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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1319642 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BCL6 mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1319643 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased expression of BCL6 protein | CTD | PMID:20348231 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1319643 | 6480464 | Tetrachlorodibenzodioxin affects the expression of BCL6 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of BCL6 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1319642 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BCL6 mRNA | CTD | PMID:21802500 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1319643 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of BCL6 mRNA | CTD | PMID:17035482 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1319643 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of BCL6 mRNA | CTD | PMID:18684927 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of BCL6 mRNA | CTD | PMID:21346803 | 3-methylcholanthrene | increases expression | ISO | RGD:1319643 | 6480464 | Methylcholanthrene results in increased expression of BCL6 mRNA | CTD | PMID:20713471 | 3-methylcholanthrene | multiple interactions | ISO | RGD:1319642 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to BCL6 promoter] | CTD | PMID:20348232 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:1319643 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA | CTD | PMID:19191707 | 4-phenylbutyric acid | increases expression | ISO | RGD:1319642 | 6480464 | 4-phenylbutyric acid results in increased expression of BCL6 mRNA | CTD | PMID:14583596 | benzene | increases expression | ISO | RGD:1319642 | 6480464 | Benzene results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | benzo[a]pyrene | increases expression | ISO | RGD:1319643 | 6480464 | Benzo(a)pyrene results in increased expression of BCL6 mRNA | CTD | PMID:20713471 | benzo[a]pyrene | increases expression | ISO | RGD:1319642 | 6480464 | Benzo(a)pyrene results in increased expression of BCL6 mRNA | CTD | PMID:21802500 | bisphenol A | decreases expression | ISO | RGD:1319642 | 6480464 | bisphenol A results in decreased expression of BCL6 mRNA | CTD | PMID:22576693 | bisphenol A | increases methylation | ISO | RGD:1319642 | 6480464 | bisphenol A results in increased methylation of BCL6 gene | CTD | PMID:22576693 | ciglitazone | multiple interactions | ISO | RGD:1319642 | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of BCL6 mRNA | CTD | PMID:16197558 | ciguatoxin CTX1B | affects expression | ISO | RGD:1319643 | 6480464 | Ciguatoxins affects the expression of BCL6 mRNA | CTD | PMID:18353800 | cisplatin | increases expression | ISO | RGD:1319642 | 6480464 | Cisplatin results in increased expression of BCL6 mRNA | CTD | PMID:21532991 | copper(2+) sulfate | increases expression | ISO | RGD:1319642 | 6480464 | Copper Sulfate results in increased expression of BCL6 mRNA | CTD | PMID:19549813 | crocidolite asbestos | increases expression | ISO | RGD:1319642 | 6480464 | Asbestos, Crocidolite results in increased expression of BCL6 mRNA | CTD | PMID:18687144 | cyclophosphamide | decreases expression | ISO | RGD:1319643 | 6480464 | Cyclophosphamide results in decreased expression of BCL6 mRNA | CTD | PMID:21041162 | cyclosporin A | decreases expression | ISO | RGD:1319642 | 6480464 | Cyclosporine results in decreased expression of BCL6 mRNA | CTD | PMID:20106945 | dexamethasone | decreases expression | ISO | RGD:1319643 | 6480464 | Dexamethasone results in decreased expression of BCL6 mRNA | CTD | PMID:21041162 | dichloromethane | increases expression | ISO | RGD:1319642 | 6480464 | Methylene Chloride results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | diethylstilbestrol | decreases expression | ISO | RGD:1319643 | 6480464 | Diethylstilbestrol results in decreased expression of BCL6 mRNA | CTD | PMID:21041162 | ethylbenzene | increases expression | ISO | RGD:1319642 | 6480464 | ethylbenzene results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | formaldehyde | increases expression | ISO | RGD:1319642 | 6480464 | Formaldehyde results in increased expression of BCL6 mRNA | CTD | PMID:20655997 | formaldehyde | increases expression | ISO | RGD:1319642 | 6480464 | Formaldehyde results in increased expression of BCL6 mRNA | CTD | PMID:20655997 PMID:23416264 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of BCL6 gene | CTD | PMID:22079235 | hydrazine | decreases expression | ISO | RGD:1319643 | 6480464 | hydrazine results in decreased expression of BCL6 mRNA | CTD | PMID:15282401 | hydrogen peroxide | affects expression | ISO | RGD:1319642 | 6480464 | Hydrogen Peroxide affects the expression of BCL6 mRNA | CTD | PMID:20044591 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA | CTD | PMID:22129741 | menadione | affects expression | ISO | RGD:1319642 | 6480464 | Vitamin K 3 affects the expression of BCL6 mRNA | CTD | PMID:20044591 | mono(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of BCL6 mRNA | CTD | PMID:16809437 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of BCL6 mRNA | CTD | PMID:22129741 | o-xylene | increases expression | ISO | RGD:1319642 | 6480464 | 2-xylene results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | ochratoxin A | decreases expression | EXP | | 6480464 | ochratoxin A results in decreased expression of BCL6 mRNA | CTD | PMID:23358140 | paracetamol | affects expression | ISO | RGD:1319643 | 6480464 | Acetaminophen affects the expression of BCL6 mRNA | CTD | PMID:15606129 | phenobarbital | decreases expression | ISO | RGD:1319643 | 6480464 | Phenobarbital results in decreased expression of BCL6 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | RGD:1319643 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BCL6 mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | ISO | RGD:1319643 | 6480464 | pirinixic acid results in increased expression of BCL6 mRNA | CTD | PMID:18445702 | raloxifene | increases expression | ISO | RGD:1319642 | 6480464 | Raloxifene results in increased expression of BCL6 mRNA | CTD | PMID:16497877 | resveratrol | increases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in increased expression of BCL6 mRNA | CTD | PMID:12002526 PMID:12569576 | resveratrol | increases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in increased expression of BCL6 mRNA | CTD | PMID:12569576 PMID:12002526 | resveratrol | decreases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in decreased expression of BCL6 protein | CTD | PMID:17088997 | silicon dioxide | decreases expression | ISO | RGD:1319643 | 6480464 | Silicon Dioxide results in decreased expression of BCL6 mRNA | CTD | PMID:19073995 | sodium dichromate | increases expression | ISO | RGD:1319643 | 6480464 | sodium bichromate results in increased expression of BCL6 mRNA | CTD | PMID:22155349 | tamoxifen | increases expression | ISO | RGD:1319642 | 6480464 | Tamoxifen results in increased expression of BCL6 mRNA | CTD | PMID:15604281 | tamoxifen | affects expression | ISO | RGD:1319643 | 6480464 | Tamoxifen affects the expression of BCL6 mRNA | CTD | PMID:20937368 | tetrachloromethane | decreases expression | ISO | RGD:1319643 | 6480464 | Carbon Tetrachloride results in decreased expression of BCL6 mRNA | CTD | PMID:17484886 | tetrachloromethane | multiple interactions | ISO | RGD:1319643 | 6480464 | PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of BCL6 mRNA] | CTD | PMID:16006527 | toluene | increases expression | ISO | RGD:1319642 | 6480464 | Toluene results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | trans-resveratrol | increases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in increased expression of BCL6 mRNA | CTD | PMID:12002526 PMID:12569576 | trans-resveratrol | increases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in increased expression of BCL6 mRNA | CTD | PMID:12569576 PMID:12002526 | trans-resveratrol | decreases expression | ISO | RGD:1319642 | 6480464 | resveratrol results in decreased expression of BCL6 protein | CTD | PMID:17088997 | trichloroethene | increases expression | ISO | RGD:1319642 | 6480464 | Trichloroethylene results in increased expression of BCL6 mRNA | CTD | PMID:20359517 | tunicamycin | increases expression | ISO | RGD:1319643 | 6480464 | Tunicamycin results in increased expression of BCL6 mRNA | CTD | PMID:17127020 | valproic acid | affects expression | ISO | RGD:1319643 | 6480464 | Valproic Acid affects the expression of BCL6 mRNA | CTD | PMID:17292431 | vanadyl sulfate | decreases expression | ISO | RGD:1319642 | 6480464 | vanadyl sulfate results in decreased expression of BCL6 mRNA | CTD | PMID:16330358 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Transcriptional misregulation in cancer |
