TOLL-LIKE RECEPTOR SIGNALING PATHWAY (PW:0000814)

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Description

Toll-like receptors (TLR) represent a large and the better understood family of pattern recognition receptors (PRR) that respond to a diverse array of exogenous molecules and also several endogenous ones. PRRs 'sensing' of pathogen-associated molecular patterns (PAMPs) or endogenously derived damage-associated molecular patterns (DAMPs) is a first line of defense initiated by the innate immune system. Ligand-activated receptors impinge on intracellular signaling pathway to elicit the expression

Pathway Diagram:

Ariadne Genomics Inc. Cd14 ---- Lbp Lbp ---- LPS LPS Cd14 Lbp LPS ---- Ly96 Ly96 Traf6 ---- Ube2n Traf6 ---- Ube2v1 Irak1 ---- Traf6 Irak2 Irak4 ---> Irak1 Irak1 Irak4 ---- Myd88 Irak4 Myd88 Unc93b1 Myd88 ---- Tlr8 Unc93b1 ---> Tlr7 Myd88 ---- Tlr7 Myd88 ---- Tirap Myd88 ---- Tlr9 Traf6 TICAM1 ---- Traf6 Ripk1 --+> nuclear factor kappa B signaling pathway TICAM1 ---- Ticam2 Ticam2 Tradd Irak4 ---> Irak2 Ripk1 ---- Tradd Ripk1 Ripk1 ---- TICAM1 TICAM1 ---- Tlr3 TICAM1 ---- Traf3 Traf3 Tbk1 Tbk1 ---> Irf3 Tbk1 ---- Traf3 LPS ---- Tlr4 Tlr3 endocytosed_Tlr4 ---- Ticam2 flagellin ---- Tlr5 Tirap Tirap ---- Tlr6 Tirap ---- Tlr2 Tirap ---- Tlr1 Ly96 ---- Tlr4 Tlr1 ---- Tlr1, 2, 6 ligands Tlr1, 2, 6 ligands ---- Tlr2 Tlr1, 2, 6 ligands ---- Tlr6 Map3k7 --+> p38 MAPK signaling pathway Tlr4 ---> endocytosed_Tlr4 Double-stranded RNA ---- Tlr3 Map3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway Map3k7 --+> nuclear factor kappa B signaling pathway Tlr7, 8, 9 ligands ---- Tlr8 Tlr7 ---- Tlr7, 8, 9 ligands Unc93b1 ---> Tlr8 Tlr8 Tlr7, 8, 9 ligands ---- Tlr9 Tlr7 Tlr9 Unc93b1 ---> Tlr9 Tlr4 Tirap ---- Tlr4 Tlr6 Tlr2 Tlr1 Tlr1 ---- Tlr2 Tlr2 ---- Tlr6 Myd88 ---- Tlr5 Tlr5 TICAM1 Ube2v1 Ube2n Traf6 --+> Map3k7 nuclear factor kappa B signaling pathway c-Jun N-terminal kinases MAPK signaling pathway p38 MAPK signaling pathway Tlr7, 8, 9 ligands Tlr1, 2, 6 ligands flagellin Double-stranded RNA Tab(s) Map3k7 Irf3 endocytosed_Tlr4
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Genes in Pathway:

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Toll-like receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6907045
G Ccl3 C-C motif chemokine ligand 3 JBrowse link 10 70,869,516 70,871,066 RGD:6907045
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:6907045
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6907045
RGD:7247704
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6907045
G Cd80 Cd80 molecule JBrowse link 11 64,815,201 64,855,293 RGD:6907045
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:6907045
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6907045
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:6907045
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:6907045
G Cxcl11 C-X-C motif chemokine ligand 11 JBrowse link 14 17,195,395 17,198,170 RGD:6907045
G Cxcl9 C-X-C motif chemokine ligand 9 JBrowse link 14 17,228,832 17,233,743 RGD:6907045
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:6907045
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6907045
G Ifna1 interferon, alpha 1 JBrowse link 5 106,951,822 106,952,908 RGD:6907045
G Ifna11 interferon alpha family, gene 11 JBrowse link 5 107,504,741 107,505,783 RGD:6907045
G Ifna2 interferon alpha 2 JBrowse link 5 107,416,117 107,416,695 RGD:6907045
G Ifna4 interferon, alpha 4 JBrowse link 5 106,922,563 106,923,132 RGD:6907045
G Ifna5 interferon, alpha 5 JBrowse link 5 107,039,347 107,039,925 RGD:6907045
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:6907045
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6907045
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6907045
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:6907045
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6907045
G Il12a interleukin 12A JBrowse link 2 165,076,945 165,083,996 RGD:6907045
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6907045
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6907045
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6907045
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:5685014
RGD:6907045
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:5685014
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:5685014
RGD:6907045
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:5685014
RGD:6907045
G Irf5 interferon regulatory factor 5 JBrowse link 4 56,804,477 56,816,271 RGD:6907045
G Irf7 interferon regulatory factor 7 JBrowse link 1 214,249,388 214,252,909 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:6907045
RGD:7247704
G LOC100911527 interferon alpha-12-like JBrowse link 5 87,328,395 87,328,946 RGD:6907045
G Ly96 lymphocyte antigen 96 JBrowse link 5 1,972,212 1,989,448 RGD:5685019
RGD:6907045
RGD:7247704
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Map2k3 mitogen activated protein kinase kinase 3 JBrowse link 10 45,089,455 45,110,802 RGD:6907045
G Map2k4 mitogen activated protein kinase kinase 4 JBrowse link 10 52,196,121 52,301,887 RGD:6907045
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6907045
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:6907045
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5685014
RGD:6907045
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 17 56,109,403 56,129,925 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 7 130,121,678 130,129,199 RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 7 130,109,214 130,120,918 RGD:6907045
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:6907045
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6907045
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:6907045
G Myd88 myeloid differentiation primary response 88 JBrowse link 8 128,022,512 128,027,462 RGD:5685014
RGD:6907045
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6907045
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6907045
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:5685014
RGD:6907045
G Spp1 secreted phosphoprotein 1 JBrowse link 14 6,673,686 6,679,965 RGD:6907045
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6907045
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5685016
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5685016
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5685016
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:5685014
RGD:6907045
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:5685014
RGD:6907045
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:5685014
RGD:6907045
G Tlr1 toll-like receptor 1 JBrowse link 14 45,062,662 45,065,014 RGD:1643119
RGD:5685014
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1643119
RGD:5684896
RGD:5685014
RGD:6907045
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1643119
RGD:5685014
RGD:6907045
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1643119
RGD:5685014
RGD:6907045
RGD:7247704
G Tlr5 toll-like receptor 5 JBrowse link 13 101,364,784 101,385,764 RGD:1643119
RGD:5685014
RGD:6907045
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1643119
RGD:5684896
RGD:5685014
RGD:6907045
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1643119
RGD:5685014
RGD:6907045
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1643119
RGD:5685014
RGD:6907045
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1643119
RGD:5685014
RGD:6907045
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6907045
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:6907045
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:5685014
G Traf3 Tnf receptor-associated factor 3 JBrowse link 6 135,610,698 135,720,247 RGD:5685014
RGD:6907045
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5685014
RGD:6907045
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:5685014
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:5685014
G Unc93b1 unc-93 homolog B1 (C. elegans) JBrowse link 1 219,172,987 219,183,941 RGD:5685014

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassTab(s)Map3k7 binding proteins
Pathwaynuclear factor kappa B signaling pathwaynf-kappaB signaling plays essential roles in the proper functioning of the immune system
Pathwayc-Jun N-terminal kinases MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Pathwayp38 MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Toll-like receptor signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleChuk , Mapk1
Abortion, SpontaneousCcl5 , Cxcl10 , Il12b , Il1b , Il6
Acanthamoeba KeratitisTlr4
AchlorhydriaTlr9
Acne ConglobataTlr4
Acne VulgarisTlr2 , Tlr4 , Tnf
Activated PI3K-delta SyndromePik3cd
Acute Coronary SyndromeCd40 , Il6 , Tlr4 , Tnf
Acute Kidney InjuryCcl3 , Ccl5 , Il1b , Il6 , Spp1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Acute Lung InjuryFadd , Il1b , Il6 , Tlr4 , Tnf
Acute Tubulointerstitial NephritisTlr2 , Tlr4
Acute-On-Chronic Liver FailureTlr4
Acute-Phase ReactionIl6
AdenocarcinomaCasp8 , Il1b , Nfkb1 , Pik3ca , Spp1 , Tnf
Adenocarcinoma of EsophagusPik3ca , Tlr4
Adenocarcinoma of LungMap2k1 , Pik3ca
Adenomatous Polyposis ColiAkt1
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AgranulocytosisIl1b
AIDS Dementia ComplexIl1b
AlbuminuriaIl1b , Il6 , Spp1 , Tnf
Alopecia AreataCxcl10 , Cxcl9
Alveolar Bone LossTnf
Alveolitis, Extrinsic AllergicCcl5 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il1b , Tlr6 , Tnf
Alzheimer DiseaseAkt1 , Ccl5 , Cd40 , Ikbkb , Il1b , Il6 , Mapk10 , Mapk14 , Mapk8 , Mapk9 , Pik3r1 , Tlr4 , Tnf
AmnesiaIl6
Amoebiasis due to Entamoeba HistolyticaTlr4
Amphetamine-Related DisordersAkt1 , Fos , Rela
AmyloidosisTnf
Amyotrophic Lateral SclerosisAkt1 , Mapk14
Amyotrophic Lateral Sclerosis 1Fos , Tnf
AnemiaIl1b , Il6 , Tnf
Anemia, AplasticCd86 , Tnf
Anemia, Hypochromic MicrocyticTnf
Anemia, Iron-DeficiencyIl6 , Tnf
Anemia, Malarial Tlr9
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
Anemia, RefractoryTnf
Anemia, Sickle CellTnf
AneurysmSpp1
Angina PectorisSpp1
Angina, StableTlr4 , Tnf
Angina, UnstableAkt1
AngiomyolipomaStat1
AnorexiaIl1b , Tnf
AnthracosisIl1b , Tnf
Anti-Glomerular Basement Membrane DiseaseCcl5 , Cd40 , Cd80 , Il1b , Mapk14 , Mapk8 , Spp1 , Tnf
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisTlr2 , Tnf
Anus NeoplasmsIfnb1
Anxiety DisordersFos , Tnf
Aortic Aneurysm, AbdominalMapk8
Aortic Aneurysm, ThoracicCxcl10 , Cxcl9
Aortic Valve Disease 1Il6
Aortic Valve, Calcification ofAkt1
Arrhythmias, CardiacMap2k4
Arsenic PoisoningIl1b , Tnf
ArteriosclerosisCcl5 , Il1b , Mapk9 , Rela , Tlr4
ArthritisCd40 , Tlr4
Arthritis, ExperimentalAkt1 , Ccl3 , Ccl5 , Cd40 , Cd80 , Ctsk , Ikbkb , Ikbkg , Il1b , Il6 , Myd88 , Pik3cd , Stat1 , Tlr2 , Tlr3 , Tnf
Arthritis, InfectiousTnf
Arthritis, JuvenileCd14 , Fos , Il6 , Jun , Mapk1
Arthritis, PsoriaticIl12b , Irak1 , Tnf
Arthritis, RheumatoidCd40 , Cd80 , Il1b , Il6 , Irak1 , Irf5 , Ly96 , Spp1 , Stat1 , Tlr2 , Tnf , Traf6
AsbestosisSpp1 , Tnf
Ascorbic Acid DeficiencyIl6
AspergillosisTlr1 , Tlr2 , Tlr6
Aspergillosis, Allergic BronchopulmonaryTlr9 , Tnf
AsphyxiaJun
AsthmaCcl5 , Cd14 , Cd40 , Cd80 , Cd86 , Chuk , Cxcl10 , Cxcl9 , Il12a , Il12b , Il1b , Il6 , Irf3 , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr6 , Tlr9 , Tnf
Asthma, Exercise-InducedCcl5
Asthma, OccupationalTnf
AstrocytomaAkt1 , Map2k3
Ataxia TelangiectasiaIl6
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Ccl3 , Cd40 , Il1b , Il6 , Tlr2 , Tlr4 , Tnf
Atrial FibrillationCd40 , Tlr2 , Tnf
AtrophyMapk3
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autism Spectrum DisorderMapk11 , Mapk12 , Mapk3 , Tlr3
Autistic DisorderIl6 , Tnf
Autoimmune DiseasesCasp8 , Il6
Autoimmune Lymphoproliferative SyndromeCasp8
BacteremiaTirap , Tlr4
Bacterial InfectionsCasp8
Bacterial Infections and MycosesIrak4
Bacterial KeratitisLy96 , Myd88 , Tlr2 , Tlr4 , Tlr5
Bardet-Biedl SyndromeAkt3
Barrett EsophagusRela
BCG and Salmonella Infection, DisseminatedIl12b
Behcet SyndromeIkbkg , Il1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
BerylliosisIl6 , Tnf
Beta-ThalassemiaIl6 , Tnf
Bile Duct NeoplasmsIl6
Biliary AtresiaCd14 , Spp1
Biliary Tract NeoplasmsIl6
Bipolar DisorderAkt1
Bone Diseases, DevelopmentalChuk
Boutonneuse FeverCxcl10 , Cxcl9
Brain AbscessTlr2
Brain ConcussionIl6
Brain DeathMap2k4 , Map2k6
Brain DiseasesIfnb1
Brain EdemaTnf
Brain InfarctionIl1b
Brain InjuriesAkt1 , Casp8 , Cd14 , Cd40 , Cxcl10 , Fos , Il1b , Il6 , Jun , Rela , Stat1 , Ticam2 , Tlr1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Brain IschemiaAkt1 , Ccl3 , Cxcl10 , Il1b , Il6 , Irak1 , Irak4 , Jun , Map2k1 , Mapk1 , Mapk3 , Mapk8 , Nfkb1 , Nfkbia , Rela , Tlr4 , Tnf
Brain NeoplasmsRela , Spp1
Breast AdenocarcinomaAkt1 , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Casp8 , Ccl5 , Cd40 , Cxcl9 , Fos , Ifnb1 , Ikbkb , Il1b , Il6 , Jun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k7 , Mapk1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Bronchial HyperreactivityCd14 , Il1b , Tlr4 , Tnf
BronchiectasisIl1b , Tnf
BronchiolitisCd40 , Cd86 , Il1b
Bronchiolitis ObliteransCcl5 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il6 , Tlr9
Bronchiolitis, ViralCcl5 , Cd14 , Cxcl10 , Il6 , Tlr4 , Tlr5 , Tnf
BronchopneumoniaCcl5
Bronchopulmonary DysplasiaIl1b
Burkitt LymphomaCd40 , Pik3r1
BurnsCd14 , Cd86 , Il1b , Il6 , Lbp , Tnf
Burns, ChemicalIl1b , Il6
CachexiaIl1b , Il6 , Tnf
Cadmium PoisoningIl6
CalcinosisIl1b , Spp1
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 7Stat1
Carbon Tetrachloride PoisoningFadd
CarcinomaLy96 , Pik3r1 , Tlr4
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticMap2k2 , Pik3ca
Carcinoma, Basal CellIl6 , Pik3ca
Carcinoma, Ductal, BreastMap2k4
Carcinoma, Ehrlich TumorCd40
Carcinoma, EndometrioidSpp1
Carcinoma, HepatocellularAkt2 , Casp8 , Ccl3 , Fos , Il1b , Il6 , Jun , Nfkbia , Pik3ca , Rac1 , Spp1 , Stat1 , Tlr4 , Tnf
Carcinoma, Intraductal, NoninfiltratingRela
Carcinoma, Non-Small-Cell LungAkt1 , Casp8 , Il1b , Map2k1 , Pik3ca , Rela , Spp1 , Tlr9 , Tnf
Carcinoma, Pancreatic DuctalCd40
Carcinoma, Renal CellAkt1 , Cd40 , Il6 , Jun , Map2k1 , Pik3ca , Rela , Tlr9 , Tnf
Carcinoma, Small CellIl6 , Tnf
Carcinoma, Squamous CellAkt1 , Il6 , Irak1 , Mapk1 , Mapk3 , Pik3ca , Ripk1 , Tlr9
Carcinoma, Squamous Cell of Head and NeckAkt1 , Casp8 , Pik3ca
Carcinoma, Transitional CellIfnb1 , Tnf
Cardiac FibrosisNfkbia
Cardiofaciocutaneous SyndromeMap2k1 , Map2k2
