ENDOMETRIAL CANCER PATHWAY (PW:0000611)

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Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name GBrowse Chr Start Stop Reference
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link 6 146,225,955 146,247,008 RGD:6907045
G Akt2 v-akt murine thymoma viral oncogene homolog 2 GBrowse link 1 85,617,612 85,667,423 RGD:6907045
G Akt3 v-akt murine thymoma viral oncogene homolog 3 GBrowse link 13 99,527,953 99,800,302 RGD:6907045
G Apc adenomatous polyposis coli GBrowse link 18 26,725,560 26,820,837 RGD:6907045
G Apc2 adenomatosis polyposis coli 2 GBrowse link 7 12,428,263 12,450,249 RGD:6907045
G Axin1 axin 1 GBrowse link 10 15,324,330 15,376,252 RGD:6907045
G Axin2 axin 2 GBrowse link 10 96,933,422 96,959,748 RGD:6907045
G Bad BCL2-associated agonist of cell death GBrowse link 1 229,189,271 229,198,306 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase GBrowse link 4 67,196,477 67,327,649 RGD:6907045
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link 5 164,067,734 164,085,297 RGD:6907045
G Ccnd1 cyclin D1 GBrowse link 1 224,960,136 224,969,658 RGD:6907045
G Cdh1 cadherin 1 GBrowse link 19 49,635,965 49,705,893 RGD:6907045
G Ctnna1 catenin (cadherin-associated protein), alpha 1, 102kDa GBrowse link 18 27,633,009 27,766,069 RGD:6907045
G Ctnna2 catenin (cadherin associated protein), alpha 2 GBrowse link 4 172,586,790 173,745,983 RGD:6907045
G Ctnna3 catenin (cadherin associated protein), alpha 3 GBrowse link 20 27,131,441 28,684,032 RGD:6907045
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link 8 128,798,888 128,825,828 RGD:4143515
RGD:6907045
G Egf epidermal growth factor GBrowse link 2
2
2
74,746,752
88,549,746
253,481,574
74,783,449
88,621,570
253,482,579
RGD:6907045
G Egfr epidermal growth factor receptor GBrowse link 14 100,438,989 100,617,315 RGD:6907045
G Elk1 ELK1, member of ETS oncogene family GBrowse link X 2,102,893 2,119,843 RGD:6907045
G Erbb2 v-erb-b2 avian erythroblastic leukemia viral oncogene 2 GBrowse link 10 86,163,531 86,187,663 RGD:4143515
RGD:6907045
G Foxo3 forkhead box O3 GBrowse link 20 48,111,014 48,206,518 RGD:6907045
G Grb2 growth factor receptor bound protein 2 GBrowse link 10
10
104,019,823
104,735,560
104,087,251
104,738,091
RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta GBrowse link 11 66,873,291 67,016,640 RGD:6907045
G Hras Harvey rat sarcoma virus oncogene GBrowse link 1 221,095,943 221,099,362 RGD:6907045
G Ilk integrin-linked kinase GBrowse link 1 177,584,793 177,591,044 RGD:6907045
G Kras Kirsten rat sarcoma viral oncogene GBrowse link 4 243,667,912 243,696,325 RGD:4143515
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 GBrowse link 2 254,781,171 254,893,756 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 GBrowse link 8 68,840,454 68,877,679 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 GBrowse link 7 11,626,294 11,645,884 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 GBrowse link 11 91,260,412 91,325,570 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 GBrowse link 1 205,172,641 205,178,843 RGD:6907045
G Mlh1 mutL homolog 1 GBrowse link 8 118,828,172 118,865,320 RGD:4143515
RGD:6907045
G Myc myelocytomatosis oncogene GBrowse link 7 103,157,452 103,162,379 RGD:6907045
G Nras neuroblastoma ras oncogene GBrowse link 2 224,983,707 224,994,303 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link 10 13,262,177 13,339,277 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha GBrowse link 2 138,491,967 138,521,934 RGD:4143515
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta GBrowse link 8 106,700,158 106,788,063 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta GBrowse link 5 170,248,202 170,274,177 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) GBrowse link 2 50,891,225 50,965,217 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) GBrowse link 16 20,273,500 20,282,051 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) GBrowse link 5 138,858,124 138,930,177 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 GBrowse link 10 54,757,809 54,822,968 RGD:6907045
G Pten phosphatase and tensin homolog GBrowse link 1 258,651,829 258,717,009 RGD:4143515
RGD:6907045
G Raf1 v-raf-leukemia viral oncogene 1 GBrowse link 4 210,819,148 210,878,226 RGD:6907045
G Sos1 Son of sevenless homolog 1 (Drosophila) GBrowse link 6 3,082,456 3,159,445 RGD:6907045
G Sos2 son of sevenless homolog 2 (Drosophila) GBrowse link 6 101,337,035 101,457,580 RGD:6907045
G Tcf3 transcription factor 3 GBrowse link 7 12,316,323 12,338,455 RGD:6907045
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) GBrowse link 10 37,389,506 37,419,457 RGD:6907045
G Tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) GBrowse link 1
1
284,077,353
283,387,566
284,118,928
283,412,364
RGD:6907045
G Tp53 tumor protein p53 GBrowse link 10 55,932,658 55,944,087 RGD:4143515
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

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