP521 mRNA

NCBI chr18:4,775,952...5,068,592
Ensembl chr18:4,787,295...5,068,458

G

zinc finger protein 710

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZNF710 promoter]

NCBI chr 1:133,966,256...134,036,593
Ensembl chr 1:134,024,267...134,036,601

G

zinc finger, matrin type 3

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZMAT3 promoter]

NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863

G

zinc finger, MIZ-type containing 1

multiple interactions

Methylcholanthrene promotes the reaction [AHR protein binds to ZMIZ1 promoter]

NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597

G

zwilch kinetochore protein

increases expression

Methylcholanthrene results in increased expression of ZWILCH mRNA

NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
role	19784
biological role	19782
aetiopathogenetic role	19166
carcinogenic agent	18496
3-methylcholanthrene	949
11,12-epoxy-3-methylcholanthrene	0
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
main group molecular entity	19756
s-block molecular entity	19595
hydrogen molecular entity	19582
hydrides	19095
organic hydride	18669
organic fundamental parent	18669
hydrocarbon	18415
cyclic hydrocarbon	17215
arene	17195
polycyclic arene	17023
ortho- and peri-fused polycyclic arene	16279
3-methylcholanthrene	949
11,12-epoxy-3-methylcholanthrene	0

paths to the root