Gene: Sirt2 (sirtuin 2) Rattus norvegicus
Symbol: Sirt2
Name: sirtuin 2
Description: ENCODES a protein that exhibits NAD-dependent protein deacetylase activity; tubulin deacetylase activity; beta-tubulin binding (ortholog); INVOLVED IN central nervous system development; myelination in peripheral nervous system; negative regulation of apoptotic process; PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH Glioma; Intermittent Claudication; Non-alcoholic Fatty Liver Disease; FOUND IN cytoplasm; glial cell projection; juxtaparanode region of axon; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride
Type: protein-coding
Also known as: 5E5 antigen; MGC105900; NAD-dependent deacetylase sirtuin-2; NAD-dependent protein deacetylase sirtuin-2; regulatory protein SIR2 homolog 2; SIR2-like protein 2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae)
Homo sapiens : SIRT2 (sirtuin 2)  HGNC
Mus musculus : Sirt2 (sirtuin 2)  MGI
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0186,948,866 - 86,971,954 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0188,130,012 - 88,153,086 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4183,873,578 - 83,896,121 (+)NCBIRGSC3.4rn4RGSC3.4
Celera178,446,589 - 78,469,133 (+)NCBI
Cytogenetic Map1q21NCBImapview

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sirt2
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621481
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2016-09-06
Status: ACTIVE