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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1604803 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TRPV4 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:735797 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TRPV4 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1604803 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TRPV4 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1604803 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TRPV4 mRNA | CTD | PMID:22298810 | 2-amino-2-deoxy-D-glucopyranose | increases expression | ISO | RGD:735797 | 6480464 | Glucosamine results in increased expression of TRPV4 mRNA | CTD | PMID:17178593 | 3',5'-cyclic AMP | increases expression | EXP | | 6480464 | Cyclic AMP results in increased expression of TRPV4 protein; more ... | CTD | PMID:22187434 | 3',5'-cyclic AMP | multiple interactions | EXP | | 6480464 | PD 98059 inhibits the reaction [Cyclic AMP results in increased expression of TRPV4 protein]; more ... | CTD | PMID:22187434 | 3-methylcholanthrene | multiple interactions | ISO | RGD:1604803 | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to TRPV4 promoter] | CTD | PMID:20348232 | 4-hydroxynon-2-enal | increases expression | ISO | RGD:735797 | 6480464 | 4-hydroxy-2-nonenal results in increased expression of TRPV4 mRNA | CTD | PMID:19191707 | aldehydo-D-glucosamine | increases expression | ISO | RGD:735797 | 6480464 | Glucosamine results in increased expression of TRPV4 mRNA | CTD | PMID:17178593 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of TRPV4 mRNA | CTD | PMID:16483693 | arachidonic acid | increases activity | ISO | RGD:1604803 | 6480464 | Arachidonic Acid results in increased activity of TRPV4 protein | CTD | PMID:20956320 | beta-D-glucosamine | increases expression | ISO | RGD:735797 | 6480464 | Glucosamine results in increased expression of TRPV4 mRNA | CTD | PMID:17178593 | calcium atom | multiple interactions | ISO | RGD:1604803 | 6480464 | TRPV4 protein promotes the reaction [phorbol-12,13-didecanoate results in increased import of Calcium] | CTD | PMID:18355916 | calcium atom | multiple interactions | ISO | RGD:735797 | 6480464 | TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] | CTD | PMID:18234883 | calcium(0) | multiple interactions | ISO | RGD:1604803 | 6480464 | TRPV4 protein promotes the reaction [phorbol-12,13-didecanoate results in increased import of Calcium] | CTD | PMID:18355916 | calcium(0) | multiple interactions | ISO | RGD:735797 | 6480464 | TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] | CTD | PMID:18234883 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of TRPV4 mRNA | CTD | PMID:16278290 | choline | multiple interactions | ISO | RGD:735797 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA | CTD | PMID:20938992 | diuron | increases expression | EXP | | 6480464 | Diuron results in increased expression of TRPV4 mRNA | CTD | PMID:21551480 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol results in increased expression of [ITGA2 protein binds to LYN protein binds to TRPV4 protein] | CTD | PMID:18234883 | ethanol | increases response to substance | EXP | | 6480464 | TRPV4 protein results in increased susceptibility to Ethanol | CTD | PMID:18234883 | folic acid | multiple interactions | ISO | RGD:735797 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA | CTD | PMID:20938992 | gadolinium atom | multiple interactions | EXP | | 6480464 | [Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine | CTD | PMID:20064552 | gadolinium atom | decreases activity | EXP | | 6480464 | Gadolinium results in decreased activity of TRPV4 protein | CTD | PMID:20064552 | L-methionine | multiple interactions | ISO | RGD:735797 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TRPV4 mRNA | CTD | PMID:20938992 | lead diacetate | affects expression | EXP | | 6480464 | lead acetate affects the expression of TRPV4 mRNA | CTD | PMID:21864555 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of TRPV4 mRNA | CTD | PMID:22641619 | paracetamol | increases expression | ISO | RGD:1604803 | 6480464 | Acetaminophen results in increased expression of TRPV4 mRNA | CTD | PMID:22230336 | prostaglandin E2 | multiple interactions | ISO | RGD:735797 | 6480464 | TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] | CTD | PMID:18234883 | S-butyl-DL-homocysteine (S,R)-sulfoximine | multiple interactions | EXP | | 6480464 | [Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine; more ... | CTD | PMID:20064552 | serotonin | multiple interactions | ISO | RGD:735797 | 6480464 | TRPV4 protein promotes the reaction [ITGA2 protein promotes the reaction [[Dinoprostone co-treated with Serotonin] results in increased import of Calcium]] | CTD | PMID:18234883 | sodium atom | affects abundance | ISO | RGD:1604803 | 6480464 | TRPV4 gene polymorphism affects the abundance of Sodium | CTD | PMID:19666518 | streptozocin | increases response to substance | EXP | | 6480464 | TRPV4 protein results in increased susceptibility to Streptozocin | CTD | PMID:18234883 | vincristine | increases response to substance | EXP | | 6480464 | TRPV4 protein results in increased susceptibility to Vincristine | CTD | PMID:18234883 | zalcitabine | increases response to substance | EXP | | 6480464 | TRPV4 protein results in increased susceptibility to Zalcitabine | CTD | PMID:18234883 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Liedtke W, etal., Cell 2000 Oct 27;103(3):525-35. |
| 2. |
MGD data from the GO Consortium |
| 3. |
RGD automated data pipeline |
| 4. |
RGD automated import pipeline for gene-chemical interactions |
| 5. |
RGD Automated Pipelines |
| 6. |
Shukla AK, etal., J Biol Chem. 2010 Sep 24;285(39):30115-25. Epub 2010 Jul 22. |
References - uncurated| PubMed | 14581619 |
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| 19066426 | |
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| 19888909 | |
| 20044482 | |
| 20093626 | |
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| 22187434 | |
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| 22865090 | |
| 22962011 | |
| 23288842 |
RGD Disease Portals| Trpv4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Trpv4 (Rattus norvegicus) |
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| TRPV4 (Homo sapiens) |
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| Trpv4 (Mus musculus) |
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Position Markers| D12Got95 |
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| Trpv4 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_023970 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06072465 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01072965 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF263521 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473973 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_023970 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_076460 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_076460 | (Get FASTA) |
| GenBank Protein | AAG28027 | (Get FASTA) |
| EDM13932 | (Get FASTA) | |
| EDM13933 | (Get FASTA) | |
| Q9ERZ8 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000001195 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000001586 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000001586 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 66026 | ENTREZGENE |
| Gene3D-CATH | ANK | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000001195 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 11003 | ENTREZGENE |
| InterPro | Ankyrin_rpt | UniProtKB/Swiss-Prot |
| Ankyrin_rpt-contain_dom | UniProtKB/Swiss-Prot | |
| Ion_trans | UniProtKB/Swiss-Prot | |
| TRP_channel | UniProtKB/Swiss-Prot | |
| TRPV_channel | UniProtKB/Swiss-Prot | |
| Vanilpoid_rcpt | UniProtKB/Swiss-Prot | |
| Vanilpoid_rcpt_2 | UniProtKB/Swiss-Prot | |
| IPI | IPI00191593 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:66026 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR10582 | UniProtKB/Swiss-Prot |
| PTHR10582:SF4 | UniProtKB/Swiss-Prot | |
| Pfam | Ank | UniProtKB/Swiss-Prot |
| Ion_trans | UniProtKB/Swiss-Prot | |
| PRINTS | TRPVRECEPTOR | UniProtKB/Swiss-Prot |
| VRL2RECEPTOR | UniProtKB/Swiss-Prot | |
| PROSITE | ANK_REP_REGION | UniProtKB/Swiss-Prot |
| ANK_REPEAT | UniProtKB/Swiss-Prot | |
| SMART | ANK | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | ANK | UniProtKB/Swiss-Prot |
| TIGRFAMs | trp | UniProtKB/Swiss-Prot |
| UniGene | Rn.64508 | ENTREZGENE |
| UniProt | TRPV4_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2003-04-09 | Trpv4 | transient receptor potential cation channel, subfamily V, member 4 | ransient receptor potential cation channel, subfamily 5, member 4 | Symbol and Name updated | 2574 | APPROVED | |
| 2002-06-10 | Trpv4 | ransient receptor potential cation channel, subfamily 5, member 4 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | expressed in neurons of the circumventricular organs, inner-ear hair cells, sensory neurons, and Merkel cells | 68824 |
| More on Trpv4 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 69337 |
| Created: | 2001-11-14 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.