Gene: Sirt2 (sirtuin 2) Rattus norvegicus
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Symbol: Sirt2
Name: sirtuin 2
Description: ENCODES a protein that exhibits NAD-dependent protein deacetylase activity; tubulin deacetylase activity; beta-tubulin binding (ortholog); INVOLVED IN central nervous system development; myelination in peripheral nervous system; negative regulation of apoptotic process; PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Glioma; Intermittent Claudication; intermittent claudication; FOUND IN cytoplasm; glial cell projection; juxtaparanode region of axon; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5E5 antigen; MGC105900; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; regulatory protein SIR2 homolog 2; SIR2-like protein 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Orthologs:
Homo sapiens (human) : SIRT2 (sirtuin 2)  HGNC  AGR
Mus musculus (house mouse) : Sirt2 (sirtuin 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Sirt2 (sirtuin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SIRT2 (sirtuin 2)
Canis lupus familiaris (dog) : SIRT2 (sirtuin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sirt2 (sirtuin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBI
Cytogenetic Map1q21NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sirt2
AGR Gene
NCBI Gene
Ensembl Gene
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RGD Object Information
RGD ID: 621481
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-11-07
Status: ACTIVE