Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Synm (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of SYNM mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | increases expression | ISO | Synm (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SYNM mRNA | CTD | PMID:22206623 | 17beta-estradiol | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Estradiol results in increased expression of SYNM mRNA | CTD | PMID:31614463 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Synm (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SYNM mRNA | CTD | PMID:20159946 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SYNM mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SYNM mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Synm (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SYNM mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SYNM mRNA | CTD | PMID:30851411 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Synm (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of SYNM mRNA | CTD | PMID:25172293 | 3,7-dihydropurine-6-thione | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of SYNM mRNA | CTD | PMID:23358152 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of SYNM mRNA | CTD | PMID:28628672 | 3-methylcholanthrene | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Methylcholanthrene results in decreased expression of SYNM mRNA | CTD | PMID:20713471 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of SYNM mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Synm (Mus musculus) | 6480464 | bisphenol S affects the methylation of SYNM gene | CTD | PMID:31683443 | 4,4'-sulfonyldiphenol | decreases expression | ISO | Synm (Mus musculus) | 6480464 | bisphenol S results in decreased expression of SYNM mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | increases expression | ISO | Synm (Mus musculus) | 6480464 | Fenretinide results in increased expression of SYNM mRNA | CTD | PMID:28973697 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SYNM mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SYNM mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SYNM mRNA | CTD | PMID:32699268 | acrylamide | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Acrylamide results in increased expression of SYNM mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | Synm (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SYNM mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | SYNM (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SYNM intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SYNM mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Tretinoin results in decreased expression of SYNM mRNA | CTD | PMID:37278767 | alpha-pinene | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SYNM mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of SYNM mRNA | CTD | PMID:32699268 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SYNM mRNA | CTD | PMID:16483693 | antirheumatic drug | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SYNM mRNA | CTD | PMID:24449571 | arsane | affects methylation | ISO | SYNM (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYNM gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | SYNM (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYNM gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SYNM mRNA] | CTD | PMID:32406909 | belinostat | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | belinostat results in decreased expression of SYNM mRNA | CTD | PMID:27188386 | benzo[a]pyrene | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of SYNM mRNA | CTD | PMID:23735875 | benzo[a]pyrene | affects methylation | ISO | SYNM (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SYNM intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | SYNM (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SYNM exon and Benzo(a)pyrene results in increased methylation of SYNM promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Synm (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SYNM mRNA | CTD | PMID:19770486 and PMID:22228805 | benzo[a]pyrene | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of SYNM mRNA | CTD | PMID:20106945 and PMID:21632981 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SYNM mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | Synm (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SYNM mRNA | CTD | PMID:32365465 | bisphenol A | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SYNM mRNA and bisphenol A results in decreased expression of SYNM protein | CTD | PMID:27685785 more ... | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SYNM mRNA | CTD | PMID:18180321 | Bisphenol B | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SYNM protein | CTD | PMID:34186270 | bisphenol F | decreases expression | ISO | Synm (Mus musculus) | 6480464 | bisphenol F results in decreased expression of SYNM mRNA | CTD | PMID:30951980 | bisphenol F | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | bisphenol F results in increased expression of SYNM protein | CTD | PMID:34186270 | cadmium atom | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SYNM mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SYNM mRNA | CTD | PMID:35301059 | calcitriol | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Calcitriol results in increased expression of SYNM mRNA | CTD | PMID:26485663 | carbamazepine | affects expression | ISO | SYNM (Homo sapiens) | 6480464 | Carbamazepine affects the expression of SYNM mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to DMN gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of SYNM mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNM mRNA | CTD | PMID:20938992 | cisplatin | increases expression | ISO | Synm (Mus musculus) | 6480464 | Cisplatin results in increased expression of SYNM mRNA | CTD | PMID:25270620 | cisplatin | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in increased expression of SYNM mRNA | CTD | PMID:27392435 | cisplatin | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SYNM mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SYNM mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SYNM mRNA | CTD | PMID:20971185 | corticosterone | increases expression | EXP | | 6480464 | Corticosterone results in increased expression of SYNM mRNA | CTD | PMID:15755911 | cyclosporin A | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SYNM mRNA | CTD | PMID:25562108 | deoxynivalenol | affects phosphorylation | ISO | Synm (Mus musculus) | 6480464 | deoxynivalenol affects the phosphorylation of SYNM protein | CTD | PMID:23811945 | dexamethasone | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of