Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of KNTC1 mRNA | CTD | PMID:24763279 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KNTC1 mRNA | CTD | PMID:22079256 | 1,1-dichloroethene | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of KNTC1 mRNA | CTD | PMID:26682919 | 1-naphthyl isothiocyanate | increases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in increased expression of KNTC1 mRNA | CTD | PMID:30723492 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of KNTC1 mRNA | CTD | PMID:32145629 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Kntc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Kntc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KNTC1 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KNTC1 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Kntc1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KNTC1 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2-palmitoylglycerol | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of KNTC1 mRNA | CTD | PMID:37199045 | 3-methylcholanthrene | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Methylcholanthrene results in increased expression of KNTC1 mRNA | CTD | PMID:20713471 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of KNTC1 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of KNTC1 mRNA | CTD | PMID:31881176 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of KNTC1 mRNA | CTD | PMID:28959563 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of KNTC1 mRNA | CTD | PMID:23630614 and PMID:25378103 | aflatoxin B1 | decreases methylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of KNTC1 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of KNTC1 mRNA | CTD | PMID:33167477 | aristolochic acid A | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of KNTC1 mRNA | CTD | PMID:33212167 | arsane | increases methylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of KNTC1 promoter | CTD | PMID:21291286 | arsenic atom | increases methylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of KNTC1 promoter | CTD | PMID:21291286 | arsenite(3-) | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to KNTC1 mRNA] | CTD | PMID:32406909 | atrazine | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of KNTC1 mRNA | CTD | PMID:22378314 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of KNTC1 gene | CTD | PMID:35440735 | azathioprine | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of KNTC1 mRNA | CTD | PMID:22623647 | benzo[a]pyrene | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of KNTC1 mRNA | CTD | PMID:20713471 and PMID:32417428 | benzo[a]pyrene | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of KNTC1 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KNTC1 intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of KNTC1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of KNTC1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | benzo[b]fluoranthene | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | benzo(b)fluoranthene results in increased expression of KNTC1 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KNTC1 mRNA | CTD | PMID:25181051 more ... | bisphenol A | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of KNTC1 mRNA | CTD | PMID:33670352 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of KNTC1 mRNA | CTD | PMID:32145629 | bisphenol A | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of KNTC1 mRNA | CTD | PMID:29275510 | buta-1,3-diene | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | 1 and 3-butadiene results in increased expression of KNTC1 mRNA | CTD | PMID:29038090 | butanal | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of KNTC1 mRNA | CTD | PMID:26079696 | caffeine | increases phosphorylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of KNTC1 protein | CTD | PMID:35688186 | calcitriol | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of KNTC1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of KNTC1 mRNA | CTD | PMID:21592394 | carbamazepine | affects expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of KNTC1 mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cefaloridine | increases expression | EXP | | 6480464 | Cephaloridine results in increased expression of KNTC1 mRNA | CTD | PMID:18500788 | cobalt dichloride | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of KNTC1 mRNA | CTD | PMID:19376846 | copper(II) sulfate | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of KNTC1 mRNA | CTD | PMID:19549813 | coumestrol | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of KNTC1 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with resveratrol] results in increased expression of KNTC1 mRNA | CTD | PMID:19167446 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of KNTC1 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of KNTC1 mRNA | CTD | PMID:20106945 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of KNTC1 mRNA | CTD | PMID:23640034 | dicrotophos | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of KNTC1 mRNA | CTD | PMID:28302478 | doxorubicin | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Doxorubicin results in increased expression of KNTC1 mRNA | CTD | PMID:36227756 | folic acid | affects expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Folic Acid affects the expression of KNTC1 mRNA | CTD | PMID:17320366 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of KNTC1 mRNA | CTD | PMID:25539665 | geraniol | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | geraniol results in decreased expression of KNTC1 mRNA | CTD | PMID:27683099 | isobutanol | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of KNTC1 mRNA | CTD | PMID:29432896 | ivermectin | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of KNTC1 protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Lead affects the expression of KNTC1 mRNA | CTD | PMID:28903495 | lidocaine | increases expression | EXP | | 6480464 | Lidocaine results in increased expression of KNTC1 mRNA | CTD | PMID:35283115 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of KNTC1 mRNA | CTD | PMID:19564919 and PMID:28341135 | N-Nitrosopyrrolidine | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in decreased expression of KNTC1 mRNA | CTD | PMID:32234424 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of KNTC1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | Kntc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of KNTC1 mRNA more ... | CTD | PMID:25658374 and PMID:34911549 | paracetamol | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KNTC1 mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of KNTC1 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of KNTC1 mRNA | CTD | PMID:29067470 | PCB138 | multiple interactions | ISO | Kntc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | phenobarbital | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of KNTC1 mRNA | CTD | PMID:23091169 | pirinixic acid | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of KNTC1 mRNA | CTD | PMID:23811191 | potassium chromate | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of KNTC1 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KNTC1 mRNA | CTD | PMID:22079256 | pregnenolone 16alpha-carbonitrile | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Pregnenolone Carbonitrile results in increased expression of KNTC1 mRNA | CTD | PMID:22698814 | propanal | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of KNTC1 mRNA | CTD | PMID:26079696 | resveratrol | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with Resveratrol] results in increased expression of KNTC1 mRNA and [Plant Extracts co-treated with Resveratrol] results in increased expression of KNTC1 mRNA | CTD | PMID:19167446 and PMID:23557933 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of KNTC1 mRNA | CTD | PMID:28374803 | senecionine | increases expression | EXP | | 6480464 | senecionine results in increased expression of KNTC1 mRNA | CTD | PMID:32419051 | Senkirkine | increases expression | EXP | | 6480464 | senkirkine results in increased expression of KNTC1 mRNA | CTD | PMID:32419051 | silicon dioxide | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Silicon Dioxide results in increased expression of KNTC1 mRNA | CTD | PMID:29341224 | sodium arsenite | decreases expression | ISO | Kntc1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of KNTC1 mRNA | CTD | PMID:17998272 | sodium arsenite | increases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of KNTC1 mRNA | CTD | PMID:29301061 | sunitinib | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of KNTC1 mRNA | CTD | PMID:31533062 | tert-butyl hydroperoxide | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of KNTC1 mRNA | CTD | PMID:15336504 | testosterone | multiple interactions | ISO | KNTC1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of KNTC1 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of KNTC1 mRNA | CTD | PMID:21592394 | tetrachloromethane | affects expression | ISO | Kntc1 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of KNTC1 mRNA | CTD | PMID:17484886 | tetrachloromethane | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of KNTC1 mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of KNTC1 mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | titanium dioxide results in increased expression of KNTC1 mRNA | CTD | PMID:23557971 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of KNTC1 mRNA | CTD | PMID:30012374 | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of KNTC1 mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of KNTC1 mRNA | CTD | PMID:25729387 | trimellitic anhydride | increases expression | ISO | Kntc1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of KNTC1 mRNA | CTD | PMID:19042947 | troglitazone | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | troglitazone results in decreased expression of KNTC1 mRNA | CTD | PMID:19140230 | trovafloxacin | decreases expression | ISO | Kntc1 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of KNTC1 mRNA | CTD | PMID:35537566 | urethane | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of KNTC1 mRNA | CTD | PMID:28818685 | valproic acid | decreases methylation | ISO | KNTC1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of KNTC1 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of KNTC1 mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | KNTC1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KNTC1 mRNA | CTD | PMID:25979313 | valproic acid | affects expression | ISO | Kntc1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of KNTC1 mRNA | CTD | PMID:17963808 | zaragozic acid A | decreases expression | ISO | Kntc1 (Mus musculus) | 6480464 | squalestatin 1 results in decreased expression of KNTC1 mRNA | CTD | PMID:27225895 | zaragozic acid A | decreases expression | EXP | | 6480464 | squalestatin 1 results in decreased expression of KNTC1 mRNA | CTD | PMID:27225895 | |