Gene: Gh1 (growth hormone 1)  Rattus norvegicus Symbol: Gh1 Name: growth hormone 1 Description: ENCODES a protein that exhibits hormone activity; growth factor activity (ortholog); growth hormone receptor binding (ortholog); INVOLVED IN female pregnancy; lung alveolus development; negative regulation of neuron death; PARTICIPATES IN Jak-Stat signaling pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Mammary Neoplasms, Experimental; FOUND IN cytosol; extracellular space; mitochondrion; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 3,3',4,4',5-pentachlorobiphenyl Type: protein-coding RefSeq Status: VALIDATED Also known as: Gh; Growth hormone 1; growth hormone 1; RNGHGP; somatotropin Is Marker For: QTLs:   Bp1   Cia5   Bp134   Latest Assembly: RGSC Genome Assembly v3.4 Position: Map Chr Position Strand Source Rat Cytogenetic Map 10 q32   NCBI RGSC Genome Assembly v5.0 10 94,237,414 - 94,239,391 - NCBI RGSC Genome Assembly v3.4 10 95,692,240 - 95,694,117 - NCBI Rat Celera Assembly 10 89,903,834 - 89,905,811 - NCBI Genome Assembly 3.1 10 95,708,476 - 95,710,261 - NCBI Model Launch Genome Browser (GBrowse) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acromegaly   ISS   704404   RGD   Diabetes Insipidus   ISS RGD:69101 2315659 protein:decreased expression:serum RGD   Diabetes Mellitus   ISS RGD:69101 2315653 protein:increased expression:vitreous body RGD   Diabetes Mellitus   ISS RGD:69101 2315658 protein:increased secretion:plasma RGD   Diabetes Mellitus, Experimental   IED   2315682   RGD   Diabetes Mellitus, Experimental   IEP   2315655 protein:decreased expression:serum, pituitary gland RGD   Diabetes Mellitus, Type 1   ISS RGD:69101 2315684   RGD   Diabetes Mellitus, Type 1   ISS RGD:69101 2315674 protein:increased expression:serum RGD   Diabetes Mellitus, Type 1   IED   2315685   RGD   Diabetes, Gestational   ISS RGD:69101 2315681 protein:increased expression: RGD   Diabetic Retinopathy   ISS RGD:69101 2315688   RGD   Dwarfism, Pituitary   ISS RGD:69101 1601313 Kowarski syndrome,OMIM:262650;DNA:point mutation:exon:D122G RGD   Dwarfism, Pituitary   ISS   704404   RGD   ISOLATED GROWTH HORMONE DEFICIENCY, TYPE IA   ISS RGD:69101 7240710   OMIM   Isolated Growth Hormone Deficiency, Type IB   ISS RGD:69101 7240710   OMIM   Isolated Growth Hormone Deficiency, Type II   ISS RGD:69101 7240710   OMIM   Kowarski syndrome   ISS RGD:69101 7240710   OMIM   Mammary Neoplasms, Experimental   IPM   2315650   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (S)-amphetamine decreases expression ISO RGD:10643 6480464 Dextroamphetamine results in decreased expression of GH mRNA CTD PMID:12558987 17alpha-ethynylestradiol multiple interactions ISO RGD:69101 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of GH1 protein CTD PMID:11172797 17alpha-ethynylestradiol increases expression ISO RGD:69101 6480464 Ethinyl Estradiol results in increased expression of GH1 protein CTD PMID:10843175 17alpha-ethynylestradiol multiple interactions ISO RGD:10643 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GH mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:10643 6480464 Estradiol results in increased expression of and results in increased secretion of GH protein CTD PMID:16015026 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of GH1 protein CTD PMID:11408345 PMID:15860553 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of GH1 mRNA CTD PMID:19463694 PMID:15240998 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of GH1 mRNA CTD PMID:15240998 PMID:19463694 17beta-estradiol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of GH1 mRNA]; more ... CTD PMID:19463694 17beta-estradiol increases secretion EXP   6480464 Estradiol results in increased secretion of GH1 protein CTD PMID:19463694 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of GH1 protein CTD PMID:15860553 PMID:11408345 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of GH1 mRNA CTD PMID:19463694 17beta-estradiol multiple interactions ISO RGD:69101 6480464 [Progesterone co-treated with Estradiol] results in increased secretion of GH1 protein CTD PMID:15772906 17beta-estradiol multiple interactions ISO RGD:69101 6480464 Estradiol inhibits the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP   6480464 [2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA CTD PMID:19327374 2,2,2-trifluoroethanol affects folding ISO RGD:69101 6480464 Trifluoroethanol affects the folding of GH1 protein CTD PMID:11064379 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10643 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GH mRNA CTD PMID:17942748 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP   6480464 [2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180 co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of GH1 mRNA CTD PMID:19327374 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 bisphenol A promotes the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; more ... CTD PMID:17928132 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:10720163 more ... 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:15240998 more ... 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:22201216 more ... 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; more ... CTD PMID:10720163 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:17090972 more ... 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:15240998 more ... 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 protein CTD PMID:22201216 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:15240998 more ... 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 P4HB protein inhibits the reaction [Triiodothyronine results in increased expression of GH1 protein]; more ... CTD PMID:22201216 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:2910914 more ... 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 Dexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:15240998 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH1 mRNA CTD PMID:2910914 PMID:17090972 3,3',5-triiodo-L-thyronine multiple interactions EXP   6480464 Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:2910914 3,3',5-triiodo-L-thyronine increases expression EXP   6480464 Triiodothyronine results in increased expression of GH mRNA CTD PMID:17928132 4-hydroxybutyric acid increases secretion ISO RGD:69101 6480464 4-hydroxybutyric acid results in increased secretion of GH1 protein CTD PMID:10657535 4-hydroxybutyric acid multiple interactions ISO RGD:69101 6480464 Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] CTD PMID:10657535 4-nonylphenol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA] CTD PMID:19145065 PMID:19463694 4-nonylphenol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein] CTD PMID:19463694 4-nonylphenol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein] CTD PMID:19145065 4-nonylphenol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA] CTD PMID:19463694 PMID:19145065 4-nonylphenol increases expression EXP   6480464 4-nonylphenol results in increased expression of GH1 mRNA CTD PMID:19145065 PMID:19463694 4-nonylphenol increases secretion EXP   6480464 4-nonylphenol results in increased secretion of GH1 protein CTD PMID:19463694 4-nonylphenol increases expression EXP   6480464 4-nonylphenol results in increased expression of GH1 protein CTD PMID:19145065 7,12-dimethyltetraphene decreases response to substance EXP   6480464 GH1 gene mutant form results in decreased susceptibility to 9,10-Dimethyl-1,2-benzanthracene CTD PMID:12082019 9-cis-retinoic acid multiple interactions EXP   6480464 alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; more ... CTD PMID:10720163 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of GH1 mRNA CTD PMID:17090972 PMID:15240998 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of GH1 mRNA CTD PMID:15240998 PMID:17090972 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of GH1 mRNA CTD PMID:17090972 9-cis-retinoic acid increases expression EXP   6480464 alitretinoin results in increased expression of GH1 mRNA CTD PMID:10720163 more ... afimoxifene multiple interactions ISO RGD:69101 6480464 4-hydroxytamoxifen promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]; more ... CTD PMID:17272397 all-trans-retinoic acid affects expression EXP   6480464 Tretinoin affects the expression of GH1 protein CTD PMID:1630583 all-trans-retinoic acid multiple interactions EXP   6480464 Tretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; more ... CTD PMID:10720163 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of GH1 mRNA CTD PMID:10720163 more ... all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of GH1 mRNA CTD PMID:15240998 PMID:17090972 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of GH1 mRNA CTD PMID:17090972 PMID:15240998 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of GH1 mRNA CTD PMID:17090972 all-trans-retinol multiple interactions EXP   6480464 GH1 protein promotes the reaction [Vitamin A affects the expression of and affects the activity of CYP2C11 protein] CTD PMID:15963505 amiodarone multiple interactions EXP   6480464 Amiodarone inhibits the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:2910914 ammonium chloride affects expression EXP   6480464 Ammonium Chloride affects the expression of GH1 mRNA CTD PMID:16483693 apomorphine increases secretion ISO RGD:69101 6480464 Apomorphine results in increased secretion of GH1 protein CTD PMID:993808 apomorphine increases expression ISO RGD:69101 6480464 Apomorphine results in increased expression of GH1 protein CTD PMID:8889285 ATP increases secretion ISO RGD:69101 6480464 Adenosine Triphosphate results in increased secretion of GH1 protein CTD PMID:12471042 ATP multiple interactions EXP   6480464 NCS1 protein promotes the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; more ... CTD PMID:12471042 ATP multiple interactions ISO RGD:69101 6480464 Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein]; more ... CTD PMID:12471042 atrazine decreases expression EXP   6480464 Atrazine results in decreased expression of GH1 mRNA CTD PMID:20529762 atrazine multiple interactions EXP   6480464 [Atrazine binds to GHRHR protein] which results in decreased expression of GH1 mRNA CTD PMID:20529762 benzo[a]pyrene multiple interactions ISO RGD:10643 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to GH promoter] CTD PMID:19654925 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of GH1 mRNA CTD PMID:19463694 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of GH1 protein CTD PMID:19145065 PMID:22842222 bisphenol A multiple interactions EXP   6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 protein] CTD PMID:19145065 bisphenol A increases secretion EXP   6480464 bisphenol A results in increased secretion of GH1 protein CTD PMID:19463694 bisphenol A multiple interactions EXP   6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of GH1 mRNA]; more ... CTD PMID:19463694 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of GH1 protein CTD PMID:19145065 bisphenol A multiple interactions EXP   6480464 bisphenol A promotes the reaction [Triiodothyronine results in increased expression of and results in increased secretion of GH protein]; more ... CTD PMID:17928132 bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:3226523 more ... bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:19420816 more ... bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:7293648 more ... bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:3745407 more ... bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:7293648 more ... bromocriptine increases expression ISO RGD:69101 6480464 Bromocriptine results in increased expression of GH1 protein CTD PMID:772175 bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:7293648 more ... bromocriptine decreases expression ISO RGD:69101 6480464 Bromocriptine results in decreased expression of GH1 protein CTD PMID:7293648 more ... butan-1-ol affects folding ISO RGD:69101 6480464 1-Butanol affects the folding of GH1 protein CTD PMID:11064379 butan-2-ol affects folding ISO RGD:69101 6480464 2-butanol affects the folding of GH1 protein CTD PMID:11064379 caffeine multiple interactions ISO RGD:69101 6480464 GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 calcitriol multiple interactions EXP   6480464 GH1 protein affects the reaction [CYP27B1 protein affects the abundance of Calcitriol] CTD PMID:11316734 capsaicin increases expression EXP   6480464 Capsaicin results in increased expression of GH1 protein CTD PMID:22150557 capsaicin decreases secretion EXP   6480464 Capsaicin results in decreased secretion of GH protein CTD PMID:12360474 capsaicin multiple interactions EXP   6480464 Naproxen inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; more ... CTD PMID:22150557 CGP 12177 multiple interactions EXP   6480464 GH1 protein promotes the reaction [CGP 12177 results in increased metabolism of Lipids] CTD PMID:14981226 chromium(6+) decreases expression EXP   6480464 chromium hexavalent ion results in decreased expression of GH1 protein CTD PMID:18602937 chromium(6+) multiple interactions EXP   6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of GH1 protein] CTD PMID:18602937 clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 CTD PMID:707001 clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine multiple interactions EXP   6480464 Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] CTD PMID:15099682 clonidine increases secretion ISO RGD:69101 6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:17889730 clonidine increases secretion EXP   6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:15099682 clonidine increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:3007707 more ... clonidine multiple interactions ISO RGD:69101 6480464 L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] CTD PMID:2568210 clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 CTD PMID:707001 clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine (amino form) multiple interactions EXP   6480464 Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] CTD PMID:15099682 clonidine (amino form) increases secretion ISO RGD:69101 6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:17889730 clonidine (amino form) increases secretion EXP   6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:15099682 clonidine (amino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:3007707 more ... clonidine (amino form) multiple interactions ISO RGD:69101 6480464 L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] CTD PMID:2568210 clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 CTD PMID:707001 clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:6150000 more ... clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:2568210 more ... clonidine (imino form) multiple interactions EXP   6480464 Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] CTD PMID:15099682 clonidine (imino form) increases secretion ISO RGD:69101 6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:17889730 clonidine (imino form) increases secretion EXP   6480464 Clonidine results in increased secretion of GH1 protein CTD PMID:15099682 clonidine (imino form) increases expression ISO RGD:69101 6480464 Clonidine results in increased expression of GH1 protein CTD PMID:3007707 more ... clonidine (imino form) multiple interactions ISO RGD:69101 6480464 L 657743 inhibits the reaction [Clonidine results in increased expression of GH1 protein] CTD PMID:2568210 cocaine multiple interactions ISO RGD:69101 6480464 Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] CTD PMID:10657535 cocaine multiple interactions EXP   6480464 Cocaine inhibits the reaction [Clonidine results in increased secretion of GH1 protein] CTD PMID:15099682 cocaine multiple interactions ISO RGD:69101 6480464 Cocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein] CTD PMID:9413023 corticotropin multiple interactions ISO RGD:69101 6480464 Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] CTD PMID:3008584 cortisol increases expression ISO RGD:69101 6480464 Hydrocortisone results in increased expression of GH1 protein CTD PMID:15833589 cyproheptadine increases expression ISO RGD:69101 6480464 Cyproheptadine results in increased expression of GH1 protein CTD PMID:642945 D-glucose multiple interactions ISO RGD:69101 6480464 Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein] CTD PMID:838844 D-glucose multiple interactions ISO RGD:69101 6480464 GH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein] CTD PMID:21559284 dehydroepiandrosterone multiple interactions ISO RGD:69101 6480464 [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 dexamethasone decreases expression EXP   6480464 Dexamethasone results in decreased expression of GH1 mRNA CTD PMID:15240998 dexamethasone multiple interactions EXP   6480464 Dexamethasone promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:15240998 disulfiram multiple interactions EXP   6480464 GH1 protein inhibits the reaction [Disulfiram results in increased expression of CYP2B2 mRNA]; more ... CTD PMID:8390837 dobutamine multiple interactions EXP   6480464 GH1 protein promotes the reaction [Dobutamine results in increased metabolism of Lipids] CTD PMID:14981226 doxorubicin multiple interactions EXP   6480464 [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; more ... CTD PMID:20051877 enalapril increases response to substance ISO RGD:69101 6480464 GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 endosulfan increases expression EXP   6480464 Endosulfan results in increased expression of GH1 protein CTD PMID:20471459 endosulfan decreases expression EXP   6480464 Endosulfan results in decreased expression of GH1 mRNA CTD PMID:20471459 estriol increases expression EXP   6480464 Estriol results in increased expression of GH1 mRNA CTD PMID:15240998 ethanol affects folding ISO RGD:69101 6480464 Ethanol affects the folding of GH1 protein CTD PMID:11064379 ethylbenzene multiple interactions EXP   6480464 GH1 protein inhibits the reaction [ethylbenzene results in increased expression of CYP2E1 protein] CTD PMID:11884239 ethylene glycol affects folding ISO RGD:69101 6480464 Ethylene Glycol affects the folding of GH1 protein CTD PMID:11064379 ethylenediaminetetraacetic acid multiple interactions EXP   6480464 Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 formaldehyde increases expression EXP   6480464 Formaldehyde results in increased expression of GH1 mRNA CTD PMID:12679049 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA] CTD PMID:19463694 PMID:19145065 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA] CTD PMID:19145065 PMID:19463694 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]; more ... CTD PMID:19463694 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; more ... CTD PMID:19145065 glucose multiple interactions ISO RGD:69101 6480464 Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein] CTD PMID:838844 glucose multiple interactions ISO RGD:69101 6480464 GH1 protein promotes the reaction [Glucose results in increased phosphorylation of TBC1D4 protein] CTD PMID:21559284 idazoxan decreases expression EXP   6480464 Idazoxan results in decreased expression of GH1 protein CTD PMID:6150737 ionomycin increases secretion ISO RGD:69101 6480464 Ionomycin results in increased secretion of GH1 protein CTD PMID:12471042 L-ascorbic acid multiple interactions EXP   6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of GH1 protein] CTD PMID:18602937 levonorgestrel multiple interactions ISO RGD:69101 6480464 [Ethinyl Estradiol co-treated with Levonorgestrel] results in increased expression of GH1 protein CTD PMID:11172797 lisinopril dihydrate multiple interactions EXP   6480464 [Lisinopril co-treated with GH1 protein] inhibits the reaction [Doxorubicin results in decreased expression of TIMP1 protein]; more ... CTD PMID:20051877 maneb multiple interactions ISO RGD:10643 6480464 [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 morphine decreases expression ISO RGD:10643 6480464 Morphine results in decreased expression of GH mRNA CTD PMID:21178816 morphine increases secretion EXP   6480464 Morphine results in increased secretion of GH1 protein CTD