SYNM mRNA | CTD | PMID:28628672 | diallyl trisulfide | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | diallyl trisulfide results in decreased expression of SYNM mRNA | CTD | PMID:34995734 | dicrotophos | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | dicrotophos results in increased expression of SYNM mRNA | CTD | PMID:28302478 | dioxygen | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SYNM mRNA | CTD | PMID:30529165 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of SYNM mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | entinostat results in increased expression of SYNM mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNM mRNA | CTD | PMID:27188386 | ethanol | increases expression | ISO | Synm (Mus musculus) | 6480464 | Ethanol results in increased expression of SYNM mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | Synm (Mus musculus) | 6480464 | Ethanol affects the splicing of SYNM mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNM mRNA | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SYNM mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | SYNM (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SYNM protein | CTD | PMID:37730182 | GW 4064 | increases expression | ISO | Synm (Mus musculus) | 6480464 | GW 4064 results in increased expression of SYNM mRNA | CTD | PMID:26655953 | indometacin | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of SYNM mRNA | CTD | PMID:28628672 | inulin | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SYNM mRNA | CTD | PMID:36331819 | ivermectin | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SYNM protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SYNM mRNA | CTD | PMID:20938992 | lead(0) | affects expression | ISO | SYNM (Homo sapiens) | 6480464 | Lead affects the expression of SYNM mRNA | CTD | PMID:28903495 | mercaptopurine | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of SYNM mRNA | CTD | PMID:23358152 | methylmercury chloride | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of SYNM mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SYNM gene | CTD | PMID:33148267 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of SYNM mRNA | CTD | PMID:28801915 | nickel atom | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Nickel results in decreased expression of SYNM mRNA | CTD | PMID:25583101 | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of SYNM mRNA | CTD | PMID:23665939 | ozone | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of SYNM mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of SYNM mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of SYNM mRNA | CTD | PMID:27106289 and PMID:34911549 | paracetamol | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SYNM mRNA | CTD | PMID:21420995 and PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SYNM mRNA | CTD | PMID:33387578 | paracetamol | affects expression | ISO | Synm (Mus musculus) | 6480464 | Acetaminophen affects the expression of SYNM mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Synm (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of SYNM mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of SYNM mRNA | CTD | PMID:36331819 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of SYNM gene | CTD | PMID:33148267 | phenylmercury acetate | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of SYNM mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SYNM mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of SYNM mRNA | CTD | PMID:22714537 | progesterone | increases expression | ISO | Synm (Mus musculus) | 6480464 | Progesterone results in increased expression of SYNM mRNA | CTD | PMID:22238285 | purine-6-thiol | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of SYNM mRNA | CTD | PMID:23358152 | rac-lactic acid | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SYNM mRNA | CTD | PMID:30851411 | SB 431542 | multiple interactions | ISO | SYNM (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of SYNM mRNA | CTD | PMID:25895662 | sodium arsenate | increases expression | ISO | Synm (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SYNM mRNA | CTD | PMID:21795629 | sodium arsenite | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SYNM mRNA | CTD | PMID:28595984 more ... | sodium arsenite | decreases expression | ISO | Synm (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SYNM mRNA | CTD | PMID:37682722 | sodium arsenite | decreases expression | EXP | | 6480464 | sodium arsenite results in decreased expression of SYNM protein | CTD | PMID:29459688 | sodium fluoride | increases expression | ISO | Synm (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of SYNM protein | CTD | PMID:28918527 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of SYNM mRNA | CTD | PMID:19281266 | sulforaphane | decreases expression | ISO | Synm (Mus musculus) | 6480464 | sulforaphane results in decreased expression of SYNM mRNA | CTD | PMID:30529165 | temozolomide | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Temozolomide results in increased expression of SYNM mRNA | CTD | PMID:31758290 | tetrachloromethane | decreases expression | ISO | Synm (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of SYNM mRNA | CTD | PMID:17484886 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of SYNM protein | CTD | PMID:16484507 | titanium dioxide | decreases expression | ISO | Synm (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of DMN mRNA and titanium dioxide results in decreased expression of SYNM mRNA | CTD | PMID:23557971 and PMID:27760801 | trichostatin A | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | trichostatin A results in increased expression of SYNM mRNA | CTD | PMID:24935251 | triclosan | decreases expression | ISO | SYNM (Homo sapiens) | 6480464 | Triclosan results in decreased expression of SYNM mRNA | CTD | PMID:30510588 | triptonide | increases expression | ISO | Synm (Mus musculus) | 6480464 | triptonide results in increased expression of SYNM mRNA | CTD | PMID:33045310 | urethane | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Urethane results in increased expression of SYNM mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | SYNM (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SYNM gene | CTD | PMID:29154799 | valproic acid | increases expression | ISO | SYNM (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SYNM mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | SYNM (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SYNM mRNA | CTD | PMID:25979313 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
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