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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of P2RY1 mRNA | CTD | PMID:21215274 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of P2RY1 mRNA | CTD | PMID:21346803 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:11043 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of P2RY1 mRNA] | CTD | PMID:19467301 | acetylsalicylic acid | decreases response to substance | ISO | RGD:736104 | 6480464 | P2RY1 SNP results in decreased susceptibility to Aspirin | CTD | PMID:15757620 | acetylsalicylic acid | decreases response to substance | ISO | RGD:736104 | 6480464 | P2RY1 polymorphism results in decreased susceptibility to Aspirin | CTD | PMID:21429568 | acetylsalicylic acid | affects response to substance | ISO | RGD:736104 | 6480464 | P2RY1 affects the susceptibility to Aspirin | CTD | PMID:17559347 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of P2RY1 mRNA | CTD | PMID:16483693 | ATP | multiple interactions | ISO | RGD:736104 | 6480464 | Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein; more ... | CTD | PMID:12694404 | ATP | multiple interactions | ISO | RGD:736104 | 6480464 | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]] | CTD | PMID:22129738 | ATP | multiple interactions | EXP | | 6480464 | [N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate binds to and results in decreased activity of P2RY1 protein] inhibits the reaction [Adenosine Triphosphate results in increased uptake of Calcium] | CTD | PMID:16973929 | ATP | affects activity | ISO | RGD:11043 | 6480464 | Adenosine Triphosphate affects the activity of P2RY1 protein | CTD | PMID:15243297 | benzo[a]pyrene | multiple interactions | ISO | RGD:11043 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of P2RY1 mRNA; more ... | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:11043 | 6480464 | Benzo(a)pyrene results in decreased expression of P2RY1 mRNA | CTD | PMID:22228805 | butan-1-ol | multiple interactions | ISO | RGD:736104 | 6480464 | 1-Butanol inhibits the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] | CTD | PMID:16236484 | butan-1-ol | multiple interactions | EXP | | 6480464 | 1-Butanol inhibits the reaction [P2RY1 protein affects the reaction [Nucleotides results in increased phosphorylation of and results in increased activity of MAPK1 protein]]; more ... | CTD | PMID:17620283 | calcium atom | multiple interactions | ISO | RGD:736104 | 6480464 | Calcium affects the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] | CTD | PMID:16236484 | calcium atom | multiple interactions | EXP | | 6480464 | [2-methylthio-ADP binds to and results in increased activity of P2RY1 protein] which results in increased uptake of Calcium; more ... | CTD | PMID:16973929 | calcium atom | multiple interactions | ISO | RGD:736104 | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; more ... | CTD | PMID:12694404 | calcium(0) | multiple interactions | ISO | RGD:736104 | 6480464 | Calcium affects the reaction [P2RY1 protein results in increased phosphorylation of and results in increased activity of AKT1 protein] | CTD | PMID:16236484 | calcium(0) | multiple interactions | EXP | | 6480464 | [2-methylthio-ADP binds to and results in increased activity of P2RY1 protein] which results in increased uptake of Calcium; more ... | CTD | PMID:16973929 | calcium(0) | multiple interactions | ISO | RGD:736104 | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium; more ... | CTD | PMID:12694404 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of P2RY1 mRNA | CTD | PMID:15620428 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of P2RY1 mRNA | CTD | PMID:21266533 | hydrogen peroxide | multiple interactions | ISO | RGD:736104 | 6480464 | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]] | CTD | PMID:22129738 | lead diacetate | increases expression | ISO | RGD:11043 | 6480464 | lead acetate results in increased expression of P2RY1 mRNA | CTD | PMID:22609695 | paracetamol | affects expression | ISO | RGD:11043 | 6480464 | Acetaminophen affects the expression of P2RY1 mRNA | CTD | PMID:17562736 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of P2RY1 mRNA | CTD | PMID:18198484 | phencyclidine | increases expression | ISO | RGD:11043 | 6480464 | Phencyclidine results in increased expression of P2RY1 mRNA | CTD | PMID:12105081 | pirinixic acid | increases expression | ISO | RGD:11043 | 6480464 | pirinixic acid results in increased expression of P2RY1 mRNA | CTD | PMID:18301758 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of P2RY1 mRNA | CTD | PMID:19162173 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of P2RY1 mRNA | CTD | PMID:12734012 | trichloroethene | multiple interactions | ISO | RGD:736104 | 6480464 | Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | trichloroethene | decreases activity | ISO | RGD:736104 | 6480464 | Trichloroethylene results in decreased activity of P2RY1 protein | CTD | PMID:12694404 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neuroactive ligand-receptor interaction |
References - curated| 1. |
Cheung KK, etal., Dev Dyn. 2003 Oct;228(2):254-66. |
| 2. |
Christofi FL, etal., J Comp Neurol. 2004 Jan 26;469(1):16-36. |
| 3. |
De Simone R, etal., J Neurochem. 2010 Oct;115(2):450-9. doi: 10.1111/j.1471-4159.2010.06937.x. Epub 2010 Aug 30. |
| 4. |
Dixon CJ, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):334-41. Epub 2004 May 19. |
| 5. |
Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67. |
| 6. |
Franke H, etal., Glia. 2009 Aug 1;57(10):1031-45. |
| 7. |
GOA data from the GO Consortium |
| 8. |
Greig AV, etal., Exp Dermatol. 2003 Dec;12(6):860-71. |
| 9. |
Gur S, etal., J Urol. 2009 May;181(5):2375-82. Epub 2009 Mar 19. |
| 10. |
Horiuchi T, etal., Stroke. 2003 Jun;34(6):1473-8. Epub 2003 May 1. |
| 11. |
Kittner H, etal., Eur J Neurosci. 2006 Oct;24(7):2049-56. |
| 12. |
Krzeminski P, etal., Brain Res Bull. 2007 Mar 30;71(6):587-92. Epub 2006 Dec 22. |
| 13. |
MGD data from the GO Consortium |
| 14. |
Miao LY, etal., Exp Gerontol. 2001 Dec;37(1):67-79. |
| 15. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 16. |
Ninomiya H, etal., Am J Physiol Heart Circ Physiol 2002 May;282(5):H1810-20. |
| 17. |
Quintas C, etal., Neurochem Int. 2009 Dec;55(7):505-13. Epub 2009 May 15. |
| 18. |
RGD automated data pipeline |
| 19. |
RGD automated import pipeline for gene-chemical interactions |
| 20. |
Song Z, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Aug;297(2):R478-84. Epub 2009 Jun 10. |
| 21. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 22. |
Tokuyama Y, etal., Biochem Biophys Res Commun 1995 Jun 6;211(1):211-8. |
| 23. |
Wurm A, etal., Glia. 2009 Nov 15;57(15):1680-90. |
| 24. |
Yajima H, etal., Neurosci Res. 2005 Apr;51(4):405-16. Epub 2005 Jan 20. |
References - uncurated| PubMed | 11390975 |
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| 18841035 | |
| 19196799 | |
| 19223012 | |
| 19396875 | |
| 19906120 | |
| 20570683 | |
| 20720114 | |
| 21487414 | |
| 21540076 | |
| 21879346 | |
| 22065011 | |
| 22349022 |
RGD Disease Portals| P2ry1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| P2ry1 (Rattus norvegicus) |
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| P2RY1 (Homo sapiens) |
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| P2ry1 (Mus musculus) |
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Position Markers| PMC123072P2 |
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| PMC34459P1 |
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| BF405988 |
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| BE117641 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012800 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06016967 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01017374 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U22830 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012800 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036932 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036932 | (Get FASTA) |
| GenBank Protein | AAA91303 | (Get FASTA) |
| EDM14829 | (Get FASTA) | |
| EDM14830 | (Get FASTA) | |
| P49651 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014232 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000019304 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000019305 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 25265 | ENTREZGENE |
| Germonline | ENSRNOG00000014232 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 1926 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| P2_purnocptor | UniProtKB/Swiss-Prot | |
| P2Y_purnocptor | UniProtKB/Swiss-Prot | |
| IPI | IPI00196297 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:25265 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PharmGKB | P2RY1 | RGD |
| PRINTS | GPCRRHODOPSN | UniProtKB/Swiss-Prot |
| P2Y1PRNOCPTR | UniProtKB/Swiss-Prot | |
| P2YPURNOCPTR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| TIGR | TC213922 | |
| UniGene | Rn.10217 | ENTREZGENE |
| UniProt | P2RY1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-01-14 | P2ry1 | purinergic receptor P2Y, G-protein coupled, 1 | P2ry1 | purinergic receptor P2Y, G-protein coupled 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-11-06 | P2ry1 | purinergic receptor P2Y, G-protein coupled 1 | P2 purinoreceptor subclass 2Y | Name updated | 2225 | APPROVED | |
| 2002-06-10 | P2ry1 | P2 purinoreceptor subclass 2Y | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localized to the apical plasma membrane and basolateral domains | 628452 |
| gene_expression | mRNA present in holangiocytes, hepatocytes and epithelial cells | 628452 |
| gene_physical_interaction | coupled with both pertussis toxin-sensitive Gi/Go and -insensitive Gq/G11 proteins | 729533 |
| gene_process | mediates vasomotor responses, neurotransmission, platelet aggregation, and secretion | 628452 |
| gene_regulation | activated mainly by ADP, to a lesser degree by ATP | 628452 |
| More on P2ry1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3242 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.