Tspan8 (tetraspanin 8) - Rat Genome Database

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Gene: Tspan8 (tetraspanin 8) Rattus norvegicus
Analyze
Symbol: Tspan8
Name: tetraspanin 8
RGD ID: 621783
Description: Enables integrin binding activity. Involved in negative regulation of blood coagulation. Predicted to be located in cell surface. Orthologous to human TSPAN8 (tetraspanin 8); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CO-29; D6.1A; tetraspanin-8; Tm4sf3; transmembrane 4 superfamily member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,331,019 - 53,365,402 (+)NCBIGRCr8
mRatBN7.2751,444,946 - 51,479,360 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,445,074 - 51,479,356 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx753,351,868 - 53,386,094 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,554,937 - 55,589,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,332,961 - 55,367,187 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,814,805 - 58,847,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,814,805 - 58,847,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,821,787 - 58,854,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,104,257 - 55,136,906 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,124,986 - 55,157,635 (+)NCBI
Celera748,232,246 - 48,265,180 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
diuron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
kojic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. Claas C, etal., J Cell Biol 1998 Apr 6;141(1):267-80.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Nazarenko I, etal., Cancer Res. 2010 Feb 15;70(4):1668-78. doi: 10.1158/0008-5472.CAN-09-2470. Epub 2010 Feb 2.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15725074   PMID:23533145   PMID:23683890   PMID:25544774   PMID:27733379   PMID:30982971   PMID:32013145   PMID:32687199   PMID:37572802  


Genomics

Comparative Map Data
Tspan8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8753,331,019 - 53,365,402 (+)NCBIGRCr8
mRatBN7.2751,444,946 - 51,479,360 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,445,074 - 51,479,356 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx753,351,868 - 53,386,094 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,554,937 - 55,589,176 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0755,332,961 - 55,367,187 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,814,805 - 58,847,564 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,814,805 - 58,847,563 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0758,821,787 - 58,854,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4755,104,257 - 55,136,906 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1755,124,986 - 55,157,635 (+)NCBI
Celera748,232,246 - 48,265,180 (+)NCBICelera
Cytogenetic Map7q22NCBI
TSPAN8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,125,096 - 71,157,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,125,085 - 71,441,898 (-)EnsemblGRCh38hg38GRCh38
GRCh371271,518,876 - 71,551,779 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361269,805,144 - 69,838,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 341269,805,143 - 69,838,046NCBI
Celera1271,182,199 - 71,215,102 (-)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1268,568,317 - 68,601,483 (-)NCBIHuRef
CHM1_11271,488,354 - 71,521,249 (-)NCBICHM1_1
T2T-CHM13v2.01271,104,602 - 71,137,962 (-)NCBIT2T-CHM13v2.0
Tspan8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,652,722 - 115,685,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,652,737 - 115,685,798 (+)EnsemblGRCm39 Ensembl
GRCm3810115,816,817 - 115,849,893 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,816,832 - 115,849,893 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710115,254,340 - 115,286,949 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610115,221,394 - 115,253,726 (+)NCBIMGSCv36mm8
Celera10117,748,806 - 117,782,287 (+)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Tspan8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,199,280 - 11,232,955 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540511,200,290 - 11,233,094 (-)NCBIChiLan1.0ChiLan1.0
TSPAN8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,158,701 - 79,407,526 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,155,101 - 79,403,926 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,653,209 - 68,686,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11271,417,577 - 71,450,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1271,417,577 - 71,450,873 (-)Ensemblpanpan1.1panPan2
TSPAN8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11012,786,824 - 12,818,257 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1012,786,867 - 12,818,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1012,725,247 - 12,756,661 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01012,919,135 - 12,950,691 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1012,919,178 - 12,950,562 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11012,784,319 - 12,816,660 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,031,549 - 13,062,936 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,155,666 - 13,187,030 (-)NCBIUU_Cfam_GSD_1.0
Tspan8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,408,788 - 45,442,759 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568285,696 - 311,864 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936568285,130 - 304,479 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSPAN8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,240,715 - 35,321,845 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1535,210,744 - 35,482,788 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2537,839,246 - 37,889,811 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSPAN8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11166,726,714 - 66,882,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1166,725,231 - 66,758,091 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037178,902,512 - 178,937,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tspan8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,633,793 - 26,669,980 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475026,634,019 - 26,668,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tspan8
210 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:16
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000005909
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74110969256793354Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat

Markers in Region
RH138974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,475,580 - 51,475,735 (+)MAPPERmRatBN7.2
Rnor_6.0758,843,790 - 58,843,944NCBIRnor6.0
Rnor_5.0758,850,751 - 58,850,905UniSTSRnor5.0
RGSC_v3.4755,133,132 - 55,133,286UniSTSRGSC3.4
Celera748,261,507 - 48,261,661UniSTS
RH 3.4 Map7475.9UniSTS
Cytogenetic Map7q22UniSTS
RH141047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,457,761 - 51,457,956 (+)MAPPERmRatBN7.2
Rnor_6.0758,827,386 - 58,827,580NCBIRnor6.0
Rnor_5.0758,834,368 - 58,834,562UniSTSRnor5.0
RGSC_v3.4755,116,904 - 55,117,098UniSTSRGSC3.4
Celera748,244,894 - 48,245,088UniSTS
RH 3.4 Map7476.01UniSTS
Cytogenetic Map7q22UniSTS
RH141354  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map7477.81UniSTS
Cytogenetic Map7q22UniSTS
BF417031  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,477,000 - 51,477,214 (+)MAPPERmRatBN7.2
Rnor_6.0758,845,208 - 58,845,421NCBIRnor6.0
Rnor_5.0758,852,169 - 58,852,382UniSTSRnor5.0
RGSC_v3.4755,134,550 - 55,134,763UniSTSRGSC3.4
Celera748,262,824 - 48,263,037UniSTS
RH 3.4 Map7477.51UniSTS
Cytogenetic Map7q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 2 32 20 16 12 16 8 11 4 31 31 11 8
Low 11 37 25 7 25 70 4 10
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039078341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC061785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000005909   ⟹   ENSRNOP00000005909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,445,074 - 51,479,356 (+)Ensembl
Rnor_6.0 Ensembl758,814,805 - 58,847,563 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100493   ⟹   ENSRNOP00000077213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl751,445,074 - 51,473,855 (+)Ensembl
RefSeq Acc Id: NM_133526   ⟹   NP_598210
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,331,187 - 53,365,402 (+)NCBI
mRatBN7.2751,445,114 - 51,479,357 (+)NCBI
Rnor_6.0758,814,805 - 58,847,564 (+)NCBI
Rnor_5.0758,821,787 - 58,854,525 (+)NCBI
RGSC_v3.4755,104,257 - 55,136,906 (+)RGD
Celera748,232,246 - 48,265,180 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078341   ⟹   XP_038934269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8753,331,019 - 53,365,402 (+)NCBI
mRatBN7.2751,444,946 - 51,479,360 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_598210   ⟸   NM_133526
- UniProtKB: O55158 (UniProtKB/TrEMBL),   A6IGL6 (UniProtKB/TrEMBL),   A0A8I5Y9E0 (UniProtKB/TrEMBL),   A6IGL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005909   ⟸   ENSRNOT00000005909
RefSeq Acc Id: XP_038934269   ⟸   XM_039078341
- Peptide Label: isoform X1
- UniProtKB: O55158 (UniProtKB/TrEMBL),   A6IGL6 (UniProtKB/TrEMBL),   A0A8I5Y9E0 (UniProtKB/TrEMBL),   A6IGL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077213   ⟸   ENSRNOT00000100493

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55158-F1-model_v2 AlphaFold O55158 1-235 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695201
Promoter ID:EPDNEW_R5725
Type:initiation region
Name:Tspan8_1
Description:tetraspanin 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0758,814,911 - 58,814,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621783 AgrOrtholog
BioCyc Gene G2FUF-34056 BioCyc
Ensembl Genes ENSRNOG00000004411 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005909 ENTREZGENE
  ENSRNOT00000005909.7 UniProtKB/TrEMBL
  ENSRNOT00000100493.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1450.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623788 IMAGE-MGC_LOAD
InterPro Tetraspanin UniProtKB/TrEMBL
  Tetraspanin_CS UniProtKB/TrEMBL
  Tetraspanin_EC2 UniProtKB/TrEMBL
  Tetraspanin_sub UniProtKB/TrEMBL
KEGG Report rno:171048 UniProtKB/TrEMBL
MGC_CLONE MGC:72317 IMAGE-MGC_LOAD
NCBI Gene 171048 ENTREZGENE
PANTHER PTHR19282 UniProtKB/TrEMBL
  TETRASPANIN-8 UniProtKB/TrEMBL
Pfam Tetraspannin UniProtKB/TrEMBL
PhenoGen Tspan8 PhenoGen
PIRSF Tetraspanin UniProtKB/TrEMBL
PRINTS TMFOUR UniProtKB/TrEMBL
PROSITE TM4_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004411 RatGTEx
Superfamily-SCOP Tetraspanin UniProtKB/TrEMBL
UniProt A0A8I5Y9E0 ENTREZGENE, UniProtKB/TrEMBL
  A6IGL6 ENTREZGENE
  A6IGL8 ENTREZGENE, UniProtKB/TrEMBL
  O55158 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6IGL6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Tspan8  tetraspanin 8      Symbol and Name updated 1299863 APPROVED
2004-02-26 Tm4sf3  transmembrane 4 superfamily member 3      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Tm4sf3  transmembrane 4 superfamily member 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with beta1, alpha3, and alpha6-beta1 integrins 634231
gene_protein 235 amino acids 634231