Kctd5 (potassium channel tetramerization domain containing 5) - Rat Genome Database

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Gene: Kctd5 (potassium channel tetramerization domain containing 5) Rattus norvegicus
Analyze
Symbol: Kctd5
Name: potassium channel tetramerization domain containing 5
RGD ID: 1304990
Description: Predicted to enable cullin family protein binding activity and identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KCTD5 (potassium channel tetramerization domain containing 5); INTERACTS WITH 2,4-dinitrotoluene; 3,3',5,5'-tetrabromobisphenol A; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BTB/POZ domain-containing protein KCTD5; LOC287109; potassium channel tetramerisation domain containing 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,583,781 - 13,609,762 (-)NCBIGRCr8
mRatBN7.21013,079,216 - 13,105,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,823,951 - 17,850,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,312,783 - 17,338,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,811,434 - 12,837,441 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,420,152 - 13,446,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,235,960 - 13,261,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,298,236 - 13,324,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,299,034 - 13,324,284 (-)NCBI
Celera1012,765,129 - 12,791,119 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Cul3-RING ubiquitin ligase complex  (IBA,IEA)
cytoplasm  (IBA)
cytosol  (IEA,ISO,ISS)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18573101   PMID:23209302   PMID:27152988  


Genomics

Comparative Map Data
Kctd5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,583,781 - 13,609,762 (-)NCBIGRCr8
mRatBN7.21013,079,216 - 13,105,197 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1017,823,951 - 17,850,039 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,312,783 - 17,338,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01012,811,434 - 12,837,441 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,420,152 - 13,446,323 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,235,960 - 13,261,939 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,298,236 - 13,324,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,299,034 - 13,324,284 (-)NCBI
Celera1012,765,129 - 12,791,119 (-)NCBICelera
Cytogenetic Map10q12NCBI
KCTD5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,682,523 - 2,709,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,682,523 - 2,709,030 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,732,524 - 2,759,031 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,672,499 - 2,699,032 (+)NCBINCBI36Build 36hg18NCBI36
Build 34162,672,498 - 2,699,030NCBI
Celera162,932,069 - 2,958,601 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,700,243 - 2,726,766 (+)NCBIHuRef
CHM1_1162,732,526 - 2,759,062 (+)NCBICHM1_1
T2T-CHM13v2.0162,702,754 - 2,729,246 (+)NCBIT2T-CHM13v2.0
Kctd5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,266,694 - 24,292,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,266,708 - 24,292,459 (-)EnsemblGRCm39 Ensembl
GRCm381724,047,720 - 24,073,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,047,734 - 24,073,485 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,184,687 - 24,210,452 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,775,360 - 23,801,059 (-)NCBIMGSCv36mm8
Celera1724,554,089 - 24,579,579 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.22NCBI
Kctd5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,658,612 - 14,684,928 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,658,612 - 14,684,928 (-)NCBIChiLan1.0ChiLan1.0
KCTD5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,187,571 - 3,214,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,968,567 - 6,995,206 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,542,488 - 1,569,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,796,117 - 2,822,819 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,796,117 - 2,822,819 (+)Ensemblpanpan1.1panPan2
KCTD5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,403,024 - 38,426,158 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,404,330 - 38,426,134 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,642,050 - 39,664,955 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,712,849 - 38,735,786 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,712,852 - 38,735,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,398,028 - 38,420,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,370,693 - 38,393,584 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,846,727 - 38,869,631 (-)NCBIUU_Cfam_GSD_1.0
Kctd5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,264,854 - 105,290,837 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366941,418,638 - 1,444,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,403,987 - 39,429,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,403,985 - 39,429,608 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,764,109 - 42,777,244 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCTD5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,451,537 - 2,468,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606828,443,954 - 28,465,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824383,434 - 410,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824383,389 - 411,824 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kctd5
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:920
Count of miRNA genes:337
Interacting mature miRNAs:445
Transcripts:ENSRNOT00000007849
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat

Markers in Region
AA924631  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21013,105,457 - 13,105,671 (+)MAPPERmRatBN7.2
Rnor_6.01013,446,396 - 13,446,609NCBIRnor6.0
Rnor_5.01013,262,200 - 13,262,413UniSTSRnor5.0
RGSC_v3.41013,324,480 - 13,324,693UniSTSRGSC3.4
Celera1012,791,380 - 12,791,593UniSTS
RH 3.4 Map10191.2UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 45 39 12 39 68 29 34 11
Low 15 12 2 7 2 8 11 6 6 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000084991   ⟹   ENSRNOP00000073503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,079,216 - 13,105,209 (-)Ensembl
Rnor_6.0 Ensembl1013,420,154 - 13,446,135 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099302   ⟹   ENSRNOP00000086690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,079,214 - 13,105,209 (-)Ensembl
RefSeq Acc Id: NM_001105768   ⟹   NP_001099238
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,583,781 - 13,609,762 (-)NCBI
mRatBN7.21013,079,216 - 13,105,197 (-)NCBI
Rnor_6.01013,420,154 - 13,446,135 (-)NCBI
Rnor_5.01013,235,960 - 13,261,939 (-)NCBI
RGSC_v3.41013,298,236 - 13,324,219 (-)RGD
Celera1012,765,129 - 12,791,119 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099238 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68712 (Get FASTA)   NCBI Sequence Viewer  
  B5DEL1 (Get FASTA)   NCBI Sequence Viewer  
  EDM03804 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073503
  ENSRNOP00000073503.1
  ENSRNOP00000086690.1
  ENSRNOP00055037079
  ENSRNOP00060012807
  ENSRNOP00065012495
RefSeq Acc Id: NP_001099238   ⟸   NM_001105768
- UniProtKB: B5DEL1 (UniProtKB/Swiss-Prot),   A0A8I6A1Q5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073503   ⟸   ENSRNOT00000084991
RefSeq Acc Id: ENSRNOP00000086690   ⟸   ENSRNOT00000099302
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEL1-F1-model_v2 AlphaFold B5DEL1 1-234 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697001
Promoter ID:EPDNEW_R7526
Type:multiple initiation site
Name:Kctd5_1
Description:potassium channel tetramerization domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01013,446,143 - 13,446,203EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304990 AgrOrtholog
BioCyc Gene G2FUF-25880 BioCyc
Ensembl Genes ENSRNOG00000057186 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055026189 UniProtKB/Swiss-Prot
  ENSRNOG00060009714 UniProtKB/Swiss-Prot
  ENSRNOG00065010202 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084991 ENTREZGENE
  ENSRNOT00000084991.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099302.1 UniProtKB/TrEMBL
  ENSRNOT00055045217 UniProtKB/Swiss-Prot
  ENSRNOT00060016390 UniProtKB/Swiss-Prot
  ENSRNOT00065016450 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.2000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.750 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:287109 UniProtKB/Swiss-Prot
NCBI Gene 287109 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kctd5 PhenoGen
RatGTEx ENSRNOG00000057186 RatGTEx
  ENSRNOG00055026189 RatGTEx
  ENSRNOG00060009714 RatGTEx
  ENSRNOG00065010202 RatGTEx
SMART BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A1Q5 ENTREZGENE, UniProtKB/TrEMBL
  B5DEL1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Kctd5  potassium channel tetramerization domain containing 5  Kctd5  potassium channel tetramerisation domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Kctd5  potassium channel tetramerisation domain containing 5   Kctd5_predicted  potassium channel tetramerisation domain containing 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kctd5_predicted  potassium channel tetramerisation domain containing 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED