Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KCTD5 mRNA | CTD | PMID:24763279 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCTD5 mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Kctd5 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KCTD5 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of KCTD5 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | KCTD5 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of KCTD5 mRNA | CTD | PMID:21179406 | 3,3',5,5'-tetrabromobisphenol A | increases expression | EXP | | 6480464 | tetrabromobisphenol A results in increased expression of KCTD5 mRNA | CTD | PMID:27914987 | 3-methylcholanthrene | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Methylcholanthrene results in decreased expression of KCTD5 mRNA | CTD | PMID:20713471 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of KCTD5 mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | Kctd5 (Mus musculus) | 6480464 | bisphenol S results in decreased methylation of KCTD5 promoter | CTD | PMID:33297965 | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of KCTD5 mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of KCTD5 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KCTD5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of KCTD5 mRNA | CTD | PMID:32699268 | acrylamide | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of KCTD5 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | KCTD5 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of KCTD5 intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KCTD5 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of KCTD5 mRNA | CTD | PMID:32699268 | amitrole | increases expression | EXP | | 6480464 | Amitrole results in increased expression of KCTD5 mRNA | CTD | PMID:30047161 | aristolochic acid A | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of KCTD5 mRNA | CTD | PMID:33212167 | arsenous acid | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KCTD5 protein] | CTD | PMID:26598702 | benzo[a]pyrene | increases methylation | ISO | KCTD5 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of KCTD5 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[e]pyrene | decreases methylation | ISO | KCTD5 (Homo sapiens) | 6480464 | benzo(e)pyrene results in decreased methylation of KCTD5 intron | CTD | PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KCTD5 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of KCTD5 mRNA | CTD | PMID:29275510 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KCTD5 mRNA | CTD | PMID:30816183 and PMID:34947998 | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of KCTD5 promoter | CTD | PMID:22457795 | CGP 52608 | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KCTD5 gene] | CTD | PMID:28238834 | chromium(6+) | affects expression | ISO | Kctd5 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of KCTD5 mRNA | CTD | PMID:28472532 | clobetasol | increases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Clobetasol results in increased expression of KCTD5 mRNA | CTD | PMID:27462272 | cobalt dichloride | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of KCTD5 mRNA | CTD | PMID:19320972 and PMID:19376846 | copper(II) sulfate | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of KCTD5 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of KCTD5 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of KCTD5 mRNA | CTD | PMID:19770486 | diarsenic trioxide | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KCTD5 protein] | CTD | PMID:26598702 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of KCTD5 mRNA | CTD | PMID:21551480 | ethanol | affects expression | ISO | Kctd5 (Mus musculus) | 6480464 | Ethanol affects the expression of KCTD5 mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | folic acid | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of KCTD5 mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | KCTD5 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of KCTD5 protein | CTD | PMID:37730182 | ivermectin | decreases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of KCTD5 protein | CTD | PMID:32959892 | Licochalcone B | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of KCTD5 mRNA | CTD | PMID:33647349 | methapyrilene | decreases methylation | ISO | KCTD5 (Homo sapiens) | 6480464 | Methapyrilene results in decreased methylation of KCTD5 intron | CTD | PMID:30157460 | methimazole | increases expression | EXP | | 6480464 | Methimazole results in increased expression of KCTD5 mRNA | CTD | PMID:30047161 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | nickel atom | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Nickel results in increased expression of KCTD5 mRNA | CTD | PMID:25583101 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of KCTD5 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | ISO | Kctd5 (Mus musculus) | 6480464 | Acetaminophen affects the expression of KCTD5 mRNA | CTD | PMID:17562736 | resveratrol | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of KCTD5 mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Rotenone results in increased expression of KCTD5 mRNA | CTD | PMID:33512557 | sulfadimethoxine | increases expression | EXP | | 6480464 | Sulfadimethoxine results in increased expression of KCTD5 mRNA | CTD | PMID:30047161 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of KCTD5 mRNA | CTD | PMID:24136188 | tetrachloromethane | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of KCTD5 mRNA | CTD | PMID:25270620 | trimellitic anhydride | increases expression | ISO | Kctd5 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of KCTD5 mRNA | CTD | PMID:19042947 | urethane | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Urethane results in increased expression of KCTD5 mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | KCTD5 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KCTD5 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | Kctd5 (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of KCTD5 mRNA | CTD | PMID:21427059 | zinc atom | decreases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of KCTD5 mRNA | CTD | PMID:22171008 | zinc atom | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KCTD5 mRNA | CTD | PMID:18593933 | zinc(0) | decreases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | Zinc deficiency results in decreased expression of KCTD5 mRNA | CTD | PMID:22171008 | zinc(0) | multiple interactions | ISO | KCTD5 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of KCTD5 mRNA | CTD | PMID:18593933 | zoledronic acid | increases expression | ISO | KCTD5 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of KCTD5 mRNA | CTD | PMID:20977926 | |