ENDOMETRIAL CANCER PATHWAY (PW:0000611)

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Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name GBrowse Evidence Chr Start Stop Reference Source
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link IEA 6 137,640,482 137,657,552 RGD:6907045 KEGG
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link IEA 1 82,686,233 82,726,544 RGD:6907045 KEGG
G Akt3 v-akt murine thymoma viral oncogene homolog 3 GBrowse link IEA 13 92,802,390 93,110,704 RGD:6907045 KEGG
G Apc adenomatous polyposis coli GBrowse link IEA 18 26,732,147 26,790,383 RGD:6907045 KEGG
G Apc2 adenomatosis polyposis coli 2 GBrowse link IEA 7 10,903,675 10,920,010 RGD:6907045 KEGG
G Axin1 axin 1 GBrowse link IEA 10 15,409,373 15,462,726 RGD:6907045 KEGG
G Axin2 axin 2 GBrowse link IEA 10 98,294,466 98,321,830 RGD:6907045 KEGG
G Bad BCL2-associated agonist of cell death GBrowse link IEA 1 209,617,373 209,626,292 RGD:6907045 KEGG
G Braf v-raf murine sarcoma viral oncogene homolog B GBrowse link IEA 4 67,117,759 67,243,058 RGD:6907045 KEGG
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link IEA 5 160,704,234 160,721,796 RGD:6907045 KEGG
G Ccnd1 cyclin D1 GBrowse link IEA 1 205,357,235 205,366,757 RGD:6907045 KEGG
G Cdh1 cadherin 1 GBrowse link IEA 19 36,442,693 36,512,091 RGD:6907045 KEGG
G Ctnna1 catenin (cadherin-associated protein), alpha 1, 102kDa GBrowse link IEA 18 27,629,915 27,769,360 RGD:6907045 KEGG
G Ctnna2 catenin (cadherin associated protein), alpha 2 GBrowse link IEA 4 110,747,551 111,922,482 RGD:6907045 KEGG
G Ctnna3 catenin (cadherin associated protein), alpha 3 GBrowse link IEA 20 25,842,315 26,947,108 RGD:6907045 KEGG
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link ISS 8 125,978,161 125,987,670 RGD:4143515 RGD
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link IEA 8 125,978,161 125,987,670 RGD:6907045 KEGG
G Egf epidermal growth factor GBrowse link IEA 2 227,103,900 227,195,062 RGD:6907045 KEGG
G Egfr epidermal growth factor receptor GBrowse link IEA 14 97,617,358 97,788,211 RGD:6907045 KEGG
G Elk1 ELK1, member of ETS oncogene family GBrowse link IEA X 12,597,863 12,604,248 RGD:6907045 KEGG
G Erbb2 v-erb-b2 avian erythroblastic leukemia viral oncogene 2 GBrowse link ISS 10 87,219,157 87,242,919 RGD:4143515 RGD
G Erbb2 v-erb-b2 avian erythroblastic leukemia viral oncogene 2 GBrowse link IEA 10 87,219,157 87,242,919 RGD:6907045 KEGG
G Foxo3 forkhead box O3 GBrowse link IEA 20 46,171,784 46,262,818 RGD:6907045 KEGG
G Grb2 growth factor receptor bound protein 2 GBrowse link IEA 10 105,722,014 105,818,649 RGD:6907045 KEGG
G Gsk3b glycogen synthase kinase 3 beta GBrowse link IEA 11 64,284,731 64,428,698 RGD:6907045 KEGG
G Hras Harvey rat sarcoma virus oncogene GBrowse link IEA 1 201,385,705 201,388,987 RGD:6907045 KEGG
G Ilk integrin-linked kinase GBrowse link IEA 1 163,481,299 163,487,550 RGD:6907045 KEGG
G Kras Kirsten rat sarcoma viral oncogene GBrowse link ISS 4 182,869,242 182,895,106 RGD:4143515 RGD
G Kras Kirsten rat sarcoma viral oncogene GBrowse link IEA 4 182,869,242 182,895,106 RGD:6907045 KEGG
G Lef1 lymphoid enhancer binding factor 1 GBrowse link IEA 2 228,550,263 228,673,131 RGD:6907045 KEGG
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link IEA 8 68,379,074 68,451,554 RGD:6907045 KEGG
G Map2k2 mitogen activated protein kinase kinase 2 GBrowse link IEA 7 10,074,654 10,094,003 RGD:6907045 KEGG
G Mapk1 mitogen activated protein kinase 1 GBrowse link IEA 11 85,968,732 86,030,387 RGD:6907045 KEGG
G Mapk3 mitogen activated protein kinase 3 GBrowse link IEA 1 185,935,044 185,941,245 RGD:6907045 KEGG
G Mlh1 mutL homolog 1 GBrowse link ISS 8 115,616,396 115,653,471 RGD:4143515 RGD
G Mlh1 mutL homolog 1 GBrowse link IEA 8 115,616,396 115,653,471 RGD:6907045 KEGG
G Myc myelocytomatosis oncogene GBrowse link IEA 7 98,953,142 98,958,060 RGD:6907045 KEGG
G Nras neuroblastoma ras oncogene GBrowse link IEA 2 198,292,650 198,300,286 RGD:6907045 KEGG
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link IEA 10 13,329,708 13,394,080 RGD:6907045 KEGG
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link ISS 2 118,640,277 118,672,440 RGD:4143515 RGD
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link IEA 2 118,640,277 118,672,440 RGD:6907045 KEGG
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link IEA 8 103,886,682 103,957,112 RGD:6907045 KEGG
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link IEA 5 166,735,274 166,761,189 RGD:6907045 KEGG
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link IEA 2 32,602,673 32,675,350 RGD:6907045 KEGG
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link IEA 16 19,171,101 19,179,650 RGD:6907045 KEGG
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link IEA 5 136,497,494 136,566,473 RGD:6907045 KEGG
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link IEA 10 55,227,872 55,248,301 RGD:6907045 KEGG
G Pten phosphatase and tensin homolog GBrowse link ISS 1 236,771,027 236,837,261 RGD:4143515 RGD
G Pten phosphatase and tensin homolog GBrowse link IEA 1 236,771,027 236,837,261 RGD:6907045 KEGG
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link IEA 4 151,752,583 151,775,609 RGD:6907045 KEGG
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link IEA 6 3,308,778 3,390,661 RGD:6907045 KEGG
G Sos2 son of sevenless homolog 2 (Drosophila) GBrowse link IEA 6 91,609,463 91,722,481 RGD:6907045 KEGG
G Tcf3 transcription factor 3 GBrowse link IEA 7 10,791,311 10,813,613 RGD:6907045 KEGG
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) GBrowse link IEA 10 37,686,862 37,716,831 RGD:6907045 KEGG
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link IEA 1 262,031,823 262,226,710 RGD:6907045 KEGG
G Tp53 tumor protein p53 GBrowse link ISS 10 56,399,721 56,411,150 RGD:4143515 RGD
G Tp53 tumor protein p53 GBrowse link IEA 10 56,399,721 56,411,150 RGD:6907045 KEGG

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the endometrial cancer pathway
Disease TermsGene Symbols
Amyotrophic Lateral SclerosisAkt1 , Casp9
Muir-Torre SyndromeMlh1
Noonan SyndromeKras
Pancreatic NeoplasmsAkt2 , Apc , Egf , Egfr , Kras , Myc , Tp53 , Pten
Wallerian DegenerationErbb2
Diabetes MellitusPten , Tcf7l2
CataractTp53
OsteoporosisMyc
OsteosarcomaTp53
Abnormalities, MultipleKras
Craniofacial AbnormalitiesPten
IschemiaAkt2 , Raf1 , Tp53
CalcinosisErbb2
Intellectual DisabilityKras
Fibromatosis, GingivalSos1
Cleft LipCdh1
InflammationAkt1 , Egfr
Fetal Growth RetardationElk1
Skin NeoplasmsTp53
AtaxiaPten
AstrocytomaAkt1 , Kras
Carcinoma, Renal CellAkt1 , Apc , Egfr , Erbb2 , Kras , Myc , Tp53 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Map2k1 , Bad , Mlh1 , Ctnna1
GlaucomaBad
ObesityAkt2 , Egfr , Myc , Pik3r1 , Bad
SeizuresPten , Ccnd1 , Bad
Uterine NeoplasmsCtnnb1
HepatomegalyPten
Diabetes Mellitus, Type 2Akt1 , Akt2 , Pik3r1 , Casp9 , Tcf7l2
Kidney DiseasesMapk1
Intervertebral Disc DisplacementAkt1
CholangiocarcinomaApc
Cardiovascular AbnormalitiesMap2k1
