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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62296 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of CASK mRNA | CTD | PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:62296 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CASK mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CASK mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CASK mRNA] | CTD | PMID:21215274 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of CASK mRNA | CTD | PMID:21346803 | 3-methylcholanthrene | decreases expression | ISO | RGD:62296 | 6480464 | Methylcholanthrene results in decreased expression of CASK mRNA | CTD | PMID:20713471 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of CASK mRNA | CTD | PMID:19162173 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:733678 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of CASK mRNA | CTD | PMID:12419474 | 7,12-dimethyltetraphene | increases expression | EXP | | 6480464 | 9,10-Dimethyl-1,2-benzanthracene results in increased expression of CASK mRNA | CTD | PMID:12376462 | aflatoxin B1 | affects expression | ISO | RGD:733678 | 6480464 | Aflatoxin B1 affects the expression of CASK protein | CTD | PMID:20106945 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CASK mRNA | CTD | PMID:16483693 | benzo[a]pyrene | decreases expression | ISO | RGD:733678 | 6480464 | Benzo(a)pyrene results in decreased expression of CASK mRNA | CTD | PMID:20106945 PMID:20064835 | benzo[a]pyrene | decreases expression | ISO | RGD:733678 | 6480464 | Benzo(a)pyrene results in decreased expression of CASK mRNA | CTD | PMID:20064835 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:733678 | 6480464 | Benzo(a)pyrene results in decreased expression of CASK mRNA | CTD | PMID:20064835 PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:62296 | 6480464 | Benzo(a)pyrene results in decreased expression of CASK mRNA | CTD | PMID:19770486 | bis(2-chloroethyl) sulfide | affects expression | EXP | | 6480464 | Mustard Gas affects the expression of CASK mRNA | CTD | PMID:15651846 | calcitriol | increases expression | ISO | RGD:733678 | 6480464 | Calcitriol results in increased expression of CASK mRNA | CTD | PMID:16002434 | cyclosporin A | increases expression | ISO | RGD:733678 | 6480464 | Cyclosporine results in increased expression of CASK mRNA | CTD | PMID:20106945 | diarsenic trioxide | increases expression | ISO | RGD:733678 | 6480464 | arsenic trioxide results in increased expression of CASK mRNA | CTD | PMID:20458559 | disodium selenite | decreases expression | ISO | RGD:62296 | 6480464 | Sodium Selenite results in decreased expression of CASK mRNA | CTD | PMID:23274088 | hydrogen peroxide | decreases expression | ISO | RGD:733678 | 6480464 | Hydrogen Peroxide results in decreased expression of CASK mRNA | CTD | PMID:12419474 | lead(0) | decreases expression | ISO | RGD:733678 | 6480464 | Lead results in decreased expression of CASK mRNA | CTD | PMID:19921347 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of CASK mRNA | CTD | PMID:20360939 | phenobarbital | affects expression | ISO | RGD:62296 | 6480464 | Phenobarbital affects the expression of CASK mRNA | CTD | PMID:23091169 | succimer | multiple interactions | ISO | RGD:62296 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CASK mRNA | CTD | PMID:21641980 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:733678 | 6480464 | tert-Butylhydroperoxide results in decreased expression of CASK mRNA | CTD | PMID:12419474 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Tight junction |
| Pathway Interaction Database | Syndecan-1-mediated signaling events (PID:200156) |
| Syndecan-2-mediated signaling events (PID:200192) | |
| Syndecan-3-mediated signaling events (PID:200198) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Tight junction |
| Pathway Interaction Database | Syndecan-1-mediated signaling events (PID:200156) |
| Syndecan-2-mediated signaling events (PID:200192) | |
| Syndecan-3-mediated signaling events (PID:200198) | |
References - curated| 1. |
Butz S, etal., Cell 1998 Sep 18;94(6):773-82. |
| 2. |
Dimitratos SD, etal., Genomics 1998 Jul 15;51(2):308-9. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Hata Y, etal., J Neurosci 1996 Apr 15;16(8):2488-94. |
| 5. |
Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30. |
| 6. |
Hsueh YP, etal., J Neurosci. 2001 Jun 1;21(11):3764-70. |
| 7. |
Lehtonen S, etal., Am J Pathol. 2004 Sep;165(3):923-36. |
| 8. |
Leonoudakis D, etal., J Biol Chem 2004 Apr 30;279(18):19051-63. Epub 2004 Feb 11. |
| 9. |
Leonoudakis D, etal., J Biol Chem. 2004 May 21;279(21):22331-46. Epub 2004 Mar 15. |
| 10. |
MGD data from the GO Consortium |
| 11. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 12. |
Olsen O and Bredt DS, J Biol Chem 2003 Feb 28;278(9):6873-8. |
| 13. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 14. |
RGD automated data pipeline |
| 15. |
RGD automated import pipeline for gene-chemical interactions |
| 16. |
RGD Automated Pipelines |
| 17. |
Schuh K, etal., J Biol Chem 2003 Mar 14;278(11):9778-83. |
| 18. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 19. |
Yap CC, etal., J Neurochem 2003 Apr;85(1):123-34. |
References - uncurated| PubMed | 10749215 |
| 11036064 | |
| 11865057 | |
| 12040031 | |
| 12151521 | |
| 12351654 | |
| 14627983 | |
| 15048107 | |
| 15266631 | |
| 18596612 | |
| 18606847 | |
| 18664494 | |
| 19275891 | |
| 19620977 | |
| 19781660 | |
| 22871113 |
RGD Disease Portals| Cask has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cask (Rattus norvegicus) |
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| CASK (Homo sapiens) |
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| Cask (Mus musculus) |
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Position Markers| DXRat48 |
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| DxGot4 |
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| RH144070 |
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| BF404609 |
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| AU049649 |
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| Cask |
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| UniSTS:256965 |
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| Cask |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022184 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06102631 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06102632 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102633 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102634 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102635 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102636 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102638 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102639 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06102640 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108976 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108977 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108978 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108979 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108980 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108981 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108982 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108983 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108984 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01108985 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474009 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U47110 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Y08769 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022184 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_071520 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_071520 | (Get FASTA) |
| GenBank Protein | AAB19127 | (Get FASTA) |
| CAA70022 | (Get FASTA) | |
| EDL97656 | (Get FASTA) | |
| EDL97657 | (Get FASTA) | |
| EDL97658 | (Get FASTA) | |
| EDL97659 | (Get FASTA) | |
| Q62915 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003054 | UniProtKB/TrEMBL |
| ENSRNOG00000039759 | UniProtKB/TrEMBL | |
| Ensembl Protein | ENSRNOP00000004187 | UniProtKB/TrEMBL |
| ENSRNOP00000057707 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000004187 | UniProtKB/TrEMBL |
| ENSRNOT00000060988 | UniProtKB/TrEMBL | |
| Entrez Gene | 29647 | ENTREZGENE |
| Germonline | ENSRNOG00000003054 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2736 | ENTREZGENE |
| InterPro | GPCR_Rhodpsn | UniProtKB/TrEMBL |
| GPCR_Rhodpsn_7TM | UniProtKB/TrEMBL | |
| Guanylate_kin | UniProtKB/Swiss-Prot | |
| Guanylate_kin/L-typ_Ca_channel | UniProtKB/Swiss-Prot | |
| Guanylate_kinase_CS | UniProtKB/Swiss-Prot | |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| L27 | UniProtKB/Swiss-Prot | |
| L27_C | UniProtKB/Swiss-Prot | |
| P-loop_NTPase | UniProtKB/Swiss-Prot | |
| P2_purnocptor | UniProtKB/TrEMBL | |
| PDZ/DHR/GLGF | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Ser/Thr_prot_kinase_dom | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29647 | ENTREZGENE, UniProtKB/Swiss-Prot |
| rno:554353 | UniProtKB/TrEMBL | |
| Pfam | 7tm_1 | UniProtKB/TrEMBL |
| Guanylate_kin | UniProtKB/Swiss-Prot | |
| L27 | UniProtKB/Swiss-Prot | |
| PDZ | UniProtKB/Swiss-Prot | |
| Pkinase | UniProtKB/Swiss-Prot | |
| SH3_2 | UniProtKB/Swiss-Prot | |
| PRINTS | GPCRRHODOPSN | UniProtKB/TrEMBL |
| P2YPURNOCPTR | UniProtKB/TrEMBL | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/TrEMBL |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/TrEMBL | |
| GUANYLATE_KINASE_1 | UniProtKB/Swiss-Prot | |
| GUANYLATE_KINASE_2 | UniProtKB/Swiss-Prot | |
| L27 | UniProtKB/Swiss-Prot | |
| PDZ | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ATP; FALSE_NEG | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST; FALSE_NEG | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | GuKc | UniProtKB/Swiss-Prot |
| L27 | UniProtKB/Swiss-Prot | |
| PDZ | UniProtKB/Swiss-Prot | |
| S_TKc | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| PDZ | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SSF52540 | UniProtKB/Swiss-Prot | |
| TIGR | TC218599 | |
| UniGene | Rn.72627 | ENTREZGENE |
| UniProt | CSKP_RAT | UniProtKB/Swiss-Prot |
| D4A8M2_RAT | UniProtKB/TrEMBL | |
| Q6XCE7_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2006-03-30 | Cask | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | calcium/calmodulin-dependent serine protein kinase | Name updated | 10779 | APPROVED | |
| 2002-06-10 | Cask | calcium/calmodulin-dependent serine protein kinase | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains a calmodulin-dependent protein kinase-like domain, PDZ, SH3, and guanylate kinase-like domains | 728219 |
| More on Cask | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 62004 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




