Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | decreases expression | EXP | | 6480464 | Dextroamphetamine results in decreased expression of CACNA1G mRNA | CTD | PMID:16715494 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:68990 | 6480464 | Ethinyl Estradiol affects the expression of CACNA1G mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:68990 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CACNA1G mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:68990 | 6480464 | Ethinyl Estradiol results in increased expression of CACNA1G mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of CACNA1G mRNA | CTD | PMID:20068009 | 17beta-estradiol | multiple interactions | ISO | RGD:68989 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of CACNA1G mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:68990 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CACNA1G mRNA | CTD | PMID:17942748 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | Mibefradil inhibits the reaction [[Forskolin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein]; more ... | CTD | PMID:17110049 | actinomycin D | multiple interactions | EXP | | 6480464 | Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] | CTD | PMID:19292980 | allethrin | multiple interactions | EXP | | 6480464 | Allethrin inhibits the reaction [CACNA1G protein results in increased transport of Calcium] | CTD | PMID:14634047 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CACNA1G mRNA | CTD | PMID:16483693 | barium(0) | increases transport | ISO | RGD:68989 | 6480464 | CACNA1G mRNA alternative form results in increased transport of Barium | CTD | PMID:11179973 | barium(0) | multiple interactions | ISO | RGD:68989 | 6480464 | Cerium inhibits the reaction [CACNA1G protein results in increased transport of Barium]; more ... | CTD | PMID:12163980 | barium(0) | increases transport | ISO | RGD:68989 | 6480464 | CACNA1G protein results in increased transport of Barium | CTD | PMID:12163980 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of CACNA1G mRNA | CTD | PMID:19167457 | cadmium dichloride | affects response to substance | ISO | RGD:68990 | 6480464 | CACNA1G affects the susceptibility to Cadmium Chloride | CTD | PMID:16282520 | calcium atom | increases transport | EXP | | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:11073957 PMID:14634047 | calcium atom | increases transport | EXP | | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:14634047 PMID:11073957 | calcium atom | multiple interactions | EXP | | 6480464 | Allethrin inhibits the reaction [CACNA1G protein results in increased transport of Calcium] | CTD | PMID:14634047 | calcium atom | multiple interactions | ISO | RGD:68990 | 6480464 | CACNG2 protein affects the reaction [CACNA1G protein results in increased transport of Calcium]; more ... | CTD | PMID:10734232 | calcium atom | increases transport | ISO | RGD:68990 | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:10734232 | calcium(0) | increases transport | EXP | | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:11073957 PMID:14634047 | calcium(0) | increases transport | EXP | | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:14634047 PMID:11073957 | calcium(0) | multiple interactions | EXP | | 6480464 | Allethrin inhibits the reaction [CACNA1G protein results in increased transport of Calcium] | CTD | PMID:14634047 | calcium(0) | multiple interactions | ISO | RGD:68990 | 6480464 | CACNG2 protein affects the reaction [CACNA1G protein results in increased transport of Calcium]; more ... | CTD | PMID:10734232 | calcium(0) | increases transport | ISO | RGD:68990 | 6480464 | CACNA1G protein results in increased transport of Calcium | CTD | PMID:10734232 | cerium | multiple interactions | ISO | RGD:68989 | 6480464 | Cerium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | choline | multiple interactions | ISO | RGD:68990 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CACNA1G gene | CTD | PMID:20938992 | erbium | multiple interactions | ISO | RGD:68989 | 6480464 | Erbium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | fluoxetine | affects expression | EXP | | 6480464 | Fluoxetine affects the expression of CACNA1G mRNA | CTD | PMID:21852994 | folic acid | multiple interactions | ISO | RGD:68990 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CACNA1G gene | CTD | PMID:20938992 | gadolinium atom | multiple interactions | ISO | RGD:68989 | 6480464 | Gadolinium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | holmium atom | multiple interactions | ISO | RGD:68989 | 6480464 | Holmium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | indole-3-methanol | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CACNA1G mRNA | CTD | PMID:22129741 | L-methionine | multiple interactions | ISO | RGD:68990 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of CACNA1G gene | CTD | PMID:20938992 | lanthanum atom | multiple interactions | ISO | RGD:68989 | 6480464 | Lanthanum inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | menadione | affects expression | ISO | RGD:68989 | 6480464 | Vitamin K 3 affects the expression of CACNA1G mRNA | CTD | PMID:20044591 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CACNA1G mRNA | CTD | PMID:22129741 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of CACNA1G mRNA | CTD | PMID:22129741 | neodymium atom | multiple interactions | ISO | RGD:68989 | 6480464 | Neodymium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | nickel atom | multiple interactions | EXP | | 6480464 | Nickel inhibits the reaction [[Forskolin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of CACNA1G protein] | CTD | PMID:17110049 | progesterone | multiple interactions | ISO | RGD:68989 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of CACNA1G mRNA | CTD | PMID:17404688 | scandium atom | multiple interactions | ISO | RGD:68989 | 6480464 | Scandium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | tamoxifen | affects expression | ISO | RGD:68990 | 6480464 | Tamoxifen affects the expression of CACNA1G mRNA | CTD | PMID:17555576 | telmisartan | multiple interactions | EXP | | 6480464 | PD 98059 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; more ... | CTD | PMID:19292980 | telmisartan | decreases expression | EXP | | 6480464 | telmisartan results in decreased expression of CACNA1G mRNA | CTD | PMID:19292980 | valproic acid | increases expression | ISO | RGD:68989 | 6480464 | Valproic Acid results in increased expression of CACNA1G mRNA | CTD | PMID:19101580 | ytterbium | multiple interactions | ISO | RGD:68989 | 6480464 | Ytterbium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | yttrium atom | multiple interactions | ISO | RGD:68989 | 6480464 | Yttrium inhibits the reaction [CACNA1G protein results in increased transport of Barium] | CTD | PMID:12163980 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Circadian entrainment | |
| MAPK signaling pathway | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription (PID:200176) |
Phenotype Annotations
Disease Annotations
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Circadian entrainment | |
| MAPK signaling pathway | |
| Type II diabetes mellitus | |
| Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription (PID:200176) |
Phenotype Annotations
References - curated| 1. |
BenMohamed F, etal., Mol Cell Biochem. 2009 Jan;320(1-2):173-83. Epub 2008 Sep 27. |
| 2. |
Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947. |
| 3. |
Dogrul A, etal., Pain 2003 Sep;105(1-2):159-68. |
| 4. |
Ferron L, etal., Circ Res. 2003 Dec 12;93(12):1241-8. Epub 2003 Nov 13. |
| 5. |
GOA data from the GO Consortium |
| 6. |
Hansen PB, etal., Circ Res. 2001 Sep 28;89(7):630-8. |
| 7. |
Iftinca M, etal., Neuroscience. 2006 Nov 3;142(4):1031-42. Epub 2006 Aug 28. |
| 8. |
Kang HW, etal., Biochim Biophys Acta. 2008 Dec;1778(12):2740-8. Epub 2008 Aug 9. |
| 9. |
Kase M, etal., Neurosci Lett. 1999 Jun 18;268(2):77-80. |
| 10. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 11. |
Latour I, etal., Glia 2003 Mar;41(4):347-53. |
| 12. |
McKay BE, etal., Eur J Neurosci. 2006 Nov;24(9):2581-94. |
| 13. |
McRory JE, etal., J Biol Chem 2001 Feb 9;276(6):3999-4011. |
| 14. |
MGD data from the GO Consortium |
| 15. |
Navarro-Gonzalez MF, etal., Clin Exp Pharmacol Physiol. 2009 Jan;36(1):55-66. Epub 2008 Aug 26. |
| 16. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 17. |
Perez-Reyes E, etal., Nature 1998 Feb 26;391(6670):896-900. |
| 18. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 19. |
RGD automated data pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 22. |
Zhou C, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L833-44. Epub 2006 Dec 15. |
| 23. |
Zhuang H, etal., Diabetes 2000 Jan;49(1):59-64. |
References - uncurated| PubMed | 16567615 |
| 17450521 | |
| 18294617 | |
| 18765948 | |
| 18930057 | |
| 19520861 | |
| 19657020 | |
| 19666840 | |
| 20505041 | |
| 21123217 | |
| 21148410 | |
| 23103495 |
RGD Disease Portals| Cacna1g has been annotated in the following RGD Disease Portals. |
|||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
![]() |
| ||||||||
Comparative Map Data| Cacna1g (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| CACNA1G (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Cacna1g (Mus musculus) |