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Il1b , Il6 , Map2k6 , Mapk1 , Mapk8 , Rac1 , Rela , Spp1 , Tnf
CardiomyopathiesAkt1 , Il1b , Il6 , Irak1 , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Tlr2 , Tnf
Cardiomyopathy, DilatedRac1 , Tnf
Cardiomyopathy, RestrictiveMap2k3 , Map2k6 , Mapk14
Cardiovascular AbnormalitiesMap2k1
Cardiovascular DiseasesTlr9
Cardiovirus InfectionsTnf
Carotid Artery DiseasesCd14 , Tlr4
Carotid StenosisTlr2 , Tlr4
Carrington SyndromeCxcl10 , Cxcl9
Celiac DiseaseCd14 , Cd80 , Il6
Cell Transformation, NeoplasticIl6 , Jun , Mapk8 , Myd88 , Nfkb1 , Rac1 , Rela
Central Nervous System DiseasesIl6
Cerebral HemorrhageCasp8 , Cd14 , Nfkb1 , Nfkbia , Rela , Spp1
Cerebral InfarctionTnf
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaRela , Tlr9
Chagas DiseaseCcl3 , Ccl5
Chlamydia InfectionsCd40 , Tnf
CholangiocarcinomaIl6
CholestasisCd14 , Il6 , Mapk13 , Mapk14 , Rela , Tnf
CholesteatomaIl1b , Tlr2 , Tlr4
Cholesteatoma, Middle EarIl6 , Rela , Tlr2 , Tlr4 , Tnf
ChorioamnionitisIl6
Choroidal NeovascularizationIkbkb , Tlr2
Chromosome 17q12 Deletion SyndromeCcl3
Chronic Allograft DysfunctionCd40 , Tnf
Chronic Allograft NephropathyCcl3
Chronic Cerebral HypoperfusionMapk14
Chronic Lymphoid LeukemiaCd86
Chronic PainTlr2 , Tlr4
Chronic PeriodontitisTlr2 , Tlr3 , Tlr4 , Tlr9
Cleft PalateChuk
Cocaine-Related DisordersFos , Mapk1 , Mapk3
Cocoon SyndromeChuk
Cognition DisordersIrak1 , Mapk14
ColitisCd40 , Chuk , Ikbkb , Il1b , Il6 , Rela , Tlr3 , Tlr4 , Tnf
Colitis, ExperimentalIl6 , Nfkbia , Tnf
Colonic NeoplasmsAkt1 , Akt2 , Ccl3 , Cxcl10 , Ikbkb , Il1b , Jun , Map2k3 , Map2k6 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tnf
Colorectal NeoplasmsAkt1 , Casp8 , Ly96 , Pik3ca , Tlr2 , Tlr4 , Tnf
Common ColdCxcl10 , Il1b
Condylomata AcuminataIl12b
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctival DiseasesIl6
Conjunctivitis, AllergicCcl5 , Il1b , Tlr2 , Tlr4 , Tlr9
Contrast-Induced NephropathyIl1b
Corneal DiseasesCd86
Corneal UlcerIl6 , Tnf
Coronary Artery DiseaseAkt1 , Cd14 , Il1b , Il6 , Irak1 , Spp1 , Tlr4 , Tnf , Traf6
Coronary DiseaseCd14 , Il1b
Coronary RestenosisCxcl10 , Mapk1 , Spp1 , Tnf
Coronavirus InfectionsIl6
Costello SyndromeMap2k1 , Map2k2
CoughTlr2 , Tnf
COWDEN SYNDROME 5Pik3ca
Craniofacial AbnormalitiesFadd
Crohn DiseaseCd40 , Il12b , Il6 , Tlr4 , Tlr9 , Tnf
CryoglobulinemiaCd86 , Tnf
CryptococcosisCd40 , Cd86
CryptorchidismNfkbia , Rela
Currarino TriadPik3ca
Cystic FibrosisCd14 , Cxcl9 , Il1b , Il6 , Tlr4 , Tlr5 , Tlr9 , Tnf
CystitisIl1b , Rela , Tnf
Cystitis, InterstitialCxcl10 , Cxcl11 , Cxcl9 , Tnf
Cytomegalovirus InfectionsCcl3 , Ccl5 , Stat1
Cytomegalovirus RetinitisTnf
Death, Sudden, CardiacIl6
Dementia, VascularIl1b
Demyelinating DiseasesCd80
Dental Pulp ExposureCd86
Depressive DisorderIl1b , Il6 , Jun
DermatitisIkbkb , Tnf
Dermatitis HerpetiformisTnf
Dermatitis, Allergic ContactCasp8 , Ccl5 , Spp1 , Tlr4 , Tlr7 , Tnf
Dermatitis, AtopicCcl5 , Cd40 , Cxcl10 , Il1b , Il6 , Mapk8 , Tlr2 , Tlr4 , Tnf
Dermatitis, ContactCasp8 , Cd86 , Tlr4 , Tlr8
Dermatitis, SeborrheicTlr2
DermatomyositisCd40 , Il1b , Tlr2 , Tlr4 , Tlr9 , Tnf
Developmental DisabilitiesAkt3
Diabetes MellitusCcl5 , Il6 , Rac1 , Tlr4
Diabetes Mellitus, ExperimentalAkt1 , Casp8 , Cd80 , Cd86 , Cxcl10 , Ikbkb , Il1b , Il6 , Map2k3 , Map2k6 , Mapk1 , Mapk3 , Nfkbia , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tnf
Diabetes Mellitus, Insulin-Dependent, 5Tab2
Diabetes Mellitus, Type 1Casp8 , Ccl5 , Cd14 , Cd40 , Cd80 , Cd86 , Cxcl10 , Il1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
Diabetes Mellitus, Type 2Akt1 , Akt2 , Casp8 , Ccl5 , Cxcl10 , Ikbkb , Il1b , Il6 , Nfkb1 , Pik3r1 , Rela , Tlr4 , Tnf
Diabetes, GestationalIl6
Diabetic AngiopathiesRela , Tnf
Diabetic CardiomyopathiesSpp1 , Tnf
Diabetic FootTlr4
Diabetic NephropathiesCcl5 , Cxcl10 , Il1b , Il6 , Mapk1 , Mapk14 , Rela , Spp1 , Tlr2 , Tlr4 , Tnf
Diabetic NeuropathiesCcl5 , Il1b , Mapk14 , Tlr4 , Tnf
Diabetic RetinopathyCcl5 , Cxcl10 , Il1b , Il6 , Tlr4 , Tnf
DiarrheaCd14
Disease Models, AnimalAkt1 , Fos , Il1b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
Disease ProgressionStat1
Disseminated Intravascular CoagulationIl6 , Tnf
Drug HypersensitivityTnf
Drug Hypersensitivity SyndromeIl1b
Drug-induced agranulocytosisIl1b
Drug-Induced Immune ThrombocytopeniaIl1b
Drug-Induced Liver InjuryCasp8 , Cxcl10 , Fadd , Il1b , Il6 , Lbp , Spp1 , Tnf , Unc93b1
Drug-Related Side Effects and Adverse ReactionsSpp1 , Tlr1 , Tlr2
Dry Eye SyndromesIl1b , Il6 , Tlr2 , Tlr3 , Tlr4 , Tnf
Dyskinesia, Drug-InducedRela
DyslipidemiasTlr2
Eales DiseaseIl1b , Il6 , Tnf
EclampsiaIl6
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Anhidrotic, with T-Cell Immunodeficiency, Autosomal DominantNfkbia
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EczemaCd14 , Cd80
EdemaCasp8 , Il1b , Il6 , Map2k6 , Tnf
Embryo LossUbe2n
EmphysemaTnf
EncephalitisCxcl10 , Il1b , Nfkbia , Rela , Tnf
Encephalitis, Herpes SimplexTlr2 , Tlr3 , Tlr4 , Tlr9 , Unc93b1
Encephalitis, Tick-BorneCd40
EncephalomyelitisSpp1
Encephalomyelitis, Autoimmune, ExperimentalCasp8 , Ccl3 , Ccl5 , Cd80 , Cd86 , Il12a , Il12b , Il6 , Stat1 , Tlr2 , Tlr4
Endometrial NeoplasmsJun , Pik3ca
EndometriosisCcl5 , Fos , Nfkbia , Tnf
EndophthalmitisIl1b , Tlr2 , Tnf
EndotoxemiaCcl5 , Cd14 , Cd40 , Il1b , Il6 , Lbp , Mapk14 , Tlr2 , Tlr4 , Tnf
Endotoxin HyporesponsivenessTlr4
EntamoebiasisIl1b , Il6
EnterocolitisIl1b
Enterocolitis, NecrotizingCd14 , Cd40 , Ikbkg , Il1b , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr9 , Tnf
Enterocolitis, NeutropenicIl1b
EosinophiliaMyd88 , Tlr2 , Tlr4
Epidermal NevusPik3ca
EpilepsyAkt1 , Fos
Epilepsy, GeneralizedMapk10
Epileptic Encephalopathy, Lennox-Gastaut TypeMapk10
Erectile DysfunctionAkt1 , Il6 , Tnf
Erythema MultiformeCd40
Erythema NodosumTnf
Esophageal NeoplasmsCasp8
EsophagitisTnf
Esophagitis, PepticCcl5 , Tnf
Exfoliation SyndromeTlr4
Experimental allergic asthmaCd86
Eye BurnsIl1b
Eye DiseasesTlr2 , Tlr3 , Tlr4 , Tnf
Eye Infections, BacterialTlr2
Eye Infections, FungalTlr2 , Tlr4
Facial AsymmetryPik3ca
Familial Mediterranean FeverIl1b , Il6 , Tlr4
Fanconi AnemiaTnf
Farmer's LungIl12b , Tnf
Fatty LiverIl1b , Il6 , Mapk8 , Nfkb1 , Rela , Tlr4 , Tnf
Femoral FracturesIl6
Fetal DiseasesChuk
FeverCcl5 , Il1b , Il6 , Tlr2 , Tnf
Fibromatosis, AggressiveTnf
FibrosisAkt1 , Il1b , Map2k7 , Spp1 , Tnf
Fibrous Dysplasia of BoneFos
Foot InjuriesIl6
Foot UlcerCxcl10
Foreign-Body ReactionSpp1
Forney Robinson Pascoe SyndromeMap3k7
FRONTOMETAPHYSEAL DYSPLASIA 2Map3k7
FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 4Tbk1
Fungal KeratitisTlr4
Gallbladder NeoplasmsIl1b
GastritisNfkbia , Tnf
Gastritis, AtrophicIl1b
Gastroesophageal RefluxTlr2
Gastrointestinal NeoplasmsPik3ca
Genetic Diseases, InbornMapk1 , Pik3r2
Genetic Predisposition to DiseaseIl1b
Giant Cell ArteritisTlr4
Giant Lymph Node HyperplasiaIl6
GingivitisIl6
GlaucomaTnf
Glaucoma, NeovascularIl6
Glaucoma, Open-AngleTnf
Glaucoma, Primary Open AngleTlr4 , Tnf
GlioblastomaAkt1 , Ctsk , Il1b , Map2k3
GliomaAkt2 , Cd40 , Cd80 , Il12a , Il12b , Pik3ca , Spp1 , Tnf
GliosisMapk1 , Mapk3
GlomerulonephritisCcl3 , Ccl5 , Fos , Il1b , Il6 , Mapk1 , Spp1 , Tlr2 , Tlr4 , Tnf
Glomerulonephritis, CrescenticCcl3 , Cd40 , Il1b , Tlr9
Glomerulonephritis, IGACd14 , Il1b , Tlr1 , Tlr9 , Tnf
Glomerulonephritis, MembranoproliferativeIl1b , Tlr1 , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr8 , Tlr9
Glomerulonephritis, MembranousCd40 , Il1b
GlomerulosclerosisIl1b , Spp1
Glomerulosclerosis, Focal SegmentalCcl3 , Il1b , Spp1 , Tnf
Glucose IntoleranceCcl5
Glucosephosphate Dehydrogenase DeficiencyIkbkg , Il6
GoutCd14 , Il1b
Graft vs Host DiseaseCd40 , Cxcl10 , Cxcl11 , Cxcl9
Gram-Negative Bacterial InfectionsIl1b
Gram-Positive Bacterial InfectionsTlr2
Granuloma, Foreign-BodyTlr9
Granuloma, Respiratory TractCxcl10 , Cxcl9 , Tlr3 , Tlr9
Granulomatous Disease, ChronicTlr5 , Tlr9
Graves DiseaseCd40 , Il1b , Il6 , Tnf
Graves OphthalmopathyTnf
Growth DisordersPik3ca
Hamartoma Syndrome, MultipleAkt1 , Pik3ca
Hashimoto DiseaseCd40 , Il6
Head and Neck NeoplasmsMapk1 , Mapk3
HeadacheIl6
Hearing LossStat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Hearing Loss, High-FrequencyTnf
Hearing Loss, Noise-InducedIl6 , Tnf
Hearing Loss, SensorineuralFadd , Tnf
Hearing Loss, SuddenIl6 , Tnf
Heart ArrestAkt1 , Ccl5 , Tnf
Heart DiseasesMapk14 , Spp1
Heart FailureFos , Il1b , Il6 , Map2k7 , Rac1 , Tnf
Heart InjuriesIl1b
Heart Septal Defects, VentricularFos
Heart Valve DiseasesIl1b , Spp1
Heat Stress DisordersIl6
Heat StrokeFos , Il1b , Il6 , Jun , Nfkb1 , Rela , Tnf
Helminthiasis, AnimalCd40
Hemangioma, CapillaryAkt3
HemangiosarcomaJun
HemarthrosisIl6
HematuriaFos
HemimegalencephalyPik3ca
HemochromatosisTnf
Hemolytic-Uremic SyndromeCcl3 , Fos , Il1b , Il6 , Tnf
HemorrhageFos
Hepatic EncephalopathyTnf
HepatitisSpp1
Hepatitis BIfnb1
Hepatitis CIfnar1 , Il1b
Hepatitis C, ChronicSpp1
Hepatitis, AlcoholicCcl5 , Tnf
Hepatitis, AutoimmuneCcl5 , Il6
Hepatitis, Viral, AnimalCd40
Hepatolenticular DegenerationIl6 , Tnf
Hepatorenal SyndromeTlr4 , Tnf
Hermanski-Pudlak SyndromeCcl5
Hernia, DiaphragmaticIl6 , Tnf
Herpes GenitalisCcl5
Herpes Simplex Encephalitis, Susceptibility To, 3Traf3
Herpes ZosterTnf
Herpesviridae InfectionsCcl5
Hidradenitis SuppurativaTnf
Hirschsprung DiseaseCd14
HIV InfectionsCcl3 , Ccl5 , Cd40 , Il6 , Tlr3 , Tnf
HIV Wasting SyndromeIl1b , Il6 , Tnf
Hodgkin DiseaseIl6 , Jun , Nfkbia
Huntington DiseaseIl6 , Nfkb1
HydronephrosisIl1b
Hyper-IgM Immunodeficiency SyndromeCd40
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaCcl5 , Fos , Il1b , Il6 , Map2k3 , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tlr2 , Tlr4 , Tnf
HyperbilirubinemiaTnf
HypercalcemiaIl6 , Tnf
HypercholesterolemiaCd40 , Il1b
HyperemiaIl1b
HypergammaglobulinemiaTlr9
HyperglycemiaCasp8 , Il1b , Il6
HyperhomocysteinemiaIl1b , Tnf
HyperinsulinismIl6
HyperkinesisFos
HyperoxaluriaCcl5 , Il6 , Nfkb1
HyperoxiaFadd , Il6 , Irak4 , Tnf
Hyperparathyroidism, SecondaryIl6
HyperplasiaAkt1 , Ikbkb , Pik3ca
HypersensitivityCcl3 , Cd14 , Cxcl9 , Il1b , Il6 , Map2k6 , Spp1 , Tnf
Hypersensitivity, DelayedCd40
Hypersensitivity, ImmediateCcl5
HypertensionAkt1 , Akt2 , Ccl5 , Cd14 , Fadd , Fos , Ikbkb , Il1b , Il6 , Jun , Mapk8 , Myd88 , Nfkbia , Pik3r1 , Rela , Tlr4 , Tnf
Hypertension, PortalIl1b , Pik3r1
Hypertension, PulmonaryCcl5 , Cd40 , Cd86 , Il1b , Il6 , Rela , Tlr4 , Tnf
Hypertension, RenalIl6 , Tnf
Hypertension, RenovascularCxcl10 , Rela , Spp1
HyperthyroidismCd40
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularRac1 , Rela
Hypertrophy, Right VentricularAkt1
HypoalbuminemiaIl6
HypoglycemiaAkt2 , Il1b , Pik3r1 , Tnf
HypogonadismIl6
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypolipoproteinemiasIl1b
HypotensionIl1b , Il6 , Tnf
HypothermiaCxcl10 , Il12a , Il12b , Tnf
HypoventilationCcl5
Hypoxia-Ischemia, BrainIl1b , Il6 , Irak1 , Irak4
Idiopathic Dilation CardiomyopathyTnf
Idiopathic Interstitial PneumoniasIl6
IleitisCd80 , Tlr2 , Tlr4
Immunodeficiency 14Pik3cd
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
Immunologic Deficiency SyndromesCasp8
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaTnf
Incontinentia PigmentiIkbkg
Infarction, Middle Cerebral ArteryCd86 , Cxcl10 , Fadd , Fos , Ikbkb , Il1b , Il6 , Nfkbia , Tnf
InfectionTnf
Infections, Recurrent, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular MalformationsFadd
Infertility, FemaleMapk1 , Mapk3
InflammationAkt1 , Ccl3 , Ccl5 , Cd40 , Chuk , Il1b , Il6 , Irf7 , Myd88 , Spp1 , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf
Inflammatory Bowel Disease 11Cd40 , Il12b , Il1b , Irf5 , Rela , Tnf
Inflammatory Bowel Disease 14Irf5
Inflammatory Bowel DiseasesIkbkb , Il6 , Tnf
Influenza, HumanCcl5 , Cd14 , Cd40 , Cd80 , Cd86 , Cxcl10 , Il12b , Il1b , Il6 , Irf7 , Stat1 , Tlr2 , Tlr3 , Tnf
Inhalation AnthraxCxcl10 , Cxcl11 , Cxcl9
Insulin ResistanceAkt2 , Ikbkb , Il1b , Il6 , Pik3r1 , Rela , Tlr4 , Tnf
InsulinomaCd40
Intervertebral Disc DisplacementAkt1 , Tnf
Intestinal PolypsJun
Intestinal Reperfusion InjuryCd14 , Il6 , Lbp
Intracranial AneurysmCtsk , Il6 , Tnf
Intracranial Arteriovenous MalformationsIl6
Intracranial HemorrhagesIl6 , Tnf
Intrahepatic Cholestasis of PregnancyTnf
Intraventricular HemorrhageIl6
Invasive Pneumococcal Disease, Recurrent Isolated, 1Irak4 , Tirap
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisIl1b
IRAK4 DeficiencyIrak4
Irritable Bowel SyndromeIkbkg
IschemiaAkt2 , Cxcl10 , Il6 , Mapk9
Ischemic Attack, TransientCd40 , Ikbkb , Il1b , Map2k4 , Nfkb1 , Tnf
Jaundice, ObstructiveCd14 , Lbp
Kearns-Sayre SyndromeIl1b
KeratitisIl6 , Tlr2 , Tlr4
Keratitis, HerpeticIl1b , Tlr2 , Tlr4 , Tlr9 , Tnf
KeratoconjunctivitisTlr2
Keratoconjunctivitis SiccaIl6 , Tnf
KeratoconusIl1b
Keratosis, SeborrheicPik3ca
Kidney CalculiSpp1
Kidney DiseasesCcl5 , Mapk1 , Spp1 , Tnf
Kidney Failure, ChronicCcl3 , Ccl5 , Cd40 , Il1b , Il6 , Nfkb1 , Rela , Tlr2 , Tlr4 , Tnf
Kidney NeoplasmsAkt1 , Jun , Mapk1 , Mapk3
Kidney Reperfusion InjuryCd14 , Cd40 , Fos , Ikbkb , Il1b , Tlr2 , Tlr4 , Tnf
Klebsiella InfectionsIl6 , Tlr9
LabyrinthitisTnf
Laryngeal NeoplasmsSpp1
Latent TuberculosisTlr1
Learning DisordersIkbkg , Il1b , Il6
LegionellosisTlr5
Legionnaires' DiseaseTlr5 , Tlr9
LeishmaniasisIl6 , Tnf
Leishmaniasis, CutaneousIl1b , Tlr2 , Tlr4 , Tlr9 , Tnf
Leishmaniasis, MucocutaneousTnf
Leishmaniasis, VisceralCd40 , Il1b , Il6 , Tnf
LeprosyTlr1 , Tlr2 , Tnf
LeptospirosisIl1b , Tlr2 , Tlr4
LethargyIl1b
LeukemiaFadd
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellCd40 , Cd86 , Il1b , Il6 , Tnf
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveCd40 , Il1b , Mapk14
Leukemia, Myeloid, AcuteCd86 , Fadd , Il6
Leukemia, Plasma CellCd40
Leukemia, Promyelocytic, AcuteAkt1
Leukemia-Lymphoma, Adult T-CellCd80 , Cd86 , Il6
LeukocytosisIl1b
LeukoencephalopathiesSpp1
Leukomalacia, PeriventricularTnf
Lichen PlanusCd40 , Ripk1
Lichen Planus, OralTlr2 , Tlr4 , Tlr9
Lichenoid EruptionsIl6
Limb Deformities, CongenitalChuk
Lipodystrophy, Familial PartialAkt2
ListeriosisTnf
Liver CirrhosisCd14 , Il6 , Lbp , Spp1 , Stat1 , Unc93b1
Liver Cirrhosis, AlcoholicIl6 , Rela , Tlr9 , Tnf
Liver Cirrhosis, BiliaryCcl5 , Cd80 , Cxcl10 , Cxcl9 , Il12a , Il12b , Nfkb1
Liver Cirrhosis, ExperimentalCcl5 , Cd86 , Cxcl10 , Cxcl9 , Fos , Il1b , Il6 , Lbp , Ly96 , Map3k8 , Nfkbia , Rela , Spp1 , Tlr2 , Tlr4 , Tnf , Unc93b1
Liver DiseasesCd86 , Nfkb1 , Rac1 , Tnf
Liver Diseases, AlcoholicIl1b , Spp1
Liver Failure, AcuteCd14 , Il6 , Mapk8 , Tlr4 , Tnf
Liver InjuryIl6
Liver NeoplasmsCasp8 , Il12a , Il12b , Jun , Map2k3 , Mapk14 , Pik3ca , Tnf
Liver Neoplasms, ExperimentalCxcl9 , Map2k1 , Spp1
Liver Reperfusion InjuryCasp8 , Cd14 , Cd40 , Fadd , Ikbkg , Il1b , Il6 , Lbp , Mapk8 , Tlr4 , Tnf , Tradd
Low Tension GlaucomaTlr4 , Tnf
Lung DiseasesCcl5 , Cd14 , Il1b , Il6 , Tlr2 , Tlr4 , Tnf
Lung Diseases, FungalTnf
Lung Diseases, InterstitialCcl5 , Cxcl10 , Cxcl9 , Tlr9
Lung InjuryCcl3 , Il6 , Nfkbia , Tlr4 , Tnf
Lung NeoplasmsAkt1 , Casp8 , Fos , Ikbkg , Il1b , Il6 , Jun , Map2k3 , Map2k7 , Map3k8 , Mapk1 , Mapk14 , Mapk3 , Pik3ca , Spp1 , Tlr4 , Tlr9 , Tnf
Lung Reperfusion InjuryIl1b , Tlr4 , Tnf
Lupus Erythematosus, CutaneousCd40
Lupus Erythematosus, DiscoidCd40
Lupus Erythematosus, SystemicCd40 , Cd80 , Il12b , Il1b , Il6 , Irf5 , Tlr4 , Tlr5 , Tlr9 , Tnf
Lupus NephritisCcl3 , Cd40 , Il1b , Tlr7 , Tlr9 , Tnf
Lyme NeuroborreliosisCd40 , Il1b
LymphangioleiomyomatosisStat1
Lymphatic MetastasisCd40 , Rela , Tlr4
LymphomaRela
Lymphoma, B-CellCd40
Lymphoma, FollicularCd40 , Myd88
Lymphoma, Large B-Cell, DiffuseCd40 , Myd88 , Nfkbia , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellPik3cd
Lymphoma, Non-HodgkinCd40
Lymphoma, T-CellAkt1
LymphopeniaIl1b , Tnf
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationTlr4
Macular Degeneration, Age-Related, 1Tlr3
Macular Degeneration, Age-Related, 10Tlr4
Macular EdemaIl6
MalariaCd40 , Spp1 , Tirap , Tnf
Malaria, FalciparumTnf
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Malformations of Cortical Development, Group IITlr6
Mammary Neoplasms, AnimalCd40 , Map2k6 , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Casp8 , Cd40 , Map2k3 , Map2k7 , Pik3r1 , Rela , Spp1 , Stat1 , Tnf
Manganese PoisoningIl1b , Tnf
Marijuana AbuseAkt1
MastitisTlr4 , Tlr9
MastoiditisRela , Tlr2 , Tlr4
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaCasp8 , Cd40 , Ifnb1 , Map2k1 , Map2k2 , Nfkb1 , Nfkbia , Pik3ca , Rac1 , Spp1 , Tlr4 , Tnf
Melanoma, AmelanoticIfnb1
Melanoma, Cutaneous MalignantCd40
Melanoma, Cutaneous Malignant, Susceptibility To, 1Pik3ca
Melanoma, ExperimentalIfnb1 , Ikbkb , Il1b
MELAS SyndromeIl1b
MelioidosisTlr5
Memory DisordersIl1b
MeningiomaAkt1
Meningitis, AsepticIl6
Meningitis, Escherichia ColiTlr2 , Tlr4 , Tlr7
Meningitis, MeningococcalTlr2 , Tlr4
Meningitis, PneumococcalIl6 , Rela , Tlr2 , Tlr4 , Tlr9 , Tnf
Meningitis, ViralTlr4
Mercury Poisoning, Nervous SystemJun
MERRF SyndromeIl1b
MesotheliomaSpp1
Mesothelioma, MalignantCcl3 , Ccl5 , Cd40 , Cxcl9 , Il12b , Il6
Metabolic Syndrome XCcl5 , Fadd , Il6 , Lbp , Tnf
Mevalonate Kinase DeficiencyTnf
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Tnf
Migraine without AuraTnf
Mild Cognitive ImpairmentIl1b
Mitochondrial MyopathiesIl1b , Il6 , Tnf
Mixed Connective Tissue DiseaseTlr3 , Tnf
Molluscum ContagiosumTlr2
Mood DisordersAkt1
Morphine DependenceFadd
Mouth NeoplasmsPik3ca
Mucocutaneous Lymph Node SyndromeCd40 , Il1b , Tlr4 , Tnf
MucositisIl1b
Multiple MyelomaCd40 , Cd86 , Il1b , Il6 , Nfkbia , Spp1 , Tnf
Multiple Organ FailureIl1b , Lbp , Mapk1 , Tnf
Multiple SclerosisCcl5 , Cd40 , Cd86 , Ifnb1 , Il12a , Il1b , Il6 , Spp1 , Tlr4 , Tnf
Multiple Sclerosis, Relapsing-RemittingCd80
Murine Acquired Immunodeficiency SyndromeCd40
Muscular AtrophyAkt1 , Chuk , Ikbkb , Tnf
Muscular DiseasesIl1b
Muscular DystrophiesTnf
Myasthenia GravisCxcl10
Myasthenia Gravis, Autoimmune, ExperimentalCxcl10 , Cxcl9
MycetomaTlr2 , Tlr4
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium Avium-Intracellulare InfectionTnf
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousIl12b , Stat1
MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TOTirap , Tlr2
MYD88 DeficiencyMyd88
Myelitis, TransverseIl6
Myelodysplastic SyndromesCd40 , Il1b , Tnf
Myocardial InfarctionAkt1 , Ccl5 , Cd14 , Il1b , Il6 , Map2k6 , Mapk1 , Nfkbia , Spp1 , Tlr4 , Tnf
Myocardial IschemiaCcl3 , Cd40 , Cxcl10 , Il1b , Il6 , Map2k3 , Map3k8 , Mapk14 , Nfkbia , Tnf
Myocardial Reperfusion InjuryAkt1 , Akt2 , Casp8 , Fadd , Il1b , Il6 , Irak1 , Map2k6 , Mapk1 , Mapk14 , Mapk8 , Mapk9 , Myd88 , Nfkbia , Rela , Spp1 , Stat1 , Tlr2 , Tlr4 , Tnf
Myocardial StunningTnf
MyocarditisCxcl10 , Irak1 , Spp1 , Tnf
Myocarditis, Autoimmune, ExperimentalIl6
MyositisTnf
MyringosclerosisTlr4
Nasal PolypsJun , Tlr2 , Tlr4 , Tlr7 , Tnf
Nasopharyngeal carcinomaAkt2 , Pik3ca
NauseaTnf
NecrosisIl1b , Il6 , Tnf
Neisseriaceae InfectionsCd40
Nematode InfectionsPik3r1
Neoplasm InvasivenessCcl5 , Il1b , Il6 , Mapk1 , Mapk3 , Myd88 , Rela , Tlr4 , Tnf
Neoplasm MetastasisAkt2 , Ccl3 , Cd86 , Fadd , Il6 , Ly96 , Mapk1 , Mapk3 , Mapk9 , Rac1 , Spp1 , Tlr4 , Tnf
Neoplasm Recurrence, LocalCxcl9
NeoplasmsIl1b , Spp1
Neoplasms, Cystic, Mucinous, and SerousSpp1
Neoplasms, ExperimentalIfnb1 , Il12a , Il12b , Rela , Spp1 , Tnf
Neoplastic Syndromes, HereditaryPik3ca
Neovascularization, PathologicSpp1
NephritisCcl3
Nephritis, HereditaryIl1b
NephrosisIl1b
Nephrotic SyndromeIl1b
Nerve DegenerationMapk1 , Mapk3 , Tnf
Nervous System DiseasesFos , Tnf
NeuralgiaTlr4 , Tnf
Neuritis, Autoimmune, ExperimentalCd14 , Cd40 , Il1b , Spp1 , Tlr2 , Tlr4 , Tlr9 , Tnf
NeuroblastomaIfnb1
Neurodegenerative DiseasesIl6
Neurogenic InflammationTnf
Neuromyelitis OpticaIl6
Neuropathy, PainfulTlr4 , Tnf
Neurotoxicity SyndromesFos
NeutropeniaIl1b , Tnf
Non-alcoholic Fatty Liver DiseaseCd14 , Ikbkg , Il6 , Tlr4 , Tnf
Noonan SyndromeMap2k1 , Map2k2
ObesityAkt1 , Akt2 , Ccl5 , Cd40 , Fadd , Ikbkb , Il1b , Il6 , Lbp , Pik3r1 , Rela , Tlr2 , Tlr4 , Tnf
Obstetric Labor, PrematureIl6
Onchocerciasis, OcularTlr4
Ophthalmoplegia, Chronic Progressive ExternalIl1b
Optic Atrophy, Hereditary, LeberIl1b
Optic Nerve InjuriesJun , Tlr4 , Tradd
Oral Squamous Cell CarcinomaIl6
Oral Submucous FibrosisTnf
OrchitisCcl5 , Cd86
Osseous Heteroplasia, ProgressiveSpp1
OsteoarthritisIl1b
OsteolysisSpp1 , Tnf
OsteopetrosisCtsk , Jun
OsteoporosisCtsk , Il1b , Il6 , Mapk14
Osteoporosis, PostmenopausalIl1b , Il6 , Tnf
OsteosarcomaJun
Otitis MediaCtsk , Il1b , Il6 , Rela , Tlr2 , Tlr4 , Tnf
Otitis Media with EffusionIl1b , Tlr2 , Tlr4 , Tnf
Otitis Media, SuppurativeTlr2 , Tlr4
Ovarian CystsNfkb1
Ovarian Epithelial CancerPik3ca
Ovarian Hyperstimulation SyndromeIl6
Ovarian NeoplasmsAkt1 , Akt2 , Ccl5 , Il6 , Map2k1 , Map2k2 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Rela , Spp1 , Tlr4 , Tnf
Oxygen-Induced RetinopathyMapk8 , Tnf
PainAkt1 , Ccl5 , Tlr2 , Tlr4 , Tnf
Pancreatic CystIl1b
Pancreatic DiseasesIl6 , Spp1
Pancreatic NeoplasmsAkt2 , Casp8 , Ccl5 , Il1b , Map2k4 , Nfkbia , Rela , Spp1 , Tnf
PancreatitisCcl5 , Cd14 , Ikbkb , Il1b , Tlr2 , Tlr3 , Tlr4
Pancreatitis, Acute NecrotizingIl1b , Il6 , Nfkbia , Rela , Tlr2 , Tlr4 , Tlr9
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Acute Tnf
Pancreatitis, Experimental, Chronic Il1b
PapillomaMap2k4
Papillomavirus InfectionsCasp8 , Tlr3 , Tlr9
ParacoccidioidomycosisTnf
Paramyxoviridae InfectionsCcl5 , Cxcl9
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Il1b , Il6 , Tnf
Parkinsonian DisordersIl1b , Rela , Tnf
Pediatric Crohn's DiseaseTnf
Pemphigoid, Benign Mucous MembraneTnf
