Myom2 (myomesin 2) - Rat Genome Database

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Gene: Myom2 (myomesin 2) Rattus norvegicus
Analyze
Symbol: Myom2
Name: myomesin 2
RGD ID: 631437
Description: Predicted to enable kinase binding activity. Involved in extraocular skeletal muscle development. Located in M band. Orthologous to human MYOM2 (myomesin 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: myomesin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81681,222,467 - 81,295,025 (-)NCBIGRCr8
mRatBN7.21674,520,148 - 74,592,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1674,520,157 - 74,592,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1679,798,390 - 79,868,019 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01683,251,971 - 83,321,596 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01678,501,420 - 78,571,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01679,587,136 - 79,672,871 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1679,587,640 - 79,671,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01679,164,821 - 79,248,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41679,330,395 - 79,402,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11679,357,340 - 79,361,498 (-)NCBI
Celera1672,338,236 - 72,408,234 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
M band  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle. Porter JD, etal., J Exp Biol 2003 Sep 1;206(Pt 17):3101-3112.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The globular head domain of titin extends into the center of the sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron microscopy of two titin-associated proteins. Vinkemeier U, etal., J Cell Sci. 1993 Sep;106 ( Pt 1):319-30.
Additional References at PubMed
PMID:8618961   PMID:12972258   PMID:20215401   PMID:20368620   PMID:20833797   PMID:24176915   PMID:37037889  


Genomics

Comparative Map Data
Myom2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81681,222,467 - 81,295,025 (-)NCBIGRCr8
mRatBN7.21674,520,148 - 74,592,658 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1674,520,157 - 74,592,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1679,798,390 - 79,868,019 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01683,251,971 - 83,321,596 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01678,501,420 - 78,571,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01679,587,136 - 79,672,871 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1679,587,640 - 79,671,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01679,164,821 - 79,248,508 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41679,330,395 - 79,402,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11679,357,340 - 79,361,498 (-)NCBI
Celera1672,338,236 - 72,408,234 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
MYOM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3882,045,046 - 2,145,456 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl82,045,046 - 2,165,552 (+)EnsemblGRCh38hg38GRCh38
GRCh3781,993,161 - 2,093,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3681,980,565 - 2,080,787 (+)NCBINCBI36Build 36hg18NCBI36
Build 3481,980,654 - 2,080,786NCBI
Celera81,935,877 - 2,035,353 (+)NCBICelera
Cytogenetic Map8p23.3NCBI
HuRef81,809,335 - 1,908,897 (+)NCBIHuRef
CHM1_181,992,917 - 2,093,330 (+)NCBICHM1_1
T2T-CHM13v2.081,823,634 - 1,924,189 (+)NCBIT2T-CHM13v2.0
Myom2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39815,107,653 - 15,183,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl815,107,653 - 15,183,541 (+)EnsemblGRCm39 Ensembl
GRCm38815,057,653 - 15,133,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl815,057,653 - 15,133,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv37815,057,653 - 15,133,419 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36815,057,630 - 15,133,518 (+)NCBIMGSCv36mm8
Celera815,222,231 - 15,297,079 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map87.63NCBI
Myom2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540357,717,151 - 57,772,254 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540357,718,120 - 57,783,338 (-)NCBIChiLan1.0ChiLan1.0
MYOM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2716,715,741 - 16,894,105 (+)NCBINHGRI_mPanPan1-v2
Mhudiblu_PPA_v085,189,688 - 5,319,538 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.181,924,662 - 2,054,706 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl81,924,661 - 2,057,695 (+)Ensemblpanpan1.1panPan2
MYOM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11654,379,342 - 54,392,955 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1649,822,565 - 49,877,815 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01661,785,970 - 61,837,393 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11654,462,472 - 54,517,516 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01659,694,871 - 59,745,918 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01660,079,361 - 60,129,897 (-)NCBIUU_Cfam_GSD_1.0
Myom2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049431,153,000 - 1,223,233 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366151,153,065 - 1,223,239 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366151,153,056 - 1,223,239 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYOM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1533,510,929 - 33,606,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11533,529,559 - 33,606,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21538,071,182 - 38,120,980 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYOM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.181,634,917 - 1,809,804 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl81,705,074 - 1,809,874 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605443,567,081 - 43,701,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myom2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248611,127,516 - 1,177,327 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248611,117,501 - 1,177,650 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myom2
646 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:131
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000015908
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat

Markers in Region
D16Got93  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01679,605,649 - 79,605,797NCBIRnor6.0
Rnor_5.01679,183,376 - 79,183,524UniSTSRnor5.0
RGSC_v3.41679,348,347 - 79,348,522RGDRGSC3.4
RGSC_v3.41679,348,348 - 79,348,522UniSTSRGSC3.4
RGSC_v3.11679,348,613 - 79,348,787RGD
Celera1672,356,222 - 72,356,396UniSTS
RH 3.4 Map16728.1RGD
RH 3.4 Map16728.1UniSTS
RH 2.0 Map16854.2RGD
Cytogenetic Map16q12.5UniSTS
BE098027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21674,521,975 - 74,522,133 (+)MAPPERmRatBN7.2
Rnor_6.01679,588,971 - 79,589,128NCBIRnor6.0
Rnor_5.01679,166,649 - 79,166,806UniSTSRnor5.0
RGSC_v3.41679,331,726 - 79,331,883UniSTSRGSC3.4
Celera1672,339,567 - 72,339,724UniSTS
RH 3.4 Map16729.0UniSTS
Cytogenetic Map16q12.5UniSTS
RH132520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21674,520,217 - 74,520,411 (+)MAPPERmRatBN7.2
Rnor_6.01679,587,213 - 79,587,406NCBIRnor6.0
Rnor_5.01679,164,891 - 79,165,084UniSTSRnor5.0
RGSC_v3.41679,329,968 - 79,330,161UniSTSRGSC3.4
Celera1672,337,809 - 72,338,002UniSTS
RH 3.4 Map16729.1UniSTS
Cytogenetic Map16q12.5UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1 3
Medium 26 5 8 8 8 8 8
Low 3 16 21 10 19 10 25 17 22 3
Below cutoff 4 4 4 49 18 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015908   ⟹   ENSRNOP00000015908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1674,520,157 - 74,590,140 (-)Ensembl
Rnor_6.0 Ensembl1679,587,640 - 79,671,719 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097431   ⟹   ENSRNOP00000090643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1674,520,157 - 74,592,772 (-)Ensembl
RefSeq Acc Id: NM_001169141   ⟹   NP_001162612
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81681,222,939 - 81,292,423 (-)NCBI
mRatBN7.21674,520,645 - 74,590,140 (-)NCBI
Rnor_6.01679,587,640 - 79,671,719 (-)NCBI
Rnor_5.01679,164,821 - 79,248,508 (-)NCBI
RGSC_v3.41679,330,395 - 79,402,689 (-)RGD
Celera1672,338,236 - 72,408,234 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253389   ⟹   XP_006253451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81681,222,467 - 81,292,474 (-)NCBI
mRatBN7.21674,520,148 - 74,590,193 (-)NCBI
Rnor_6.01679,587,136 - 79,671,833 (-)NCBI
Rnor_5.01679,164,821 - 79,248,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094595   ⟹   XP_038950523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81681,222,467 - 81,295,025 (-)NCBI
mRatBN7.21674,520,148 - 74,592,658 (-)NCBI
RefSeq Acc Id: XM_063275476   ⟹   XP_063131546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81681,222,467 - 81,294,879 (-)NCBI
RefSeq Acc Id: XM_063275477   ⟹   XP_063131547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81681,222,467 - 81,293,570 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001162612   ⟸   NM_001169141
- UniProtKB: G3V7K1 (UniProtKB/TrEMBL),   A6IWD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253451   ⟸   XM_006253389
- Peptide Label: isoform X1
- UniProtKB: G3V7K1 (UniProtKB/TrEMBL),   A6IWD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015908   ⟸   ENSRNOT00000015908
RefSeq Acc Id: XP_038950523   ⟸   XM_039094595
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000090643   ⟸   ENSRNOT00000097431
RefSeq Acc Id: XP_063131546   ⟸   XM_063275476
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063131547   ⟸   XM_063275477
- Peptide Label: isoform X1
Protein Domains
Fibronectin type-III   Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7K1-F1-model_v2 AlphaFold G3V7K1 1-1464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700218
Promoter ID:EPDNEW_R10742
Type:single initiation site
Name:Myom2_1
Description:myomesin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01679,671,742 - 79,671,802EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631437 AgrOrtholog
BioCyc Gene G2FUF-10755 BioCyc
Ensembl Genes ENSRNOG00000011754 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015908.7 UniProtKB/TrEMBL
  ENSRNOT00000097431.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
KEGG Report rno:306616 UniProtKB/TrEMBL
NCBI Gene 306616 ENTREZGENE
PANTHER BENT, ISOFORM F UniProtKB/TrEMBL
  MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 UniProtKB/TrEMBL
  PTHR13817:SF181 UniProtKB/TrEMBL
  PTHR14340:SF24 UniProtKB/TrEMBL
  STRETCHIN-MLCK, ISOFORM U UniProtKB/TrEMBL
  TITIN UniProtKB/TrEMBL
Pfam fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
PhenoGen Myom2 PhenoGen
PRINTS FNTYPEIII UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011754 RatGTEx
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A8I6AC90_RAT UniProtKB/TrEMBL
  A6IWD0 ENTREZGENE, UniProtKB/TrEMBL
  G3V7K1 ENTREZGENE, UniProtKB/TrEMBL
  Q80UL0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Myom2  myomesin 2      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is postnatally downregulated 633368