Atox1 (antioxidant 1 copper chaperone) - Rat Genome Database

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Gene: Atox1 (antioxidant 1 copper chaperone) Rattus norvegicus
Analyze
Symbol: Atox1
Name: antioxidant 1 copper chaperone
RGD ID: 621684
Description: Enables ATPase binding activity. Involved in copper ion export; negative regulation of apoptotic process; and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human ATOX1 (antioxidant 1 copper chaperone); PARTICIPATES IN cisplatin drug pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atx1; ATX1 (antioxidant protein 1) homolog 1; ATX1 (antioxidant protein 1) homolog 1 (yeast); ATX1 antioxidant protein 1 homolog; ATX1 antioxidant protein 1 homolog (yeast); ATX1 homolog protein Rah1; copper transport protein ATOX1; metal transport protein ATX1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Hcuc1 Hcuc4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,065,525 - 40,080,627 (-)NCBIGRCr8
mRatBN7.21039,564,855 - 39,579,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,564,857 - 39,579,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,248,692 - 44,263,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,738,793 - 43,753,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,242,467 - 39,257,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,790,850 - 40,805,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,790,845 - 40,805,941 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,622,323 - 40,637,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,858,190 - 40,873,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,871,817 - 40,886,834 (-)NCBI
Celera1038,896,595 - 38,911,631 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-methylcholanthrene  (EXP)
4-hydroxy-TEMPO  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
acetylcholine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alpha-D-galactose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
D-glucose  (ISO)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
galactose  (ISO)
glucose  (ISO)
glyphosate  (ISO)
hexamethylene diisocyanate  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
superoxide  (ISO)
tetrachloromethane  (ISO)
tetraethylenepentamine  (ISO)
thioacetamide  (EXP)
toluene  (EXP)
Tributyltin oxide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Molecular cloning of rat ATX1 homologue protein. Hiromura M and Sakurai H, Biochem Biophys Res Commun 1999 Nov 19;265(2):509-12.
4. The copper transport protein Atox1 promotes neuronal survival. Kelner GS, etal., J Biol Chem 2000 Jan 7;275(1):580-4.
5. Novel role of copper transport protein antioxidant-1 in neointimal formation after vascular injury. Kohno T, etal., Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):805-13. doi: 10.1161/ATVBAHA.112.300862. Epub 2013 Jan 24.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model. Monnot AD, etal., Exp Biol Med (Maywood). 2012 Mar;237(3):327-33. doi: 10.1258/ebm.2011.011170.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Determinants for simultaneous binding of copper and platinum to human chaperone Atox1: hitchhiking not hijacking. Palm-Espling ME, etal., PLoS One. 2013 Jul 30;8(7):e70473. doi: 10.1371/journal.pone.0070473. Print 2013.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. A novel role for the immunophilin FKBP52 in copper transport. Sanokawa-Akakura R, etal., J Biol Chem 2004 Jul 2;279(27):27845-8. Epub 2004 May 7.
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14. Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis. Tokuda E, etal., J Neurochem. 2009 Oct;111(1):181-91. doi: 10.1111/j.1471-4159.2009.06310.x. Epub 2009 Jul 27.
Additional References at PubMed
PMID:8889548   PMID:10473283   PMID:10497213   PMID:11391006   PMID:12029094   PMID:15489334   PMID:37859596  


Genomics

Comparative Map Data
Atox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81040,065,525 - 40,080,627 (-)NCBIGRCr8
mRatBN7.21039,564,855 - 39,579,892 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,564,857 - 39,579,950 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1044,248,692 - 44,263,704 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,738,793 - 43,753,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01039,242,467 - 39,257,480 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,790,850 - 40,805,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,790,845 - 40,805,941 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,622,323 - 40,637,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,858,190 - 40,873,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,871,817 - 40,886,834 (-)NCBI
Celera1038,896,595 - 38,911,631 (-)NCBICelera
Cytogenetic Map10q22NCBI
ATOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,742,822 - 151,758,631 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,742,316 - 151,772,532 (-)EnsemblGRCh38hg38GRCh38
GRCh375151,122,383 - 151,138,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365151,102,576 - 151,118,403 (-)NCBINCBI36Build 36hg18NCBI36
Build 345151,102,576 - 151,118,533NCBI
Celera5147,203,796 - 147,219,624 (-)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5146,267,764 - 146,283,598 (-)NCBIHuRef
CHM1_15150,554,807 - 150,570,651 (-)NCBICHM1_1
T2T-CHM13v2.05152,281,791 - 152,297,603 (-)NCBIT2T-CHM13v2.0
Atox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391155,337,463 - 55,352,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1155,337,467 - 55,352,065 (-)EnsemblGRCm39 Ensembl
GRCm381155,446,637 - 55,461,208 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1155,446,641 - 55,461,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,260,145 - 55,274,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,931,478 - 55,946,013 (-)NCBIMGSCv36mm8
MGSCv361155,290,066 - 55,304,561 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1133.07NCBI
Atox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554086,156,334 - 6,168,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554086,156,334 - 6,168,423 (-)NCBIChiLan1.0ChiLan1.0
ATOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,971,589 - 146,986,802 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15145,111,134 - 145,126,336 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05147,166,744 - 147,181,970 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15153,169,467 - 153,184,505 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5153,169,467 - 153,184,505 (-)Ensemblpanpan1.1panPan2
ATOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1457,599,927 - 57,611,863 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl457,600,005 - 57,611,862 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,419,665 - 57,428,499 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,042,538 - 58,054,372 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,042,619 - 58,054,371 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1457,858,631 - 57,867,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0457,957,162 - 57,966,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0458,460,492 - 58,469,405 (+)NCBIUU_Cfam_GSD_1.0
Atox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213112,512,973 - 112,558,583 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651510,962,263 - 10,977,232 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651510,962,315 - 10,982,274 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,299,321 - 71,314,597 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,299,321 - 71,314,598 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21677,444,306 - 77,444,387 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238681
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1140,631,831 - 40,632,274 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038137,908,256 - 137,908,700 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,295,252 - 37,310,229 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,295,240 - 37,310,229 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atox1
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:36
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000017588
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat

Markers in Region
RH129645  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map10415.0UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017588   ⟹   ENSRNOP00000017588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,564,857 - 39,579,950 (-)Ensembl
Rnor_6.0 Ensembl1040,790,845 - 40,805,941 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119198   ⟹   ENSRNOP00000097743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1039,564,857 - 39,572,939 (-)Ensembl
RefSeq Acc Id: NM_053359   ⟹   NP_445811
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,065,525 - 40,080,561 (-)NCBI
mRatBN7.21039,564,855 - 39,579,892 (-)NCBI
Rnor_6.01040,790,850 - 40,805,886 (-)NCBI
Rnor_5.01040,622,323 - 40,637,362 (-)NCBI
RGSC_v3.41040,858,190 - 40,873,226 (-)RGD
Celera1038,896,595 - 38,911,631 (-)RGD
Sequence:
RefSeq Acc Id: XM_063269986   ⟹   XP_063126056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81040,065,529 - 40,080,627 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_445811   ⟸   NM_053359
- UniProtKB: Q549B3 (UniProtKB/Swiss-Prot),   Q9WUC4 (UniProtKB/Swiss-Prot),   A6HEM9 (UniProtKB/TrEMBL),   A0A8I6ASE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017588   ⟸   ENSRNOT00000017588
RefSeq Acc Id: ENSRNOP00000097743   ⟸   ENSRNOT00000119198
RefSeq Acc Id: XP_063126056   ⟸   XM_063269986
- Peptide Label: isoform X1
Protein Domains
HMA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUC4-F1-model_v2 AlphaFold Q9WUC4 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697203
Promoter ID:EPDNEW_R7727
Type:initiation region
Name:Atox1_1
Description:antioxidant 1 copper chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01040,805,854 - 40,805,914EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621684 AgrOrtholog
BioCyc Gene G2FUF-25078 BioCyc
Ensembl Genes ENSRNOG00000013118 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017588 ENTREZGENE
  ENSRNOT00000017588.7 UniProtKB/TrEMBL
  ENSRNOT00000119198.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919265 IMAGE-MGC_LOAD
InterPro Heavy-metal-associated_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84355 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72749 IMAGE-MGC_LOAD
NCBI Gene 84355 ENTREZGENE
PANTHER COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/Swiss-Prot
  COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/Swiss-Prot
  COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/TrEMBL
  COPPER TRANSPORT PROTEIN ATOX1 UniProtKB/TrEMBL
Pfam HMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atox1 PhenoGen
PROSITE HMA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013118 RatGTEx
Superfamily-SCOP SSF55008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ASE1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9K4_RAT UniProtKB/TrEMBL
  A6HEM9 ENTREZGENE, UniProtKB/TrEMBL
  ATOX1_RAT UniProtKB/Swiss-Prot
  Q549B3 ENTREZGENE
  Q9WUC4 ENTREZGENE
UniProt Secondary Q549B3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-07 Atox1  antioxidant 1 copper chaperone  Atox1  ATX1 antioxidant protein 1 homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atox1  ATX1 antioxidant protein 1 homolog (yeast)  Atox1  ATX1 (antioxidant protein 1) homolog 1 (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Atox1  ATX1 (antioxidant protein 1) homolog 1 (yeast)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Atox1  ATX1 (antioxidant protein 1) homolog 1 (yeast)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains an MTCXXC copper-binding site in the N terminus and a KTGK lysine-rich region in the C terminus 632007
gene_expression expressed in neurons, abundant in neuronal subtypes with high levels of metal, including copper, iron, and zinc 632006
gene_expression mRNA expressed in liver, small intestine, and testis 632007
gene_protein 68 amino acids with a predicted molecular mass of 7.2 kDa 632007