PemphigusCd40
Penile NeoplasmsPik3ca
Peptic UlcerIl1b
Periodontal DiseasesCd80 , Il6
PeriodontitisCd14 , Il1b , Il6 , Lbp , Tnf
Peripheral Nerve InjuriesIl1b , Il6 , Tnf
Peripheral Nervous System DiseasesIl6 , Jun , Tlr3
Peripheral Vascular DiseasesIl6
PeritonitisCd40 , Tnf
Pick Disease of the BrainFos , Map2k6
Picornaviridae InfectionsTnf
Placenta DiseasesTnf
PlagueIl1b
Plaque, AtheroscleroticTlr2 , Tlr4
PlasmacytomaTnf
Plasmodium Falciparum Blood Infection LevelTnf
Pleural DiseasesIl6
Pleural EffusionTnf
Pleural NeoplasmsSpp1
PleurisyCcl5 , Cxcl10 , Cxcl9 , Il1b , Il6 , Tnf
Pneumococcal InfectionsTirap , Tlr9
PneumoniaCd14 , Cxcl10 , Cxcl9 , Ifnar1 , Ikbkb , Il1b , Il6 , Myd88 , Spp1 , Tlr2 , Tlr4 , Tnf
Pneumonia, AspirationTnf
Pneumonia, BacterialCd14 , Cd40 , Cd80 , Chuk , Cxcl10 , Cxcl11 , Cxcl9 , Ifnar1 , Il1b , Irf3 , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tlr9 , Tnf
Pneumonia, MycoplasmaCcl5 , Tnf
Pneumonia, PneumococcalCcl5 , Cd14 , Cxcl9 , Il6 , Mapk1 , Mapk3 , Tlr2 , Tnf
Pneumonia, PneumocystisCd40 , Tlr2
Pneumonia, StaphylococcalCd86 , Ifnar1 , Il1b
Pneumonia, ViralCxcl10 , Cxcl9 , Ifnar1 , Tlr9 , Tnf
Polychondritis, RelapsingTnf
Polycystic Kidney, Autosomal DominantCd14 , Fos , Spp1
Polycystic Kidney, Autosomal RecessiveAkt1 , Cd14 , Pik3ca
Polycystic Ovary SyndromeTab1
PolymicrogyriaAkt3
PolymyositisIl1b , Il6 , Tnf
PolyneuropathiesIl6
Polyradiculoneuropathy, Chronic Inflammatory DemyelinatingCcl5
Postoperative Atrial FibrillationIl6
Postoperative Cognitive DysfunctionIl1b
Poxviridae InfectionsTlr3
Pre-EclampsiaCcl5 , Cd40 , Tlr3 , Tlr4 , Tnf
Precancerous ConditionsMap2k7 , Mapk8 , Mapk9 , Nfkbia
Precursor Cell Lymphoblastic Leukemia-LymphomaCasp8 , Cd86
Prediabetic StateIl6
Pregnancy Complications, CardiovascularIl6 , Tnf
Premature BirthIl6
Presenile and Senile DementiaIl1b
Prostatic HyperplasiaRela
Prostatic Intraepithelial NeoplasiaMap2k4 , Map2k6 , Map2k7 , Rela
Prostatic NeoplasmsAkt1 , Chuk , Il6 , Irak4 , Jun , Map2k1 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Mapk10 , Mapk3 , Pik3ca , Pik3cd , Pik3r1 , Rela , Spp1 , Stat1 , Tirap , Tlr2 , Tlr4 , Tlr5 , Tlr6 , Tnf
ProteinuriaCxcl10 , Il6 , Spp1 , Tlr9
Proteus SyndromeAkt1
Pseudomonas Aeruginosa KeratitisIl1b , Il6 , Tlr2 , Tlr4
Pseudomonas InfectionsCcl5 , Il1b , Tlr5 , Tnf
PsoriasisCd40 , Ikbkb , Il12b , Il1b , Il6 , Irak1 , Nfkbia , Tlr2 , Tlr4 , Tnf
Psychoses, Substance-InducedAkt1
Pulmonary AspergillosisTlr2 , Tlr4
Pulmonary ContusionIl6
Pulmonary Disease, Chronic ObstructiveCcl5 , Cd40 , Cd80 , Cd86 , Cxcl10 , Cxcl11 , Cxcl9 , Il12b , Il1b , Il6 , Map2k4 , Mapk8 , Tlr4 , Tnf
Pulmonary EdemaIl1b , Tlr4 , Tnf
Pulmonary EmphysemaCxcl10 , Cxcl9 , Nfkbia , Tlr2 , Tlr4 , Tnf
Pulmonary FibrosisCcl3 , Ccl5 , Cd86 , Il12b , Il1b , Il6 , Spp1 , Stat1 , Tlr2 , Tlr4 , Tlr9 , Tnf
Pulmonary Heart DiseaseTnf
PulpitisTlr4
Purpura, Schoenlein-HenochCd86
Purpura, Thrombocytopenic, IdiopathicCd40 , Cd86
PycnodysostosisCtsk
PyelonephritisTlr1
QuadriplegiaIl6
Radiation Injuries, ExperimentalIl1b , Mapk1 , Mapk3 , Tnf
Radiation PneumonitisTnf
RadiculopathySpp1 , Tnf
RASopathiesMap2k1 , Map2k2
Rectal NeoplasmsPik3ca
Renal Artery ObstructionCd40
Renal FibrosisCcl3 , Mapk1 , Tlr2 , Tlr4
Renal InsufficiencyCd80 , Il1b , Spp1 , Tlr2 , Tlr4
Renal Insufficiency, ChronicIl1b , Tlr9
Reoviridae InfectionsStat1
Reperfusion InjuryAkt1 , Casp8 , Ccl3 , Ccl5 , Cd40 , Cxcl10 , Cxcl9 , Fos , Il12a , Il1b , Il6 , Jun , Mapk8 , Mapk9 , Myd88 , Pik3r1 , Rela , Spp1 , Stat1 , Tlr2 , Tlr3 , Tlr4 , Tnf
Respiration DisordersCcl5
Respiratory Distress Syndrome, AdultCxcl10 , Il1b , Tlr3 , Tlr5 , Tlr9 , Tnf
Respiratory HypersensitivityIl1b , Il6 , Tlr4 , Tnf
Respiratory SoundsTlr4 , Tlr9
Respiratory Syncytial Virus InfectionsCcl5 , Cxcl10 , Cxcl9 , Il6 , Tlr2 , Tlr3 , Tlr4 , Tlr6 , Tlr7 , Tlr8 , Tnf
Respiratory Tract DiseasesTnf
Respiratory Tract InfectionsIrf3 , Tnf
Retina Reperfusion InjuryIl1b , Il6 , Map2k4 , Tlr4 , Tnf
Retinal Artery OcclusionIl6 , Tnf
Retinal DetachmentIl6 , Tnf
Retinal DiseasesMap2k3 , Tnf
Retinal VasculitisIl6
Retinal Vein OcclusionIl1b , Il6
RetinitisIl1b
Retinitis PigmentosaRipk1
Retinopathy of PrematurityIl1b
Rett SyndromeIrak1
Rheumatoid Arthritis, Systemic JuvenileIl6
RhinitisCd14 , Cd80 , Il1b , Tlr2 , Tlr6 , Tnf
Rhinitis, AllergicCd40 , Il1b , Tlr2 , Tlr4 , Tlr9
Rhinitis, Allergic, PerennialCd40 , Cd86
Rhinitis, Allergic, SeasonalCcl5 , Tlr3 , Tlr4
RhinosinusitisIl1b , Tlr2 , Tlr4 , Tnf
Salmonella InfectionsIl12b
Salmonella Infections, AnimalTlr5
Sandhoff DiseaseCcl3
SarcoidosisCd14
Sarcoidosis, PulmonaryCcl5 , Cxcl10 , Cxcl11 , Cxcl9 , Tlr2 , Tnf
SarcomaPik3ca , Tnf
Sarcoma, KaposiIl6
SarcopeniaIl6 , Nfkbia
Schistosomiasis MansoniCd40 , Cd86 , Tlr9
SchizophreniaAkt1 , Il1b , Il6 , Mapk3 , Pik3cb , Tnf
Schizophrenia, ChildhoodRela
Sciatic NeuropathyCcl5 , Il1b , Il6 , Nfkbia , Tlr2 , Tlr4 , Tnf
ScleritisTnf
Scleroderma, DiffuseIl6 , Tlr2
Scleroderma, LocalizedTnf
Scleroderma, SystemicCcl3 , Cd86 , Cxcl10 , Cxcl9 , Il1b , Il6 , Irak1 , Irf5
ScrapieSpp1 , Stat1
SeizuresCcl5 , Fos , Ifnb1 , Il1b , Il6 , Spp1 , Tnf
Seizures, FebrileIl1b
Senior Loken SyndromeAkt3
SepsisCasp8 , Ccl5 , Cd40 , Il12b , Il1b , Il6 , Irak4 , Lbp , Mapk1 , Mapk3 , Rela , Stat1 , Tlr2 , Tlr4 , Tnf
Septic PeritonitisIl6 , Pik3r1
Severe Acute Respiratory SyndromeCxcl10 , Cxcl9
Sezary SyndromeMapk1
ShockTnf
Shock, HemorrhagicIl1b , Il6 , Mapk1 , Rela , Tnf
Shock, SepticIl6 , Tnf
SHORT SyndromePik3r1
Shwartzman PhenomenonIl6
SilicosisIl1b , Tnf
SinusitisIl1b , Tlr2 , Tlr4 , Tlr9
Sjogren's SyndromeIl12a , Il6 , Tnf
Skin AbnormalitiesChuk
Skin DiseasesIl1b , Il6 , Tnf
Skin NeoplasmsAkt1 , Casp8 , Map2k4 , Rela
Sleep Apnea, ObstructiveCcl5 , Il1b , Il6 , Rela , Tnf
Sleep DeprivationMap2k4
Sleep Wake DisordersIl1b
Small-For-Size SyndromeIl1b
Smith-Magenis SyndromeCcl3 , Ccl5 , Map2k3 , Map2k6
Soft Tissue NeoplasmsTnf
Somatosensory DisordersTlr3
Spinal Cord CompressionTnf
Spinal Cord InjuriesAkt1 , Ccl5 , Cxcl10 , Fadd , Il1b , Il6 , Jun , Nfkbia , Rela , Spp1 , Tlr1 , Tnf
SpondylarthropathiesIl6
Spondylitis, AnkylosingIl12b , Il6 , Irak1 , Tlr4 , Tlr5
Spondylocostal Dysostosis 5Mapk3
SporotrichosisTlr4
Staphylococcal InfectionsTlr2
Status AsthmaticusIl1b
Status EpilepticusCasp8 , Ccl3 , Cd40 , Fos , Il1b , Jun , Rela , Tnf
Stevens-Johnson SyndromeTnf
Stomach NeoplasmsCasp8 , Il1b , Il6 , Jun , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Spp1 , Tnf
Stomach UlcerIl1b , Tnf
Stomatognathic DiseasesFadd
Streptococcal InfectionsCd86 , Tlr2
StrokeAkt1 , Cd40 , Il1b , Il6 , Mapk8 , Tlr4 , Tnf
Subacute Combined DegenerationCd40
Subarachnoid HemorrhageTlr4 , Tnf
Subretinal fibrosisIl6
Substance Withdrawal SyndromeFos , Mapk1 , Mapk3
Supranuclear Palsy, ProgressiveMap2k6
Systemic CandidiasisTnf
Systemic Inflammatory Response SyndromeIl1b
TachycardiaTnf
Telangiectasia, Hereditary HemorrhagicTnf
Temporomandibular Joint DisordersTnf
Tendon InjuriesFos
ThalassemiaIl1b , Tnf
ThrombocytopeniaIl1b , Il6 , Tnf
ThrombocytosisIl1b
ThrombosisCd40 , Pik3cb , Tnf
Thyroid NeoplasmsCxcl10 , Il12b , Il1b , Il6 , Map2k3 , Spp1 , Tnf
Thyroiditis, AutoimmuneIl6 , Tlr3 , Tnf
Tissue AdhesionsCcl5
Tobacco Use DisorderTlr3
Tongue NeoplasmsFos , Tlr5 , Tnf
Toxoplasma ChorioretinitisIl6
Toxoplasmosis, AnimalCcl5
TrachomaTnf
Transplant RejectionCcl3 , Cd40 , Ikbkb , Il1b , Nfkbia , Tlr2 , Tlr4 , Tlr9 , Tnf
Trauma, Nervous SystemSpp1 , Stat1
TrichinellosisTnf
Trigeminal NeuralgiaFos , Il1b , Mapk1 , Mapk3 , Mapk8 , Mapk9 , Tnf
TuberculosisCd86 , Cxcl9 , Spp1 , Tirap , Tlr1 , Tlr4 , Tnf
Tuberculosis, MeningealTnf
Tuberculosis, PleuralIl1b , Tlr4
Tuberculosis, PulmonaryCcl5 , Cd14 , Cd86 , Il1b , Il6 , Jun , Tlr1 , Tlr2 , Tlr4 , Tlr9 , Tnf
TularemiaCd86
Tympanic Membrane PerforationIl6
UremiaSpp1
Ureteral ObstructionAkt1 , Cd14 , Il1b , Tlr9 , Tnf
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsAkt1 , Ifnb1 , Il1b , Map2k4 , Rela , Spp1 , Tlr2 , Tlr4 , Tnf
Urinary CalculiSpp1
Urinary IncontinenceMapk1
Urinary Tract InfectionsIl1b , Tlr2 , Tlr4 , Tlr5
UrticariaIl1b , Tnf
Uterine Cervical NeoplasmsCasp8 , Fos , Map2k3 , Map2k6 , Rela , Tnf
UveitisCcl5 , Cxcl10 , Il1b , Il6 , Rela , Tlr4 , Tnf
Uveitis, AnteriorCcl3 , Tlr2 , Tlr4 , Tnf
Uveitis, Autoimmune, ExperimentalTlr4
Uveitis, IntermediateTnf
Uveitis, PosteriorCcl5
Uveomeningoencephalitic SyndromeTnf
VaricoceleIl1b
Vascular CalcificationCd40
Vascular DiseasesTnf
Vascular System InjuriesSpp1 , Tnf
Venous ThromboembolismTnf
Venous ThrombosisIl1b
Ventilator-Induced Lung InjuryAkt1 , Il1b , Nfkbia
Ventricular DysfunctionTnf
Ventricular Dysfunction, LeftIl6
Virus DiseasesIfnar1
VitiligoCd80 , Tlr2 , Tlr4 , Tnf
Vitreoretinopathy, ProliferativeIl6
Vulvar VestibulitisIl1b , Tnf
Waldenstrom MacroglobulinemiaIl6 , Myd88
Wallerian DegenerationTlr2 , Tlr4
WartsTlr2
Weight GainLbp , Pik3ca , Tnf
Weill-Marchesani SyndromeTnf
Wet Macular DegenerationIl6 , Mapk8 , Tlr2 , Tlr3
Wilms TumorStat1
Wounds and InjuriesIl6 , Spp1 , Tnf
Wounds, PenetratingTnf
Pathway Annotations Associated with Genes in the Toll-like receptor signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
adenosine signaling pathwayAkt1 , Chuk , Ikbkb , Jun , Map2k2 , Map2k6 , Map2k7 , Mapk1 , Mapk11 , Mapk8 , Nfkb1 , Nfkbia , Pik3ca
aldosterone signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
allograft rejection pathwayCd40 , Cd80 , Cd86 , Il12a , Il12b , Tnf
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered ubiquitin/proteasome degradation pathwayUbe2n
Alzheimer disease pathwayCasp8 , Fadd , Il1b , Mapk1 , Mapk3 , Tnf , Ube2n
amyotrophic lateral sclerosis disease pathwayMap2k3 , Map2k6 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1 , Tnf
antigen processing and presentation pathwayTnf
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Ripk1 , Tnf , Tradd
Arf family mediated signaling pathwayRac1
asthma disease pathwayCd40 , Tnf
ataxia telangiectasia-mutated (ATM) signaling pathwayUbe2n
autoimmune thyroid disease pathwayCd40 , Cd80 , Cd86 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
autophagy pathwayIfna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , LOC100911527
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Fos , Ikbkb , Ikbkg , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela
bladder cancer pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
Bone morphogenetic proteins signaling pathwayMap3k7 , Mapk1 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap2k4 , Map2k7 , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Spp1
cardiovascular system disease pathwayCd14
cell-extracellular matrix signaling pathwaySpp1
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Map2k4 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Ripk1 , Stat1 , Tnf , Tradd
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Ccl3 , Ccl5 , Chuk , Cxcl10 , Cxcl11 , Cxcl9 , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Fos , Jun , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
cytokine mediated signaling pathwayCcl3 , Ccl5 , Cd40 , Cxcl10 , Cxcl11 , Cxcl9 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Il12a , Il12b , Il1b , Il6 , LOC100911527 , Tnf
diabetic nephropathy pathwaySpp1
dilated cardiomyopathy pathwayTnf
E-cadherin signaling pathwayAkt1 , Akt2 , Pik3ca , Pik3r1 , Rac1
eicosanoid signaling pathwayAkt1 , Mapk11 , Mapk14 , Pik3r5 , Rac1
endocytosis pathwayTraf6
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Endoplasmic Reticulum-associated degradation pathwayMap2k7 , Mapk10 , Mapk8 , Mapk9
endothelin signaling pathwayAkt1 , Fos , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Rac1
Entamoeba histolyca infection pathwayCd14 , Il12a , Il12b , Il1b , Il6 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tlr2 , Tlr4 , Tnf
ephrin - ephrin receptor bidirectional signaling axisMap2k1 , Map2k4 , Map3k7 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3r1 , Pik3r5 , Rac1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
erythropoietin signaling pathwayMapk14 , Mapk8 , Nfkb1 , Pik3r1 , Stat1
extrinsic apoptotic pathwayCasp8
FasL mediated signaling pathwayAkt1 , Casp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k6 , Map2k7 , Mapk10 , Mapk11 , Mapk14 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Tnf
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
fibroblast growth factor signaling pathwayAkt1 , Fos , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Spp1 , Stat1
forkhead class A signaling pathwayAkt1 , Fos , Jun
glioma pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
glutamate signaling pathwayMapk1 , Mapk3
glypican signaling pathwayMapk8 , Mapk9
gonadotropin-releasing hormone signaling pathwayJun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9
graft-versus-host disease pathwayCd80 , Cd86 , Il1b , Il6 , Tnf
granulocyte-macrophage colony-stimulating factor signaling pathwayFos , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
Hedgehog signaling pathwayAkt1 , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Irf3 , Irf7 , LOC100911527 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Ripk1 , Stat1 , Tbk1 , Tlr3 , Tnf , Tradd , Traf3 , Traf6
Huntington disease pathwayCasp8
hypertrophic cardiomyopathy pathwayIl6 , Tnf
hypoxia inducible factor pathwayAkt1 , Fos , Jun
inflammatory response pathwayMapk8
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Ccl5 , Cxcl10 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Il12a , Il12b , Il1b , Il6 , Irak4 , Irf3 , Irf7 , Jun , LOC100911527 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tbk1 , Tlr3 , Tlr4 , Tlr7 , Tnf
innate immune response pathwayCd14
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Rac1
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
insulin-like growth factor signaling pathwayAkt1 , Pik3ca , Pik3r1
interleukin-1 signaling pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Jun , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
Interleukin-10 signaling pathwayStat1
interleukin-12 signaling pathwayCcl3 , Fos , Il12a , Il12b , Il1b , Map2k3 , Map2k6 , Mapk14 , Nfkb1 , Rela , Stat1
interleukin-2 signaling pathwayFos , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk11 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3r1 , Stat1
interleukin-23 signaling pathwayCxcl9 , Il12b , Il1b , Il6 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Stat1 , Tnf
interleukin-27 signaling pathwayIl12a , Il12b , Il1b , Il6 , Stat1 , Tnf
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Mapk14 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Fos , Il6 , Jun , Lbp , Map2k4 , Map2k6 , Mapk11 , Mapk14 , Pik3ca , Pik3r1 , Rac1 , Stat1
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Il12a , Il12b , Il6 , LOC100911527 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Stat1
kidney disease pathwaySpp1
Leishmania infection pathwayFos , Il12a , Il12b , Il1b , Irak1 , Irak4 , Jun , Map3k7 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Myd88 , Nfkb1 , Nfkbia , Rela , Stat1 , Tlr2 , Tlr4 , Tnf , Traf6
long term depressionMap2k1 , Map2k2 , Mapk1 , Mapk3
long term potentiationMap2k1 , Map2k2 , Mapk1 , Mapk3
measles infection pathwayAkt1 , Akt2 , Akt3 , Chuk , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbke , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak4 , Irf3 , Irf7 , LOC100911527 , Map3k7 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tbk1 , Tlr2 , Tlr4 , Tlr7 , Tlr9 , Traf6
melanoma pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Cd14 , Chuk , Fos , Ikbkb , Ikbkg , Il1b , Jun , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Rac1 , Rela , Tnf , Traf6
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Casp8 , Cd14 , Fadd , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak2 , Irak4 , Lbp , LOC100911527 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Rela , Stat1 , Tirap , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf , Tradd , Traf6
myocarditis pathwayCasp8 , Cd40 , Cd80 , Cd86 , Rac1
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1 , Rac1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Ikbkb , Irak1 , Irak2 , Irak4 , Jun , Map2k1 , Map2k2 , Map2k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Traf6
NOD-like receptor signaling pathwayCasp8 , Ccl5 , Chuk , Ikbkb , Ikbkg , Il1b , Il6 , Map3k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Rela , Tnf , Traf6
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
nuclear factor kappa B signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk14 , Nfkb1 , Nfkbia , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Tnf , Traf6
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb
p38 MAPK signaling pathwayMap2k3 , Map2k6 , Map3k7 , Map3k8 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Rac1 , Tab1 , Tab2 , Traf6
p53 signaling pathwayAkt1 , Casp8 , Mapk14 , Mapk8 , Mapk9
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Nfkb1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Stat1
phagocytosis pathwayCd14 , Rac1 , Tlr2 , Tlr4 , Tlr6
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
Plasmodium infection pathwayCd40 , Il12a , Il1b , Il6 , Myd88 , Tlr2 , Tlr4 , Tlr9 , Tnf
platelet-derived growth factor signaling pathwayFos , Jun , Map2k1 , Map2k2 , Map2k4 , Map2k7 , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Stat1
primary immunodeficiency disease pathwayCd40 , Ikbkg
prion diseases pathwayCcl5 , Il1b , Il6 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela
Reelin signaling pathwayAkt1 , Map2k7 , Mapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayCasp8 , Chuk , Cxcl10 , Fadd , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Il12a , Il12b , Irf3 , Irf7 , LOC100911527 , Map3k7 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk8 , Mapk9 , Nfkb1 , Nfkbia , Rela , Ripk1 , Tbk1 , Tnf , Tradd , Traf3 , Traf6
rheumatoid arthritis disease pathwayCcl3 , Ccl5 , Cd80 , Cd86 , Ctsk , Fos , Il1b , Il6 , Jun , Tlr2 , Tlr4 , Tnf
Rho/Rac/Cdc42 mediated signaling pathwayJun , Map2k4 , Mapk8 , Rac1
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Chuk , Ikbkb , Ikbkg , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Traf3 , Traf6
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Fos , Jun , Mapk1 , Mapk14 , Mapk3 , Mapk8 , Rac1
syndecan signaling pathwayCcl5 , Mapk1 , Mapk3 , Mapk8 , Rac1
systemic lupus erythematosus pathwayCd40 , Cd80 , Cd86 , Tnf
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Chuk , Fos , Ikbkb , Ikbkg , Jun , Map2k1 , Map2k2 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk9 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tnf
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3 , Spp1
thyroid cancer pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
tioguanine pharmacodynamics pathwayRac1
titanium dioxide nanoparticle response pathwayCasp8 , Tlr4
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Casp8 , Ccl3 , Ccl5 , Cd14 , Cd40 , Cd80 , Cd86 , Chuk , Ctsk , Cxcl10 , Cxcl11 , Cxcl9 , Fadd , Fos , Ifna1 , Ifna11 , Ifna2 , Ifna4 , Ifna5 , Ifnar1 , Ifnb1 , Ikbkb , Ikbke , Ikbkg , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak2 , Irak4 , Irf3 , Irf5 , Irf7 , Jun , Lbp , LOC100911527 , Ly96 , Map2k1 , Map2k2 , Map2k3 , Map2k4 , Map2k6 , Map2k7 , Map3k7 , Map3k8 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rela , Ripk1 , Spp1 , Stat1 , Tab1 , Tab2 , Tab3 , Tbk1 , Ticam2 , Tirap , Tlr1 , Tlr2 , Tlr3 , Tlr4 , Tlr5 , Tlr6 , Tlr7 , Tlr8 , Tlr9 , Tnf , Tollip , Tradd , Traf3 , Traf6 , Ube2n , Ube2v1 , Unc93b1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Casp8 , Cd40 , Chuk , Ikbkb , Ikbkg , Il12a , Il12b , Irak1 , Irak4 , Ly96 , Map2k3 , Map2k6 , Map3k7 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Stat1 , Tlr2 , Tlr4 , Tnf , Traf6
Trail mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k4 , Mapk1 , Mapk3 , Mapk8 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Ripk1 , Tradd
transforming growth factor-beta Smad dependent signaling pathwayMap3k7 , Tab1 , Tab2
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Tnf
Trypanosoma brucei infection pathwayIl12a , Il12b , Il1b , Il6 , Myd88 , Tlr9 , Tnf
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Casp8 , Ccl3 , Ccl5 , Chuk , Fadd , Fos , Ifnb1 , Ikbkb , Ikbkg , Il12a , Il12b , Il1b , Il6 , Irak1 , Irak4 , Jun , Map2k4 , Mapk1 , Mapk10 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Mapk8 , Mapk9 , Myd88 , Nfkb1 , Nfkbia , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rela , Tlr2 , Tlr4 , Tlr6 , Tlr9 , Tnf , Traf6
tumor necrosis factor mediated signaling pathwayCasp8 , Chuk , Fadd , Ikbkb , Ikbkg , Map2k3 , Map2k7 , Map3k7 , Nfkb1 , Rela , Ripk1 , Stat1 , Tab1 , Tab2 , Tab3 , Tnf , Tradd
type 1 diabetes mellitus pathwayCd80 , Cd86 , Il12a , Il12b , Il1b , Tnf
type 2 diabetes mellitus pathwayAkt2 , Ikbkb , Mapk1 , Mapk10 , Mapk3 , Mapk8 , Mapk9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tnf
type II interferon signaling pathwayAkt1 , Il1b , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Stat1
ubiquitin/proteasome degradation pathwayTraf6 , Ube2n
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Map2k3 , Map2k6 , Mapk1 , Mapk11 , Mapk12 , Mapk13 , Mapk14 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Wnt signaling pathwayJun , Map3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1
Wnt signaling, non-canonical pathwayMap3k7 , Mapk10 , Mapk8 , Mapk9 , Rac1 , Tab1 , Tab2
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the Toll-like receptor signaling pathway

References Associated with the Toll-like receptor signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: