Gene: Map2k1 (mitogen activated protein kinase kinase 1) Rattus norvegicus
Symbol: Map2k1
Name: mitogen activated protein kinase kinase 1
Description: ENCODES a protein that exhibits ATP binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; INVOLVED IN activation of MAPK activity; cell proliferation; Golgi inheritance; PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; ASSOCIATED WITH impaired smooth muscle contractility; ASSOCIATED WITH Liver Neoplasms, Experimental; Prostatic Neoplasms; Brain Ischemia (ortholog); FOUND IN axon; cell cortex; cytosol; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,6-dinitrotoluene
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; MAPK/ERK kinase 1; MAPKK 1; Mek1; mitogen-activated protein kinase kinase 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0869,134,218 - 69,722,573 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0868,840,454 - 68,877,679 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4868,379,074 - 68,451,554 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1868,398,125 - 68,470,608 (-)NCBI
Celera864,090,188 - 64,161,314 (-)NCBI
Cytogenetic Map8q24NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k1
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 70495
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2016-10-11
Status: ACTIVE