Lrrc8d (leucine rich repeat containing 8 VRAC subunit D) - Rat Genome Database

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Gene: Lrrc8d (leucine rich repeat containing 8 VRAC subunit D) Rattus norvegicus
Analyze
Symbol: Lrrc8d
Name: leucine rich repeat containing 8 VRAC subunit D
RGD ID: 1309601
Description: Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Part of monoatomic ion channel complex. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine rich repeat containing 5; leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D; LOC305131; Lrrc5; MGC93739; volume-regulated anion channel subunit LRRC8D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,335,114 - 4,411,549 (-)NCBIGRCr8
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,031,137 - 4,046,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,331,273 - 5,346,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,034,927 - 4,050,056 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Celera144,193,278 - 4,208,420 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
hypochlorous acid  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
endoplasmic reticulum membrane  (IEA)
membrane  (ISO,ISS)
monoatomic ion channel complex  (IBA,IEA,IMP,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes. Schober AL, etal., J Physiol. 2017 Nov 15;595(22):6939-6951. doi: 10.1113/JP275053. Epub 2017 Sep 12.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19946888   PMID:24790029   PMID:26824658   PMID:28193731  


Genomics

Comparative Map Data
Lrrc8d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,335,114 - 4,411,549 (-)NCBIGRCr8
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx144,031,137 - 4,046,274 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,331,273 - 5,346,414 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,034,927 - 4,050,056 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Celera144,193,278 - 4,208,420 (-)NCBICelera
Cytogenetic Map14p22NCBI
LRRC8D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,821,032 - 89,936,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,821,014 - 89,936,611 (+)EnsemblGRCh38hg38GRCh38
GRCh37190,286,591 - 90,402,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36190,060,101 - 90,174,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 34189,999,533 - 90,113,580NCBI
Celera188,532,275 - 88,647,680 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,403,943 - 88,519,276 (+)NCBIHuRef
CHM1_1190,401,923 - 90,517,356 (+)NCBICHM1_1
T2T-CHM13v2.0189,664,217 - 89,779,829 (+)NCBIT2T-CHM13v2.0
Lrrc8d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,847,829 - 105,963,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,847,835 - 105,980,302 (+)EnsemblGRCm39 Ensembl
GRCm385105,699,963 - 105,815,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,699,969 - 105,832,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv375106,128,988 - 106,244,234 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365105,934,781 - 106,055,512 (+)NCBIMGSCv36mm8
Celera5102,815,568 - 102,929,479 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Lrrc8d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,237,651 - 4,240,227 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554234,237,263 - 4,360,352 (-)NCBIChiLan1.0ChiLan1.0
LRRC8D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,088,794 - 137,203,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,244,564 - 136,359,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,481,871 - 92,606,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,232,146 - 91,346,539 (+)NCBIpanpan1.1PanPan1.1panPan2
LRRC8D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,692,352 - 58,805,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,692,792 - 58,695,368 (-)NCBICanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha661,401,528 - 61,514,644 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0659,086,742 - 59,089,777 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)NCBIROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,777,879 - 58,890,397 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0659,211,040 - 59,323,995 (-)NCBIUU_Cfam_GSD_1.0
Lrrc8d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,984,575 - 100,097,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365378,850,411 - 8,963,448 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365378,850,411 - 8,963,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,542,451 - 43,659,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,542,806 - 43,545,382 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603374,274,555 - 74,391,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247427,822,880 - 7,946,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247427,822,880 - 7,947,731 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc8d
1005 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:41
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000002888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat

Markers in Region
D14Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,041,872 - 4,042,062 (+)MAPPERmRatBN7.2
Rnor_6.0145,097,667 - 5,097,856NCBIRnor6.0
Rnor_5.0145,089,537 - 5,089,726UniSTSRnor5.0
RGSC_v3.4145,116,492 - 5,116,681UniSTSRGSC3.4
RGSC_v3.4145,116,491 - 5,116,681RGDRGSC3.4
RGSC_v3.1145,116,492 - 5,116,681RGD
Celera144,204,900 - 4,205,089UniSTS
RH 3.4 Map1479.2RGD
RH 3.4 Map1479.2UniSTS
RH 2.0 Map14105.5RGD
SHRSP x BN Map142.29RGD
FHH x ACI Map141.33RGD
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 57 41 19 41 74 35 35 11
Low 17 8 11 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002888   ⟹   ENSRNOP00000002888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,030,260 - 4,045,384 (-)Ensembl
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094660   ⟹   ENSRNOP00000096115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,721 - 4,135,877 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105738   ⟹   ENSRNOP00000091428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,854 - 4,106,975 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106093   ⟹   ENSRNOP00000081098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,854 - 4,118,076 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109682   ⟹   ENSRNOP00000090251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,812 - 4,129,314 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112887   ⟹   ENSRNOP00000087579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,812 - 4,135,626 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117756   ⟹   ENSRNOP00000092059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,473 - 4,134,929 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118999   ⟹   ENSRNOP00000096292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,473 - 4,134,803 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119904   ⟹   ENSRNOP00000078114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl144,029,473 - 4,134,957 (-)Ensembl
RefSeq Acc Id: NM_001008338   ⟹   NP_001008339
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,335,114 - 4,350,236 (-)NCBI
mRatBN7.2144,030,259 - 4,045,384 (-)NCBI
Rnor_6.0145,086,053 - 5,101,177 (-)NCBI
Rnor_5.0145,077,476 - 5,157,358 (-)NCBI
RGSC_v3.4145,104,878 - 5,120,038 (-)RGD
Celera144,193,278 - 4,208,420 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091810   ⟹   XP_038947738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,335,114 - 4,411,549 (-)NCBI
mRatBN7.2144,029,971 - 4,134,922 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001008339   ⟸   NM_001008338
- UniProtKB: A0A0H2UHA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002888   ⟸   ENSRNOT00000002888
RefSeq Acc Id: XP_038947738   ⟸   XM_039091810
- Peptide Label: isoform X1
- UniProtKB: Q5U308 (UniProtKB/Swiss-Prot),   A6K5Q0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090251   ⟸   ENSRNOT00000109682
RefSeq Acc Id: ENSRNOP00000092059   ⟸   ENSRNOT00000117756
RefSeq Acc Id: ENSRNOP00000078114   ⟸   ENSRNOT00000119904
RefSeq Acc Id: ENSRNOP00000081098   ⟸   ENSRNOT00000106093
RefSeq Acc Id: ENSRNOP00000096115   ⟸   ENSRNOT00000094660
RefSeq Acc Id: ENSRNOP00000087579   ⟸   ENSRNOT00000112887
RefSeq Acc Id: ENSRNOP00000091428   ⟸   ENSRNOT00000105738
RefSeq Acc Id: ENSRNOP00000096292   ⟸   ENSRNOT00000118999
Protein Domains
LRRC8 pannexin-like TM region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U308-F1-model_v2 AlphaFold Q5U308 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309601 AgrOrtholog
BioCyc Gene G2FUF-16554 BioCyc
Ensembl Genes ENSRNOG00000002121 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002888 ENTREZGENE
  ENSRNOT00000002888.5 UniProtKB/TrEMBL
  ENSRNOT00000094660.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105738.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106093.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109682.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112887.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117756.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118999.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119904.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107805 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93739 IMAGE-MGC_LOAD
NCBI Gene 305131 ENTREZGENE
PANTHER LEUCINE RICH REPEAT CONTAINING 8 VRAC SUBUNIT A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR48051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pannexin_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrc8d PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002121 RatGTEx
SMART LRR_SD22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHA3 ENTREZGENE, UniProtKB/TrEMBL
  A6K5Q0 ENTREZGENE, UniProtKB/TrEMBL
  LRC8D_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Lrrc8d  leucine rich repeat containing 8 VRAC subunit D  Lrrc8d  leucine rich repeat containing 8 family, member D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrrc8d  leucine rich repeat containing 8 family, member D  Lrrc8d  leucine rich repeat containing 8D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Lrrc8d  leucine rich repeat containing 8D  Lrrc8d  leucine rich repeat containing 8 family, member D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrrc8d  leucine rich repeat containing 8 family, member D  Lrrc5  leucine-rich repeat-containing 5  Symbol and Name updated 1299863 APPROVED
2005-12-06 Lrrc5  leucine-rich repeat-containing 5  Lrrc5_predicted  leucine-rich repeat-containing 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrrc5_predicted  leucine-rich repeat-containing 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED