RENAL CELL CANCER PATHWAY (PW:0001017)

View Ontology Report

Description

Renal cell cancer (RCC), of which clear cell RCC is the most common type, accounts for ~2% of cancers. Its incidence appears to be rising and with its poor overall survival rate, it likely represents the deadliest urological neoplasm. The majority of cases are sporadic, but several familial and inherited cases have been reported. A major culprit gene is Von Hippel-Lindau (Vhl), the component of E3 ubiquitine ligase complex that targets the hypoxia inducible factor (Hif) alpha for degradation und

Pathway Diagram:

Elsevier Inc. downregulated miRNA ---> upregulated target translation potential RCC miRNA ---> Carcinoma, Renal Cell upregulated miRNA ---> downregulated target translation potential RCC miRNA drug pathways in RCC targeted therapy drug pathways in RCC targeted therapy ---| Carcinoma, Renal Cell other RCC candidate genes Vhl Sdhd Sdhb Fh altered expression of target genes altered hypoxia inducible factor pathway ---> altered expression of target genes other RCC candidate genes ---> Carcinoma, Renal Cell altered hypoxia inducible factor pathway altered citric acid cycle pathway ---> altered hypoxia inducible factor pathway upregulated miRNA downregulated miRNA upregulated target translation downregulated target translation Carcinoma, Renal Cell altered citric acid cycle pathway
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns
renal cell cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6907045
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 JBrowse link 1 146,399,217 146,556,437 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:6907045
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:6907045
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:6907045
G Crkl CRK like proto-oncogene, adaptor protein JBrowse link 11 87,338,606 87,356,644 RGD:6907045
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:6907045
G Egln1 egl-9 family hypoxia-inducible factor 1 JBrowse link 19 57,660,194 57,701,158 RGD:6907045
G Egln2 egl-9 family hypoxia-inducible factor 2 JBrowse link 1 83,969,456 83,977,665 RGD:6907045
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:6907045
G Elob elongin B JBrowse link 10 13,163,032 13,168,217 RGD:6907045
G Eloc elongin C JBrowse link 5 2,042,991 2,059,357 RGD:6907045
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6907045
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6907045
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:6907045
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:6907135
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:6907045
G Gab1 GRB2-associated binding protein 1 JBrowse link 19 30,794,290 30,903,819 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Hgf hepatocyte growth factor JBrowse link 4 15,435,460 15,505,377 RGD:6907045
G Hif1a hypoxia inducible factor 1 alpha subunit JBrowse link 6 96,810,868 96,856,303 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6907045
G Kdm5c lysine demethylase 5C JBrowse link X 22,302,664 22,349,298 RGD:6907133
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6907045
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 11 72,829,407 72,865,815 RGD:6907045
G Pak3 p21 (RAC1) activated kinase 3 JBrowse link X 114,784,452 115,042,683 RGD:6907045
G Pak4 p21 (RAC1) activated kinase 4 JBrowse link 1 85,162,462 85,201,746 RGD:6907045
G Pak6 p21 (RAC1) activated kinase 6 JBrowse link 3 110,442,175 110,486,317 RGD:6907045
G Pak7 p21 (RAC1) activated kinase 7 JBrowse link 3 129,042,232 129,357,512 RGD:6907045
G Pbrm1 polybromo 1 JBrowse link 16 7,103,714 7,202,899 RGD:6907133
RGD:6907137
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6907045
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6907045
G Pgf placental growth factor JBrowse link 6 108,994,016 109,004,598 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:6907045
G Rac1 ras-related C3 botulinum toxin substrate 1 JBrowse link 12 13,090,316 13,111,841 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:6907045
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:6907045
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:6907045
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:6907045
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6907134
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6907134
G Setd2 SET domain containing 2 JBrowse link 8 118,802,478 118,888,224 RGD:6907133
RGD:6907137
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 6 109,913,757 109,936,217 RGD:6907045
G Uty ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome JBrowse link Y 1,065,274 1,206,127 RGD:6907133
RGD:6907137
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6907045
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:6907045
G Vegfc vascular endothelial growth factor C JBrowse link 16 40,440,371 40,555,178 RGD:6907045
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6907045
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:6907045
RGD:6907133

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential RCC miRNAderegulated microRNA in RCC
Small Moleculedrug pathways in RCC targeted therapydrugs used in the treatment of RCC
Gene GroupOther RCC candidate genesRCC candidate genes from large-sclae sequencing

Pathway Gene Annotations

Disease Annotations Associated with Genes in the renal cell cancer pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abnormalities, MultipleCdc42 , Crebbp , Kras , Mapk1
Abortion, SpontaneousArnt , Pgf , Tgfb1
Acromicric DysplasiaTgfb1
Acute Chest SyndromeVegfa
Acute Kidney InjuryEgln1 , Egln3 , Epas1 , Hif1a , Met , Tgfa , Tgfb1 , Vegfa
Acute Lung InjuryPak1 , Tgfb1 , Vegfa
Acute-Phase ReactionHif1a
AdenocarcinomaKras , Met , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungAkt1 , Braf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Nras , Pik3ca , Ptpn11 , Raf1 , Sos1
ADENOCARCINOMA OF STOMACHAkt1 , Braf , Crebbp , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Ptpn11 , Raf1
Adenocarcinoma, Bronchiolo-AlveolarKras
Adenocarcinoma, FollicularKras
Adenocarcinoma, ProstaticAkt1 , Braf , Hras , Map2k1 , Pik3ca
AdenomaKras , Vhl
Adenoma, Liver CellHras , Kras
Adenomatous Polyposis ColiAkt1
Adrenal Gland NeoplasmsCdc42
Adrenocortical CarcinomaBraf , Nras , Pik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
AIDS Dementia ComplexPdgfb
Alveolitis, Extrinsic AllergicVegfa
Alzheimer DiseaseAkt1 , Cdc42 , Crebbp , Ep300 , Hif1a , Hras , Pak1 , Pdgfb , Pik3r1 , Slc2a1 , Vegfa
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Pgf , Vegfa
Amyotrophic Lateral Sclerosis 1Crebbp , Pdgfa
AnaplasiaHif1a
AnemiaKras
Anemia, AplasticTgfb1
Anemia, Sickle CellPgf , Tgfb1
AnetodermaTgfb1
Angina, UnstableAkt1
AnoxiaPgf
Anti-Glomerular Basement Membrane DiseaseRapgef1
Aortic Aneurysm, ThoracicTgfb2
Aortic Valve InsufficiencyPtpn11 , Tgfb1 , Tgfb2
Aortic Valve StenosisPtpn11
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular DysplasiaTgfb3
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1Tgfb3
Arterial ThrombosisHif1a
ArteriosclerosisHgf , Met , Tgfb1
Arteriovenous FistulaVegfa
Arthritis, ExperimentalAkt1 , Cdc42 , Hif1a , Nras , Pgf , Pik3cd , Vegfa
Arthritis, JuvenileJun , Kras , Mapk1
Arthritis, RheumatoidEpas1 , Hgf , Hif1a , Pdgfb , Pgf , Vegfa
AsphyxiaHif1a , Jun
AsthmaHif1a , Pdgfb , Pgf , Tgfb1 , Vegfa
Asthma, OccupationalTgfb1
AstrocytomaAkt1 , Braf , Hgf , Hif1a , Kras , Met , Ptpn11
AtaxiaSlc2a1
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1 , Egln1 , Pgf , Vegfa , Vegfc
Atrial FibrillationHgf , Hif1a , Vegfa
AtrophyMapk3
Attention Deficit Disorder with HyperactivityCrebbp , Vegfa
Autism Spectrum DisorderMapk3
Autistic DisorderHras , Kdm5c , Met
Autoimmune DiseasesTgfb2
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
AzoospermiaEpas1
Bardet-Biedl SyndromeAkt3
Barrett EsophagusHgf
Basal Ganglia Calcification, Idiopathic, 5Pdgfb
Basal Ganglia DiseasesPdgfb
Behcet SyndromeTgfb1 , Vegfa
Benign Skin NeoplasmsHras
BerylliosisTgfb1
Bile Duct NeoplasmsMet
Biliary Tract NeoplasmsHgf
Bipolar DisorderAkt1 , Cdc42
Birt-Hogg-Dube SyndromeFlcn
BlindnessVegfa
Bone Diseases, DevelopmentalTgfb2
Bone Diseases, EndocrinePdgfa
Brain EdemaVegfa
Brain InfarctionHgf , Pdgfb
Brain InjuriesAkt1 , Epas1 , Jun , Pdgfa , Pdgfb , Vegfa , Vegfb
Brain IschemiaAkt1 , Hif1a , Jun , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pgf , Tgfb1
Brain NeoplasmsVegfa
Breast AdenocarcinomaAkt1 , Kras , Pik3ca
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Braf , Crkl , Ep300 , Hif1a , Hras , Jun , Kdm5c , Kras , Map2k1 , Map2k2 , Mapk1 , Met , Pak1 , Pak2 , Pdgfa , Pgf , Pik3ca , Pik3r1 , Raf1 , Setd2 , Slc2a1 , Tgfb1 , Uty , Vegfa , Vegfb , Vegfc
Bronchitis, ChronicVegfa
Bronchopulmonary DysplasiaEpas1 , Hif1a
Burkitt LymphomaPik3r1
BurnsHif1a
CachexiaTgfb1
Cafe au lait Spots, MultipleSos1
CalcinosisPdgfb , Tgfb1
Camurati-Engelmann SyndromeTgfb1
CarcinogenesisBraf , Kras
Carcinoid Tumors, IntestinalSdhd
CarcinomaCdc42 , Hif1a , Hras , Kras , Met , Pdgfa , Pik3r1 , Tgfb1 , Vhl
Carcinoma in SituAkt1
Carcinoma, Adenoid CysticCrebbp , Ep300 , Hras , Map2k2 , Pik3ca , Setd2
Carcinoma, Basal CellPik3ca
Carcinoma, DuctalHif1a , Slc2a1
Carcinoma, Ductal, BreastCrkl , Hif1a
Carcinoma, EndometrioidAkt1 , Kras , Pik3r2
Carcinoma, HepatocellularAkt1 , Akt2 , Braf , Crebbp , Ep300 , Hgf , Hif1a , Hras , Jun , Kras , Met , Nras , Pdgfb , Pik3ca , Rac1 , Slc2a1 , Tgfa , Tgfb1
Carcinoma, Intraductal, NoninfiltratingHif1a , Pak2 , Slc2a1 , Vegfa
Carcinoma, Large CellMet
Carcinoma, Merkel CellSdhd
Carcinoma, Non-Small-Cell LungAkt1 , Akt2 , Braf , Epas1 , Hif1a , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Raf1 , Tgfa , Vegfa
Carcinoma, Pancreatic DuctalKras , Met , Tgfb1 , Vegfa , Vhl
Carcinoma, PapillaryVegfc
Carcinoma, Renal CellAkt1 , Eloc , Epas1 , Fh , Flcn , Hif1a , Jun , Kdm5c , Kras , Map2k1 , Met , Nras , Pak1 , Pbrm1 , Pik3ca , Sdhb , Sdhd , Setd2 , Slc2a1 , Uty , Vegfa , Vegfc , Vhl
Carcinoma, Squamous CellAkt1 , Crebbp , Ep300 , Hgf , Hras , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
Carcinoma, Squamous Cell of Head and NeckAkt1 , Braf , Crebbp , Ep300 , Hras , Map2k1 , Map2k2 , Mapk1 , Pik3ca , Rac1
Carcinoma, Transitional CellCrebbp , Ep300 , Hras , Kras , Nras , Pak1
CarcinosarcomaTgfb1
Cardiac FibrosisPak1 , Tgfb1
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
Cardiofaciocutaneous Syndrome 2Kras
CARDIOFACIOCUTANEOUS SYNDROME 3Map2k1
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Ep300 , Epas1 , Hif1a , Mapk1 , Met , Pak1 , Rac1 , Raf1 , Tgfb1
CardiomyopathiesAkt1 , Ep300 , Hgf , Kras , Mapk1 , Mapk3 , Vegfa
Cardiomyopathy, DilatedEgln1 , Kras , Pgf , Ptpn11 , Rac1 , Raf1
CARDIOMYOPATHY, DILATED, 1NNRaf1
Cardiomyopathy, HypertrophicKras , Ptpn11 , Raf1 , Sos1 , Tgfb1
Cardiomyopathy, Hypertrophic, FamilialKras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Carney TriadSdhb
Carney-Stratakis SyndromeSdhb , Sdhd
Carotid Artery DiseasesHgf , Pgf , Tgfb1
Carotid Body TumorSdhd
CataractMap2k1 , Slc2a1
Cecal NeoplasmsKras
Celiac DiseaseEts1
Cell Transformation, NeoplasticEpas1 , Hras , Jun , Kras , Rac1 , Slc2a1 , Tgfb1
Central Nervous System DiseasesHgf
Cerebral HemorrhageVegfa
Ceroid Lipofuscinosis, Neuronal, 6Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaVegfa
CholangiocarcinomaHgf , Kras , Met , Pbrm1 , Tgfb1
CholangitisTgfb2
Cholangitis, SclerosingHif1a
CholestasisPdgfb
CholesteatomaHgf , Vegfa
Cholesteatoma, Middle EarHif1a , Vegfa
Choreoathetosis/Spasticity, EpisodicSlc2a1
ChorioamnionitisTgfb1
ChoriocarcinomaPdgfb
Choroidal NeovascularizationHgf , Vegfa , Vegfb
Chromosome AberrationsEpas1
Chronic Allograft NephropathyPdgfa , Pdgfb
Chronic Cerebral HypoperfusionHif1a
Chronic Lung Allograft DysfunctionEpas1
Chronic Lymphoid LeukemiaBraf , Hras , Kras , Nras , Ptpn11
Clear-Cell Metastatic Renal Cell CarcinomaEp300 , Vegfa
Cleft PalateTgfb1 , Tgfb2 , Tgfb3
Cocaine-Related DisordersMapk1 , Mapk3
Cognition DisordersMet
ColitisPgf , Vegfa
Colitis, IschemicVegfa
Colonic NeoplasmsAkt1 , Akt2 , Braf , Crkl , Ep300 , Flcn , Hif1a , Jun , Kras , Nras , Pik3ca , Pik3r1 , Slc2a1 , Vegfa , Vegfc
Colorectal NeoplasmsAkt1 , Akt2 , Arnt , Braf , Crebbp , Ep300 , Flcn , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Tgfb1
Combined Oxidative Phosphorylation Deficiency 8Sdhd
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicTgfb1
Copper-Overload CirrhosisHgf , Met , Tgfb1
Corneal NeovascularizationVegfa
Coronary Artery DiseaseAkt1 , Hgf , Tgfb1 , Vegfa
Coronary DiseaseVegfa
Coronary RestenosisMapk1
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Ptpn11
COWDEN SYNDROME 5Pik3ca
Cowden-Like SyndromeSdhb , Sdhd
Cranioectodermal DysplasiaTgfb3
Craniofacial AbnormalitiesEp300 , Tgfb2
CraniopharyngiomaBraf
Crohn DiseasePgf , Vegfa
Cryohydrocytosis, Stomatin-Deficient, with Mental Retardation, Seizures, Cataracts, and Massive HepatosplenomegalySlc2a1
Currarino TriadPik3ca
CyanosisTgfb2
Cystic FibrosisTgfb1
CystsFlcn
Deafness, Autosomal Recessive 39Hgf
Deafness, Autosomal Recessive 97Met
Depressive DisorderJun
Dermatitis HerpetiformisVegfa
Dermatitis, Allergic ContactVegfa
Dermatitis, AtopicTgfb1
Dermatitis, ContactVegfa
DermatofibrosarcomaPdgfb
DermatomyositisHgf
Developmental DisabilitiesAkt3 , Slc2a1
Diabetes ComplicationsHif1a , Vegfa
Diabetes MellitusHgf , Rac1 , Slc2a1
Diabetes Mellitus, ExperimentalAkt1 , Ep300 , Ets1 , Hgf , Hif1a , Hras , Mapk1 , Mapk3 , Met , Pdgfb , Pgf , Pik3r1 , Rap1b , Slc2a1 , Tgfb1 , Tgfb2 , Vegfa , Vegfb
Diabetes Mellitus, Type 1Ets1 , Tgfb1
Diabetes Mellitus, Type 2Akt1 , Akt2 , Arnt , Ep300 , Epas1 , Ets1 , Hgf , Hif1a , Pik3r1 , Slc2a1 , Tgfb1 , Vegfa
Diabetic AngiopathiesVegfa
Diabetic NephropathiesEp300 , Epas1 , Hgf , Hif1a , Mapk1 , Pdgfa , Pdgfb , Pgf , Slc2a1 , Tgfb1 , Uty , Vegfa
Diabetic NeuropathiesHgf , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Diabetic RetinopathyEp300 , Hgf , Hif1a , Hras , Pgf , Vegfa
Diaphyseal Dysplasia 1, ProgressiveTgfb1
DiGeorge SyndromeCrkl
Dilatation, PathologicTgfb1
Disease Models, AnimalAkt1 , Kras , Mapk1 , Mapk3
Disease ProgressionHras , Vegfb
Drug-Induced Liver InjuryArnt
Dry Eye SyndromesTgfb1
Duodenal UlcerTgfb1 , Vegfa
Dysembryoplastic Neuroepithelial TumorBraf
DystoniaSlc2a1
Ehlers-Danlos SyndromeTgfb1
Encephalomyelitis, Autoimmune, ExperimentalPdgfb , Tgfb1 , Tgfb2 , Vegfa
EnchondromatosisPtpn11
Endometrial HyperplasiaKras
Endometrial NeoplasmsEp300 , Jun , Kras , Met , Pik3ca , Vegfa
EndometriosisArnt , Kras , Tgfb2 , Vegfa
Endomyocardial FibrosisTgfb1
EndotoxemiaEp300 , Pgf
Eosinophilic EsophagitisTgfb1
Epidermal NevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1 , Pgf , Slc2a1
Epilepsy, AbsenceSlc2a1
Epilepsy, Idiopathic GeneralizedSlc2a1
Epilepsy, Temporal LobeCdc42 , Pgf , Vegfa
Erectile DysfunctionAkt1 , Tgfb1 , Vegfa
Erythema MultiformeVegfa
Erythrocytosis, Familial, 1Egln1 , Epas1
Erythrocytosis, Familial, 2Vhl
Erythrocytosis, Familial, 3Egln1
Erythrocytosis, Familial, 4Epas1
Esophageal NeoplasmsMet
Esophageal Squamous Cell CarcinomaCrebbp , Ep300 , Hif1a , Uty
Esthesioneuroblastoma, OlfactoryHif1a
Exostoses, Multiple HereditaryPtpn11
Eye AbnormalitiesTgfb2
Facial AsymmetryPik3ca
Facial Nerve InjuriesHgf
Fatty LiverEpas1
Fetal Growth RetardationPdgfa , Pdgfb , Ptpn11 , Slc2a1
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Hgf , Sos1
FibrosarcomaCdc42
FibrosisAkt1 , Pdgfb , Tgfb1
Fumaric AciduriaFh
Gallbladder NeoplasmsHgf , Kras , Met , Tgfa , Tgfb1
GastrinomaMet
GastroenteritisTgfa
Gastrointestinal NeoplasmsPik3ca
Gastrointestinal Stromal TumorsBraf , Kras , Sdhb
Genetic Diseases, InbornCdc42 , Crebbp , Egln1 , Mapk1 , Pik3r2
Genetic Predisposition to DiseaseTgfa
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
Gingival HyperplasiaPdgfb
GingivitisVegfa
GlaucomaCrebbp , Tgfb2 , Vegfa
Glaucoma, Angle-ClosureHgf
Glaucoma, NeovascularVegfa
GlioblastomaAkt1 , Braf , Crebbp , Hif1a , Hras , Met , Nras , Pdgfb , Pgf , Pik3ca , Pik3r1 , Vegfa
GliomaAkt2 , Braf , Hgf , Met , Pik3ca , Raf1
GliosarcomaVegfa
GliosisMapk1 , Mapk3
GlomerulonephritisEp300 , Mapk1 , Pdgfb , Vegfa
Glomerulonephritis, IGATgfb1
Glomerulonephritis, MembranoproliferativeEp300
GlomerulosclerosisSlc2a1
Glomerulosclerosis, Focal SegmentalTgfb1
Glomus Tympanicum TumorVegfa
Glut1 Deficiency SyndromeSlc2a1
GLUT1 Deficiency Syndrome 2Slc2a1
Graft vs Host DiseaseHgf , Pdgfb , Vegfa
Granulosa Cell TumorVegfa
Graves DiseaseVegfa
Growth DisordersPik3ca
Growth Hormone-Secreting Pituitary AdenomaPtpn11
HamartomaFlcn
Hamartoma Syndrome, MultipleAkt1 , Pik3ca , Sdhd
Head and Neck NeoplasmsMapk1 , Mapk3 , Pik3ca , Tgfa , Vegfa
Head Injuries, PenetratingPdgfb
Hearing LossHgf
Hearing Loss, Noise-InducedHif1a
Heart ArrestAkt1 , Ep300
Heart Defects, CongenitalHif1a , Tgfb2 , Vegfa
Heart DiseasesEp300 , Tgfb1 , Vegfa
Heart FailureHif1a , Pgf , Rac1 , Vegfa
Heart Septal Defects, VentricularBraf , Pgf , Tgfb3