Granulosa Cell TumorCtnnb1
CardiomegalyAkt1 , Egfr , Myc , Pten , Mapk1
Carcinoma, squamous cell of head and neckPten
Head and Neck NeoplasmsEgfr , Pten
Cardiofaciocutaneous syndromeKras , Map2k1 , Braf , Map2k2
HypoglycemiaAkt2 , Pik3r1
Hirschsprung DiseaseErbb2
Demyelinating DiseasesMyc
Stomach NeoplasmsApc , Erbb2 , Kras , Tp53 , Cdh1 , Pik3ca
Intestinal NeoplasmsApc
TeratomaCtnnb1
Nose NeoplasmsTp53
Cardiomyopathy, DilatedEgfr , Erbb2 , Kras
HyperplasiaApc , Egfr
PterygiumTp53
Hypertension, PulmonaryEgfr , Myc
Urethral ObstructionMapk1
Hamartoma Syndrome, MultiplePten
Lung NeoplasmsEgfr , Erbb2 , Kras , Tp53 , Cdh1 , Ctnnb1 , Braf , Pik3ca , Ctnna1
Gallbladder NeoplasmsApc , Egf
Carcinoma in SituAkt1 , Pten , Ctnnb1
Carcinoma, Basal CellTp53
Fatty LiverPten
PneumoniaEgf
Desmoid disease, hereditaryApc
Adenomatous Polyposis ColiApc
Colorectal Neoplasms, Hereditary NonpolyposisMlh1
Polycystic Kidney DiseasesMyc
PapillomaEgfr
Xeroderma PigmentosumTp53
Ovarian NeoplasmsAkt1 , Akt2 , Egfr , Erbb2 , Kras , Pik3r1 , Tp53 , Map2k2 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Map2k1 , Braf , Lef1 , Pik3ca , Ctnna1
Optic Atrophy, Hereditary, LeberTp53
Polycystic Kidney, Autosomal DominantMyc
MelanomaTp53 , Pten , Braf
Esophageal NeoplasmsEgfr , Myc , Tp53 , Ctnna1
Acute Kidney InjuryEgf , Myc
Gastrointestinal NeoplasmsPten , Pik3ca
Breast NeoplasmsAkt1 , Akt2 , Egfr , Erbb2 , Kras , Myc , Pik3r1 , Tp53 , Casp9 , Map2k2 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Map2k1 , Mapk1 , Bad , Pik3ca , Mlh1 , Ctnna1
Lung DiseasesEgfr
Colitis, UlcerativeTp53
Polycystic Kidney, Autosomal RecessiveMyc
Polycystic kidney disease, type 1Myc
Hypersensitivity, ImmediateEgfr
Wilms TumorErbb2 , Myc , Ctnnb1
HyperparathyroidismMyc
Kidney Failure, ChronicKras
Uterine Cervical NeoplasmsEgfr , Erbb2 , Hras , Kras , Nras , Tp53 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Mlh1 , Ctnna1
AdenocarcinomaApc
Urinary Bladder NeoplasmsAkt1 , Egfr , Erbb2 , Hras , Kras , Myc , Tp53 , Casp9 , Pten , Cdh1 , Ctnnb1 , Mlh1 , Ctnna1
Carcinoma, Squamous CellTp53 , Pten , Ccnd1
VACTERL hydrocephalyPten
Alzheimer DiseaseAkt1 , Apc , Pik3r1 , Tp53 , Gsk3b , Elk1
Carcinoma, Adenoid CysticTp53
Huntington DiseaseElk1
Diabetes Mellitus, Type 1Casp9 , Egfr
AdenomaApc
Lymphoma, T-CellTp53
Thyroid NeoplasmsTp53
Turcot syndromeMlh1
Colorectal NeoplasmsAkt1 , Apc , Egfr , Kras , Nras , Tp53 , Ccnd1 , Axin2 , Ctnnb1 , Braf , Axin1 , Pik3ca , Mlh1
Sarcoma, KaposiTp53
Rectal NeoplasmsNras , Pik3ca
HypertensionAkt2 , Egfr , Kras , Pik3r1
Kidney NeoplasmsAkt1 , Erbb2
LEOPARD SyndromeRaf1
LEOPARD syndrome, 2Raf1
Tongue NeoplasmsTp53
Hypomagnesemia primaryEgf
Parkinson DiseaseAkt1 , Egfr , Erbb2
Parkinsonian DisordersEgfr
Prostatic NeoplasmsAkt1 , Egfr , Erbb2 , Kras , Myc , Nras , Pik3r1 , Tp53 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Map2k1 , Braf , Ilk , Bad , Foxo3 , Ctnna1
Prostatic HyperplasiaMyc , Pten , Bad
Carcinoma, HepatocellularAkt2 , Apc , Myc , Tp53 , Cdh1 , Ctnnb1 , Axin1 , Pik3ca
Penile NeoplasmsCcnd1
Meningioma, familialPten
SarcomaTp53
Insulin ResistanceAkt2 , Pik3r1 , Pten , Tcf7l2
Proteus SyndromeAkt1
Aortic Valve StenosisEgfr
Neoplasms, Germ Cell and EmbryonalErbb2 , Mlh1
Noonan syndrome 3Kras
Laryngeal NeoplasmsEgfr
Hypertension, PortalPik3r1 , Pten
PeritonitisPik3r1
Adenocarcinoma of lungMyc
Nasopharyngeal carcinomaTp53
Nasopharyngeal NeoplasmsTp53 , Ccnd1
HyperinsulinismPten
Clear-cell metastatic renal cell carcinomaMyc
GlomerulonephritisMapk1
Burkitt LymphomaMyc