| Pathway Interaction Database | Direct p53 effectors (PID:200120) |
| FoxO family signaling (PID:200108) | |
| IL4-mediated signaling events (PID:200022) | |
| Signaling events mediated by HDAC Class II (PID:200023) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Transcriptional misregulation in cancer |
| Pathway Interaction Database | Direct p53 effectors (PID:200120) |
| FoxO family signaling (PID:200108) | |
| IL4-mediated signaling events (PID:200022) | |
| Signaling events mediated by HDAC Class II (PID:200023) | |
References - curated| 1. |
GOA data from the GO Consortium |
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MGD data from the GO Consortium |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated import pipeline for gene-chemical interactions |
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RGD comprehensive gene curation |
| 6. |
Ueda C, etal., Oncogene. 2002 Jan 17;21(3):368-76. |
References - uncurated
RGD Disease Portals| Bcl6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Bcl6 (Rattus norvegicus) |
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| BCL6 (Homo sapiens) |
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| Bcl6 (Mus musculus) |
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Position Markers| U41465 |
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| AU047979 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001107084 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06069229 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06069230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070126 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01070127 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC166425 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473999 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001107084 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001100554 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001100554 | (Get FASTA) |
| GenBank Protein | AAI66425 | (Get FASTA) |
| EDL78099 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001843 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000002522 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000002522 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 303836 | ENTREZGENE |
| Gene3D-CATH | BTB/POZ_fold | UniProtKB/TrEMBL |
| Znf_C2H2/integrase_DNA-bd | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 7640 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7097735 | IMAGE-MGC_LOAD |
| InterPro | BTB/POZ-like | UniProtKB/TrEMBL |
| BTB/POZ_fold | UniProtKB/TrEMBL | |
| BTB_POZ | UniProtKB/TrEMBL | |
| Znf_C2H2 | UniProtKB/TrEMBL | |
| Znf_C2H2-like | UniProtKB/TrEMBL | |
| Znf_C2H2/integrase_DNA-bd | UniProtKB/TrEMBL | |
| IPI | IPI00362078 | UniProtKB/TrEMBL |
| KEGG Report | rno:303836 | ENTREZGENE, UniProtKB/TrEMBL |
| MGC_CLONE | MGC:187400 | IMAGE-MGC_LOAD |
| Pfam | BTB | UniProtKB/TrEMBL |
| PROSITE | BTB | UniProtKB/TrEMBL |
| ZINC_FINGER_C2H2_1 | UniProtKB/TrEMBL | |
| ZINC_FINGER_C2H2_2 | UniProtKB/TrEMBL | |
| SMART | BTB | UniProtKB/TrEMBL |
| ZnF_C2H2 | UniProtKB/TrEMBL | |
| Superfamily-SCOP | BTB/POZ_fold | UniProtKB/TrEMBL |
| UniGene | Rn.20571 | ENTREZGENE |
| UniProt | B2GUV8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-09-25 | Bcl6 | B-cell CLL/lymphoma 6 | Bcl6 | B-cell leukemia/lymphoma 6 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Bcl6 | B-cell leukemia/lymphoma 6 | Bcl6_predicted | B-cell leukemia/lymphoma 6 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Bcl6_predicted | B-cell leukemia/lymphoma 6 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Bcl6 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1309345 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