Heat StrokeJun
HemangioblastomaHif1a
HEMANGIOBLASTOMA, CEREBELLARVhl
HemangiomaSlc2a1
Hemangioma, CapillaryAkt3
Hemangioma, Capillary InfantileSlc2a1
HemangiosarcomaHras , Jun , Kras , Vegfa , Vegfc
HemimegalencephalyPik3ca
Hemophilia ATgfb1
Hepatic EncephalopathyHif1a
Hepatitis, AnimalMet
Hepatitis, AutoimmuneTgfb1
Hepatitis, ChronicHgf , Met , Tgfb1
HepatoblastomaTgfa
Hereditary Paraganglioma-Pheochromocytoma SyndromesSdhb , Sdhd
Hernia, DiaphragmaticTgfb1
Hernias, Diaphragmatic, CongenitalEp300 , Met , Vegfa
Hirschsprung DiseaseSlc2a1
Hirschsprung Disease 1Crebbp
HirsutismEp300
HIV InfectionsCdc42
Hodgkin DiseaseJun
Holt-Oram SyndromeTgfb2
Hot FlashesHif1a
Huntington DiseaseKdm5c
HyperalgesiaEp300 , Hif1a , Mapk1 , Mapk3 , Raf1
HyperbilirubinemiaHgf
HypercholesterolemiaVegfa
Hypercholesterolemia, FamilialFh
HyperemiaEgln1
HyperglycemiaEpas1
HyperlipidemiasTgfb1
HyperoxaluriaRap1a
HyperoxiaTgfb1
Hyperoxic Lung InjuryPdgfb
HyperplasiaAkt1 , Hif1a , Pik3ca , Tgfb1 , Vegfa
HypersensitivityTgfb1
HypertensionAkt1 , Akt2 , Egln1 , Ep300 , Hgf , Hif1a , Jun , Kras , Pdgfb , Pgf , Pik3r1 , Slc2a1 , Tgfb1 , Tgfb3 , Vegfa , Vhl
Hypertension, PortalPik3r1 , Vegfa
Hypertension, PulmonaryEpas1 , Hif1a , Pdgfa , Pdgfb , Pgf , Tgfa , Tgfb1 , Vegfb
Hypertension, RenovascularPdgfa
HypertrophyMapk1 , Mapk3
Hypertrophy, Left VentricularPbrm1 , Rac1
Hypertrophy, Right VentricularAkt1 , Tgfa , Tgfb1
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
HypothyroidismSlc2a1
Hypoxia, BrainEp300
Hypoxia-Ischemia, BrainHif1a , Pdgfb , Vegfa
Idiopathic Basal Ganglia Calcification 1Pdgfb
Immunodeficiency 14Pik3cd
Immunodeficiency 36Pik3r1
InfarctionEpas1 , Hif1a
Infarction, Middle Cerebral ArteryHif1a , Slc2a1
Infertility, FemaleMapk1 , Mapk3
InflammationAkt1 , Pdgfb , Pgf , Tgfa , Tgfb1 , Vegfa
Inflammatory Bowel Disease 11Vegfa
Inflammatory Bowel DiseasesCul2 , Hgf , Pdgfb , Vegfa
Insulin ResistanceAkt2 , Pik3r1
InsulinomaTgfa , Tgfb1
Intellectual DisabilityEp300 , Kdm5c , Kras , Slc2a1
Intermittent ClaudicationEpas1
Intervertebral Disc DegenerationCrk , Tgfb1
Intervertebral Disc DiseaseHif1a
Intervertebral Disc DisplacementAkt1
Intestinal PolypsJun
Intracranial Arteriovenous MalformationsHgf , Vegfa
Invasive Pulmonary AspergillosisVegfa
Iron OverloadEpas1
IschemiaAkt2 , Raf1
Ischemic Attack, TransientEp300 , Hif1a
KeratoconusHgf
Keratosis, ActinicTgfb1
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1 , Tgfb1
Kidney Diseases, CysticVhl
Kidney Failure, ChronicPgf , Tgfb1
Kidney NeoplasmsAkt1 , Braf , Flcn , Jun , Kras , Mapk1 , Mapk3 , Met , Raf1 , Vhl
Kidney Reperfusion InjuryEgln1 , Egln3 , Ep300 , Hif1a , Pdgfb
Lead Poisoning, Nervous SystemEp300
Learning DisordersVegfa
LeiomyomaPdgfa , Pdgfb
LentigoHgf
LEOPARD SyndromeBraf , Ptpn11 , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaNras , Ptpn11 , Setd2
Leukemia, ExperimentalNras
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellBraf , Hras , Kras , Nras , Ptpn11
Leukemia, Megakaryoblastic, of Down SyndromeNras
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveBraf , Nras , Vegfa
Leukemia, MyeloidVegfa
Leukemia, Myeloid, AcuteCrebbp , Hgf , Hras , Kras , Met , Nras , Ptpn11
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileKras , Nras , Ptpn11
Leukemia, Promyelocytic, AcuteAkt1 , Nras
Leukemia-Lymphoma, Adult T-CellNras
LeukocytosisKras , Nras
Leydig Cell TumorPdgfa , Pdgfb
Limb Deformities, CongenitalTgfb2
Limb IschemiaHgf , Hif1a , Vegfa
Lipodystrophy, Familial PartialAkt2
Liver CirrhosisArnt , Hgf , Pdgfb , Pgf , Tgfb1 , Vegfa
Liver Cirrhosis, AlcoholicTgfb1
Liver Cirrhosis, BiliaryHif1a
Liver Cirrhosis, ExperimentalHgf , Met , Pdgfa , Pgf , Tgfb1 , Tgfb3 , Vegfa
Liver DiseasesRac1
Liver Diseases, AlcoholicHif1a
Liver Diseases, ParasiticKras
Liver FailureVegfa
Liver Failure, AcuteHgf , Met
Liver InjuryHgf , Pdgfb
Liver NeoplasmsAkt1 , Braf , Crebbp , Flcn , Hgf , Hras , Jun , Kras , Met , Nras , Pik3ca , Raf1 , Slc2a1 , Tgfa
Liver Neoplasms, ExperimentalHgf , Hras , Kras , Map2k1 , Met , Tgfa
Loeys-Dietz SyndromeTgfb2
Loeys-Dietz Syndrome 4Tgfb2 , Tgfb3
Loeys-Dietz Syndrome 5Tgfb3
Lung DiseasesHif1a , Pdgfa , Tgfb1 , Vegfa
Lung Diseases, InterstitialHgf , Tgfb1
Lung InjuryTgfa
Lung NeoplasmsAkt1 , Braf , Crkl , Hras , Jun , Kras , Mapk1 , Mapk3 , Met , Pik3ca , Raf1 , Tgfb1 , Vhl
Lupus Erythematosus, SystemicEts1 , Pgf
Luscan-Lumish SyndromeSetd2
LymphangiectasisRaf1
LymphangioleiomyomatosisVegfd
Lymphatic MetastasisPdgfa , Pdgfb , Vegfa , Vegfc , Vegfd
LymphedemaPgf
LYMPHEDEMA, HEREDITARY, IDVegfc
LymphomaKras , Nras
Lymphoma, B-CellNras
Lymphoma, FollicularCrebbp
Lymphoma, Large B-Cell, DiffusePik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellPik3cd
Lymphoma, Non-HodgkinBraf , Map2k1 , Nras , Pik3ca
Lymphoma, T-CellAkt1 , Ep300
Lymphoma, T-Cell, CutaneousBraf
Macrocephaly/Megalencephaly Syndrome, Autosomal RecessiveAkt3
Macular DegenerationVegfa
Macular EdemaVegfa
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalCdc42 , Hras , Pdgfa , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Cdc42 , Hif1a , Hras , Pak4 , Pdgfa , Pik3r1 , Tgfb1 , Vegfa
Mandibular NeoplasmsBraf
Marijuana AbuseAkt1
MedulloblastomaCrebbp , Ep300 , Nras , Pik3ca
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
MegalencephalyAkt3
Megalencephaly Cutis Marmorata Telangiectatica CongenitaAkt3 , Pik3ca , Pik3r2
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaAkt1 , Arnt , Braf , Crebbp , Ep300 , Flcn , Hras , Kras , Map2k1 , Map2k2 , Nras , Pik3ca , Pik3r1 , Rac1 , Raf1 , Sdhd , Vegfa , Vegfc
Melanoma, Cutaneous MalignantHif1a
