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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:734020 | 6480464 | Ethinyl Estradiol results in decreased expression of CD3D mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:734020 | 6480464 | Ethinyl Estradiol affects the expression of CD3D mRNA | CTD | PMID:14976129 PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:734020 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD3D mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:734020 | 6480464 | Ethinyl Estradiol affects the expression of CD3D mRNA | CTD | PMID:17555576 PMID:14976129 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:734020 | 6480464 | Tetrachlorodibenzodioxin affects the expression of CD3D mRNA | CTD | PMID:18343893 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:734020 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CD3D mRNA | CTD | PMID:16611356 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:734020 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CD3D mRNA | CTD | PMID:16611356 PMID:16960034 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:734020 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of CD3D mRNA | CTD | PMID:16960034 PMID:16611356 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:734020 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of CD3D mRNA | CTD | PMID:17942748 | 2,6-di-tert-butyl-4-methylphenol | decreases expression | ISO | RGD:734020 | 6480464 | Butylated Hydroxytoluene results in decreased expression of CD3D mRNA | CTD | PMID:19925653 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:734020 | 6480464 | 4,4'-diaminodiphenylmethane results in decreased expression of CD3D mRNA | CTD | PMID:18648102 | aflatoxin B1 | affects expression | ISO | RGD:736987 | 6480464 | Aflatoxin B1 affects the expression of CD3D protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:736987 | 6480464 | Aflatoxin B1 results in increased expression of CD3D mRNA | CTD | PMID:21632981 PMID:22100608 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CD3D mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:736987 | 6480464 | Benzo(a)pyrene results in increased expression of CD3D mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:736987 | 6480464 | Benzo(a)pyrene results in increased expression of CD3D mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | ISO | RGD:736987 | 6480464 | Benzo(a)pyrene results in increased expression of CD3D mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:734020 | 6480464 | Benzo(a)pyrene results in decreased expression of CD3D mRNA | CTD | PMID:21569818 | benzo[a]pyrene | increases expression | ISO | RGD:736987 | 6480464 | Benzo(a)pyrene results in increased expression of CD3D mRNA | CTD | PMID:21871943 PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:736987 | 6480464 | Benzo(a)pyrene results in increased expression of CD3D mRNA | CTD | PMID:20106945 PMID:21871943 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of CD3D mRNA | CTD | PMID:18180321 | chloroprene | decreases expression | ISO | RGD:734020 | 6480464 | Chloroprene results in decreased expression of CD3D mRNA | CTD | PMID:23125180 | clofibrate | increases expression | ISO | RGD:734020 | 6480464 | Clofibrate results in increased expression of CD3D mRNA | CTD | PMID:17585979 | copper(2+) sulfate | increases expression | ISO | RGD:736987 | 6480464 | Copper Sulfate results in increased expression of CD3D mRNA | CTD | PMID:19549813 | cyclophosphamide | decreases expression | ISO | RGD:734020 | 6480464 | Cyclophosphamide results in decreased expression of CD3D mRNA | CTD | PMID:21041162 | dexamethasone | decreases expression | ISO | RGD:734020 | 6480464 | Dexamethasone results in decreased expression of CD3D mRNA | CTD | PMID:21041162 | diethylstilbestrol | decreases expression | ISO | RGD:734020 | 6480464 | Diethylstilbestrol results in decreased expression of CD3D mRNA | CTD | PMID:21041162 | hexachlorobenzene | decreases expression | EXP | | 6480464 | Hexachlorobenzene results in decreased expression of CD3D mRNA | CTD | PMID:15159207 | isotretinoin | increases expression | ISO | RGD:736987 | 6480464 | Isotretinoin results in increased expression of CD3D mRNA | CTD | PMID:20436886 | nitroglycerin | increases expression | EXP | | 6480464 | Nitroglycerin results in increased expression of CD3D mRNA | CTD | PMID:12102619 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of CD3D mRNA | CTD | PMID:19784758 | paracetamol | increases expression | ISO | RGD:736987 | 6480464 | Acetaminophen results in increased expression of CD3D mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of CD3D mRNA | CTD | PMID:19784758 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of CD3D mRNA | CTD | PMID:19784758 | parathion | increases expression | EXP | | 6480464 | Parathion results in increased expression of CD3D mRNA | CTD | PMID:19784758 | pirinixic acid | decreases expression | ISO | RGD:734020 | 6480464 | pirinixic acid results in decreased expression of CD3D mRNA | CTD | PMID:17426115 | quercetin | increases expression | ISO | RGD:736987 | 6480464 | Quercetin results in increased expression of CD3D mRNA | CTD | PMID:21632981 | tamibarotene | decreases expression | ISO | RGD:734020 | 6480464 | Am 80 results in decreased expression of CD3D mRNA; more ... | CTD | PMID:20861477 | tamoxifen | affects expression | ISO | RGD:734020 | 6480464 | Tamoxifen affects the expression of CD3D mRNA | CTD | PMID:17555576 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chagas disease (American trypanosomiasis) |
| Hematopoietic cell lineage | |
| HTLV-I infection | |
| Measles | |
| Primary immunodeficiency | |
| T cell receptor signaling pathway | |
| Pathway Interaction Database | CXCR4-mediated signaling events (PID:200099) |
| Downstream signaling in naïve CD8+ T cells (PID:200215) | |
| IL12 signaling mediated by STAT4 (PID:200229) | |
| IL12-mediated signaling events (PID:200045) | |
| TCR signaling in naïve CD4+ T cells (PID:200027) | |
| TCR signaling in naïve CD8+ T cells (PID:200075) | |
References - curated| 1. |
Alarcon B, etal., Immunol Rev 2003 Feb;191:38-46. |
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Dadi HK, etal., N Engl J Med 2003 Nov 6;349(19):1821-8. |
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GOA data from the GO Consortium |
| 4. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
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MGD data from the GO Consortium |
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NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 7. |
Pan Q, etal., J Biol Chem 2004 Dec 3;279(49):51068-74. Epub 2004 Sep 30. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
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RGD comprehensive gene curation |
| 14. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 15. |
van den Elsen P, etal., Nature 1985 Apr 11-17;314(6011):542-4. |
References - uncurated
RGD Disease Portals| Cd3d has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cd3d (Rattus norvegicus) |
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| CD3D (Homo sapiens) |
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| Cd3d (Mus musculus) |
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Position Markers| RH94582 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_013169 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06054547 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01054371 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X53430 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013169 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037301 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_037301 | (Get FASTA) |
| GenBank Protein | CAA37521 | (Get FASTA) |
| EDL95345 | (Get FASTA) | |
| P19377 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015994 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000021489 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000021488 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25710 | ENTREZGENE |
| Gene3D-CATH | Ig-like_fold | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000015994 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 585 | ENTREZGENE |
| InterPro | CD3_delta | UniProtKB/Swiss-Prot |
| CD3_gsu/dsu | UniProtKB/Swiss-Prot | |
| Ig-like_fold | UniProtKB/Swiss-Prot | |
| Phos_immunorcpt_sig_ITAM | UniProtKB/Swiss-Prot | |
| IPI | IPI00194403 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25710 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | CD3_delta | UniProtKB/Swiss-Prot |
| CD3_gamma_delta | UniProtKB/Swiss-Prot | |
| Pfam | ITAM | UniProtKB/Swiss-Prot |
| PROSITE | ITAM_1 | UniProtKB/Swiss-Prot |
| SMART | ITAM | UniProtKB/Swiss-Prot |
| TIGR | TC223607 | |
| UniGene | Rn.10329 | ENTREZGENE |
| UniProt | CD3D_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-06-27 | Cd3d | CD3 molecule delta polypeptide | Cd3d | CD3 antigen delta polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Cd3d | CD3 antigen delta polypeptide | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | human homolog is a component of the antigen receptor on T cells | 634716 |
| More on Cd3d | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2304 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