|
Position Markers| D10Wox53 |
|
||||||||||||||||||||||||||||||
| RH130173 |
|
||||||||||||||||||||||||||||||
| RH142184 |
|
||||||||||||||||||||||||||||||
| BE098192 |
|
||||||||||||||||||||||||||||||
| RH137526 |
|
||||||||||||||||||||||||||||||
| CACNA1G-1 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_031601 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06065305 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06065306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06065307 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01065660 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01065661 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF027984 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF125161 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF203698 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF290212 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF116282 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF116283 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF116284 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF116285 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EF116286 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293202 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293203 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293204 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293205 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293206 | (Get FASTA) | Search GEO for Microarray Profiles | |
| EU293207 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FJ227500 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_031601 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_113789 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_113789 | (Get FASTA) |
| GenBank Protein | AAC67372 | (Get FASTA) |
| AAD26858 | (Get FASTA) | |
| AAF26716 | (Get FASTA) | |
| AAG35186 | (Get FASTA) | |
| ABL63737 | (Get FASTA) | |
| ABL63738 | (Get FASTA) | |
| ABL63739 | (Get FASTA) | |
| ABL63740 | (Get FASTA) | |
| ABL63741 | (Get FASTA) | |
| ABX89945 | (Get FASTA) | |
| ABX89946 | (Get FASTA) | |
| ABX89947 | (Get FASTA) | |
| ABX89948 | (Get FASTA) | |
| ABX89949 | (Get FASTA) | |
| ABX89950 | (Get FASTA) | |
| ACJ71730 | (Get FASTA) | |
| O54898 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002981 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000052461 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000061436 | UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000055597 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000067416 | UniProtKB/TrEMBL | |
| Entrez Gene | 29717 | ENTREZGENE |
| Germonline | ENSRNOG00000002981 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 22544 | ENTREZGENE |
| InterPro | Ion_trans | UniProtKB/Swiss-Prot |
| VDCC_T_a1su | UniProtKB/Swiss-Prot | |
| VDCCAlpha1 | UniProtKB/TrEMBL | |
| IPI | IPI00779802 | UniProtKB/Swiss-Prot |
| IPI00950405 | UniProtKB/TrEMBL | |
| KEGG Report | rno:29717 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Ion_trans | UniProtKB/Swiss-Prot |
| PharmGKB | CACNA1G | RGD |
| PRINTS | CACHANNEL | UniProtKB/TrEMBL |
| TVDCCALPHA1 | UniProtKB/Swiss-Prot | |
| TIGR | TC218456 | |
| UniGene | Rn.86960 | ENTREZGENE |
| UniProt | CAC1G_RAT | UniProtKB/Swiss-Prot |
| F1LSB3_RAT | UniProtKB/TrEMBL | |
| F1M9P2_RAT | UniProtKB/TrEMBL | |
| Q9WUB8_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Cacna1g | calcium channel, voltage-dependent, T type, alpha 1G subunit | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localizes to the plasma membrane of astrocytes | 727502 |
| gene_expression | expressed throughout the newborn and juvenile brain | 62421 |
| gene_expression | expressed in cultured astrocytes | 727502 |
| gene_expression | expressed in amygdala, cerebellum and thalamus | 68747 |
| gene_process | mediates voltage-dependent entry of calcium into nerve, muscle, and endocrine cells | 68748 |
| gene_process | responsible for central neuron rebound burst firing and implicated in slow wave sleep and epilepsy | 68748 |
| gene_process | may play a role in hormone secretion and smooth muscle excitability | 68748 |
| gene_process | may be involved in pacemaker activity, neuronal oscillations and resonance | 68747 |
| More on Cacna1g | |
![]() |
Entrez Gene |
![]() |
Ensembl Gene |
![]() | Genome Browser |
![]() |
NCBI Map Viewer |
![]() |
Vista |
![]() |
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 68942 |
| Created: | 2001-11-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