Melanoma, Cutaneous Malignant, Susceptibility To, 1Akt1 , Braf , Flcn , Hras , Map2k1 , Map2k2 , Nras , Pik3ca , Rac1 , Raf1
Melanoma, ExperimentalHgf
Memory DisordersHif1a , Vegfa
Meningeal NeoplasmsAkt1
MeningiomaAkt1 , Hgf , Pdgfb
Meningioma, FamilialPdgfb
MeningomyeloceleSlc2a1
Mental Retardation, X-LinkedPak3
Mental Retardation, X-Linked 30Pak3
Mental Retardation, X-Linked NonsyndromicPak3
Mental Retardation, X-Linked, Syndromic, Jarid1c-RelatedKdm5c
Mercury Poisoning, Nervous SystemJun
Mesangial Proliferative GlomerulonephritisRapgef1
MesotheliomaPdgfa
Mesothelioma, MalignantHgf , Met , Raf1 , Setd2 , Slc2a1 , Tgfb2
Metabolic Syndrome XHgf , Tgfb1 , Vegfa
Metabolism, Inborn ErrorsSlc2a1
MetachondromatosisPtpn11
MicrocephalyEp300 , Slc2a1
MicrognathismEp300
Micronuclei, Chromosome-DefectiveHif1a
Microsatellite InstabilityBraf , Setd2
Microvascular Complications of Diabetes, Susceptibility To, 1Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 2Vegfa
Microvascular Complications of Diabetes, Susceptibility To, 7Vegfa
Mitochondrial Complex II DeficiencySdhd
Monoclonal B-Cell LymphocytosisRapgef1
Mood DisordersAkt1
Mouth NeoplasmsEts1 , Hras , Kras , Nras , Pik3ca
Mucocutaneous Lymph Node SyndromeVegfa
MucositisTgfa
Multicystic Dysplastic KidneyPdgfa
Multiple MyelomaBraf , Hras , Kras , Met , Nras , Pik3ca , Ptpn11 , Tgfb1 , Vegfa
Multiple Organ FailureMapk1
Multiple SclerosisVegfa
Muscle HypotoniaEp300
Muscle WeaknessSlc2a1
Muscular AtrophyAkt1
Muscular DiseasesTgfb1
Muscular Dystrophy, DuchenneTgfb1
Musculoskeletal AbnormalitiesEpas1 , Tgfb2
Mycosis FungoidesHif1a
Myelodysplastic SyndromesHras , Kras , Nras
Myeloproliferative DisordersKras , Nras
Myocardial InfarctionAkt1 , Egln1 , Egln3 , Epas1 , Hgf , Hif1a , Mapk1 , Pgf , Tgfb1 , Tgfb2 , Vegfa , Vegfb
Myocardial IschemiaCrk , Hgf , Hif1a , Pgf , Vegfa
Myocardial Reperfusion InjuryAkt1 , Akt2 , Egln1 , Hif1a , Mapk1 , Rap1a , Slc2a1 , Tgfb1 , Vegfa
Myopathy, Congenital, with Excess of Muscle SpindlesHras
MyopiaEp300 , Hgf
MyositisHgf
Nasal PolypsHgf , Jun , Met , Tgfb1 , Vegfa
Nasopharyngeal CarcinomaAkt2 , Kras , Pik3ca
Nasopharyngeal NeoplasmsHras , Nras , Pik3ca
NecrosisCdc42
Nematode InfectionsPik3r1
NeointimaPak1 , Pdgfb
Neoplasm InvasivenessHgf , Hif1a , Hras , Mapk1 , Mapk3 , Met , Tgfb1
Neoplasm MetastasisAkt2 , Braf , Hgf , Kras , Mapk1 , Mapk3 , Met , Pdgfb , Rac1 , Tgfb1 , Vegfa
Neoplasm Recurrence, LocalVegfa
NeoplasmsBraf , Hras , Kras , Map2k1 , Met , Nras , Pik3ca , Pik3r1 , Vegfa , Vhl
Neoplasms, Cystic, Mucinous, and SerousMet
Neoplasms, ExperimentalArnt , Hgf , Hras , Kras , Nras , Vegfa
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryFh , Flcn , Met , Pik3ca , Sdhb , Sdhd , Vhl
Neovascularization, PathologicVegfa
Nephritis, HereditaryHras
Nephrolithiasis, Calcium OxalateTgfb1
Nephrosis, Puromycin AminonucleosidePak2
Nephrotic SyndromeTgfb1
Nerve DegenerationMapk1 , Mapk3 , Tgfa , Vegfa
Nerve Sheath NeoplasmsHgf , Met
Nervous System DiseasesSlc2a1
NeuralgiaTgfb1
Neuritis, Autoimmune, ExperimentalEpas1 , Hif1a
NeuroblastomaHgf , Hras , Kras , Met , Nras , Pik3ca , Ptpn11
Neurocutaneous MelanosisNras
Neurodevelopmental DisordersPtpn11 , Setd2
Neuroendocrine TumorsBraf
Neurofibromatosis 1Vegfa
Neurofibromatosis 2Vegfa
NeurofibrosarcomaNras , Vegfa
Neuroma, AcousticVegfa
Neuropathy, PainfulEp300
NevusBraf
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Non-alcoholic Fatty Liver DiseaseTgfb1
Nonproliferative Diabetic RetinopathyPdgfb
Nonseminomatous Germ Cell TumorBraf
Nonsyndromic DeafnessMet
Noonan like syndromePtpn11 , Sos1
Noonan SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Hgf , Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
NOONAN SYNDROME 9Sos2
Nose NeoplasmsHgf
ObesityAkt1 , Akt2 , Ep300 , Hgf , Pgf , Pik3r1 , Slc2a1 , Tgfb1
Obesity, MorbidHif1a
Obsessive-Compulsive DisorderHras
Occupational DiseasesTgfb1
OligohydramniosPdgfa , Pdgfb
Oncocytoma, RenalFlcn
Optic Nerve InjuriesEp300 , Hgf , Jun , Pdgfb
Oral Squamous Cell CarcinomaMet
Oral Submucous FibrosisTgfb1
OsteoarthritisEpas1 , Hif1a , Slc2a1
Osteoarthritis, KneeEpas1 , Tgfa
OsteochondrodysplasiasTgfb1 , Tgfb2 , Vegfa
OsteochondromaPtpn11
Osteofibrous DysplasiaMet
OsteopetrosisJun
OsteoporosisTgfb1
Osteoporosis, PostmenopausalHif1a , Tgfb1
OsteosarcomaAkt1 , Jun , Met , Vegfa
Otitis MediaVegfa
Otitis Media with EffusionVegfa
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Crkl , Hif1a , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Pak1 , Pik3ca , Pik3r1 , Slc2a1 , Vegfa , Vegfc , Vegfd
Oxygen-Induced RetinopathyHif1a , Vegfa
PainAkt1 , Hgf
Pancreatic AdenocarcinomaHras , Kras , Map2k2 , Pik3ca
Pancreatic CarcinomaKras
Pancreatic CystVhl
Pancreatic NeoplasmsAkt2 , Hgf , Hif1a , Kras , Met , Pbrm1 , Tgfa , Tgfb1 , Vegfb , Vhl
PancreatitisHgf , Met , Pdgfa , Pdgfb
Pancreatitis, Experimental, Acute Kras
PancytopeniaEpas1
Papillary Renal Cell Carcinoma, SporadicBraf , Hras , Pik3ca
PapillomaHras , Tgfb1
Papilloma, InvertedVegfa
ParagangliomaSdhb , Sdhd
Paraganglioma, Extra-AdrenalSdhd
Paragangliomas 3Sdhb
Paragangliomas 4Sdhb
Paragangliomas with Sensorineural Hearing LossSdhd
ParaplegiaAkt1 , Kdm5c
Paraquat LungTgfb1
Parkinson DiseaseAkt1 , Hgf
Parkinsonian DisordersVhl
Pemphigoid, BullousVegfa
Penile IndurationTgfb1
Penile NeoplasmsHras , Kras , Pik3ca
Periapical DiseasesPdgfb
Periodontal AtrophyVegfa
PeriodontitisMet
Peripheral Nervous System DiseasesJun
Peritoneal FibrosisTgfb1
Peritoneal NeoplasmsSlc2a1
PheochromocytomaSdhb , Sdhd , Vhl
Phobic DisordersHras
Phyllodes TumorHif1a , Setd2
Pleomorphic Xanthoastrocytoma Braf , Hgf , Met
Pleural DiseasesTgfb1
PneumoniaTgfb1
Pneumonia, BacterialPgf
Pneumonia, PneumococcalMapk1 , Mapk3