PMID:7201058 N-methyl-N-nitrosurea decreases response to substance EXP   6480464 GH1 gene mutant form results in decreased susceptibility to Methylnitrosourea CTD PMID:12082019 naproxen multiple interactions EXP   6480464 [Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; more ... CTD PMID:22150557 nicotinic acid multiple interactions ISO RGD:69101 6480464 Glucose inhibits the reaction [[Niacin results in decreased abundance of Fatty Acids, Nonesterified] which results in increased secretion of GH1 protein] CTD PMID:838844 paraquat multiple interactions ISO RGD:10643 6480464 [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 pentetic acid multiple interactions EXP   6480464 Pentetic Acid promotes the reaction [alitretinoin results in increased expression of GH1 mRNA]; more ... CTD PMID:10720163 permethrin multiple interactions EXP   6480464 GH1 protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 phenobarbital multiple interactions EXP   6480464 GH1 protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 pirinixic acid increases expression EXP   6480464 pirinixic acid results in increased expression of GH1 mRNA CTD PMID:19162173 progesterone multiple interactions ISO RGD:69101 6480464 [Progesterone co-treated with Estradiol] results in increased secretion of GH1 protein CTD PMID:15772906 progesterone increases secretion ISO RGD:69101 6480464 Progesterone results in increased secretion of GH1 protein CTD PMID:15772906 propan-1-ol affects folding ISO RGD:69101 6480464 1-Propanol affects the folding of GH1 protein CTD PMID:11064379 propan-2-ol affects folding ISO RGD:69101 6480464 2-Propanol affects the folding of GH1 protein CTD PMID:11064379 propane-1,2-diol affects folding ISO RGD:69101 6480464 Propylene Glycol affects the folding of GH1 protein CTD PMID:11064379 pyridoxal 5'-phosphate decreases secretion EXP   6480464 Pyridoxal Phosphate results in decreased secretion of GH1 protein CTD PMID:16690808 raloxifene multiple interactions ISO RGD:69101 6480464 Raloxifene promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein] CTD PMID:17272397 sodium atom increases abundance ISO RGD:69101 6480464 GH1 protein results in increased abundance of Sodium CTD PMID:17324600 PMID:17311540 sodium atom increases abundance ISO RGD:69101 6480464 GH1 protein results in increased abundance of Sodium CTD PMID:17311540 PMID:17324600 sodium atom multiple interactions EXP   6480464 GH1 protein affects the transport of [Sodium co-treated with Chlorides]; more ... CTD PMID:18388193 sodium atom affects transport EXP   6480464 GH1 protein affects the transport of Sodium CTD PMID:18388193 sumatriptan multiple interactions EXP   6480464 Sumatriptan inhibits the reaction [Capsaicin results in increased expression of GH1 protein]; more ... CTD PMID:22150557 tamoxifen decreases secretion EXP   6480464 Tamoxifen results in decreased secretion of GH1 protein CTD PMID:1350760 tamoxifen multiple interactions EXP   6480464 Tamoxifen promotes the reaction [SST protein results in decreased secretion of GH1 protein] CTD PMID:1350760 tert-butanol affects folding ISO RGD:69101 6480464 tert-Butyl Alcohol affects the folding of GH1 protein CTD PMID:11064379 testosterone multiple interactions ISO RGD:69101 6480464 [Dehydroepiandrosterone co-treated with Testosterone co-treated with GH1] results in decreased expression of EPO protein CTD PMID:15161484 testosterone increases secretion EXP   6480464 Testosterone results in increased secretion of GH protein CTD PMID:3830058 testosterone increases expression EXP   6480464 Testosterone results in increased expression of GH protein CTD PMID:10100480 thioacetamide affects response to substance EXP   6480464 GH1 protein affects the susceptibility to Thioacetamide CTD PMID:11255791 urethane multiple interactions ISO RGD:10643 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of GH mRNA CTD PMID:12400877 zinc atom multiple interactions ISO RGD:69101 6480464 Zinc promotes the reaction [GH1 protein binds to PRLR protein] CTD PMID:12915731 zinc atom multiple interactions EXP   6480464 GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]; more ... CTD PMID:10985758 zinc atom multiple interactions EXP   6480464 Zinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; more ... CTD PMID:10720163 zinc sulfate multiple interactions EXP   6480464 Zinc Sulfate affects the reaction [GH protein results in increased expression of IGF1 mRNA] CTD PMID:9685221 zinc(0) multiple interactions ISO RGD:69101 6480464 Zinc promotes the reaction [GH1 protein binds to PRLR protein] CTD PMID:12915731 zinc(0) multiple interactions EXP   6480464 Zinc inhibits the reaction [Pentetic Acid promotes the reaction [alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; more ... CTD PMID:10720163 zinc(0) multiple interactions EXP   6480464 GH1 protein inhibits the reaction [Zinc deficiency results in decreased expression of GHR mRNA]; more ... CTD PMID:10985758 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) bone maturation   ISO RGD:69101 1624291 PMID:20110402 RGD PMID:20110402 cellular response to insulin stimulus   ISO RGD:10643 1624291 MGI:MGI:3769319|PMID:16513828 RGD MGI:MGI:3769319 PMID:16513828 cellular response to insulin stimulus   IEA Ensembl:ENSMUSP00000099360 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 female pregnancy   IEP   2315640   RGD   glucose transport   ISO RGD:69101 1624291 PMID:9144201 RGD PMID:9144201 growth hormone receptor signaling pathway   ISO RGD:69101 1624291 PMID:8063815 RGD PMID:8063815 JAK-STAT cascade   ISO RGD:69101 1624291 PMID:8063815 RGD PMID:8063815 lung alveolus development   IMP   2315627   RGD   negative regulation of neuron death   IDA   1624960   RGD   neuroblast proliferation   IDA   2315620   RGD   positive regulation of activation of JAK2 kinase activity   ISO RGD:69101 1624291 PMID:12552091 RGD PMID:12552091 positive regulation of activation of JAK2 kinase activity   ISO RGD:69101 1624291 PMID:8063815 RGD PMID:8063815 positive regulation of cell differentiation   TAS   728551   RGD   positive regulation of growth   IMP   2315643   RGD   positive regulation of insulin-like growth factor receptor signaling pathway   ISO RGD:69101 1624291 PMID:7565946 RGD PMID:7565946 positive regulation of JAK-STAT cascade   ISO RGD:69101 1624291 PMID:8923468 RGD PMID:8923468 positive regulation of multicellular organism growth   ISO RGD:10643 1624291 MGI:MGI:1342540 RGD MGI:MGI:3617295 PMID:16467156 positive regulation of multicellular organism growth   IEA Ensembl:ENSMUSP00000099360 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of multicellular organism growth   ISO RGD:69101 1624291 PMID:8496314 RGD PMID:8496314 positive regulation of multicellular organism growth   ISO RGD:69101 1624291 PMID:7565946 RGD PMID:7565946 positive regulation of multicellular organism growth   ISO RGD:69101 1624291 PMID:20110402 RGD PMID:20110402 positive regulation of neurogenesis   IDA   2315620   RGD   positive regulation of peptidyl-tyrosine phosphorylation   ISO RGD:69101 1624291 PMID:7782332 RGD PMID:7782332 positive regulation of phosphatidylinositol 3-kinase cascade   ISO RGD:69101 1624291 PMID:7782332 RGD PMID:7782332 positive regulation of receptor internalization NOT ISO RGD:69101 1624291 PMID:9360546 RGD PMID:9360546 positive regulation of steroid hormone biosynthetic process   IDA   1600072 PMID:17023532 BHF-UCL   positive regulation of tyrosine phosphorylation of Stat3 protein   ISO RGD:69101 1624291 PMID:12552091 RGD PMID:12552091 positive regulation of tyrosine phosphorylation of Stat3 protein   ISO RGD:69101 1624291 PMID:8923468 RGD PMID:8923468 positive regulation of tyrosine phosphorylation of Stat5 protein   ISO RGD:69101 1624291 PMID:12552091 RGD PMID:12552091 positive regulation of tyrosine phosphorylation of Stat5 protein   ISO RGD:69101 1624291 PMID:8923468 RGD PMID:8923468 regulation of growth   TAS   625703   RGD   response to cytokine stimulus   IEP   2315636   RGD   response to estradiol stimulus   ISO RGD:69101 1624291 PMID:12552091 RGD PMID:12552091 response to food   ISO RGD:10643 1624291 MGI:MGI:3769319|PMID:16513828 RGD MGI:MGI:3769319 PMID:16513828 response to food   IEA Ensembl:ENSMUSP00000099360 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to light stimulus   IDA   2315626   RGD   response to peptide hormone stimulus   IEP   2315623   RGD   signal transduction   IDA   625703   RGD   Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytosol   IDA   1624961   RGD   extracellular region   TAS   1600115 Reactome:REACT_115681 Reactome Reactome:REACT_115681 extracellular region   TAS   1600115 Reactome:REACT_116109 Reactome Reactome:REACT_116109 extracellular region   TAS   1600115 Reactome:REACT_116097 Reactome Reactome:REACT_116097 extracellular region   TAS   1600115 Reactome:REACT_115998 Reactome Reactome:REACT_115998 extracellular region   TAS   1600115 Reactome:REACT_115948 Reactome Reactome:REACT_115948 extracellular space   IDA   2306671   RGD   extracellular space   ISO RGD:69101 1624291 PMID:11549663 RGD PMID:11549663 extracellular space   ISO RGD:10643 1624291 MGI:MGI:3607618|PMID:15985453 RGD MGI:MGI:3607618 PMID:15985453 extracellular space   ISO RGD:10643 1624291 MGI:MGI:76745|PMID:7664670 RGD MGI:MGI:76745 PMID:7664670 mitochondrion   IDA   1624961   RGD   nucleus   IDA   2315624   RGD   nucleus   ISO RGD:10643 1624291 MGI:MGI:87717|PMID:9144201 RGD MGI:MGI:87717 PMID:9144201 plasma membrane   ISO RGD:10643 1624291 MGI:MGI:87717|PMID:9144201 RGD MGI:MGI:87717 PMID:9144201 plasma membrane   IEA Ensembl:ENSMUSP00000099360 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 secretory granule   ISO RGD:10643 1624291 MGI:MGI:63703|PMID:1329576 RGD MGI:MGI:63703 PMID:1329576 secretory granule   IDA   2315687   RGD   trans-Golgi network   ISO RGD:10643 1624291 MGI:MGI:87717|PMID:9144201 RGD MGI:MGI:87717 PMID:9144201 trans-Golgi network   IEA Ensembl:ENSMUSP00000099360 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) growth factor activity   ISO RGD:69101 1624291 UniProtKB:P10912-1 RGD PMID:9360546 growth hormone receptor binding   TAS   625493   RGD   growth hormone receptor binding   ISO RGD:69101 1624291 PMID:6303755 RGD PMID:6303755 growth hormone receptor binding   ISO RGD:69101 1624291 UniProtKB:P10912 RGD PMID:2825030 growth hormone receptor binding   ISO RGD:69101 1624291 UniProtKB:P10912 RGD PMID:1549776 growth hormone receptor binding   ISO RGD:10643 1624291 UniProtKB:P16882 RGD MGI:MGI:1347647 PMID:10556780 hormone activity   TAS   625493   RGD   hormone activity   IDA   1624960   RGD   metal ion binding   IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037 prolactin receptor binding   ISO RGD:69101 1624291 UniProtKB:P16471 RGD PMID:7984244 protein binding   ISO RGD:69101 1624291 UniProtKB:P10912 RGD PMID:8943276 protein binding   ISO RGD:69101 1624291 UniProtKB:P10912 RGD PMID:9353194 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Jak-Stat signaling pathway   IEA RGD:2686 6907045   KEGG rno:04630 External Database Links KEGG Pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal retinal vasculature morphology   IEA   704404   RGD   Disease Annotations Acromegaly  (ISS) Diabetes Insipidus  (ISS) Diabetes Mellitus  (ISS) Diabetes Mellitus, Experimental  (IED,IEP) Diabetes Mellitus, Type 1  (IED,ISS) Diabetes, Gestational  (ISS) Diabetic Retinopathy  (ISS) Dwarfism, Pituitary  (ISS) ISOLATED GROWTH HORMONE DEFICIENCY, TYPE IA  (ISS) Isolated Growth Hormone Deficiency, Type IB  (ISS) Isolated Growth Hormone Deficiency, Type II  (ISS) Kowarski syndrome  (ISS) Mammary Neoplasms, Experimental  (IPM) Gene-Chemical Interaction Annotations (S)-amphetamine  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP,ISO) 2,2',4,4',5,5'-hexachlorobiphenyl  (EXP) 2,2,2-trifluoroethanol  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 3,3',4,4',5-pentachlorobiphenyl  (EXP) 3,3',5-triiodo-L-thyronine  (EXP) 4-hydroxybutyric acid  (ISO) 4-nonylphenol  (EXP) 7,12-dimethyltetraphene  (EXP) 9-cis-retinoic acid  (EXP) afimoxifene  (ISO) all-trans-retinoic acid  (EXP) all-trans-retinol  (EXP) amiodarone  (EXP) ammonium chloride  (EXP) apomorphine  (ISO) ATP  (EXP,ISO) atrazine  (EXP) benzo[a]pyrene  (ISO) bisphenol A  (EXP) bromocriptine  (ISO) butan-1-ol  (ISO) butan-2-ol  (ISO) caffeine  (ISO) calcitriol  (EXP) capsaicin  (EXP) CGP 12177  (EXP) chromium(6+)  (EXP) clonidine  (EXP,ISO) clonidine (amino form)  (EXP,ISO) clonidine (imino form)  (EXP,ISO) cocaine  (EXP,ISO) corticotropin  (ISO) cortisol  (ISO) cyproheptadine  (ISO) D-glucose  (ISO) dehydroepiandrosterone  (ISO) dexamethasone  (EXP) disulfiram  (EXP) dobutamine  (EXP) doxorubicin  (EXP) enalapril  (ISO) endosulfan  (EXP) estriol  (EXP) ethanol  (ISO) ethylbenzene  (EXP) ethylene glycol  (ISO) ethylenediaminetetraacetic acid  (EXP) formaldehyde  (EXP) fulvestrant  (EXP) glucose  (ISO) idazoxan  (EXP) ionomycin  (ISO) L-ascorbic acid  (EXP) levonorgestrel  (ISO) lisinopril dihydrate  (EXP) maneb  (ISO) morphine  (EXP,ISO) N-methyl-N-nitrosurea  (EXP) naproxen  (EXP) nicotinic acid  (ISO) paraquat  (ISO) pentetic acid  (EXP) permethrin  (EXP) phenobarbital  (EXP) pirinixic acid  (EXP) progesterone  (ISO) propan-1-ol  (ISO) propan-2-ol  (ISO) propane-1,2-diol  (ISO) pyridoxal 5'-phosphate  (EXP) raloxifene  (ISO) sodium atom  (EXP,ISO) sumatriptan  (EXP) tamoxifen  (EXP) tert-butanol  (ISO) testosterone  (EXP,ISO) thioacetamide  (EXP) urethane  (ISO) zinc atom  (EXP,ISO) zinc sulfate  (EXP) zinc(0)  (EXP,ISO) Gene Ontology Annotations Biological Process bone maturation  (ISO) cellular response to insulin stimulus  (IEA,ISO) female pregnancy  (IEP) glucose transport  (ISO) growth hormone receptor signaling pathway  (ISO) JAK-STAT cascade  (ISO) lung alveolus development  (IMP) negative regulation of neuron death  (IDA) neuroblast proliferation  (IDA) positive regulation of activation of JAK2 kinase activity  (ISO) positive regulation of cell differentiation  (TAS) positive regulation of growth  (IMP) positive regulation of insulin-like growth factor receptor signaling pathway  (ISO) positive regulation of JAK-STAT cascade  (ISO) positive regulation of multicellular organism growth  (IEA,ISO) positive regulation of neurogenesis  (IDA) positive regulation of peptidyl-tyrosine phosphorylation  (ISO) positive regulation of phosphatidylinositol 3-kinase cascade  (ISO) positive regulation of receptor internalization  (ISO) positive regulation of steroid hormone biosynthetic process  (IDA) positive regulation of tyrosine phosphorylation of Stat3 protein  (ISO) positive regulation of tyrosine phosphorylation of Stat5 protein  (ISO) regulation of growth  (TAS) response to cytokine stimulus  (IEP) response to estradiol stimulus  (ISO) response to food  (IEA,ISO) response to light stimulus  (IDA) response to peptide hormone stimulus  (IEP) signal transduction  (IDA) Cellular Component cytosol  (IDA) extracellular region  (TAS) extracellular space  (IDA,ISO) mitochondrion  (IDA) nucleus  (IDA,ISO) plasma membrane  (IEA,ISO) secretory granule  (IDA,ISO) trans-Golgi network  (IEA,ISO) Molecular Function growth factor activity  (ISO) growth hormone receptor binding  (ISO,TAS) hormone activity  (IDA,TAS) metal ion binding  (IEA) prolactin receptor binding  (ISO) protein binding  (ISO) Molecular Pathway Annotations Jak-Stat signaling pathway  (IEA) External Database Links KEGG Pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction PI3K-Akt signaling pathway Phenotype Annotations abnormal retinal vasculature morphology  (IEA) References - curated 1. Baranowska B, etal., J Physiol Pharmacol. 2009 Mar;60(1):151-6. 2. Barreca T, etal., J Clin Endocrinol Metab. 1980 Dec;51(6):1279-82. 3. Beyea JA, etal., Mol Cell Biochem. 2009 Jan;321(1-2):197-204. Epub 2008 Nov 5. 4. Brown JL, etal., Endocrine 2002 Dec;19(3):327-32. 5. Christophidis LJ, etal., Growth Horm IGF Res. 2009 Dec;19(6):497-506. Epub 2009 Jun 12. 6. Csaba G and Kovacs P, Horm Metab Res. 2009 Aug;41(8):621-5. Epub 2009 Apr 15. 7. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96 8. de Almeida Leme JA, etal., Pituitary. 2009;12(4):304-8. Epub 2009 Apr 16. 9. El-Kasti MM, etal., J Neuroendocrinol. 2008 Mar;20(3):309-22. Epub 2008 Jan 16. 10. GOA data from the GO Consortium 11. Gomes RJ, etal., Cell Biochem Funct. 2009 Apr 20. 12. Horner JM, etal., J Clin Endocrinol Metab. 1981 Dec;53(6):1148-53. 13. Hymer WC, etal., Growth Horm IGF Res. 2009 Jun;19(3):274-9. Epub 2008 Dec 16. 14. Ikawa A, etal., Histol Histopathol 2002 Apr;17(2):419-26. 15. Jeay S, etal., Endocrinology 2001 Jan;142(1):147-56. 16. Ji S, etal., J Biol Chem 2002 Aug 9;277(32):28384-93. 17. Lee Y, etal., J Endocrinol. 2008 Nov;199(2):191-9. Epub 2008 Aug 27. 18. Locatelli V, etal., Brain Res. 1985 Aug 19;341(1):35-40. 19. Lopez-Espinoza I, etal., Diabetes Res. 1986 Mar;3(3):119-25. 20. Mathews LS, etal., J Biol Chem 1989 Jun 15;264(17):9905-10. 21. Matsumoto K, etal., Mol Reprod Dev. 1993 Sep;36(1):53-8. 22. MGD data from the GO Consortium 23. Moderscheim TA, etal., Brain Res. 2007 Mar 16;1137(1):29-34. Epub 2006 Dec 20. 24. Navalesi R, etal., Diabetes. 1975 Apr;24(4):317-27. 25. NCBI rat LocusLink and RefSeq merged data July 26, 2002 26. Online Mendelian Inheritance in Man, OMIM (TM). 27. Perret-Vivancos C, etal., Exp Cell Res. 2006 Feb 1;312(3):215-32. 28. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 29. Pontiroli AE, etal., J Endocrinol Invest. 1988 May;11(5):389-91. 30. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5 31. RGD automated data pipeline 32. RGD automated import pipeline for gene-chemical interactions 33. RGD Automated Pipelines 34. RGD comprehensive gene curation 35. Ribaux P, etal., Endocrinology 2002 Oct;143(10):3766-72. 36. Serri O and Brazeau P, Neuroendocrinology. 1987 Aug;46(2):162-6. 37. Shen Q, etal., Endocrinology. 2007 Oct;148(10):4536-44. Epub 2007 Jun 21. 38. Shiino M and Ishibashi T, Histol Histopathol. 1988 Jul;3(3):263-8. 39. Takahashi Y, etal., J Clin Invest. 1997 Sep 1;100(5):1159-65. 40. Thirone AC, etal., Diabetes 2002 Jul;51(7):2270-81. 41. Vanelli M, etal., J Endocrinol Invest. 1986 Aug;9(4):293-7. 42. Zhao J, etal., Zygote 2002 Feb;10(1):85-94. 43. Ziaei M, etal., Neurosci Lett. 2009 Aug 21;460(1):87-91. Epub 2009 May 20. References - uncurated PubMed 12477932   14530511   14532269   15223841   15456855   15480745   15545705   15582725   15790724   16083987   16139950   16272159   16340176   16574776   16867182   17023532   17363453   17485162   17706597   17993760   18079205   18363807   18372242   18483176   18628614   19016354   19106217   19115393   19297186   19553459   19589870   19797429   19815586   20015464   20016135   20378540   20814072   21195069   21291903   21592969   22026435   22080499   22217849   22370764   22865430   22922167   23185594   339105   6272224   6946433   8521139   8889548 RGD Disease Portals Gh1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Biological Process Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Respiratory Pathways Genomics Position Markers BGH   Map Chr Position Strand Source Rat Cytogenetic Map 10 q32   UniSTS RGSC Genome Assembly v5.0 10 94,237,697 - 94,237,973   UniSTS RGSC Genome Assembly v3.4 10 95,692,424 - 95,692,700   UniSTS Rat Celera Assembly 10 89,904,117 - 89,904,393   UniSTS QTLs in Region (RGSC Genome Assembly v3.4) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 631530 Tls3 T-lymphoma susceptibility QTL 3 6.7 .0001 T-lymphoma susceptibility propylnitrosourea induced 10 53781298 100090301 Rat 631535 Cm51 Cardiac mass QTL 51 3 Cardiac mass 10 53792967 96584953 Rat 631542 Bp82 Blood pressure QTL 82 6.8 Blood pressure systolic 10 27184741 103551039 Rat 61449 Ciaa2 CIA Autoantibody QTL 2 7.1 Anti-type II collagen autoantibody titer collagen induced 10 64308668 95695218 Rat 1558652 Bw57 Body weight QTL 57 4.2 .0008 Body weight 10 95361338 140361338 Rat 1357344 Bp249 Blood pressure QTL 249 .0001 Blood pressure 10 69986912 102587587 Rat 631555 Bp134 Blood pressure QTL 134 .001 Blood pressure salt-loaded systolic 10 84262804 95694117 Rat 70171 Cari1 Carrageenan-induced inflammation QTL 1 4.9 .0005 Carrageenan-induced inflammation exudate volume 10 55851811 101848470 Rat 70193 Mcs7 Mammary carcinoma susceptibility QTL 7 2.38 Mammary tumor susceptibility 10 76698917 121698917 Rat 70364 Bp72 Blood pressure QTL 72 Blood pressure 10 55633982 100633982 Rat 61427 Cia16 Collagen induced arthritis QTL 16 3.2 Joint/bone inflammation type II collagen induced 10 6380753 100633982 Rat 724530 Bp149 Blood pressure QTL 149 .0001 Blood pressure 10 95066219 99588446 Rat 61387 Bp1 Blood pressure QTL 1 5.1 Blood pressure 10 53800677 101848470 Rat 631567 Bp91 Blood pressure QTL 91 .0001 Blood pressure systolic 10 56848683 101848683 Rat 1358188 Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 3.9 Gland mass pituitary 10 77092169 100633512 Rat 1298069 Bp168 Blood pressure QTL 168 5.5 Blood pressure salt-loaded systolic 10 27184741 102587587 Rat 1298078 Stresp5 Stress response QTL 5 2.99 .00025 Hormone level corticosterone 10 43458380 108776963 Rat 61354 Pia10 Pristane induced arthritis QTL 10 .01 Joint/bone inflammation pristane induced 10 24006429 160657542 Rat 61396 Bp9 Blood pressure QTL 9 4.8 .0001 Blood pressure salt-loaded systolic 10 72871396 117871396 Rat 634320 Niddm49 Non-insulin dependent diabetes mellitus QTL 49 4.41 Glucose level postprandial 10 92782172 101848683 Rat 1300107 Rf18 Renal function QTL 18 3.4 Renal function salt-loaded urine volume 10 82474813 102865929 Rat 1300137 Bp186 Blood pressure QTL 186 3.57 Blood pressure salt-loaded time series calculation 10 95066219 140066219 Rat 1354641 Bvd2 Brain ventricular dilatation QTL 2 6.36 .001 Head/brain development brain ventricular dilatation 10 79981838 124981838 Rat 1354608 Cm33 Cardiac mass QTL 33 2.8 Cardiac mass left ventricle 10 56930545 97589703 Rat 1358915 Stresp7 Stress response QTL 7 3.52 Hormone level norepinephrine 10 68955627 113955627 Rat 1554317 Bmd4 Bone mineral density QTL 4 9.4 .0001 Bone mineral density spine volumetric BMD by pQCT 10 20233281 104013574 Rat 1359017 Hrtrt21 Heart rate QTL 21 2.4 Heart rate stress-induced tachycardia 10 68526078 101292630 Rat 1549846 Scl47 Serum cholesterol level QTL 47 3.6 Lipid level baseline serum cholesterol 10 54091148 99091148 Rat 1576308 Schws1 Schwannoma susceptibility QTL 1 .0041 Neural tumor susceptibility tumor incidence, length of survival time 10 63816942 108816942 Rat 1576319 Cia29 Collagen induced arthritis QTL 29 Joint/bone inflammation type II collagen-induced 10 35131252 95695218 Rat 6893336 Cm75 Cardiac mass QTL 75 .1 .87 Cardiac mass body weight adjusted 10 67677924 100865886 Rat 1558643 Cm44 Cardiac mass QTL 44 4.8 .0000368 Cardiac mass body weight adjusted 10 67677924 100865886 Rat 1579915 Bp280 Blood pressure QTL 280 .001 Blood pressure mean arterial pressure 10 94837236 99588446 Rat 2293646 Bss25 Bone structure and strength QTL 25 10.96 .0001 Bone structure 10 74167134 119167134 Rat 2293663 Bss33 Bone structure and strength QTL 33 9.34 .0001 Bone structure 10 74167134 119167134 Rat 2292438 Bp311 Blood pressure QTL 311 Blood pressure arterial 10 79857808 99588446 Rat 2292617 Ept18 Estrogen-induced pituitary tumorigenesis QTL 18 3.9 Gland mass pituitary 10 77092169 100633512 Rat 1600367 Mcs15 Mammary carcinoma susceptibility QTL 15 4.5 Mammary tumor susceptibility 10 89575059 108822775 Rat 2303118 Mamtr7 Mammary tumor resistance QTL 7 .003 Mammary tumor resistance 10 9762188 108776963 Rat 2298548 Neuinf7 Neuroinflammation QTL 7 2.2 Neuroinflammation 10 65668446 132729388 Rat 2303589 Bw87 Body weight QTL 87 2 Body weight 10 86057484 131057484 Rat 2301398 Kidm38 Kidney mass QTL 38 .002 Kidney mass 10 87834315 100429624 Rat 2300172 Bmd57 Bone mineral density QTL 57 9.8 .0001 Bone mineral density 10 74167134 119167134 Rat 2293698 Bss43 Bone structure and strength QTL 43 5.33 .0001 Bone structure 10 62984501 107984501 Rat 2300218 Hpcl2 Hepatic cholesterol level QTL 2 Lipid level cholesterol 10 46483646 100090301 Rat 2306792 Ean4 Experimental allergic neuritis QTL 4 4 Peripheral nerve inflammation demyelination 10 87849516 98392508 Rat 2306793 Ean5 Experimental allergic neuritis QTL 5 4.7 Peripheral nerve inflammation demyelination 10 76043832 98392296 Rat 2313856 Bp342 Blood pressure QTL 342 4.4 .0001 Blood pressure 10 91455572 100633982 Rat 2317039 Aia6 Adjuvant induced arthritis QTL 6 4.31 Joint/bone inflammation adjuvant induced 10 70229781 115229781 Rat 2317029 Aia19 Adjuvant induced arthritis QTL 19 2.98 Joint/bone inflammation adjuvant induced 10 70229781 115229781 Rat 2316949 Gluco60 Glucose level QTL 60 3.7 Glucose level postprandial 10 14721135 154166503 Rat 2317754 Glom25 Glomerulus QTL 25 3.5 Renal pathology urine protein level 10 86810917 131810917 Rat 4889492 Pancm2 Pancreatic morphology QTL 2 3.2 Pancreatic morphology 10 81350126 126350126 Rat 4889948 Bss91 Bone structure and strength QTL 91 4 Bone structure 10 86316831 96799937 Rat 6893357 Bw102 Body weight QTL 102 .5 .36 Body weight 10 84262804 106479988 Rat 6893366 Bw106 Body weight QTL 106 .3 .47 Body weight 10 74652410 119652410 Rat 2306970 Anxrr22 Anxiety related response QTL 22 5.95 Anxiety response 10 67677924 102796362 Rat 1549831 Bss6 Bone structure and strength QTL 6 4 Bone strength Lumbar vertebra L5 ultimate force 10 61314296 106314296 Rat 61363 Oia3 Oil induced arthritis QTL 3 .001 Joint/bone inflammation oil induced 10 91455572 136455572 Rat 61332 Eau3 Experimental allergic uveoretinitis QTL 3 .004 Uvea inflammation score 10 35713452 101848683 Rat 631538 Oia5 Oil induced arthritis QTL 5 Joint/bone inflammation arthritis susceptibility 10 91168332 136168332 Rat 61325 Aia5 Adjuvant induced arthritis QTL 5 .01 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 61436 Cia5 Collagen induced arthritis QTL 5 4.9 Joint/bone inflammation arthritis severity 10 95692240 140692240 Rat 631269 Cia22 Collagen induced arthritis QTL 22 8.9 Joint/bone inflammation arthritis severity 10 41339689 152260081 Rat 631270 Cia23 Collagen induced arthritis QTL 23 3.9 Joint/bone inflammation arthritis severity 10 41339689 152260081 Rat 631267 Cia20 Collagen induced arthritis QTL 20 3.2 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 631268 Cia21 Collagen induced arthritis QTL 21 3.1 Joint/bone inflammation arthritis severity 10 14721135 159833317 Rat 70164 Bw21 Body weight QTL 21 4.36 .00005 Body weight 10 55851811 103550924 Rat Sequence Nucleotide Sequences Nucleotide RefSeqs NM_001034848 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AABR06065797 (Get FASTA) Search GEO for Microarray Profiles   AAHX01066261 (Get FASTA) Search GEO for Microarray Profiles   BC166872 (Get FASTA) Search GEO for Microarray Profiles   BC168778 (Get FASTA) Search GEO for Microarray Profiles   BI278832 (Get FASTA) Search GEO for Microarray Profiles   CB316202 (Get FASTA) Search GEO for Microarray Profiles   CH473948 (Get FASTA) Search GEO for Microarray Profiles   GQ890681 (Get FASTA) Search GEO for Microarray Profiles   