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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1322205 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIK3CD mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1322206 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PIK3CD gene] | CTD | PMID:20819909 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1322206 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PIK3CD mRNA | CTD | PMID:20819909 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1322206 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PIK3CD mRNA | CTD | PMID:19465110 | 2-butoxyethanol | decreases expression | ISO | RGD:1322206 | 6480464 | n-butoxyethanol results in decreased expression of PIK3CD mRNA | CTD | PMID:19812364 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1322206 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of PIK3CD mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1322206 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of PIK3CD mRNA | CTD | PMID:19191707 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1322205 | 6480464 | decitabine results in increased expression of PIK3CD mRNA | CTD | PMID:17940511 | all-trans-retinoic acid | increases expression | ISO | RGD:1322205 | 6480464 | Tretinoin results in increased expression of PIK3CD mRNA | CTD | PMID:15498508 | arsenic atom | increases expression | ISO | RGD:1322205 | 6480464 | Arsenic results in increased expression of PIK3CD mRNA | CTD | PMID:19945496 | benzene | multiple interactions | ISO | RGD:1322206 | 6480464 | TRP53 protein affects the reaction [Benzene results in increased expression of PIK3CD mRNA] | CTD | PMID:12928149 | benzene | increases expression | ISO | RGD:1322206 | 6480464 | Benzene results in increased expression of PIK3CD | CTD | PMID:15935813 | benzene | multiple interactions | ISO | RGD:1322206 | 6480464 | TRP53 protein promotes the reaction [Benzene results in increased expression of PIK3CD] | CTD | PMID:15935813 | benzene | increases expression | ISO | RGD:1322206 | 6480464 | Benzene results in increased expression of PIK3CD mRNA | CTD | PMID:12928149 | benzo[a]pyrene | decreases expression | ISO | RGD:1322205 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CD mRNA | CTD | PMID:20106945 PMID:20064835 | benzo[a]pyrene | increases expression | ISO | RGD:1322206 | 6480464 | Benzo(a)pyrene results in increased expression of PIK3CD mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CD mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases expression | ISO | RGD:1322206 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CD mRNA | CTD | PMID:21569818 | benzo[a]pyrene | decreases expression | ISO | RGD:1322205 | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3CD mRNA | CTD | PMID:20064835 PMID:20106945 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:1322206 | 6480464 | Mustard Gas results in increased expression of PIK3CD mRNA | CTD | PMID:18955075 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PIK3CD mRNA | CTD | PMID:19167457 | cadmium dichloride | affects expression | ISO | RGD:1322206 | 6480464 | Cadmium Chloride affects the expression of PIK3CD mRNA | CTD | PMID:18974090 | calcium atom | affects transport | ISO | RGD:1322206 | 6480464 | PIK3CD protein affects the transport of Calcium | CTD | PMID:16179367 | calcium(0) | affects transport | ISO | RGD:1322206 | 6480464 | PIK3CD protein affects the transport of Calcium | CTD | PMID:16179367 | carmustine | affects response to substance | ISO | RGD:1322205 | 6480464 | PIK3CD mRNA affects the susceptibility to Carmustine | CTD | PMID:16365179 | celastrol | decreases expression | ISO | RGD:1322205 | 6480464 | tripterine results in decreased expression of PIK3CD mRNA | CTD | PMID:17010675 | chloroprene | decreases expression | ISO | RGD:1322206 | 6480464 | Chloroprene results in decreased expression of PIK3CD mRNA | CTD | PMID:23125180 | copper(2+) sulfate | increases expression | ISO | RGD:1322205 | 6480464 | Copper Sulfate results in increased expression of PIK3CD mRNA | CTD | PMID:19549813 | elemental selenium | increases expression | ISO | RGD:1322205 | 6480464 | Selenium results in increased expression of PIK3CD mRNA | CTD | PMID:19244175 | elemental selenium | multiple interactions | ISO | RGD:1322205 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of PIK3CD mRNA | CTD | PMID:19244175 | fonofos | increases methylation | ISO | RGD:1322205 | 6480464 | Fonofos results in increased methylation of PIK3CD promoter | CTD | PMID:22847954 | gedunin | decreases expression | ISO | RGD:1322205 | 6480464 | gedunin results in decreased expression of PIK3CD mRNA | CTD | PMID:17010675 | glycyrrhetinate | decreases activity | ISO | RGD:1322206 | 6480464 | 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein | CTD | PMID:21644799 | glycyrrhetinic acid | decreases activity | ISO | RGD:1322206 | 6480464 | 18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein | CTD | PMID:21644799 | glycyrrhizinic acid | decreases activity | ISO | RGD:1322206 | 6480464 | Glycyrrhizic Acid results in decreased activity of PIK3CD protein | CTD | PMID:21644799 | LY294002 | decreases activity | ISO | RGD:1322206 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CD protein | CTD | PMID:16179367 | N-nitrosodimethylamine | increases expression | ISO | RGD:1322205 | 6480464 | Dimethylnitrosamine results in increased expression of PIK3CD mRNA | CTD | PMID:17547211 | parathion | increases methylation | ISO | RGD:1322205 | 6480464 | Parathion results in increased methylation of PIK3CD promoter | CTD | PMID:22847954 | phenol | increases expression | ISO | RGD:1322205 | 6480464 | Phenol results in increased expression of PIK3CD mRNA | CTD | PMID:17547211 | selenium atom | increases expression | ISO | RGD:1322205 | 6480464 | Selenium results in increased expression of PIK3CD mRNA | CTD | PMID:19244175 | selenium atom | multiple interactions | ISO | RGD:1322205 | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of PIK3CD mRNA | CTD | PMID:19244175 | tamibarotene | increases expression | ISO | RGD:1322205 | 6480464 | Am 80 results in increased expression of PIK3CD mRNA; more ... | CTD | PMID:15498508 | temozolomide | affects response to substance | ISO | RGD:1322205 | 6480464 | PIK3CD mRNA affects the susceptibility to temozolomide | CTD | PMID:16365179 | terbufos | increases methylation | ISO | RGD:1322205 | 6480464 | terbufos results in increased methylation of PIK3CD promoter | CTD | PMID:22847954 | tetracycline | decreases expression | ISO | RGD:1322206 | 6480464 | Tetracycline results in decreased expression of PIK3CD mRNA | CTD | PMID:16917069 | trichostatin A | increases expression | ISO | RGD:1322205 | 6480464 | trichostatin A results in increased expression of PIK3CD mRNA | CTD | PMID:17940511 | valproic acid | increases expression | ISO | RGD:1322205 | 6480464 | Valproic Acid results in increased expression of PIK3CD mRNA | CTD | PMID:19101580 | wortmannin | decreases activity | ISO | RGD:1322206 | 6480464 | wortmannin results in decreased activity of PIK3CD protein | CTD | PMID:21644799 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Acute myeloid leukemia |
| Aldosterone-regulated sodium reabsorption | |
| Amoebiasis | |
| Apoptosis | |
| B cell receptor signaling pathway | |
| Bacterial invasion of epithelial cells | |
| Carbohydrate digestion and absorption | |
| Chagas disease (American trypanosomiasis) | |
| Chemokine signaling pathway | |
| Cholinergic synapse | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Endometrial cancer | |
| Epstein-Barr virus infection | |
| ErbB signaling pathway | |
| Fc epsilon RI signaling pathway | |
| Fc gamma R-mediated phagocytosis | |
| Focal adhesion | |
| Glioma | |
| Hepatitis B | |
| Hepatitis C | |
| HIF-1 signaling pathway | |
| HTLV-I infection | |
| Influenza A | |
| Inositol phosphate metabolism | |
| Insulin signaling pathway | |
| Jak-STAT signaling pathway | |
| Leukocyte transendothelial migration | |
| Measles | |
| Melanoma | |
| mTOR signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Neurotrophin signaling pathway | |
| Non-small cell lung cancer | |
| Osteoclast differentiation | |
| Pancreatic cancer | |
| Pathways in cancer | |
| Phosphatidylinositol signaling system | |
| PI3K-Akt signaling pathway | |
| Progesterone-mediated oocyte maturation | |
| Prostate cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Toxoplasmosis | |
| Type II diabetes mellitus | |
| VEGF signaling pathway | |
| Viral carcinogenesis | |
| Pathway Interaction Database | Class I PI3K signaling events (PID:200116) |
| CXCR3-mediated signaling events (PID:200175) | |
| CXCR4-mediated signaling events (PID:200099) | |
| EGF receptor (ErbB1) signaling pathway (PID:200101) | |
| ErbB1 downstream signaling (PID:200133) | |
| ErbB2/ErbB3 signaling events (PID:200140) | |
| ErbB4 signaling events (PID:200011) | |
| FAS (CD95) signaling pathway (PID:200080) | |
| Internalization of ErbB1 (PID:200171) | |
| Nephrin/Neph1 signaling in the kidney podocyte (PID:200152) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Signaling events mediated by TCPTP (PID:200078) | |
| TRAIL signaling pathway (PID:200068) | |
References - curated| 1. |
GOA data from the GO Consortium |
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Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56. |
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MGD data from the GO Consortium |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 6. |
Randis TM, etal., Eur J Immunol. 2008 May;38(5):1215-24. |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
References - uncurated
RGD Disease Portals| Pik3cd has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pik3cd (Rattus norvegicus) |
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| PIK3CD (Homo sapiens) |
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| Pik3cd (Mus musculus) |
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Position Markers| RH133425 |
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| RH142729 |
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| BE109926 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108978 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06040965 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01040856 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01040857 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC099153 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108978 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001102448 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001102448 | (Get FASTA) |
| GenBank Protein | EDL81170 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000016846 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000061674 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000066179 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 366508 | ENTREZGENE |
| Gene3D-CATH | 0.70 | UniProtKB/TrEMBL |
| 070.11 | UniProtKB/TrEMBL | |
| HomoloGene Group ID | 3686 | ENTREZGENE |
| InterPro | ARM-type_fold | UniProtKB/TrEMBL |
| C2_Ca/lipid-bd_dom_CaLB | UniProtKB/TrEMBL | |
| Kinase-like_dom | UniProtKB/TrEMBL | |
| PI3/4_kinase_cat_dom | UniProtKB/TrEMBL | |
| PI3/4_kinase_CS | UniProtKB/TrEMBL | |
| PI3K_C2_dom | UniProtKB/TrEMBL | |
| PI3K_p85-bd | UniProtKB/TrEMBL | |
| PI3K_Ras-bd_dom | UniProtKB/TrEMBL | |
| PI_Kinase | UniProtKB/TrEMBL | |
| PInositide-3_kin_accessory_dom | UniProtKB/TrEMBL | |
| IPI | IPI00949003 | UniProtKB/TrEMBL |
| KEGG Report | rno:366508 | ENTREZGENE |
| PANTHER | PI_Kinase | UniProtKB/TrEMBL |
| Pfam | PI3_PI4_kinase | UniProtKB/TrEMBL |
| PI3K_C2 | UniProtKB/TrEMBL | |
| PI3K_p85B | UniProtKB/TrEMBL | |
| PI3K_rbd | UniProtKB/TrEMBL | |
| PI3Ka | UniProtKB/TrEMBL | |
| PROSITE | PI3_4_KINASE_1 | UniProtKB/TrEMBL |
| PI3_4_KINASE_2 | UniProtKB/TrEMBL | |
| PI3_4_KINASE_3 | UniProtKB/TrEMBL | |
| PI3K_ABD | UniProtKB/TrEMBL | |
| PI3K_C2 | UniProtKB/TrEMBL | |
| PI3K_RBD | UniProtKB/TrEMBL | |
| PIK_HELICAL | UniProtKB/TrEMBL | |
| SMART | PI3K_C2 | UniProtKB/TrEMBL |
| PI3K_p85B | UniProtKB/TrEMBL | |
| PI3K_rbd | UniProtKB/TrEMBL | |
| PI3Ka | UniProtKB/TrEMBL | |
| PI3Kc | UniProtKB/TrEMBL | |
| Superfamily-SCOP | ARM-type_fold | UniProtKB/TrEMBL |
| C2_CaLB | UniProtKB/TrEMBL | |
| Kinase_like | UniProtKB/TrEMBL | |
| UniGene | Rn.11530 | ENTREZGENE |
| UniProt | D4A5Q1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-10-10 | Pik3cd | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | Pik3cd | phosphoinositide-3-kinase, catalytic, delta polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2010-04-23 | Pik3cd | phosphoinositide-3-kinase, catalytic, delta polypeptide | Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | Pik3cd_predicted | phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Pik3cd_predicted | phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Pik3cd | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1310990 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