PneumothoraxFlcn
Pneumothorax, Primary SpontaneousFlcn
Polyarteritis NodosaVegfa
Polycystic Kidney DiseasesEpas1 , Hif1a
Polycystic Kidney, Autosomal RecessiveAkt1 , Pik3ca
Polycystic Ovary SyndromeGab1 , Vegfa
PolycythemiaEgln1 , Epas1 , Vhl
PolymicrogyriaAkt3
PolymyositisHgf
Polyomavirus InfectionsHgf
Polypoidal Choroidal VasculopathyVegfa
Pre-EclampsiaEpas1 , Pgf , Vegfa
Precancerous ConditionsAkt1 , Hras , Vegfa
Precursor Cell Lymphoblastic Leukemia-LymphomaArnt , Crebbp , Kras , Nras , Uty
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras , Ptpn11
Pregnancy in DiabeticsVegfa
Premature BirthPgf
Pressure UlcerHif1a , Vegfa
Primary MyelofibrosisTgfb1
Proliferative Diabetic RetinopathyPdgfb
Prostatic Intraepithelial NeoplasiaKras
Prostatic NeoplasmsAkt1 , Braf , Crebbp , Crkl , Ep300 , Hif1a , Jun , Kras , Map2k1 , Mapk3 , Met , Nras , Pak4 , Pak6 , Pdgfa , Pik3ca , Pik3cd , Pik3r1 , Tgfa , Tgfb1 , Uty , Vegfa
ProteinuriaPak1 , Pak2 , Tgfb1 , Vegfa
Proteus SyndromeAkt1
Pseudoxanthoma ElasticumVegfa
PsoriasisEpas1 , Hif1a , Tgfa , Tgfb1 , Vegfa
Psychoses, Substance-InducedAkt1
PterygiumVegfa , Vegfc
Pulmonary Disease, Chronic ObstructiveTgfb1 , Vegfa
Pulmonary EdemaTgfa , Vegfa
Pulmonary EmphysemaPgf , Tgfb1
Pulmonary EosinophiliaEpas1
Pulmonary FibrosisHgf , Pdgfa , Pdgfb , Tgfa , Tgfb1
Pulmonary Hypertension, Hypoxia-Induced Egln1 , Egln3
Pulmonary Valve StenosisHras
Purpura, Thrombocytopenic, IdiopathicTgfb1
PyelonephritisPgf
Radiation InjuriesHif1a
Radiation Injuries, ExperimentalHif1a , Mapk1 , Mapk3
Radiation PneumonitisTgfb1
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Ptpn11 , Raf1 , Sos1
Rectal NeoplasmsNras , Pik3ca
RecurrenceHras , Kras , Vegfc
Reed's SyndromeFh
Reflex, AbnormalKdm5c
Renal FibrosisEpas1 , Kras , Mapk1
Renal InsufficiencyHif1a
Reperfusion InjuryAkt1 , Cdc42 , Ep300 , Ets1 , Hgf , Hif1a , Jun , Met , Pik3r1 , Slc2a1 , Vegfc , Vegfd
Respiratory System AbnormalitiesTgfb2 , Tgfb3
Retina Reperfusion InjuryHgf , Vegfa
Retinal DegenerationHgf , Pak3 , Pak4
Retinal DiseasesEpas1 , Pdgfb , Vegfa
Retinal NeovascularizationHgf , Hif1a , Vegfa , Vegfb
Retinal TelangiectasisVegfa
Retinal Vein OcclusionVegfa , Vegfb
Retinitis PigmentosaHgf , Vegfa
Retinopathy of PrematurityHgf , Vegfa
RhabdomyosarcomaVegfa
Rheumatoid Arthritis, Systemic JuvenileHgf
RhinitisCdc42 , Tgfb1 , Vegfa
Rhinitis, Allergic, SeasonalVegfa
RhinosinusitisHgf
Rubinstein-Taybi SyndromeCrebbp , Ep300
SarcoidosisTgfb1
Sarcoidosis, PulmonaryTgfb1
SarcomaMet , Pik3ca
Sarcoma, ExperimentalKras , Nras
Sarcoma, KaposiHgf
Sarcoma, MyeloidKras
SchizophreniaAkt1 , Crkl , Hgf , Kdm5c , Mapk3 , Met , Pak1 , Pak2 , Pik3cb
Sciatic NeuropathyHgf
Scleroderma, LimitedPgf
Scleroderma, LocalizedHgf , Tgfb1
Scleroderma, SystemicHgf , Vegfa
ScoliosisCrebbp
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresHgf , Pdgfb , Slc2a1
SeminomaHras , Kras , Vegfa
Senior Loken SyndromeAkt3
SepsisEp300 , Mapk1 , Mapk3 , Pgf , Tgfb1
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Crebbp , Mapk1
Shock, HemorrhagicMapk1
SHORT SyndromePik3r1
SinusitisMet , Pdgfb
Sjogren's SyndromeTgfb1
Skin NeoplasmsAkt1 , Crkl , Hgf , Hif1a , Hras , Tgfb1 , Vegfa
Skin UlcerPdgfa
Small Cell Lung CarcinomaAkt1 , Crebbp , Ep300 , Pik3ca
Small-For-Size SyndromeVegfa
Smith-Magenis SyndromeGrb2
Spinal Cord InjuriesAkt1 , Cdc42 , Hgf , Hif1a , Jun , Met , Pdgfb , Tgfb1 , Tgfb2 , Vegfa , Vhl
Splenic NeoplasmsHras
SplenomegalyKras , Nras
Spondylitis, AnkylosingPgf
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the LungAkt1 , Braf , Crebbp , Ep300 , Hras , Kras , Pik3ca , Ptpn11
Squamous Cell Carcinoma of the TongueHgf , Met
Status EpilepticusJun , Pgf , Vegfa
Stevens-Johnson SyndromeEp300 , Rbx1
Still's Disease, Adult-OnsetHgf , Vegfa
Stomach NeoplasmsHras , Jun , Kras , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Tgfa
Stomach UlcerVegfa
StrokeAkt1 , Hgf , Pak1 , Pgf , Tgfa , Tgfb1 , Vegfa
Subarachnoid HemorrhageHif1a
Substance Withdrawal SyndromeMapk1 , Mapk3
Sudden Infant DeathVegfa
Tachycardia, VentricularRaf1
Takenouchi-Kosaki SyndromeCdc42
Telangiectasia, Hereditary Hemorrhagic, Type 1Tgfb1
Temporomandibular Joint DisordersHif1a
Testicular Germ Cell TumorHras
Testis Reperfusion InjuryHif1a
Tetralogy of FallotPtpn11
Thrombocythemia, EssentialPdgfa , Pdgfb , Tgfb1
ThrombocytopeniaTgfb1
ThrombosisHgf , Pik3cb
Thrombotic MicroangiopathiesVegfa
Thumb DeformityCrebbp
ThymomaHras , Pbrm1
Thyroid Cancer, FollicularBraf , Hras , Nras
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid NeoplasmsBraf , Hif1a , Hras , Kras , Pdgfa
Tibial FracturesPdgfb , Pgf
Tobacco Addiction, Susceptibility ToEgln2
Tongue NeoplasmsHras , Vegfa , Vegfc
Tracheal StenosisTgfb1
Trichilemmoma Hras
Trigeminal NeuralgiaMapk1 , Mapk3
Tuberculosis, PulmonaryJun
Tumor Predisposition SyndromeFh , Flcn , Met , Sdhb , Sdhd , Vhl
Tympanic Membrane PerforationVegfa
UlcerHif1a
UremiaTgfb1
Ureteral ObstructionAkt1 , Pak2 , Pdgfb , Tgfb1 , Tgfb2
Urethral ObstructionMapk1 , Tgfb1
Urinary Bladder Neck ObstructionHif1a
Urinary Bladder NeoplasmsAkt1 , Crebbp , Ep300 , Hras , Kras , Vegfc , Vegfd , Vhl
Urinary IncontinenceMapk1
Urogenital AbnormalitiesTgfb2
Urologic NeoplasmsHif1a , Vegfa
UrticariaTgfb1
Uterine Cervical NeoplasmsAkt1 , Crebbp , Ep300 , Hras , Kras , Mapk1 , Nras , Pik3ca , Vegfa
Uterine NeoplasmsBraf , Hras , Kras , Map2k1 , Nras , Pik3ca , Pik3r1 , Rac1 , Sos1
Uveal MelanomaVegfa
UveitisTgfb1
VaricoceleHif1a
Vascular DiseasesHgf
Ventilator-Induced Lung InjuryAkt1
Ventricular Premature ComplexesTgfb3
Ventricular RemodelingTgfb1
VitiligoHgf , Tgfb1
Vitreoretinopathy, ProliferativeHgf
von Hippel-Lindau DiseaseEpas1 , Vhl
Wallerian DegenerationPgf , Tgfb1 , Tgfb2
Weight GainPik3ca
Werner SyndromeHif1a
Wet Macular DegenerationPdgfb , Vegfa
Wilms TumorHif1a , Pak1 , Slc2a1 , Vegfc , Vhl
Wounds and InjuriesHgf , Pdgfa , Pdgfb , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa
Wounds, PenetratingHgf , Pgf
Pathway Annotations Associated with Genes in the renal cell cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
adenosine signaling pathwayAkt1 , Braf , Cdc42 , Hras , Jun , Map2k2 , Mapk1 , Pak1 , Pik3ca , Rap1a
aldosterone signaling pathwayCrebbp , Kras , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered citric acid cycle pathwayFh , Sdhb , Sdhd
altered epidermal growth factor/neuregulin signaling pathwayTgfa
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered hypoxia inducible factor pathwayVhl
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered p53 signaling pathwayEts1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca
altered scatter factor/hepatocyte growth factor signaling pathwayMet
altered SWI/SNF family mediated chromatin remodeling pathwayPbrm1
altered transforming growth factor-beta Smad dependent signaling pathwayTgfb1
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expressionVegfa
altered vascular endothelial growth factor signaling pathway involving the main playersVegfa
Alzheimer disease pathwayMapk1 , Mapk3 , Sdhb , Sdhd
amyotrophic lateral sclerosis disease pathwayRac1
androgen signaling pathwayCrebbp , Ep300
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Arf family mediated signaling pathwayRac1
aryl hydrocarbon receptor signaling pathwayArnt , Arnt2
azathioprine pharmacodynamics pathwayRac1
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Sos1 , Sos2
bevacizumab pharmacodynamics pathwayVegfa
bile acid transport pathwaySlc2a1
bladder cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Bone morphogenetic proteins signaling pathwayMapk1
brain-derived neurotrophic factor signaling pathwayGrb2
c-Jun N-terminal kinases MAPK signaling pathwayCdc42 , Rac1 , Rapgef1
cell cycle pathway, mitoticCrebbp , Ep300 , Rbx1 , Tgfb1 , Tgfb2 , Tgfb3
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pdgfa , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Rap1a , Rap1b , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfb1 , Tgfb2 , Tgfb3
citric acid cycle pathwayFh , Sdhb , Sdhd
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Jun , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
cortisol signaling pathwayCrebbp , Ep300
cytokine mediated signaling pathwayHgf , Met , Pdgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfc , Vegfd
dilated cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
E-cadherin signaling pathwayAkt1 , Akt2 , Cdc42 , Crk , Hgf , Pik3ca , Pik3r1 , Rac1 , Rap1a , Rap1b
eicosanoid signaling pathwayAkt1 , Pik3r5 , Rac1
electron transport chain pathwaySdhb , Sdhd
endocytosis pathwayCdc42 , Hras , Met , Tgfb1 , Tgfb2 , Tgfb3
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Endoplasmic Reticulum-associated degradation pathwayRbx1
endothelin signaling pathwayAkt1 , Cdc42 , Crk , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Rac1 , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
ephrin - ephrin receptor bidirectional signaling axisCdc42 , Crk , Crkl , Grb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pak1 , Pik3ca , Pik3r1 , Pik3r5 , Rac1 , Rap1a , Rap1b
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Sos1 , Sos2 , Tgfa
erythropoietin signaling pathwayCrkl , Gab1 , Grb2 , Hras , Pik3r1 , Ptpn11 , Rap1a , Sos1
estrogen signaling pathwayCrebbp , Ep300
facilitative sugar transporter mediated glucose transport pathwaySlc2a1
FasL mediated signaling pathwayAkt1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Crk , Crkl , Map2k1 , Mapk1 , Mapk3 , Pak1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Gab1 , Grb2 , Hgf , Jun , Mapk1 , Mapk3 , Pak4 , Pik3ca , Pik3r1 , Ptpn11 , Sos1
forkhead class A signaling pathwayAkt1 , Crebbp , Ep300 , Jun
fumaric aciduria disease pathwayFh , Sdhb , Sdhd
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
Glut1 deficiency syndrome pathwaySlc2a1
glutamate signaling pathwayMapk1 , Mapk3
glypican signaling pathwayTgfb1 , Tgfb2 , Tgfb3 , Vegfa
gonadotropin-releasing hormone signaling pathwayCdc42 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Crebbp , Map2k1 , Pik3ca , Pik3r1 , Tgfb2
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
histone modification pathwayCrebbp , Ep300 , Kdm5c , Pbrm1 , Setd2 , Uty
Huntington disease pathwayCrebbp , Ep300 , Sdhb , Sdhd
hypertrophic cardiomyopathy pathwayTgfb1 , Tgfb2 , Tgfb3
hypoxia inducible factor pathwayAkt1 , Arnt , Arnt2 , Crebbp , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Hif1a , Jun , Rbx1 , Slc2a1 , Vegfa , Vhl
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Crk , Pak1 , Rac1 , Rapgef1
insulin secretion pathwayCdc42
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Crk , Crkl , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Raf1 , Rapgef1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Crk , Crkl , Grb2 , Hras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
interleukin-1 signaling pathwayJun , Pik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Ptpn11 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-27 signaling pathwayTgfb1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-4 signaling pathwayAkt1 , Ets1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1 , Ptpn11
interleukin-6 signaling pathwayAkt1 , Gab1 , Grb2 , Jun , Pik3ca , Pik3r1 , Ptpn11 , Rac1 , Sos1 , Sos2
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Grb2 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Sos1 , Sos2
lactose biosynthetic pathwaySlc2a1
Leishmania infection pathwayJun , Mapk1 , Mapk3 , Tgfb1 , Tgfb2 , Tgfb3
leptin system pathwayPtpn11
long term depressionBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Crebbp , Ep300 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Rap1a , Rap1b
lysine degradation pathwaySetd2
measles infection pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
melanoma pathwayAkt1 , Akt2 , Akt3 , Braf , Hgf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
mercaptopurine pharmacodynamics pathwayRac1
mercaptopurine pharmacokinetics pathwayRac1
mitochondrial complex II deficiency pathwayFh , Sdhb , Sdhd
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pdgfa , Pdgfb , Rac1 , Raf1 , Rap1a , Rap1b , Sos1 , Sos2 , Tgfb1 , Tgfb2 , Tgfb3
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Flcn , Hif1a , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Crebbp , Ep300 , Mapk1 , Mapk3 , Raf1 , Tgfb1 , Tgfb2 , Tgfb3
myocarditis pathwayRac1
N-cadherin signaling pathwayCdc42 , Pik3ca , Pik3r1 , Ptpn11 , Rac1
neddylation pathwayCul2 , Rbx1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Rapgef1 , Sos1 , Sos2
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
Notch signaling pathwayCrebbp , Ep300
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1 , Rbx1
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp , Rbx1
nucleotide excision repair pathwayRbx1
oxidative phosphorylation pathwaySdhb , Sdhd
p38 MAPK signaling pathwayCdc42 , Rac1
p53 signaling pathwayAkt1 , Crebbp , Ep300
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Kras , Map2k1 , Mapk1 , Mapk3 , Met , Pbrm1 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Raf1 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb , Vegfc , Vegfd
Parkinson disease pathwaySdhb , Sdhd
phagocytosis pathwayRac1
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1 , Rap1a
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Raf1
phosphoinositide metabolic pathwayPik3ca , Pik3cd , Pik3r1
Plasmodium infection pathwayHgf , Met , Tgfb1 , Tgfb2 , Tgfb3
platelet-derived growth factor signaling pathwayBraf , Crk , Crkl , Gab1 , Grb2 , Hras , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Sos1
prion diseases pathwayMap2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Crebbp , Ep300 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdgfa , Pdgfb , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tgfa
proteasome degradation pathway involving cullin-dependent ubiquitin ligasesCul2 , Rbx1 , Vhl
pyruvate dehydrogenase E2 deficiency pathwayFh , Sdhb , Sdhd
pyruvate dehydrogenase E3 deficiency pathwayFh , Sdhb , Sdhd
Ras family mediated signaling pathwaySos1
Reelin signaling pathwayAkt1 , Crkl , Pik3ca , Pik3r1 , Rap1a
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Arnt , Arnt2 , Braf , Cdc42 , Crebbp , Crk , Crkl , Cul2 , Egln1 , Egln2 , Egln3 , Elob , Eloc , Ep300 , Epas1 , Ets1 , Fh , Flcn , Gab1 , Grb2 , Hgf , Hif1a , Hras , Jun , Kdm5c , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Met , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pbrm1 , Pdgfa , Pdgfb , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Rap1a , Rap1b , Rapgef1 , Rbx1 , Sdhb , Sdhd , Setd2 , Slc2a1 , Sos1 , Sos2 , Tgfa , Tgfb1 , Tgfb2 , Tgfb3 , Uty , Vegfa , Vegfb , Vegfc , Vegfd , Vhl
rheumatoid arthritis disease pathwayJun , Pgf , Tgfb1 , Tgfb2 , Tgfb3 , Vegfa , Vegfb
Rho/Rac/Cdc42 mediated signaling pathwayCdc42 , Crk , Jun , Pak1 , Rac1 , Rapgef1
RNA polymerase I transcription pathwayCrebbp
scatter factor/hepatocyte growth factor signaling pathwayCrkl , Gab1 , Grb2 , Hgf , Met , Pik3r1 , Ptpn11
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
somatostatin signaling pathwayPtpn11
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Cdc42 , Jun , Mapk1 , Mapk3 , Pak1 , Pdgfb , Rac1 , Vegfa
SWI/SNF family mediated chromatin remodeling pathwayPbrm1
syndecan signaling pathwayHgf , Hras , Mapk1 , Mapk3 , Rac1 , Tgfb1
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Cdc42 , Grb2 , Hras , Jun , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak1 , Pak2 , Pak3 , Pak4 , Pak6 , Pak7 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras
tioguanine pharmacodynamics pathwayRac1
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Jun , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Rac1
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayCrebbp , Grb2 , Sos1 , Tgfb1 , Tgfb2 , Tgfb3
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp , Ep300 , Mapk1 , Mapk3 , Rbx1 , Tgfb1 , Tgfb2 , Tgfb3
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Jun , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tgfb1 , Tgfb2 , Tgfb3
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Crebbp , Crkl , Ep300 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1 , Ptpn11 , Rap1a , Rap1b
ubiquitin/proteasome degradation pathwayCul2 , Elob , Eloc , Rbx1 , Vhl
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Cdc42 , Egln1 , Egln2 , Egln3 , Gab1 , Grb2 , Hif1a , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pak2 , Pgf , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Ptpn11 , Rac1 , Raf1 , Vegfa , Vegfb , Vegfc , Vegfd
Wnt signaling pathwayCrebbp , Ep300 , Jun , Rac1 , Rbx1
Wnt signaling, canonical pathwayCrebbp
Wnt signaling, non-canonical pathwayCdc42 , Rac1
Wnt signaling, the planar cell polarity pathwayRac1
Phenotype Annotations Associated with Genes in the renal cell cancer pathway

References Associated with the renal cell cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: