ENDOMETRIAL CANCER PATHWAY (PW:0000611)

View Ontology Report

Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer-related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
RGD:13432140
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:6907045
RGD:13432145
G Apc2 APC2, WNT signaling pathway regulator JBrowse link 7 12,258,468 12,280,459 RGD:6907045
G Axin1 axin 1 RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6907045
RGD:13432159
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
RGD:13432162
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
RGD:13432196
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6907045
G Ctnna2 catenin alpha 2 JBrowse link 4 107,880,611 109,042,724 RGD:6907045
G Ctnna3 catenin alpha 3 JBrowse link 20 25,063,124 26,640,428 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:4143515
RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:4143515
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:4143515
RGD:6907045
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:4143515
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:4143515
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:4143515
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the endometrial cancer pathway
Disease TermsGene Symbols
Colitis, UlcerativeTp53
Pathway Annotations Associated with Genes in the endometrial cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk
altered mismatch repair pathwayMlh1
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
bladder cancer pathwayBraf , Ccnd1 , Cdh1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cytokine mediated signaling pathwayEgf , Egfr
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk , Pdpk1
endocytosis pathwayEgf , Egfr , Hras
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Egf , Egfr , Elk1 , Erbb2 , Foxo3 , Grb2 , Gsk3b , Hras , Ilk , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Cdh1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
gonadotropin-releasing hormone signaling pathwayEgfr , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
Huntington disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1 , Elk1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
integrin mediated signaling pathwayIlk
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayElk1 , Mapk1 , Mapk3
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdh1 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tp53
mismatch repair pathwayMlh1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Sos1 , Sos2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayAxin1 , Ctnna1 , Ctnnb1 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b , Pten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Elk1 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
protein kinase C (PKC) signaling pathwayPdpk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Mapk1 , Mapk3
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Tcf3 , Tcf7 , Tcf7l2 , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnna1 , Ctnnb1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Lef1 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Phenotype Annotations Associated with Genes in the endometrial cancer pathway

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: