Gene: Pknox2 (PBX/knotted 1 homeobox 2) Rattus norvegicus

Analyze

Symbol:

Pknox2

Name:

PBX/knotted 1 homeobox 2

RGD ID:

1590611

Description:

Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and actin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm; cytoskeleton; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PKNOX2 (PBX/knotted 1 homeobox 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeobox protein Meis2-like; homeobox protein PKNOX2; LOC680549; similar to Pbx/knotted 1 homeobox 2; uncharacterized protein LOC680549

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PKNOX2 (PBX/knotted 1 homeobox 2)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pknox2 (Pbx/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pknox2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PKNOX2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PKNOX2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pknox2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PKNOX2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PKNOX2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pknox2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pknox2 (PBX/knotted 1 homeobox 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UBE2M (ubiquitin conjugating enzyme E2 M)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PKNOX2 (PBX/knotted 1 homeobox 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pknox2 (Pbx/knotted 1 homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pknox2 (pbx/knotted 1 homeobox 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TOS8	Alliance	DIOPT (OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pknox2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	44,789,464 - 45,051,933 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	44,789,467 - 44,979,754 (-)	Ensembl				GRCr8
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	36,600,636 - 36,790,940 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	40,610,916 - 40,800,359 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	38,893,988 - 39,083,446 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	36,756,879 - 36,946,335 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	44,848,927 - 45,038,367 (-)	NCBI
Lyon_Normotensive	8	47,019,274 - 47,208,723 (-)	NCBI
Lyon_Hypertensive	8	45,561,850 - 45,751,297 (-)	NCBI
F344_StmMcwi	8	36,894,916 - 37,084,363 (-)	NCBI
Rnor_6.0	8	39,361,698 - 39,551,700 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	39,361,218 - 39,551,700 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	8	39,364,740 - 39,554,742 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	38,136,835 - 38,325,406 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	37,651,569 - 37,840,535 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

alcohol dependence (ISO)

Familial Prostate Cancer (ISO)

melanoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

thymoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-di-tert-butyl-4-methylphenol (ISO)

3-methylcholanthrene (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

carmustine (EXP)

CGP 52608 (ISO)

chloroprene (ISO)

cocaine (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dichloroacetic acid (ISO)

diclofenac (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

fulvestrant (ISO)

mercury dibromide (ISO)

methapyrilene (ISO)

methotrexate (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tioguanine (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of transcription by RNA polymerase II (IBA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA,ISO)

Cellular Component

actin cytoskeleton (IEA,ISO)

cytoplasm (IEA,ISO)

microtubule cytoskeleton (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

actin filament binding (IEA,ISO)

actin monomer binding (IEA,ISO)

DNA binding (IEA,ISO)

DNA-binding transcription factor activity (IBA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA,ISO)

sequence-specific DNA binding (IEA,ISO)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count.	Chen G, etal., Addict Biol. 2017 Nov;22(6):1475-1485. doi: 10.1111/adb.12402. Epub 2016 May 5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12412021	PMID:15339927	PMID:16847320	PMID:17049510

Genomics

Comparative Map Data

Pknox2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	44,789,464 - 45,051,933 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	44,789,467 - 44,979,754 (-)	Ensembl				GRCr8
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	36,600,636 - 36,790,940 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	40,610,916 - 40,800,359 (-)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	38,893,988 - 39,083,446 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	36,756,879 - 36,946,335 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	44,848,927 - 45,038,367 (-)	NCBI
Lyon_Normotensive	8	47,019,274 - 47,208,723 (-)	NCBI
Lyon_Hypertensive	8	45,561,850 - 45,751,297 (-)	NCBI
F344_StmMcwi	8	36,894,916 - 37,084,363 (-)	NCBI
Rnor_6.0	8	39,361,698 - 39,551,700 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	39,361,218 - 39,551,700 (-)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	8	39,364,740 - 39,554,742 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	38,136,835 - 38,325,406 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	37,651,569 - 37,840,535 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

PKNOX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	125,164,751 - 125,433,389 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	125,164,537 - 125,434,287 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	11	125,034,647 - 125,303,285 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	124,539,769 - 124,808,495 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	124,726,419 - 124,808,264	NCBI
Celera	11	122,194,601 - 122,463,611 (+)	NCBI		Celera
Cytogenetic Map	11	q24.2	NCBI
HuRef	11	120,976,463 - 121,244,840 (+)	NCBI		HuRef
CHM1_1	11	124,920,619 - 125,189,521 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	125,193,419 - 125,462,086 (+)	NCBI		T2T-CHM13v2.0

Pknox2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	36,802,278 - 37,058,637 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	36,801,548 - 37,059,214 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	36,890,979 - 37,147,342 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	36,890,982 - 37,147,407 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	9	36,698,567 - 36,954,899 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	36,640,653 - 36,896,985 (-)	NCBI		MGSCv36	mm8
Celera	9	34,095,372 - 34,359,379 (-)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	20.7	NCBI

Pknox2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	26,372,846 - 26,468,926 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955412	26,214,671 - 26,468,737 (+)	NCBI	ChiLan1.0	ChiLan1.0

PKNOX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	125,807,624 - 126,128,241 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	126,912,553 - 127,240,365 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	119,991,916 - 120,259,800 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	123,906,012 - 124,173,865 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	124,072,715 - 124,173,865 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

PKNOX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	9,054,138 - 9,363,750 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	9,056,134 - 9,178,159 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	9,098,622 - 9,408,616 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	8,994,772 - 9,302,925 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	8,994,772 - 9,251,650 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	9,065,978 - 9,375,742 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	9,036,663 - 9,346,271 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	9,072,792 - 9,382,834 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pknox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	4	108,524,575 - 108,791,576 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404947	107,342,759 - 107,612,737 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936743	1,661,791 - 1,858,278 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936743	1,661,783 - 1,860,299 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PKNOX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	52,349,714 - 52,610,680 (+)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	9	52,303,022 - 52,608,505 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	58,127,081 - 58,195,478 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PKNOX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	1	121,033,278 - 121,302,609 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666043	9,519,677 - 9,788,985 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	1	116,332,851 - 116,604,758 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	116,523,593 - 116,605,161 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Pknox2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624927	1,197,610 - 1,459,777 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624927	1,275,956 - 1,460,170 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	5	45,266,893 - 45,484,992 (-)	Ensembl

Pknox2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	33,067,549 - 33,141,946 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Variants

Variants in Pknox2
1914 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	99
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000048875
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357398	Slep3	Serum leptin concentration QTL 3	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	12964165	57964165	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	12964165	57964165	Rat
12880023	Bw184	Body weight QTL 184		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	10382540	55382540	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
12880028	Cm103	Cardiac mass QTL 103		0.02	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	10382540	55382540	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
61337	Bp22	Blood pressure QTL 22	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	51589833	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	12964165	57964165	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
12880025	Cm102	Cardiac mass QTL 102		0.044	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	8	10382540	55382540	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
12880044	Am9	Aortic mass QTL 9		0.007	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	10382540	55382540	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	34125902	55607752	Rat
2302367	Slep5	Serum leptin concentration QTL 5	3.43		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	8	17994105	50763951	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat
70206	Alc20	Alcohol consumption QTL 20	2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	8	39106258	49610361	Rat

Markers in Region

D8Rat219

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	44,866,762 - 44,866,892 (+)	Marker Load Pipeline
mRatBN7.2	8	36,677,937 - 36,678,067 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	39,438,423 - 39,438,552	NCBI	Rnor6.0
Rnor_5.0	8	39,441,465 - 39,441,594	UniSTS	Rnor5.0
RGSC_v3.4	8	38,212,433 - 38,212,563	RGD	RGSC3.4
RGSC_v3.4	8	38,212,434 - 38,212,563	UniSTS	RGSC3.4
Celera	8	37,764,313 - 37,764,442	UniSTS
RGSC_v3.1	8	38,221,199 - 38,221,329	RGD
SHRSP x BN Map	8	27.78	UniSTS
SHRSP x BN Map	8	27.78	RGD
Cytogenetic Map	8	q21	UniSTS

RH141386

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	36,600,644 - 36,600,843 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	39,361,227 - 39,361,425	NCBI	Rnor6.0
Rnor_5.0	8	39,364,269 - 39,364,467	UniSTS	Rnor5.0
RGSC_v3.4	8	38,134,940 - 38,135,138	UniSTS	RGSC3.4
RH 3.4 Map	8	311.4	UniSTS
Cytogenetic Map	8	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
274	150	729	1591	4051	952	1668	127	815	470	797	155	5225	2565	446	3963	38	1317	735	908	159	157

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271278	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001271279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082136	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082137	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082138	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039082148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266120	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000048875 ⟹ ENSRNOP00000048926

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	36,600,636 - 36,700,364 (-)	Ensembl
Rnor_6.0 Ensembl	8	39,361,698 - 39,460,844 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076025 ⟹ ENSRNOP00000068263

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	39,404,748 - 39,551,700 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076158 ⟹ ENSRNOP00000068159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	44,789,467 - 44,850,488 (-)	Ensembl
mRatBN7.2 Ensembl	8	36,600,636 - 36,661,664 (-)	Ensembl
Rnor_6.0 Ensembl	8	39,361,458 - 39,437,270 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076232 ⟹ ENSRNOP00000068088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	36,609,889 - 36,700,364 (-)	Ensembl
Rnor_6.0 Ensembl	8	39,361,218 - 39,460,844 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076540

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	39,370,432 - 39,379,840 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091894 ⟹ ENSRNOP00000070748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	44,789,947 - 44,979,754 (-)	Ensembl
mRatBN7.2 Ensembl	8	36,601,116 - 36,790,940 (-)	Ensembl
Rnor_6.0 Ensembl	8	39,361,698 - 39,551,700 (-)	Ensembl

RefSeq Acc Id:

NM_001271278 ⟹ NP_001258207

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,947 - 44,979,754 (-)	NCBI
mRatBN7.2	8	36,601,116 - 36,790,940 (-)	NCBI
Dahl_SR_JrHsd	8	44,848,927 - 45,038,367 (-)	NCBI
Lyon_Normotensive	8	47,019,274 - 47,208,723 (-)	NCBI
Lyon_Hypertensive	8	45,561,850 - 45,751,297 (-)	NCBI
F344_StmMcwi	8	36,894,916 - 37,084,363 (-)	NCBI
Rnor_6.0	8	39,361,698 - 39,551,700 (-)	NCBI
Rnor_5.0	8	39,364,740 - 39,554,742 (-)	NCBI
Celera	8	37,651,569 - 37,840,535 (+)	NCBI

Sequence:

show sequence

CAGGTGAAGCCTGGAACAAGACTTTAAAGGGTTTCTGGTCTTCCATGCTGCTCACTAGAAAAGA
GGCCCTGAACTGTACTCTCCCTGTAGCTGACTAGAAGTGTTTCTGGCCCAGCTGGAAGTGAGAA
GAGGGGGCTGAACCCCCTGAAGACCATCCTAGAGGCGGTGGCATCATCCAACAATCCTCCATGT
GAATCAATCCCATGATGCAACATGCCTCCCCAGCCCCAGCTCTGACAATGATGGCCACGCAGAA
TGTCCCTCCCCCACCCTACCAGGACAGCCCCCAGATGACAGCAACTGCCCAGCCACCTTCCAAG
GCCCAGGCTGTTCACATCGCAGCACCCTCAGCCACCGCCAGCACACCTGTGCCCAGTGCCCCCA
TTGATCCCCAGGCCCAGCTTGAAGCAGACAAGCGAGCTGTGTACAGGCACCCTCTTTTCCCGCT
CCTGACGCTGCTGTTTGAGAAATGTGAACAGGCCACCCAGGGCTCAGAGTGCATCACCTCCGCC
AGCTTTGATGTGGACATCGAGAACTTTGTCCACCAGCAGGAGCAGGAACACAAACCCTTCTTCA
GCGATGACCCAGAACTGGACAATCTGATGGTGAAGGCGATCCAGGTCCTGAGGATCCACCTGCT
AGAGTTGGAAAAAGTCAATGAACTCTGCAAGGACTTTTGCAACCGTTATATCACCTGCCTCAAA
ACCAAGATGCACAGCGATAACCTGCTCAGGAATGACCTCGGGGGGCCCTACTCCCCCAACCAGC
CCTCCATAAACCTTCACTCACAGGACCTCCTGCAGAATTCCCCCAATTCCATGTCTGGAGTCTC
CAATAACCCCCAGGGAATTGTGGTCCCAGCCTCAGCACTCCAGCAGGGCAACATCGCCATGACA
ACCGTCAACTCACAAGTCGTGTCAGGTGGAGCCTTATATCAACCGGTTACCATGGTAACCTCCC
AGGGTCAGGTGGTCACCCAAGCAATCCCCCAGGGAGCCATCCAGATCCAGAACACACAGGTTAA
CCTTGACCTCACCTCCCTCCTGGACAATGAGGATAAGAAGTCCAAGAACAAACGAGGAGTCTTG
CCCAAGCATGCCACCAATATAATGCGTTCTTGGCTCTTCCAGCATCTCATGCACCCCTACCCAA
CCGAAGATGAGAAGAGGCAGATTGCAGCCCAGACAAACCTCACCCTCCTGCAAGTAAACAACTG
GTTCATCAATGCCAGGAGGCGCATCCTGCAGCCCATGCTTGATGCCAGCAACCCAGATCCTGCT
CCCAAAGCCAAGAAAATCAAGTCTCAGCACCGGCCCACCCAAAGATTCTGGCCCAATTCCATTG
CTGCTGGAGTCCTGCAGCAGCAGGGTGGCACCCCAGGGACGAACCCTGATGGTTCCATCAACTT
GGACAACCTGCAGTCCCTGTCCTCAGACAATGCCACCATGGCCATGCAGCAGGCAATGATGGCT
GCCCATGATGACTCCTTGGATGGGACAGAAGAAGAGGATGAAGATGATATGGAGGAGGAGGAAG
AGGAGGAGGAGGAGCTGGAGGAGGAGGAGGCTGATGAGCTACAGACAACAAATGTCAGCGACCT
GGGCTTGGAACACAGTGACTCCCTGGAGTAGTCAGGCAGCCCAGATGGCATTGGTCACCGGGCA
GGAAAGGAGTGTCATCAGGAGGGTTCAGGGTGGGGGGAAGGGAATATGGGCAGGCAGCATTAAG
AAAGTTGGGCCCTAGCTTCCCCGGAATCATAGCTTGAAGAAATGCAGAGACACCCTGTTCCTTT
CCAACCACCAAGCTTCAGTGAAAACCTAGTCCCAGACCCTCAGACTGCAGTGCACTCCATTGCC
GGGGGCCAGTCAAACAGCCTGTGAAGAAAGACAGCTTGAGATCTGGACTCACCACAAACCGGAG
GACAGATGACACCCGTGGCTCCACACGGAAAAGGACTTGAGTTGTTTACAAGCCCTGCCCTGTG
AGGTGGACAGGCGCTATTTGCAGAGTGGACCTTTGCTAAGGGGCAGACTTGGGAGGGAAGGATG
AGAGAGAAGGGGTCTAACATTTTCCCCCAGGAGAATCTGAGCTCCCTTGAAAGACACTCATGGA
CAGGAGGGAGCCTAAATGCATAACCAGTGGCCAGAGGAGTAGGAGGGCCTGAGACAACACCACA
CACTGCCTATCAGAGTGAGACATGGATGGCACAGGGCTCCAACTTGCCCTGCCGGGGCCCTGTC
TCTTAGCACAGTGGCCATGGACTAAGGAGAGGGGGAAGGAAACCAAAGAGACTCCTTCTTCCTC
TCTCTCGGAAATATATTGTCGGTGGGTCCACCCTGAAGAGGTTAAAAGCAACTCTCCATCTGGG
TCAGCTCTAGGACCAAGCAGGCGGCAGAACCTGGATCGGGAGCCATATTAAGATGACTCTGGGG
ATCGCAGCAGTCCCTAAGTGATCACATCACAGCTCCTGTAACAGTAGGACATGATATCTTATGA
GATGCTCCTACCCTCAGTGGAGTTCTTCAGAAACCCAGCCTCCTCCATAAGCCTTGAGAGAGGT
GGGGCCAGGGATTCTTTTCACTCCGCAGGTCTCCGTGCAACCCTCTGCTCCCAAGCTGGCACTA
CCAGCTTCTGGCCGCCTCCTTCATTCTATTCTCCAGAGAAGGCAGAAGAAACAGTGGAAAGCAT
TATCCCAATGGGAAGCCAGGGTCTGAAGAAGGTGCTACTGCTCTTCCCTTCGGTACCCAACATG
GCAGAGGATATAGCGCACAGCTAATCTGTACACGCCATTGTGCTTGGCGCTGGAGGAACTGGGG
CAGCCTGGGAGGAAGCTTCCTACCATCTGCCCTCATACACACCCTCCAAGCCCAGCATGGAGGA
TCCAGGATTGGCATCTGCTGCTCCTGTCCCCTCCCACCCTATGGCTGTGAAAGACAGGACTGAC
CACACGTGTGTTTTCCATTGGGTTTAATGTGACGGATGTGCAGTTTCATTTGTAAATGTGCATT
GGCCATCTCCTTCAGTGCTGGGATGTGAACGGCTATCTGGCTCAACCAGAGGGGACCCTTGGGA
CCTTCTGAGCCTTCTCCTCCTCTA

hide sequence

RefSeq Acc Id:

NM_001271279 ⟹ NP_001258208

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,947 - 44,889,186 (-)	NCBI
mRatBN7.2	8	36,601,116 - 36,700,364 (-)	NCBI
Dahl_SR_JrHsd	8	44,848,927 - 44,947,810 (-)	NCBI
Lyon_Normotensive	8	47,019,274 - 47,118,162 (-)	NCBI
Lyon_Hypertensive	8	45,561,850 - 45,660,738 (-)	NCBI
F344_StmMcwi	8	36,894,916 - 36,993,798 (-)	NCBI
Rnor_6.0	8	39,361,698 - 39,460,844 (-)	NCBI
Rnor_5.0	8	39,364,740 - 39,554,742 (-)	NCBI
Celera	8	37,742,046 - 37,840,535 (+)	NCBI

Sequence:

show sequence

ACTTCCTTAGCTTGCACATCTCCACACAGGGAAGGAAGGAGGCCAGAGACTACAGATGCCTGCT
GGGGAATTGCAGCGTGGACATTGTACTCTCCCTGTAGCTGACTAGAAGTGTTTCTGGCCCAGCT
GGAAGTGAGAAGAGGGGGCTGAACCCCCTGAAGACCATCCTAGAGGCGGTGGCATCATCCAACA
ATCCTCCATGTGAATCAATCCCATGATGCAACATGCCTCCCCAGCCCCAGCTCTGACAATGATG
GCCACGCAGAATGTCCCTCCCCCACCCTACCAGGACAGCCCCCAGAGCACGGACACAGATCCTA
TTATGAACTCCCAAGCTGTGATACGCCTGTTTCCTTCTAAGCATACGCATTCATTTACTCGTTG
ACTCTTTTTCTCATCGAACATCAGTCGTTTTTATTTAGATGACAGCAACTGCCCAGCCACCTTC
CAAGGCCCAGGCTGTTCACATCGCAGCACCCTCAGCCACCGCCAGCACACCTGTGCCCAGTGCC
CCCATTGATCCCCAGGCCCAGCTTGAAGCAGACAAGCGAGCTGTGTACAGGCACCCTCTTTTCC
CGCTCCTGACGCTGCTGTTTGAGAAATGTGAACAGGCCACCCAGGGCTCAGAGTGCATCACCTC
CGCCAGCTTTGATGTGGACATCGAGAACTTTGTCCACCAGCAGGAGCAGGAACACAAACCCTTC
TTCAGCGATGACCCAGAACTGGACAATCTGATGGTGAAGGCGATCCAGGTCCTGAGGATCCACC
TGCTAGAGTTGGAAAAAGTCAATGAACTCTGCAAGGACTTTTGCAACCGTTATATCACCTGCCT
CAAAACCAAGATGCACAGCGATAACCTGCTCAGGAATGACCTCGGGGGGCCCTACTCCCCCAAC
CAGCCCTCCATAAACCTTCACTCACAGGACCTCCTGCAGAATTCCCCCAATTCCATGTCTGGAG
TCTCCAATAACCCCCAGGGAATTGTGGTCCCAGCCTCAGCACTCCAGCAGGGCAACATCGCCAT
GACAACCGTCAACTCACAAGTCGTGTCAGGTGGAGCCTTATATCAACCGGTTACCATGGTAACC
TCCCAGGGTCAGGTGGTCACCCAAGCAATCCCCCAGGGAGCCATCCAGATCCAGAACACACAGG
TTAACCTTGACCTCACCTCCCTCCTGGACAATGAGGATAAGAAGTCCAAGAACAAACGAGGAGT
CTTGCCCAAGCATGCCACCAATATAATGCGTTCTTGGCTCTTCCAGCATCTCATGCACCCCTAC
CCAACCGAAGATGAGAAGAGGCAGATTGCAGCCCAGACAAACCTCACCCTCCTGCAAGTAAACA
ACTGGTTCATCAATGCCAGGAGGCGCATCCTGCAGCCCATGCTTGATGCCAGCAACCCAGATCC
TGCTCCCAAAGCCAAGAAAATCAAGTCTCAGCACCGGCCCACCCAAAGATTCTGGCCCAATTCC
ATTGCTGCTGGAGTCCTGCAGCAGCAGGGTGGCACCCCAGGGACGAACCCTGATGGTTCCATCA
ACTTGGACAACCTGCAGTCCCTGTCCTCAGACAATGCCACCATGGCCATGCAGCAGGCAATGAT
GGCTGCCCATGATGACTCCTTGGATGGGACAGAAGAAGAGGATGAAGATGATATGGAGGAGGAG
GAAGAGGAGGAGGAGGAGCTGGAGGAGGAGGAGGCTGATGAGCTACAGACAACAAATGTCAGCG
ACCTGGGCTTGGAACACAGTGACTCCCTGGAGTAGTCAGGCAGCCCAGATGGCATTGGTCACCG
GGCAGGAAAGGAGTGTCATCAGGAGGGTTCAGGGTGGGGGGAAGGGAATATGGGCAGGCAGCAT
TAAGAAAGTTGGGCCCTAGCTTCCCCGGAATCATAGCTTGAAGAAATGCAGAGACACCCTGTTC
CTTTCCAACCACCAAGCTTCAGTGAAAACCTAGTCCCAGACCCTCAGACTGCAGTGCACTCCAT
TGCCGGGGGCCAGTCAAACAGCCTGTGAAGAAAGACAGCTTGAGATCTGGACTCACCACAAACC
GGAGGACAGATGACACCCGTGGCTCCACACGGAAAAGGACTTGAGTTGTTTACAAGCCCTGCCC
TGTGAGGTGGACAGGCGCTATTTGCAGAGTGGACCTTTGCTAAGGGGCAGACTTGGGAGGGAAG
GATGAGAGAGAAGGGGTCTAACATTTTCCCCCAGGAGAATCTGAGCTCCCTTGAAAGACACTCA
TGGACAGGAGGGAGCCTAAATGCATAACCAGTGGCCAGAGGAGTAGGAGGGCCTGAGACAACAC
CACACACTGCCTATCAGAGTGAGACATGGATGGCACAGGGCTCCAACTTGCCCTGCCGGGGCCC
TGTCTCTTAGCACAGTGGCCATGGACTAAGGAGAGGGGGAAGGAAACCAAAGAGACTCCTTCTT
CCTCTCTCTCGGAAATATATTGTCGGTGGGTCCACCCTGAAGAGGTTAAAAGCAACTCTCCATC
TGGGTCAGCTCTAGGACCAAGCAGGCGGCAGAACCTGGATCGGGAGCCATATTAAGATGACTCT
GGGGATCGCAGCAGTCCCTAAGTGATCACATCACAGCTCCTGTAACAGTAGGACATGATATCTT
ATGAGATGCTCCTACCCTCAGTGGAGTTCTTCAGAAACCCAGCCTCCTCCATAAGCCTTGAGAG
AGGTGGGGCCAGGGATTCTTTTCACTCCGCAGGTCTCCGTGCAACCCTCTGCTCCCAAGCTGGC
ACTACCAGCTTCTGGCCGCCTCCTTCATTCTATTCTCCAGAGAAGGCAGAAGAAACAGTGGAAA
GCATTATCCCAATGGGAAGCCAGGGTCTGAAGAAGGTGCTACTGCTCTTCCCTTCGGTACCCAA
CATGGCAGAGGATATAGCGCACAGCTAATCTGTACACGCCATTGTGCTTGGCGCTGGAGGAACT
GGGGCAGCCTGGGAGGAAGCTTCCTACCATCTGCCCTCATACACACCCTCCAAGCCCAGCATGG
AGGATCCAGGATTGGCATCTGCTGCTCCTGTCCCCTCCCACCCTATGGCTGTGAAAGACAGGAC
TGACCACACGTGTGTTTTCCATTGGGTTTAATGTGACGGATGTGCAGTTTCATTTGTAAATGTG
CATTGGCCATCTCCTTCAGTGCTGGGATGTGAACGGCTATCTGGCTCAACCAGAGGGGACCCTT
GGGACCTTCTGAGCCTTCTCCTCCTCTA

hide sequence

RefSeq Acc Id:

XM_039082131 ⟹ XP_038938059

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,925 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI

RefSeq Acc Id:

XM_039082132 ⟹ XP_038938060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,050,799 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,862,010 (-)	NCBI

RefSeq Acc Id:

XM_039082133 ⟹ XP_038938061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,920 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI

RefSeq Acc Id:

XM_039082134 ⟹ XP_038938062

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,915,743 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,726,911 (-)	NCBI

RefSeq Acc Id:

XM_039082135 ⟹ XP_038938063

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,921,673 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,732,781 (-)	NCBI

RefSeq Acc Id:

XM_039082136 ⟹ XP_038938064

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,917,664 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,730,176 (-)	NCBI

RefSeq Acc Id:

XM_039082137 ⟹ XP_038938065

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,917,664 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,730,176 (-)	NCBI

RefSeq Acc Id:

XM_039082138 ⟹ XP_038938066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,917,591 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,728,725 (-)	NCBI

RefSeq Acc Id:

XM_039082139 ⟹ XP_038938067

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,917,652 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,730,176 (-)	NCBI

RefSeq Acc Id:

XM_039082140 ⟹ XP_038938068

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,889,081 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,700,766 (-)	NCBI

RefSeq Acc Id:

XM_039082142 ⟹ XP_038938070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,921 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI

RefSeq Acc Id:

XM_039082143 ⟹ XP_038938071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,921 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI

RefSeq Acc Id:

XM_039082145 ⟹ XP_038938073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,851,985 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,663,139 (-)	NCBI

RefSeq Acc Id:

XM_039082146 ⟹ XP_038938074

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,933 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,863,131 (-)	NCBI

RefSeq Acc Id:

XM_039082148 ⟹ XP_038938076

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,822,458 (-)	NCBI
mRatBN7.2	8	36,600,633 - 36,633,631 (-)	NCBI

RefSeq Acc Id:

XM_063266115 ⟹ XP_063122185

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,042,777 (-)	NCBI

RefSeq Acc Id:

XM_063266116 ⟹ XP_063122186

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,915,744 (-)	NCBI

RefSeq Acc Id:

XM_063266117 ⟹ XP_063122187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 45,051,920 (-)	NCBI

RefSeq Acc Id:

XM_063266119 ⟹ XP_063122189

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,979,751 (-)	NCBI

RefSeq Acc Id:

XM_063266120 ⟹ XP_063122190

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,917,652 (-)	NCBI

RefSeq Acc Id:

XM_063266121 ⟹ XP_063122191

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	44,789,464 - 44,850,478 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001258207	(Get FASTA)	NCBI Sequence Viewer
	NP_001258208	(Get FASTA)	NCBI Sequence Viewer
	XP_038938059	(Get FASTA)	NCBI Sequence Viewer
	XP_038938060	(Get FASTA)	NCBI Sequence Viewer
	XP_038938061	(Get FASTA)	NCBI Sequence Viewer
	XP_038938062	(Get FASTA)	NCBI Sequence Viewer
	XP_038938063	(Get FASTA)	NCBI Sequence Viewer
	XP_038938064	(Get FASTA)	NCBI Sequence Viewer
	XP_038938065	(Get FASTA)	NCBI Sequence Viewer
	XP_038938066	(Get FASTA)	NCBI Sequence Viewer
	XP_038938067	(Get FASTA)	NCBI Sequence Viewer
	XP_038938068	(Get FASTA)	NCBI Sequence Viewer
	XP_038938070	(Get FASTA)	NCBI Sequence Viewer
	XP_038938071	(Get FASTA)	NCBI Sequence Viewer
	XP_038938073	(Get FASTA)	NCBI Sequence Viewer
	XP_038938074	(Get FASTA)	NCBI Sequence Viewer
	XP_038938076	(Get FASTA)	NCBI Sequence Viewer
	XP_063122185	(Get FASTA)	NCBI Sequence Viewer
	XP_063122186	(Get FASTA)	NCBI Sequence Viewer
	XP_063122187	(Get FASTA)	NCBI Sequence Viewer
	XP_063122189	(Get FASTA)	NCBI Sequence Viewer
	XP_063122190	(Get FASTA)	NCBI Sequence Viewer
	XP_063122191	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84053	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068159
	ENSRNOP00000068159.2
	ENSRNOP00000070748
	ENSRNOP00000070748.2

RefSeq Acc Id:	NP_001258207 ⟸ NM_001271278
- Peptide Label:	isoform 1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHIAAPSATASTPVPSAPIDPQ AQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDP ELDNLMVKAIQVLRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSIN LHSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQV VTQAIPQGAIQIQNTQVNLDLTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDE KRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGV LQQQGGTPGTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEE ELEEEEADELQTTNVSDLGLEHSDSLE hide sequence

RefSeq Acc Id:	NP_001258208 ⟸ NM_001271279
- Peptide Label:	isoform 2
- UniProtKB:	A0A096MJK1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTATAQPPSKAQAVHIAAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQA TQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKD FCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVVPAS ALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSLLDNED KKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQP MLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTPGTNPDGSINLDNLQSLSSDNA TMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEELEEEEADELQTTNVSDLGLEHSDSLE hide sequence

Ensembl Acc Id:

ENSRNOP00000048926 ⟸ ENSRNOT00000048875

Ensembl Acc Id:

ENSRNOP00000070748 ⟸ ENSRNOT00000091894

Ensembl Acc Id:

ENSRNOP00000068088 ⟸ ENSRNOT00000076232

Ensembl Acc Id:

ENSRNOP00000068263 ⟸ ENSRNOT00000076025

Ensembl Acc Id:

ENSRNOP00000068159 ⟸ ENSRNOT00000076158

RefSeq Acc Id:	XP_038938070 ⟸ XM_039082142
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938071 ⟸ XM_039082143
- Peptide Label:	isoform X2
- UniProtKB:	A0A096MJK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938074 ⟸ XM_039082146
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038938059 ⟸ XM_039082131
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938061 ⟸ XM_039082133
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938060 ⟸ XM_039082132
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938063 ⟸ XM_039082135
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938067 ⟸ XM_039082139
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938064 ⟸ XM_039082136
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938065 ⟸ XM_039082137
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938066 ⟸ XM_039082138
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938062 ⟸ XM_039082134
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938068 ⟸ XM_039082140
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938073 ⟸ XM_039082145
- Peptide Label:	isoform X2
- UniProtKB:	A0A096MJK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038938076 ⟸ XM_039082148
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063122187 ⟸ XM_063266117
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063122185 ⟸ XM_063266115
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063122189 ⟸ XM_063266119
- Peptide Label:	isoform X2
- UniProtKB:	A0A096MJK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063122190 ⟸ XM_063266120
- Peptide Label:	isoform X2
- UniProtKB:	A0A096MJK1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063122186 ⟸ XM_063266116
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JYQ2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063122191 ⟸ XM_063266121
- Peptide Label:	isoform X4

Protein Domains

Homeobox

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1590611	AgrOrtholog
BioCyc Gene	G2FUF-31098	BioCyc
Ensembl Genes	ENSRNOG00000028856	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000076158	ENTREZGENE
	ENSRNOT00000076158.4	UniProtKB/TrEMBL
	ENSRNOT00000091894	ENTREZGENE
	ENSRNOT00000091894.3	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox_KN_domain	UniProtKB/TrEMBL
	Homeodomain	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	PKNOX/Meis_N	UniProtKB/TrEMBL
	TALE_homeobox	UniProtKB/TrEMBL
KEGG Report	rno:680549	UniProtKB/TrEMBL
NCBI Gene	680549	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN TRANSCRIPTION FACTORS	UniProtKB/TrEMBL
Pfam	Homeobox_KN	UniProtKB/TrEMBL
	Meis_PKNOX_N	UniProtKB/TrEMBL
PhenoGen	Pknox2	PhenoGen
PROSITE	HOMEOBOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000028856	RatGTEx
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A0A096MJK1	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2JYQ2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-09	Pknox2	PBX/knotted 1 homeobox 2	LOC680549	similar to Pbx/knotted 1 homeobox 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-05-24	LOC680549	similar to Pbx/knotted 1 homeobox 2	LOC100364346	homeobox protein Meis2-like	Data merged from RGD:2321212	1643240	APPROVED
2010-05-05	LOC100364346	homeobox protein Meis2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-01-09	LOC680549	similar to Pbx/knotted 1 homeobox 2	LOC682375	similar to Pbx/knotted 1 homeobox 2	Data merged from RGD:1584574	1643240	APPROVED
2006-11-20	LOC680549	similar to Pbx/knotted 1 homeobox 2			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682375	similar to Pbx/knotted 1 homeobox 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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