Tap2 (transporter 2, ATP binding cassette subfamily B member) - Rat Genome Database

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Gene: Tap2 (transporter 2, ATP binding cassette subfamily B member) Rattus norvegicus
Analyze
Symbol: Tap2
Name: transporter 2, ATP binding cassette subfamily B member
RGD ID: 3818
Description: Enables several functions, including TAP binding activity; adenyl ribonucleotide binding activity; and protein homodimerization activity. Contributes to MHC class I protein binding activity and peptide antigen binding activity. Involved in several processes, including peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; and protection from natural killer cell mediated cytotoxicity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I and positive regulation of T cell mediated cytotoxicity. Part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member); PARTICIPATES IN antigen processing and presentation pathway; phagocytosis pathway; primary immunodeficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4-(ethoxymethylene)-2-phenyloxazol-5-one.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abcb3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Cim; LOC103689996; MGC108646; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; Transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Edcs3
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,638,257 - 4,652,296 (-)NCBIGRCr8
mRatBN7.2204,636,347 - 4,650,387 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,636,357 - 4,650,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,388,631 - 5,403,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,750,374 - 4,764,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,233,719 - 5,246,401 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,995,544 - 4,009,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,198,258 - 5,212,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,995,544 - 4,009,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,075,031 - 6,089,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,259,226 - 7,273,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,770,446 - 4,784,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,770,672 - 4,784,715 (-)NCBI
Celera206,237,501 - 6,251,447 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
dichlorine  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
Genipin  (ISO)
genistein  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits. Antoniou AN, etal., Immunology. 2002 Jun;106(2):182-9.
2. Susceptibility to Reiter's syndrome is associated with alleles of TAP genes. Barron KS, etal., Arthritis Rheum. 1995 May;38(5):684-9.
3. The relationship of TAP1 and TAP2 dimorphisms to multiple sclerosis susceptibility. Bell RB and Ramachandran S, J Neuroimmunol. 1995 Jun;59(1-2):201-4.
4. The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2. Bouabe H and Knittler MR, Eur J Biochem 2003 Nov;270(22):4531-46.
5. A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers. Bullido MJ, etal., Neurobiol Aging. 2007 Apr;28(4):519-23. Epub 2006 Apr 3.
6. TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus. Caillat-Zucman S, etal., C R Acad Sci III. 1992;315(13):535-9.
7. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. Correa PA, etal., Ann Rheum Dis. 2003 Apr;62(4):363-5.
8. Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. Deshpande A, etal., J Infect Dis. 2008 Feb 1;197(3):371-81.
9. Functional role of C-terminal sequence elements in the transporter associated with antigen processing. Ehses S, etal., J Immunol. 2005 Jan 1;174(1):328-39.
10. TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population. Feng M, etal., Hum Immunol. 2009 Apr;70(4):257-61. Epub 2009 Feb 4.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk. Gostout BS, etal., Gynecol Oncol. 2003 Mar;88(3):326-32.
13. Contribution of TAP genes to genetic predisposition for diffuse panbronchiolitis. Keicho N, etal., Tissue Antigens. 1999 Apr;53(4 Pt 1):366-73.
14. Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2. Keusekotten K, etal., J Biol Chem. 2006 Jun 30;281(26):17545-51. Epub 2006 Apr 19.
15. Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline. Kim JH, etal., J Hum Genet. 2011 Jul 28. doi: 10.1038/jhg.2011.75.
16. Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules. Knittler MR, etal., Curr Biol. 1999 Sep 23;9(18):999-1008.
17. Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. Kramer U, etal., Genes Immun. 2007 Sep;8(6):513-7. Epub 2007 Jun 21.
18. Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression. Liu Q, etal., Scand J Gastroenterol. 2009;44(8):960-9.
19. Genetic variation of antigen processing machinery components and association with cervical carcinoma. Mehta AM, etal., Genes Chromosomes Cancer. 2007 Jun;46(6):577-86.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. TAP1 and TAP2 polymorphism in multiple sclerosis patients. Middleton D, etal., Hum Immunol. 1994 Jun;40(2):131-4.
22. TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosis. Moins-Teisserenc H, etal., Hum Immunol. 1995 Mar;42(3):195-202.
23. Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. Moins-Teisserenc HT, etal., Lancet. 1999 Nov 6;354(9190):1598-603.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter. Powis SJ, etal., Nature 1991 Dec 19-26;354(6354):528-31.
27. Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes. Qu HQ, etal., Diabetes. 2007 Jan;56(1):270-5.
28. Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis. Rajalingam R, etal., Tissue Antigens. 1997 Feb;49(2):168-72.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. Rufer E, etal., J Immunol. 2007 Nov 1;179(9):5717-27.
33. Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells. Salcedo M, etal., J Immunol. 1994 Feb 15;152(4):1702-8.
34. TAP1 and TAP2 genes in nickel allergy. Silvennoinen-Kassinen S, etal., Int Arch Allergy Immunol. 1997 Sep;114(1):94-6.
35. Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients. Song YW, etal., Hum Immunol. 2005 Jul;66(7):810-7.
36. Significance of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in susceptibility to dengue viral infection. Soundravally R and Hoti SL, J Clin Immunol. 2008 May;28(3):256-62.
37. Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE. Takeuchi F, etal., Ann Rheum Dis. 1996 Dec;55(12):924-6.
38. TAP2 alleles in inflammatory arthritis. Tuokko J, etal., Scand J Rheumatol. 1998;27(3):225-9.
39. Three-dimensional structure of transporter associated with antigen processing (TAP) obtained by single Particle image analysis. Velarde G, etal., J Biol Chem. 2001 Dec 7;276(49):46054-63. Epub 2001 Oct 10.
40. The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex. Verweij MC, etal., J Immunol. 2008 Oct 1;181(7):4894-907.
Additional References at PubMed
PMID:1300480   PMID:1350326   PMID:1538751   PMID:1538753   PMID:7538543   PMID:7673167   PMID:8206525   PMID:8496691   PMID:8955196   PMID:10605026   PMID:10835348   PMID:11133832  
PMID:12477932   PMID:15518576   PMID:15793001   PMID:16299293   PMID:19946888   PMID:24586191  


Genomics

Comparative Map Data
Tap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,638,257 - 4,652,296 (-)NCBIGRCr8
mRatBN7.2204,636,347 - 4,650,387 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,636,357 - 4,650,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,388,631 - 5,403,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,750,374 - 4,764,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,233,719 - 5,246,401 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,995,544 - 4,009,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,198,258 - 5,212,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,995,544 - 4,009,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,075,031 - 6,089,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,259,226 - 7,273,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,770,446 - 4,784,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,770,672 - 4,784,715 (-)NCBI
Celera206,237,501 - 6,251,447 (-)NCBICelera
Cytogenetic Map20p12NCBI
TAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,821,831 - 32,838,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,821,833 - 32,838,739 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,789,608 - 32,806,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,897,588 - 32,914,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,897,587 - 32,914,482NCBI
Celera634,338,665 - 34,355,440 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,531,964 - 32,548,753 (-)NCBIHuRef
CHM1_1632,790,604 - 32,807,372 (-)NCBICHM1_1
T2T-CHM13v2.0632,643,187 - 32,660,143 (-)NCBIT2T-CHM13v2.0
Tap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,423,453 - 34,435,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,422,501 - 34,435,295 (+)EnsemblGRCm39 Ensembl
GRCm381734,204,479 - 34,216,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,341,424 - 34,353,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,814,778 - 33,826,596 (+)NCBIMGSCv36mm8
Celera1736,957,240 - 36,969,164 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Tap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,477,341 - 1,498,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,480,217 - 1,499,032 (-)NCBIChiLan1.0ChiLan1.0
TAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,300,349 - 47,313,984 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,171,904 - 43,185,535 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,394,586 - 32,408,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,513,321 - 33,523,780 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,507,332 - 33,523,750 (-)Ensemblpanpan1.1panPan2
TAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,407,512 - 2,417,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,378,126 - 2,432,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,489,442 - 2,499,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,689,106 - 2,699,061 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,652,372 - 2,699,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,406,835 - 2,416,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,488,331 - 2,497,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,562,598 - 2,572,236 (-)NCBIUU_Cfam_GSD_1.0
Tap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,036,847 - 38,046,599 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,913,663 - 25,923,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,913,699 - 25,923,419 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,045,685 - 25,056,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,045,085 - 25,056,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,412,165 - 29,423,473 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,266,870 - 39,277,658 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,614,899 - 32,625,447 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,827,706 - 23,837,356 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,827,782 - 23,845,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tap2
727 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:33
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000000527
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
7175099Tcs2T cell selection QTL 2T cell selectionexpression2045040024693102Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
Tap2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,637,492 - 4,638,945 (-)MAPPERmRatBN7.2
mRatBN7.2204,637,492 - 4,638,945 (+)MAPPERmRatBN7.2
Rnor_6.0204,006,989 - 4,008,441NCBIRnor6.0
Rnor_6.0205,199,311 - 5,200,763NCBIRnor6.0
Rnor_5.0207,260,372 - 7,261,824UniSTSRnor5.0
Rnor_5.0206,086,535 - 6,087,987UniSTSRnor5.0
RGSC_v3.4204,771,592 - 4,773,044UniSTSRGSC3.4
Celera206,238,647 - 6,240,099UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 1 5 1 3 2
Below cutoff 3 18 39 27 15 27 4 10 17 29 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000527   ⟹   ENSRNOP00000000527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,636,357 - 4,650,407 (-)Ensembl
Rnor_6.0 Ensembl203,995,544 - 4,009,587 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074261   ⟹   ENSRNOP00000067594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,198,258 - 5,212,624 (-)Ensembl
RefSeq Acc Id: NM_032056   ⟹   NP_114445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,638,257 - 4,652,296 (-)NCBI
mRatBN7.2204,636,347 - 4,650,387 (-)NCBI
Rnor_6.0203,995,544 - 4,009,587 (+)NCBI
Rnor_5.0207,259,226 - 7,273,268 (-)NCBI
RGSC_v3.4204,770,446 - 4,784,488 (-)RGD
Celera206,237,501 - 6,251,447 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_114445   ⟸   NM_032056
- UniProtKB: Q6MGA3 (UniProtKB/TrEMBL),   A6JJD9 (UniProtKB/TrEMBL),   Q63522 (UniProtKB/TrEMBL),   A0A023ILQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000527   ⟸   ENSRNOT00000000527
RefSeq Acc Id: ENSRNOP00000067594   ⟸   ENSRNOT00000074261
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36372-F1-model_v2 AlphaFold P36372 1-703 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701326
Promoter ID:EPDNEW_R11849
Type:initiation region
Name:Tap2_1
Description:transporter 2, ATP binding cassette subfamily B member
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,995,548 - 3,995,608EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3818 AgrOrtholog
BioCyc Gene G2FUF-4555 BioCyc
Ensembl Genes ENSRNOG00000000455 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046031 Ensembl
Ensembl Transcript ENSRNOT00000000527 ENTREZGENE
  ENSRNOT00000000527.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381526 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_Tap-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tap2/ABCB3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24812 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108646 IMAGE-MGC_LOAD
NCBI Gene 24812 ENTREZGENE
PANTHER ANTIGEN PEPTIDE TRANSPORTER 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP BINDING CASSETTE SUBFAMILY B MEMBER 9 UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/TrEMBL
  TRANSPORTER 1, ATP BINDING CASSETTE SUBFAMILY B MEMBER UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tap2 PhenoGen
PIRSF ABC_prm/ATPase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TAP1PROTEIN UniProtKB/TrEMBL
  TAP2PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000455 RatGTEx
  ENSRNOG00000046031 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A023IKJ0_RAT UniProtKB/TrEMBL
  A0A023IKJ3_RAT UniProtKB/TrEMBL
  A0A023ILP9_RAT UniProtKB/TrEMBL
  A0A023ILQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A023IM48_RAT UniProtKB/TrEMBL
  A0A023IMI8_RAT UniProtKB/TrEMBL
  A0A023IMI9_RAT UniProtKB/TrEMBL
  A6JJD9 ENTREZGENE
  A6JJE0_RAT UniProtKB/TrEMBL
  P36372 ENTREZGENE
  Q63522 ENTREZGENE, UniProtKB/TrEMBL
  Q6MGA3 ENTREZGENE, UniProtKB/TrEMBL
  TAP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary A6JJD9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Tap2  transporter 2, ATP binding cassette subfamily B member  LOC103689996  antigen peptide transporter 2  Data merged from RGD:9419934 737654 PROVISIONAL
2016-06-29 Tap2  transporter 2, ATP binding cassette subfamily B member  Tap2  transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103689996  antigen peptide transporter 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Tap2  transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)     Transporter 2, ABC (ATP binding cassette)  Name updated 629478 APPROVED
2002-06-10 Tap2  Transporter 2, ABC (ATP binding cassette)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein Tap2 and Tap1 are subunits of Tap, the transporter associated with antigen processing 1300480