U62779 (Get FASTA) Search GEO for Microarray Profiles   V01237 (Get FASTA) Search GEO for Microarray Profiles   V01238 (Get FASTA) Search GEO for Microarray Profiles   V01239 (Get FASTA) Search GEO for Microarray Profiles   X12967 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_001034848 RefSeq Status: VALIDATED Type: CODING Protein Acc Id: NP_001030020 Peptide Label: precursor Position: Map Chr Position Strand Source RGSC Genome Assembly v5.0 10 94,237,414 - 94,239,391 - NCBI RGSC Genome Assembly v3.4 10 95,692,240 - 95,694,117 - RGD Rat Celera Assembly 10 89,903,834 - 89,905,811 - NCBI Protein Sequences Protein RefSeqs NP_001030020 (Get FASTA) GenBank Protein AAB04025 (Get FASTA)   AAI66872 (Get FASTA)   ACX46986 (Get FASTA)   CAA24547 (Get FASTA)   CAA24548 (Get FASTA)   CAA24549 (Get FASTA)   EDM06381 (Get FASTA)   EDM06382 (Get FASTA)   EDM06383 (Get FASTA)   EDM06384 (Get FASTA)   EDM06385 (Get FASTA)   EDM06386 (Get FASTA)   EDM06387 (Get FASTA)   EDM06388 (Get FASTA)   EDM06389 (Get FASTA)   EDM06390 (Get FASTA)   EDM06391 (Get FASTA)   EDM06392 (Get FASTA)   EDM06393 (Get FASTA)   P01244 (Get FASTA) Promoters RGD ID: 6850024 Promoter ID: EP07104 Type: single initiation site Name: RN_SOMA Description: Growth hormone, GH1 or GH gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 44; Mammalian growth hormone Tissues & Cell Lines: pituitary Experiment Methods: Nuclease protection with homologous sequence ladder; RNA sequencing by primer extension; experiments performed with; closely related gene Position: Map Chr Position Strand Source RGSC Genome Assembly v3.4 10 95,694,117 - 95,694,177   EPD Strain Variation Strain Sequence Variants ACI/Eur (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 ACI/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN-Lx (ICL) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: SOLID Secondary Analysis: BWA, GATK, Samtools Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: MC-A654-5QB00 BN-Lx (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Academy of Sciences of the Czech Republic (Dr.Michal Pravenec) Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/NHsdMcwi (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) BN/SsN (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Buf/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) COP/Crl (MCW & UW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Univiersity of Wisconsin (Jim Shull) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 Breeder: Charles River Grant Information: NIH (CA77876) F344/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHH/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 FHH/EurMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) FHL/EurMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 GH/OmrMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v2.3-5 LE/Stm (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: Dr. Tadao Serikawa, Kyoto Japan. Grant Information: EURATRANS (HEALTH-F4-2010-241504) M520/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) MR/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHR/Olalpcv (ICL) Visual CSV TAB Printer Sequenced By: Imperial College London (Dr Timothy Aitman) University of British Columbia (Dr. Steven Jones) Platform: Illumina Hi-seq 2000 and GAII Secondary Analysis: BWA, GATK Breeder: Institute of Physiology, Academy of Sciences of the Czech Republic, Prague Grant Information: LSHG-CT-2005-019015, HEALTH-F4-2010-241504 SHR/Olalpcv (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Imperial College London (Dr Timothy Aitman) Platform: Illumina Secondary Analysis: GATK Grant Information: EURATRANS (HEALTH-F4-2010-241504) SHRSP/Gcrc (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruch Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: University of Glasgow, Anna Dominiczak Grant Information: EURATRANS (HEALTH-F4-2010-241504) SR/JrHsd (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Breeder: Harlan SS/JrHsdMcwi (MCW) Visual CSV TAB Printer Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob) Platform: Illumina HiSeq 2000 Secondary Analysis: BWA v0.5.9-r16 and GATK v1.3-14 Grant Information: R01 HL089930 SS/JrHsdMcwi (MDC) Visual CSV TAB Printer Sequenced By: Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: Illumina/Solexa, Genome Analyzer II Secondary Analysis: CASAVA Software v1.7 Breeder: Medical College of Wisconsin Grant Information: EURATRANS (HEALTH-F4-2010-241504) WKY/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) WN/N (KNAW) Visual CSV TAB Printer Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner) Platform: SOLID Secondary Analysis: SAP42 (Developed at RNAAS) Breeder: National Institutes of Health Grant Information: EURATRANS (HEALTH-F4-2010-241504) Additional Information External Database Links Database Acc Id Source(s) Ensembl Genes ENSRNOG00000011207 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Protein ENSRNOP00000015818 ENTREZGENE, UniProtKB/Swiss-Prot Ensembl Transcript ENSRNOT00000015818 ENTREZGENE, UniProtKB/Swiss-Prot Entrez Gene 24391 ENTREZGENE Gene3D-CATH 4_helix_cytokine_core UniProtKB/Swiss-Prot Germonline ENSRNOG00000011207 UniProtKB/Swiss-Prot HomoloGene Group ID 47932 ENTREZGENE IMAGE_CLONE IMAGE:6922077 IMAGE-MGC_LOAD InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot   4_helix_cytokine_core UniProtKB/Swiss-Prot   Somatotropin UniProtKB/Swiss-Prot   Somatotropin_CS UniProtKB/Swiss-Prot KEGG Report rno:24391 ENTREZGENE, UniProtKB/Swiss-Prot MGC_CLONE MGC:188794 IMAGE-MGC_LOAD PANTHER Somatotropin UniProtKB/Swiss-Prot Pfam Hormone_1 UniProtKB/Swiss-Prot PRINTS SOMATOTROPIN UniProtKB/Swiss-Prot PROSITE SOMATOTROPIN_1 UniProtKB/Swiss-Prot   SOMATOTROPIN_2 UniProtKB/Swiss-Prot Superfamily-SCOP 4_helix_cytokine UniProtKB/Swiss-Prot UniGene Rn.146351 ENTREZGENE UniProt B2RYR2_RAT UniProtKB/TrEMBL   SOMA_RAT UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2002-06-10 Gh1  growth hormone 1      Symbol and Name status set to approved 1490 APPROVED RGD Curation Notes Note Type Note Reference gene_expression expressed in hemopoietic cells 61524 gene_expression expressed in hemopoietic cells 625493 gene_function hormone and a ligand for growth hormone receptor 625703 gene_process plays an important role in growth regulation 625703 gene_process causes a dose and time dependent increase in tyrosine phosphorylation of Stat 5 protein; induces cytokine inducible SH2-containing protein 2 (Cish2) 625703 gene_regulation insulin blocks growth hormone functions in hepatocytes 625703

More on Gh1 Entrez Gene Ensembl Gene Genome Browser NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 2686 Created: 2000-05-25 Species: Rattus norvegicus Last Modified: 2013-05-28 Status: ACTIVE