Pre-EclampsiaErbb2
Papillary renal cell carcinoma, sporadicMyc
Lewy Body DiseaseElk1
Sarcoma family syndrome of Li and FraumeniTp53
Li-Fraumeni SyndromeTp53
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Phyllodes TumorEgfr , Tp53 , Ctnnb1
Wounds and InjuriesEgf
Stomach DiseasesPten
Lymphoproliferative DisordersNras
AnaphylaxisPik3r1
InfectionCtnnb1
Myocardial IschemiaErbb2
Angina, UnstableAkt1
Aortic Valve InsufficiencyEgfr
Heart DiseasesCasp9
Arthritis, ExperimentalNras , Pik3cd
AsthmaEgfr , Cdh1
GliomaAkt2 , Egfr , Erbb2 , Tp53 , Pten , Bad , Pik3ca
Autistic DisorderPten
Sarcoma, ExperimentalKras , Nras
Bacterial InfectionsCasp9
Digestive System NeoplasmsApc
Bipolar DisorderAkt1
Urologic NeoplasmsErbb2
Brain InjuriesAkt1 , Bad , Elk1
Ventilator-Induced Lung InjuryAkt1
BurnsBad , Ccnd1
Substance-Related DisordersPten
Adenocarcinoma, Bronchiolo-AlveolarEgfr
Carcinoma, Intraductal, NoninfiltratingErbb2 , Tp53 , Ccnd1
Carcinoma, Non-Small-Cell LungAkt1 , Egfr , Erbb2 , Kras , Tp53 , Pten , Map2k1 , Braf , Pik3ca
Carcinoma, Transitional CellApc , Egfr , Erbb2 , Hras , Kras , Nras , Tp53 , Ccnd1 , Ctnnb1 , Ctnna1
Brain IschemiaAkt1 , Map2k1 , Bad , Mapk1
Ischemic Attack, TransientPten , Elk1
Hydatidiform MoleMlh1
Colonic NeoplasmsAkt2 , Apc , Myc , Ctnnb1 , Pik3ca , Pik3r1
Coronary Artery DiseaseAkt1
ThrombosisPik3cb
NeoplasmsErbb2
Diabetes Mellitus, ExperimentalEgfr , Hras , Myc , Casp9 , Mapk1 , Bad , Pik3r1
Diabetic NephropathiesEgf , Tp53 , Pten , Mapk1 , Tcf7l2
Diabetic RetinopathyEgfr , Casp9 , Hras
GerminomaBraf
Heart FailureErbb2
Encephalomyelitis, Autoimmune, ExperimentalCasp9
Endometrial HyperplasiaKras
Leukemia, Myeloid, AcuteKras
Femoral FracturesLef1
Diabetes, GestationalTcf7l2
Mouth NeoplasmsErbb2 , Hras , Nras , Tp53
GlioblastomaAkt1 , Pten
Graft vs Host DiseaseTp53
Graves DiseaseTp53
Neoplasms, Multiple PrimaryMlh1
Heart ArrestAkt1
von Hippel-Lindau DiseaseCcnd1
Erectile DysfunctionCcnd1
LeiomyomaMyc , Pten
Leukemia, Plasma CellMyc
Multiple MyelomaKras , Ccnd1 , Myc
Leukoplakia, OralTp53
Liver Neoplasms, ExperimentalCcnd1 , Map2k1
Lupus NephritisEgf
Lymphatic MetastasisEgfr , Erbb2 , Tp53 , Pten , Cdh1 , Ctnnb1 , Ctnna1
Neoplasm MetastasisAkt2 , Erbb2 , Tp53 , Pten , Cdh1 , Ctnnb1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Egfr , Erbb2 , Hras , Tp53 , Casp9 , Pten , Ccnd1 , Ctnnb1 , Ilk
Paranasal Sinus NeoplasmsTp53
MedulloblastomaApc , Tp53
MetaplasiaAxin2
Multiple Organ FailureMapk1
Myocardial InfarctionAkt1 , Mapk1
Oral Submucous FibrosisTp53
Oropharyngeal NeoplasmsTp53
Paget's Disease, MammaryErbb2
PancreatitisEgf
ParaplegiaAkt1
Pulmonary FibrosisEgfr , Cdh1 , Bad
SchizophreniaAkt1 , Egfr
Sebaceous Gland NeoplasmsLef1
Shock, HemorrhagicMapk1 , Bad , Myc
Spinal Cord InjuriesEgfr
Tobacco Use DisorderEgfr
Urinary IncontinenceMapk1
VaricoceleCasp9
Vulvar NeoplasmsTp53 , Mlh1
Zollinger-Ellison SyndromeEgf
Dementia, VascularTp53
ProlactinomaMyc
Reperfusion InjuryAkt1 , Egf , Pik3r1 , Tp53 , Casp9 , Pten , Ccnd1 , Bad
Myocardial Reperfusion InjuryAkt1 , Akt2 , Tp53 , Mapk1 , Bad
Leukemia, B-CellMyc
Leukemia-Lymphoma, Adult T-CellTp53
AIDS-Associated NephropathyEgf
Endometrial NeoplasmsErbb2 , Kras , Tp53 , Pten , Ccnd1 , Cdh1 , Ctnnb1 , Pik3ca , Mlh1 , Ctnna1
HELLP SyndromeErbb2
Hypertrophy, Left VentricularEgfr , Pten
Keratosis, SeborrheicPik3ca
Lichen Planus, OralTp53
SeminomaHras , Kras
Endodermal Sinus TumorCtnnb1
Carcinoma, Acinar CellApc
Carcinoma, EndometrioidEgfr , Erbb2 , Kras , Pten , Cdh1 , Ctnnb1
Carcinoma, LobularErbb2 , Ccnd1 , Cdh1 , Ctnnb1 , Ctnna1
Cervical Intraepithelial NeoplasiaPten , Ccnd1 , Cdh1 , Mlh1 , Ctnna1
PilomatrixomaCtnnb1
Rhabdoid TumorMyc
Cholesteatoma, Middle EarTp53
Lymphoma, B-Cell, Marginal ZoneTp53
Prostatic Intraepithelial NeoplasiaKras , Pten , Ccnd1
Carotid Artery InjuriesMyc
Papilloma, Choroid PlexusTp53
Enterocolitis, NecrotizingEgf
StrokeAkt1 , Ctnnb1
Carcinoma, Pancreatic DuctalEgf
Coronary RestenosisTp53 , Mapk1
Pulmonary Disease, Chronic ObstructiveEgfr
AtherosclerosisAkt1
Lynch Syndrome IIMlh1
Costello SyndromeHras
Low Tension GlaucomaTp53
FIBROMATOSIS, GINGIVAL, 1Sos1
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 1Pten
NOONAN SYNDROME 7Braf
LEOPARD SYNDROME 3Braf
Trigeminal Nerve InjuriesTp53
Thyroid cancer, follicularHras , Nras , Pten
Nevus, EpidermalHras , Nras , Pik3ca
Glaucoma, Primary Open AngleTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
Caudal Duplication AnomalyAxin1
Macrocephaly Autism SyndromePten
Adrenocortical Carcinoma, HereditaryTp53
Hypomagnesemia 4, RenalEgf
Lung Reperfusion InjuryMyc
Kidney Reperfusion InjuryMyc
Renal FibrosisMapk1 , Myc
Liver InjuryMyc
Transplant RejectionMyc
Odontogenic MyxomaTp53
Squamous Cell Carcinoma of the TongueEgfr , Tp53
Pathway Annotations Associated with Genes in the endometrial cancer pathway
Pathway TermsGene Symbols
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Myc , Nras , Raf1 , Tp53 , Map2k2 , Akt3 , Map2k1 , Mapk1 , Grb2 , Braf , Sos2 , Sos1 , Elk1
Wnt signaling pathwayApc , Myc , Tp53 , Ccnd1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Axin1 , Tcf3 , Tcf7 , Apc2 , Tcf7l2
apoptotic cell death pathwayAkt1 , Akt2 , Pik3r1 , Tp53 , Casp9 , Akt3 , Pik3r2 , Bad , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
Alzheimer disease pathwayCasp9 , Mapk1 , Gsk3b , Bad , Mapk3
amyotrophic lateral sclerosis disease pathwayTp53 , Casp9 , Bad
Huntington disease pathwayTp53 , Casp9
Parkinson disease pathwayCasp9
prion diseases pathwayMap2k2 , Map2k1 , Mapk1 , Elk1 , Mapk3
long term potentiationHras , Kras , Mapk3 , Nras , Map2k2 , Map2k1 , Mapk1 , Braf , Raf1
long term depressionHras , Kras , Mapk3 , Nras , Map2k2 , Map2k1 , Mapk1 , Gsk3b , Braf , Raf1
cell cycle pathway, mitoticMyc , Tp53 , Ccnd1 , Gsk3b
G1 phase pathwayCcnd1
S phase pathwayCcnd1
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayHras , Kras , Mapk3 , Nras , Raf1 , Map2k2 , Map2k1 , Mapk1 , Braf
intrinsic apoptotic pathwayCasp9 , Bad
Hedgehog signaling pathwayAkt1 , Map2k1 , Gsk3b , Pik3ca , Pik3r1
insulin signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Bad , Pdpk1 , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Sos1 , Pik3cd , Pik3r5 , Elk1
inositol phosphate metabolic pathwayPten , Pik3ca , Pik3cb , Pik3cd
Ras family mediated signaling pathwaySos1
nerve growth factor signaling pathwaySos1
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Bad , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Elk1
mTOR signaling pathwayAkt1 , Akt2 , Hras , Mapk3 , Nras , Pik3r1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Braf , Pdpk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5 , Raf1
Wnt signaling, canonical pathwayApc , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Axin1 , Tcf7 , Tcf7l2
Notch signaling pathwayCcnd1 , Myc
type 2 diabetes mellitus pathwayAkt2 , Mapk3 , Pik3r1 , Pik3r2 , Mapk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
Jak-Stat signaling pathwayAkt1 , Akt2 , Myc , Pik3r1 , Akt3 , Pik3r2 , Ccnd1 , Grb2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Sos2
