Alcam (activated leukocyte cell adhesion molecule) - Rat Genome Database

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Gene: Alcam (activated leukocyte cell adhesion molecule) Rattus norvegicus
Analyze
Symbol: Alcam
Name: activated leukocyte cell adhesion molecule
RGD ID: 619972
Description: Predicted to enable identical protein binding activity. Predicted to be involved in axon extension involved in axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retinal ganglion cell axon guidance. Predicted to act upstream of or within motor neuron axon guidance. Predicted to be located in several cellular components, including external side of plasma membrane; immunological synapse; and neuronal cell body. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD166 antigen; HB2; KG-CAM; SB-10 antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,804,932 - 62,005,250 (+)NCBIGRCr8
mRatBN7.21148,336,123 - 48,536,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,336,169 - 48,537,954 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1157,110,123 - 57,309,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,771,802 - 49,971,585 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,895,907 - 49,095,677 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,780,735 - 50,985,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,781,127 - 50,985,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01153,964,563 - 54,165,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,424,243 - 49,630,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11149,481,831 - 49,687,660 (+)NCBI
Celera1148,024,575 - 48,218,199 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
clobetasol  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fonofos  (ISO)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
heptachlor  (EXP)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
miconazole  (ISO)
mitomycin C  (ISO)
Muraglitazar  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-1,4-benzoquinone imine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
dendrite  (IEA)
external side of plasma membrane  (IEA,ISO)
immunological synapse  (IEA,ISO,ISS)
neuronal cell body  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
T cell receptor complex  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trisomy 10p due to t(5;10)(p15;p11) segregating in a large sibship. Back E, etal., Hum Genet 1978 Feb 23;41(1):11-7.
2. Mesenchymal stem cell surface antigen SB-10 corresponds to activated leukocyte cell adhesion molecule and is involved in osteogenic differentiation. Bruder SP, etal., J Bone Miner Res 1998 Apr;13(4):655-63.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins. Matsumoto A, etal., J Biol Chem 1997 Jul 4;272(27):16778-82.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Shan L, etal., Toxicol Pathol. 2005;33(7):768-75.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8004458   PMID:9209500   PMID:15294938   PMID:15345243   PMID:15489334   PMID:16267219   PMID:16352806   PMID:16650408   PMID:19056867   PMID:19481784   PMID:20458337   PMID:21423176  
PMID:22243278   PMID:26146185   PMID:28720382  


Genomics

Comparative Map Data
Alcam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,804,932 - 62,005,250 (+)NCBIGRCr8
mRatBN7.21148,336,123 - 48,536,296 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1148,336,169 - 48,537,954 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1157,110,123 - 57,309,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,771,802 - 49,971,585 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,895,907 - 49,095,677 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,780,735 - 50,985,083 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,781,127 - 50,985,083 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01153,964,563 - 54,165,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41149,424,243 - 49,630,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11149,481,831 - 49,687,660 (+)NCBI
Celera1148,024,575 - 48,218,199 (+)NCBICelera
Cytogenetic Map11q21NCBI
ALCAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383105,366,909 - 105,576,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3105,366,909 - 105,576,900 (+)EnsemblGRCh38hg38GRCh38
GRCh373105,085,753 - 105,295,744 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363106,568,403 - 106,778,434 (+)NCBINCBI36Build 36hg18NCBI36
Build 343106,568,879 - 106,776,709NCBI
Celera3103,484,109 - 103,694,111 (+)NCBICelera
Cytogenetic Map3q13.11NCBI
HuRef3102,460,407 - 102,670,632 (+)NCBIHuRef
CHM1_13105,048,389 - 105,258,778 (+)NCBICHM1_1
T2T-CHM13v2.03108,084,937 - 108,294,916 (+)NCBIT2T-CHM13v2.0
Alcam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391652,069,359 - 52,273,444 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1652,069,359 - 52,274,437 (-)EnsemblGRCm39 Ensembl
GRCm381652,248,996 - 52,453,081 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,248,996 - 52,454,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv371652,249,109 - 52,453,110 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361652,170,261 - 52,373,422 (-)NCBIMGSCv36mm8
Celera1652,580,657 - 52,784,804 (-)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1632.88NCBI
Alcam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554276,494,124 - 6,545,963 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554276,494,657 - 6,544,668 (+)NCBIChiLan1.0ChiLan1.0
ALCAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22103,319,297 - 103,529,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13103,325,067 - 103,534,696 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03102,468,354 - 102,677,932 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13109,407,296 - 109,616,518 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3109,407,992 - 109,616,518 (+)Ensemblpanpan1.1panPan2
ALCAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13310,983,363 - 11,195,170 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3310,983,363 - 11,370,085 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3311,088,414 - 11,300,048 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03311,141,772 - 11,353,405 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3311,141,772 - 11,353,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13311,011,197 - 11,222,028 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03311,078,031 - 11,289,490 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03311,486,320 - 11,697,980 (+)NCBIUU_Cfam_GSD_1.0
Alcam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602145,582,988 - 145,771,697 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936701895,376 - 1,084,172 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936701895,414 - 1,084,155 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALCAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13153,794,993 - 153,998,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113153,794,991 - 153,998,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213162,988,454 - 163,045,771 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALCAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12275,261,104 - 75,475,201 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2275,260,970 - 75,321,082 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604191,034,797 - 91,244,770 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alcam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473144,091,769 - 44,280,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473144,092,505 - 44,280,022 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alcam
792 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:87
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000002738
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat

Markers in Region
D11Got122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,515,156 - 48,515,439 (+)MAPPERmRatBN7.2
Rnor_6.01150,963,785 - 50,964,067NCBIRnor6.0
Rnor_5.01154,144,338 - 54,144,620UniSTSRnor5.0
RGSC_v3.41149,608,932 - 49,609,214UniSTSRGSC3.4
Celera1148,197,060 - 48,197,342UniSTS
Cytogenetic Map11q21UniSTS
BE119309  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,524,043 - 48,524,252 (+)MAPPERmRatBN7.2
Rnor_6.01150,972,672 - 50,972,880NCBIRnor6.0
Rnor_5.01154,153,225 - 54,153,433UniSTSRnor5.0
RGSC_v3.41149,617,819 - 49,618,027UniSTSRGSC3.4
Celera1148,205,947 - 48,206,155UniSTS
Cytogenetic Map11q21UniSTS
BE116234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,518,246 - 48,518,443 (+)MAPPERmRatBN7.2
Rnor_6.01150,966,875 - 50,967,071NCBIRnor6.0
Rnor_5.01154,147,428 - 54,147,624UniSTSRnor5.0
RGSC_v3.41149,612,022 - 49,612,218UniSTSRGSC3.4
Celera1148,200,150 - 48,200,346UniSTS
Cytogenetic Map11q21UniSTS
RH138841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,379,167 - 48,379,335 (+)MAPPERmRatBN7.2
Rnor_6.01150,829,414 - 50,829,581NCBIRnor6.0
Rnor_5.01154,011,065 - 54,011,232UniSTSRnor5.0
RGSC_v3.41149,468,285 - 49,468,452UniSTSRGSC3.4
Celera1148,067,231 - 48,067,398UniSTS
RH 3.4 Map15185.3UniSTS
Cytogenetic Map11q21UniSTS
RH139064  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21148,535,717 - 48,535,887 (+)MAPPERmRatBN7.2
Rnor_6.01150,984,505 - 50,984,674NCBIRnor6.0
Rnor_5.01154,165,058 - 54,165,227UniSTSRnor5.0
RGSC_v3.41149,629,493 - 49,629,662UniSTSRGSC3.4
Celera1148,217,621 - 48,217,790UniSTS
Cytogenetic Map11q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 57 41 19 41 74 33 41 11
Low 13 8 10 2 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002738   ⟹   ENSRNOP00000002738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1148,336,169 - 48,537,016 (+)Ensembl
Rnor_6.0 Ensembl1150,781,127 - 50,985,083 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104562   ⟹   ENSRNOP00000080494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1148,336,169 - 48,537,954 (+)Ensembl
RefSeq Acc Id: NM_031753   ⟹   NP_113941
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,805,457 - 62,005,250 (+)NCBI
mRatBN7.21148,336,515 - 48,536,296 (+)NCBI
Rnor_6.01150,781,127 - 50,985,083 (+)NCBI
Rnor_5.01153,964,563 - 54,165,636 (+)NCBI
RGSC_v3.41149,424,243 - 49,630,071 (+)RGD
Celera1148,024,575 - 48,218,199 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270772   ⟹   XP_063126842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,804,932 - 62,002,469 (+)NCBI
RefSeq Acc Id: XM_063270773   ⟹   XP_063126843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,804,932 - 62,002,469 (+)NCBI
RefSeq Acc Id: XM_063270774   ⟹   XP_063126844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,804,932 - 61,989,800 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_113941   ⟸   NM_031753
- Peptide Label: precursor
- UniProtKB: O55172 (UniProtKB/Swiss-Prot),   O35112 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002738   ⟸   ENSRNOT00000002738
RefSeq Acc Id: ENSRNOP00000080494   ⟸   ENSRNOT00000104562
RefSeq Acc Id: XP_063126842   ⟸   XM_063270772
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQS5 (UniProtKB/TrEMBL),   A6IQS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126843   ⟸   XM_063270773
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UHD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126844   ⟸   XM_063270774
- Peptide Label: isoform X3
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35112-F1-model_v2 AlphaFold O35112 1-583 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619972 AgrOrtholog
BioCyc Gene G2FUF-21474 BioCyc
Ensembl Genes ENSRNOG00000001989 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002738.6 UniProtKB/TrEMBL
  ENSRNOT00000104562 ENTREZGENE
  ENSRNOT00000104562.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621856 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79559 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72388 IMAGE-MGC_LOAD
NCBI Gene 79559 ENTREZGENE
PANTHER CELL SURFACE GLYCOPROTEIN MUC18-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11973:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alcam PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001989 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZQS5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHD3 ENTREZGENE, UniProtKB/TrEMBL
  A6IQS3 ENTREZGENE, UniProtKB/TrEMBL
  CD166_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O55172 ENTREZGENE
UniProt Secondary O55172 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Alcam  activated leukocyte cell adhesion molecule      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Alcam  activated leukocyte cell adhesion molecule      Symbol and Name status set to provisional 70820 PROVISIONAL