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Pik3r1 , Casp9 , Pten , Akt3 , Pik3r2 , Gsk3b , Bad , Pdpk1 , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Pik3cd , Raf1
insulin-like growth factor signaling pathwayAkt1 , Hras , Pik3r1 , Raf1 , Grb2 , Bad , Pdpk1 , Pik3ca , Sos1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Casp9 , Map2k2 , Akt3 , Pik3r2 , Ctnnb1 , Map2k1 , Mapk1 , Grb2 , Braf , Bad , Pdpk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Ctnna1 , Pik3r5
angiotensin II signaling pathwayPdpk1
endocytosis pathwayEgf , Egfr , Hras
integrin mediated signaling pathwayIlk
platelet-derived growth factor signaling pathwayHras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Map2k2 , Pten , Pik3r2 , Map2k1 , Mapk1 , Grb2 , Braf , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Elk1
p53-dependent G1/S DNA damage checkpoint pathwayTp53
ephrin - ephrin receptor bidirectional signaling axisHras , Mapk3 , Nras , Pik3r1 , Map2k1 , Mapk1 , Grb2 , Pik3ca , Pik3r5
fibroblast growth factor signaling pathwayAkt1 , Mapk3 , Pik3r1 , Cdh1 , Mapk1 , Grb2 , Pdpk1 , Pik3ca , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk3 , Mapk1 , Myc
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
hypoxia inducible factor pathwayAkt1 , Elk1
Reelin signaling pathwayAkt1 , Pik3r1 , Gsk3b , Pik3ca
transforming growth factor-beta Smad dependent signaling pathwayCtnnb1 , Grb2 , Pdpk1 , Axin1 , Foxo3 , Sos1
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
endothelin signaling pathwayAkt1 , Hras , Mapk3 , Map2k2 , Map2k1 , Mapk1 , Raf1
interleukin-6 signaling pathwayAkt1 , Myc , Pik3r1 , Grb2 , Pik3ca , Sos1 , Sos2
Ras mediated signaling pathwayErbb2
glycogen biosynthetic pathwayGsk3b
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
aldosterone signaling pathwayKras , Mapk3 , Pik3r1 , Pik3r2 , Mapk1 , Pdpk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
neurotrophic factor signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Bad , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Sos1 , Pik3cd , Pik3r5
scatter factor/hepatocyte growth factor signaling pathwayPik3r1 , Grb2
phosphatidylinositol 3-kinase signaling pathwayPik3r1 , Pten , Pik3r2 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
altered Wnt signaling, canonical pathwayApc , Axin2 , Ctnnb1 , Axin1
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayKras , Map2k1 , Braf , Raf1
prostate cancer pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Casp9 , Map2k2 , Pten , Akt3 , Pik3r2 , Ccnd1 , Ctnnb1 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Bad , Lef1 , Pdpk1 , Sos2 , Tcf3 , Pik3ca , Pik3cb , Pik3r3 , Tcf7 , Sos1 , Pik3cd , Pik3r5 , Tcf7l2
bladder cancer pathwayEgf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Myc , Nras , Raf1 , Tp53 , Map2k2 , Ccnd1 , Cdh1 , Map2k1 , Mapk1 , Braf
endometrial cancer pathwayAkt1 , Akt2 , Apc , Egf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Tp53 , Casp9 , Map2k2 , Pten , Akt3 , Pik3r2 , Ccnd1 , Axin2 , Cdh1 , Ctnnb1 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Ilk , Bad , Lef1 , Pdpk1 , Sos2 , Axin1 , Tcf3 , Pik3ca , Pik3cb , Mlh1 , Pik3r3 , Ctnna2 , Tcf7 , Apc2 , Foxo3 , Sos1 , Pik3cd , Ctnna1 , Ctnna3 , Pik3r5 , Tcf7l2 , Elk1
colorectal cancer pathwayAkt1 , Akt2 , Apc , Kras , Mapk3 , Myc , Pik3r1 , Raf1 , Tp53 , Casp9 , Akt3 , Pik3r2 , Ccnd1 , Axin2 , Ctnnb1 , Map2k1 , Mapk1 , Gsk3b , Braf , Bad , Lef1 , Axin1 , Tcf3 , Pik3ca , Pik3cb , Mlh1 , Pik3r3 , Tcf7 , Apc2 , Pik3cd , Pik3r5 , Tcf7l2
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Pten , Akt3 , Pik3ca
pancreatic cancer pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Kras , Mapk3 , Pik3r1 , Raf1 , Tp53 , Casp9 , Pten , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Braf , Bad , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b
syndecan signaling pathwayEgfr , Hras , Mapk3 , Mapk1
mismatch repair pathwayMlh1
altered mismatch repair pathwayMlh1
FasL mediated signaling pathwayAkt1 , Pik3r1 , Pik3r2 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r3
Trail mediated signaling pathwayMapk3 , Pik3r1 , Pik3r2 , Mapk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r3
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
thyroid cancer pathwayHras , Kras , Mapk3 , Myc , Nras , Tp53 , Map2k2 , Ccnd1 , Cdh1 , Ctnnb1 , Map2k1 , Mapk1 , Braf , Lef1 , Tcf3 , Tcf7 , Tcf7l2
small cell lung cancer pathwayAkt1 , Akt2 , Myc , Pik3r1 , Tp53 , Casp9 , Pten , Akt3 , Pik3r2 , Ccnd1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
non-small cell lung cancer pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Casp9 , Map2k2 , Pten , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Grb2 , Braf , Bad , Pdpk1 , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Sos1 , Pik3cd , Pik3r5
acute myeloid leukemia pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Grb2 , Braf , Bad , Lef1 , Sos2 , Tcf3 , Pik3ca , Pik3cb , Pik3r3 , Tcf7 , Sos1 , Pik3cd , Pik3r5 , Tcf7l2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Tp53 , Map2k2 , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Grb2 , Braf , Bad , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5
glioma pathwayAkt1 , Akt2 , Egf , Egfr , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Map2k2 , Pten , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Grb2 , Braf , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5
p53 signaling pathwayAkt1 , Tp53 , Casp9 , Pten , Ccnd1 , Gsk3b
altered p53 signaling pathwayTp53
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2
Toll-like receptor signaling pathwayAkt1 , Akt2 , Mapk3 , Pik3r1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
NOD-like receptor signaling pathwayMapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Sos2
B cell receptor signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Sos2
cytokine mediated signaling pathwayEgf , Egfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Grb2 , Braf , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Sos1 , Pik3cd , Pik3r5 , Sos2
protein kinase C (PKC) signaling pathwayPdpk1
glutamate signaling pathwayMapk1 , Mapk3
gefitinib pharmacodynamics pathwayEgfr
interleukin-1 signaling pathwayPik3ca , Pik3r1
type II interferon signaling pathwayAkt1 , Mapk3 , Map2k1 , Mapk1 , Pik3ca , Pik3r1
interleukin-2 signaling pathwayHras , Mapk3 , Myc , Nras , Pik3r1 , Raf1 , Map2k2 , Map2k1 , Mapk1 , Grb2 , Pik3ca , Sos1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayPik3ca , Pik3r1
forkhead class A signaling pathwayAkt1
sphingosine 1-phosphate signaling pathwayAkt1 , Mapk3 , Akt3 , Mapk1 , Elk1
ceramide signaling pathwayAkt1 , Akt2 , Egf , Egfr , Erbb2 , Kras , Mapk3 , Myc , Pik3r1 , Raf1 , Tp53 , Casp9 , Map2k2 , Akt3 , Pik3r2 , Ccnd1 , Map2k1 , Mapk1 , Braf , Bad , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
phosphatidylinositol 3-kinase class I signaling pathwayHras , Nras , Pik3r1 , Pten , Pik3r2 , Pdpk1 , Pik3ca , Pik3cb , Pik3r3 , Foxo3 , Pik3cd , Pik3r5
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
granulocyte-macrophage colony-stimulating factor signaling pathwayHras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Map2k1 , Mapk1 , Grb2 , Pik3ca , Sos1
erythropoietin signaling pathwayHras , Pik3r1 , Grb2 , Sos1
E-cadherin signaling pathwayAkt1 , Akt2 , Egf , Egfr , Pik3r1 , Ccnd1 , Cdh1 , Ctnnb1 , Pik3ca , Ctnna1
N-cadherin signaling pathwayCtnnb1 , Axin1 , Pik3ca , Ctnna1 , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Grb2 , Braf , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Sos2
basal cell carcinoma pathwayApc , Tp53 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Axin1 , Tcf3 , Tcf7 , Apc2 , Tcf7l2
melanoma pathwayAkt1 , Akt2 , Egf , Egfr , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Map2k2 , Pten , Akt3 , Pik3r2 , Ccnd1 , Cdh1 , Map2k1 , Mapk1 , Braf , Bad , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
arrhythmogenic right ventricular cardiomyopathy pathwayCtnnb1 , Lef1 , Tcf3 , Ctnna2 , Tcf7 , Ctnna1 , Ctnna3 , Tcf7l2
myocarditis pathwayCasp9 , Ccnd1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Mapk3 , Casp9 , Akt3 , Mapk1 , Bad , Raf1
Leishmania infection pathwayMapk1 , Elk1 , Mapk3
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Mapk3 , Pik3r1 , Akt3 , Pik3r2 , Mapk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Mapk3 , Pik3r1 , Casp9 , Akt3 , Pik3r2 , Mapk1 , Bad , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
Entamoeba histolyca infection pathwayPik3r1 , Pik3r2 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
influenza A virus infection pathwayAkt1 , Akt2 , Mapk3 , Pik3r1 , Casp9 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Gsk3b , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5 , Raf1
hepatitis C virus infection pathwayAkt1 , Akt2 , Egf , Egfr , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Tp53 , Akt3 , Pik3r2 , Mapk1 , Gsk3b , Grb2 , Braf , Bad , Sos2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5
measles infection pathwayAkt1 , Akt2 , Pik3r1 , Tp53 , Akt3 , Pik3r2 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5
gonadotropin-releasing hormone signaling pathwayEgfr , Hras , Kras , Mapk3 , Nras , Raf1 , Map2k2 , Map2k1 , Mapk1 , Grb2 , Sos1 , Elk1 , Sos2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Mapk3 , Pik3r1 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Pik3ca , Pik3cb , Pik3r3 , Pik3cd , Pik3r5 , Raf1
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk , Pdpk1
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Hras , Kras , Mapk3 , Nras , Pik3r1 , Raf1 , Map2k2 , Akt3 , Pik3r2 , Map2k1 , Mapk1 , Grb2 , Pik3ca , Pik3cb , Pik3r3 , Sos1 , Pik3cd , Pik3r5 , Sos2
titanium dioxide nanoparticle response pathwayTp53
Phenotype Annotations Associated with Genes in the endometrial cancer pathway
Phenotype TermsGene Symbols
increased cell proliferationCcnd1
impaired smooth muscle contractilityMap2k1
increased metastatic potentialErbb2
abnormal estrous cycleEgfr
neurodegenerationGsk3b
heart left ventricle hypertrophyEgfr
abnormal liver regenerationCcnd1
liver fibrosisIlk
enhanced cellular glucose importMyc
renal fibrosisEgfr
abnormal amino acid levelMyc
abnormal retinal apoptosisHras
abnormal dendrite morphologyIlk
abnormal cellular respirationMyc
decreased mitochondria sizeMyc
abnormal mitochondrial crista morphologyMyc
decreased fibroblast proliferationMyc

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: