ENDOMETRIAL CANCER PATHWAY (PW:0000611)

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Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,940 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc adenomatous polyposis coli JBrowse link 18 27,011,706 27,106,323 RGD:6907045
G Apc2 adenomatosis polyposis coli 2 JBrowse link 7 12,258,468 12,280,466 RGD:6907045
G Axin1 axin 1 RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,197,829 222,207,454 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,487 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,572 28,055,972 RGD:6907045
G Ctnna2 catenin alpha 2 JBrowse link 4 107,880,611 109,042,663 RGD:6907045
G Ctnna3 catenin alpha 3 JBrowse link 20 26,510,292 26,640,429 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,617,770 129,628,378 RGD:4143515
RGD:6907045
G Egf epidermal growth factor JBrowse link 2
2
235,049,350
235,074,826
235,062,491
235,177,275
RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,209,543 RGD:6907045
G Hras Harvey rat sarcoma virus oncogene JBrowse link 1 214,178,278 214,181,686 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:6907045
G Kras Kirsten rat sarcoma viral oncogene JBrowse link 4 179,483,086 179,515,609 RGD:4143515
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,117 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,252 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,785 88,273,288 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:4143515
RGD:6907045
G Myc myelocytomatosis oncogene JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nras neuroblastoma RAS viral oncogene homolog JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:4143515
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,363,440 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,816,385 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,416,432 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,965 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,688 55,078,977 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:4143515
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) JBrowse link 10 37,616,022 37,647,851 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1
1
275,997,089
276,686,911
276,012,932
276,730,517
RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,187,013 56,198,449 RGD:4143515
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the endometrial cancer pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Abnormalities, MultipleCtnnb1 , Kras , Mapk1 , Pten
Activated PI3K-delta SyndromePik3cd
Acute Kidney InjuryBad , Egf , Egfr , Myc
Acute Lung InjuryEgfr
AdenocarcinomaApc , Tp53
Adenocarcinoma of LungBraf , Erbb2 , Myc
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
AdenomaApc
Adenoma, ColorectalApc
Adenoma, Liver CellPten
Adenomatous Polyposis ColiApc
Adenomatous Polyposis Coli, AttenuatedApc
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureTp53
AIDS-Associated NephropathyEgf
Alzheimer DiseaseAkt1 , Apc , Bad , Ctnnb1 , Egf , Egfr , Elk1 , Foxo3 , Gsk3b , Hras , Pik3r1 , Tp53
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Gsk3b
Angina, UnstableAkt1
AnodontiaAxin2
Aortic Valve InsufficiencyEgfr
Aortic Valve StenosisEgfr
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular Dysplasia, Familial, 13Ctnna3
Arthritis, ExperimentalAkt1 , Nras , Pik3cd
Arthritis, RheumatoidFoxo3
AsthmaCdh1 , Egfr
AstrocytomaAkt1 , Kras , Tp53
AtaxiaPten
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1
Autism Spectrum DisorderMapk3
Autistic DisorderHras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Bacterial InfectionsCasp9
Bipolar DisorderAkt1 , Gsk3b
Bone Marrow NeoplasmsTp53
Brain InjuriesAkt1 , Bad , Elk1 , Gsk3b
Brain IschemiaAkt1 , Bad , Map2k1 , Mapk1
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialApc , Pik3r3
Breast NeoplasmsAkt1 , Akt2 , Apc , Bad , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mlh1 , Myc , Pik3ca , Pik3r1 , Pten , Tp53
Burkitt LymphomaMyc
BurnsBad , Ccnd1 , Gsk3b
Cafe au lait Spots, MultipleSos1
CalcinosisCtnnb1 , Erbb2
CarcinogenesisGsk3b
Carcinoma in SituAkt1 , Ctnnb1 , Pten
Carcinoma, Acinar CellApc
Carcinoma, Adenoid CysticTp53
Carcinoma, Basal CellTp53
Carcinoma, EndometrioidCdh1 , Ctnnb1 , Egfr , Erbb2 , Kras , Pten
Carcinoma, HepatocellularAkt2 , Apc , Axin1 , Cdh1 , Ctnnb1 , Myc , Pik3ca , Tp53
Carcinoma, Intraductal, NoninfiltratingCcnd1 , Erbb2 , Tp53
Carcinoma, LobularCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Erbb2
Carcinoma, MucoepidermoidCdh1
Carcinoma, Non-Small-Cell LungAkt1 , Braf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Nras , Pik3ca , Pten , Tp53
Carcinoma, Pancreatic DuctalEgf
Carcinoma, Renal CellAkt1 , Apc , Bad , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Map2k1 , Mlh1 , Myc , Pten , Tp53
Carcinoma, Squamous CellCcnd1 , Hras , Tp53
Carcinoma, Squamous Cell of Head and NeckEgfr , Pten
Carcinoma, Transitional CellApc , Ccnd1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Nras , Tp53
Cardiofaciocutaneous SyndromeBraf , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Gsk3b , Mapk1 , Myc , Pten
CardiomyopathiesIlk
Cardiomyopathy, DilatedCtnna3 , Egfr , Erbb2 , Ilk , Kras , Raf1
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionCtnna3
Cardiomyopathy, HypertrophicCtnna3 , Ctnnb1 , Ilk , Kras , Raf1 , Sos1
Cardiomyopathy, Hypertrophic, FamilialCtnna3 , Ilk , Kras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery InjuriesFoxo3 , Myc
CataractTp53
Caudal Duplication AnomalyAxin1
Cervical Intraepithelial NeoplasiaCcnd1 , Cdh1 , Ctnna1 , Mlh1 , Pten
Chemotherapy-Induced Febrile NeutropeniaTp53
CholangiocarcinomaApc
Cholesteatoma, Middle EarTp53
Choroid Plexus CarcinomaTp53
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipCdh1
Colitis, UlcerativeTp53
Colonic NeoplasmsAkt1 , Akt2 , Apc , Axin2 , Bad , Braf , Ctnnb1 , Myc , Pik3ca , Pik3r1 , Tp53
Colorectal Cancer, Hereditary Nonpolyposis, Type 1Mlh1
Colorectal NeoplasmsAkt1 , Apc , Axin1 , Axin2 , Braf , Ccnd1 , Ctnnb1 , Egfr , Kras , Mlh1 , Nras , Pik3ca , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisMlh1
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Coronary Artery DiseaseAkt1
Coronary RestenosisMapk1 , Myc , Tp53
Costello SyndromeHras
Cystadenocarcinoma, SerousTp53
DementiaEgfr
Dementia, VascularTp53
Demyelinating DiseasesMyc
Depressive DisorderGsk3b
Desmoid Disease, HereditaryApc , Ctnnb1
Diabetes MellitusPten , Tcf7l2
Diabetes Mellitus, ExperimentalAkt1 , Bad , Casp9 , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Myc , Pik3r1 , Tp53
Diabetes Mellitus, Type 1Casp9 , Egfr
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Casp9 , Gsk3b , Pik3r1 , Tcf7l2
Diabetes, GestationalTcf7l2
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pten , Tcf7l2 , Tp53
Diabetic NeuropathiesBad
Diabetic RetinopathyCasp9 , Egfr , Hras
Digestive System NeoplasmsApc
Encephalomyelitis, Autoimmune, ExperimentalCasp9
Endodermal Sinus TumorCtnnb1
Endometrial HyperplasiaKras
Endometrial NeoplasmsCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Erbb2 , Kras , Mlh1 , Pik3ca , Pten , Tp53
Enterocolitis, NecrotizingEgf
Epidermal NevusHras , Kras , Nras , Pik3ca
Epilepsy, Temporal LobeFoxo3
Erectile DysfunctionAkt1 , Bad , Ccnd1
Esophageal NeoplasmsCtnna1 , Egfr , Myc , Tp53
Esophagitis, PepticEgfr
Fatty LiverPten
Femoral FracturesLef1
Fetal Growth RetardationElk1
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
Gallbladder NeoplasmsApc , Egf
Gardner SyndromeApc
Gastrointestinal NeoplasmsPik3ca , Pten
Genetic Diseases, InbornCtnnb1 , Mapk1 , Pik3r2 , Pten
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
GlaucomaBad
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Pten
GliomaAkt2 , Bad , Egfr , Erbb2 , Pik3ca , Pten , Tp53
GlomerulonephritisMapk1
Graft vs Host DiseaseTp53
Granulosa Cell TumorCtnnb1
Graves DiseaseTp53
Hamartoma Syndrome, MultiplePik3ca , Pten
Head and Neck NeoplasmsEgfr
Hearing Loss, Cisplatin-InducedGsk3b
Heart ArrestAkt1
Heart DiseasesCasp9
Heart FailureErbb2
HELLP SyndromeErbb2
HepatoblastomaApc , Ctnnb1 , Tp53
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
HepatomegalyPten
Hirschsprung DiseaseErbb2
Huntington DiseaseEgfr , Elk1
Hydatidiform MoleMlh1
HyperinsulinismPten
HyperparathyroidismMyc
HyperplasiaApc , Egfr
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Bad , Egfr , Gsk3b , Kras , Pik3r1
Hypertension, PortalPik3r1 , Pten
Hypertension, PulmonaryEgfr , Myc , Tp53
Hypertrophy, Left VentricularEgfr , Foxo3 , Pten
Hypertrophy, Right VentricularAkt1
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia 4, RenalEgf
Hypomagnesemia PrimaryEgf
HypothyroidismBad
Hypoxia-Ischemia, BrainFoxo3
Immunodeficiency 14Pik3cd
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Infarction, Middle Cerebral ArteryBad
InfectionCtnnb1
InflammationAkt1 , Egfr
Insulin ResistanceAkt2 , Bad , Pik3r1 , Pten , Tcf7l2
Intellectual DisabilityKras
Intermittent ClaudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsApc
Intimal HyperplasiaFoxo3
IschemiaAkt2 , Raf1 , Tp53
Ischemic Attack, TransientCasp9 , Elk1 , Pten
Keratosis, SeborrheicPik3ca
Kidney DiseasesMapk1
Kidney NeoplasmsAkt1 , Erbb2
Kidney Reperfusion InjuryMyc
Laryngeal NeoplasmsEgfr
LeiomyomaMyc , Pten
LEOPARD SyndromeBraf , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaTp53
Leukemia, B-CellMyc
Leukemia, Lymphocytic, Chronic, B-CellTp53
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Myeloid, AcuteKras , Nras , Tp53
Leukemia, Myelomonocytic, JuvenileKras , Nras
Leukemia-Lymphoma, Adult T-CellTp53
Leukoplakia, OralTp53
Lewy Body DiseaseElk1
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Lip NeoplasmsTp53
Liver InjuryBad , Myc
Liver NeoplasmsCtnnb1 , Pik3ca , Tp53
Liver Neoplasms, ExperimentalCcnd1 , Map2k1 , Myc
Liver Reperfusion InjuryBad
Long QT SyndromeCtnna3 , Ilk
Low Tension GlaucomaTp53
Lung DiseasesEgfr
Lung NeoplasmsBraf , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Mlh1 , Pik3ca , Tp53
Lung Reperfusion InjuryMyc
Lupus NephritisEgf
Lymphatic MetastasisCdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Pten , Tp53
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Non-HodgkinBraf , Tp53
Lymphoma, T-CellTp53
Lynch Syndrome IIMlh1
Macrocephaly Autism SyndromePten
Macular DegenerationBad
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Ctnnb1 , Egfr , Erbb2 , Hras , Ilk , Myc , Pten , Tp53
Median NeuropathyErbb2
MedulloblastomaApc , Ctnnb1 , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MelanomaBraf , Nras , Pik3ca , Pten , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Nras , Pik3ca , Pten , Tp53
MeningiomaPten
Meningioma, FamilialPten
Mental Retardation, Autosomal Dominant 19Ctnnb1
MetaplasiaAxin2
Monoclonal B-Cell LymphocytosisApc
Mood DisordersAkt1
Mouth NeoplasmsErbb2 , Hras , Nras , Tp53
Muir-Torre SyndromeMlh1
Multiple MyelomaCcnd1 , Kras , Tp53
Multiple Organ FailureMapk1
Myelodysplastic SyndromesNras , Tp53
Myeloproliferative DisordersKras
Myocardial InfarctionAkt1 , Gsk3b , Mapk1
Myocardial IschemiaErbb2
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Gsk3b , Mapk1 , Tp53
Myoclonus, Familial CorticalMyc
Myopathy, Congenital, with Excess of Muscle SpindlesHras
Nasopharyngeal carcinomaTp53
Nasopharyngeal NeoplasmsCcnd1 , Tp53
Nematode InfectionsPik3r1
Neoplasm MetastasisAkt2 , Cdh1 , Ctnnb1 , Erbb2 , Pten , Tp53
NeoplasmsErbb2 , Tp53
Neoplasms, Germ Cell and EmbryonalErbb2 , Mlh1
Neoplasms, Multiple PrimaryMlh1
Neoplastic Syndromes, HereditaryApc , Axin2 , Cdh1 , Ctnna1 , Mlh1 , Pik3ca , Pten , Tp53
Neurocutaneous MelanosisNras
NeutropeniaTp53
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
Nonseminomatous Germ Cell TumorBraf
Noonan like syndromeSos1
Noonan SyndromeBraf , Kras , Nras , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
Nose NeoplasmsTp53
ObesityAkt2 , Bad , Egfr , Foxo3 , Myc , Pik3r1
Odontogenic MyxomaTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
Optic Atrophy, Hereditary, LeberTp53
Oral Submucous FibrosisTp53
Oropharyngeal NeoplasmsTp53
Osseous Heteroplasia, ProgressiveCtnnb1
OsteoarthritisBad
Osteoarthritis, KneeCtnnb1
OsteoporosisMyc
OsteosarcomaTp53
Ovarian Epithelial CancerPik3ca
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Lef1 , Map2k1 , Map2k2 , Mlh1 , Pik3ca , Pik3r1 , Pten , Tp53
Paget's Disease, MammaryErbb2
Pancreatic CarcinomaKras
Pancreatic NeoplasmsAkt2 , Apc , Egf , Egfr , Ilk , Kras , Myc , Pten , Tcf7l2 , Tp53
PancreatitisEgf
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
Papillary Renal Cell Carcinoma, SporadicMyc
PapillomaEgfr
Papilloma, Choroid PlexusTp53
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Egf , Egfr , Erbb2 , Gsk3b
Parkinsonian DisordersBad , Egfr
Patterned Dystrophy of Retinal Pigment EpitheliumCtnna1
Penile NeoplasmsCcnd1
Periampullary AdenomaApc
Phyllodes TumorCtnnb1 , Egfr , Tp53
PilomatrixomaCtnnb1
PneumoniaEgf
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
Polycystic Kidney, Autosomal DominantMyc
Polycystic Kidney, Autosomal RecessiveAkt1 , Myc , Pik3ca
Pre-EclampsiaErbb2
Precursor B-Cell Lymphoblastic Leukemia-LymphomaTp53
Precursor Cell Lymphoblastic Leukemia-LymphomaKras
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras
Primary MyelofibrosisTp53
ProlactinomaMyc
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Myc , Pten
Prostatic Intraepithelial NeoplasiaCcnd1 , Kras , Myc , Pten
Prostatic NeoplasmsAkt1 , Bad , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Foxo3 , Ilk , Kras , Map2k1 , Myc , Nras , Pik3ca , Pik3r1 , Pten , Tp53
Proteus SyndromeAkt1 , Pten
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53
Pulmonary Disease, Chronic ObstructiveEgfr
Pulmonary FibrosisBad , Cdh1 , Egfr
Pulmonary Valve StenosisHras
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Rectal NeoplasmsPik3ca
Renal FibrosisKras , Mapk1 , Myc
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Egf , Pik3r1 , Pten , Tp53
Retina Reperfusion InjuryBad
Rhabdoid TumorMyc
RhabdomyosarcomaTp53
SarcomaPik3ca , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, ExperimentalKras , Nras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
SchizophreniaAkt1 , Egf , Egfr , Elk1 , Gsk3b
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresBad , Ccnd1 , Pten
SeminomaHras , Kras
SepsisBad , Gsk3b
Septic PeritonitisPik3r1
Shock, HemorrhagicBad , Mapk1 , Myc
SHORT SyndromePik3r1
Skin NeoplasmsCtnnb1 , Tp53
Small-For-Size SyndromeBad
Spinal Cord InjuriesAkt1 , Egfr , Foxo3 , Tp53
Spinal Cord Reperfusion InjuryBad
Squamous Cell Carcinoma of the TongueEgfr , Tp53
Status EpilepticusFoxo3 , Gsk3b
Stomach DiseasesPten
Stomach NeoplasmsApc , Cdh1 , Erbb2 , Kras , Pik3ca , Tp53
Stomach UlcerBad
StrokeAkt1 , Ctnnb1
Substance-Related DisordersPten
Tachycardia, VentricularRaf1
TeratomaCtnnb1
Testicular Germ Cell TumorHras
ThrombosisPik3cb
Thyroid Cancer, FollicularBraf , Hras , Nras , Pten
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsTp53
Tobacco Use DisorderEgfr
Tongue NeoplasmsTp53
Transplant RejectionMyc
Trigeminal Nerve InjuriesTp53
Turcot SyndromeMlh1
Ureteral ObstructionAkt1
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsAkt1 , Casp9 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mlh1 , Myc , Pten , Tp53
Urinary IncontinenceMapk1
Urologic NeoplasmsErbb2
Uterine Cervical NeoplasmsCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mlh1 , Nras , Pten , Tp53
Uterine NeoplasmsCtnnb1
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
von Hippel-Lindau DiseaseCcnd1
Vulvar NeoplasmsMlh1 , Tp53
Wallerian DegenerationErbb2
Wilms TumorCtnnb1 , Erbb2 , Myc
Wounds and InjuriesEgf
Xeroderma PigmentosumTp53
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the endometrial cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk
altered mismatch repair pathwayMlh1
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
bladder cancer pathwayBraf , Ccnd1 , Cdh1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cytokine mediated signaling pathwayEgf , Egfr
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk , Pdpk1
endocytosis pathwayEgf , Egfr , Hras
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Egf , Egfr , Elk1 , Erbb2 , Foxo3 , Grb2 , Gsk3b , Hras , Ilk , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Cdh1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
gonadotropin-releasing hormone signaling pathwayEgfr , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
Huntington disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1 , Elk1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
integrin mediated signaling pathwayIlk
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayElk1 , Mapk1 , Mapk3
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdh1 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tp53
mismatch repair pathwayMlh1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Sos1 , Sos2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayAxin1 , Ctnna1 , Ctnnb1 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Elk1 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
protein kinase C (PKC) signaling pathwayPdpk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Mapk1 , Mapk3
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Tcf3 , Tcf7 , Tcf7l2 , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnna1 , Ctnnb1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Lef1 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Phenotype Annotations Associated with Genes in the endometrial cancer pathway

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: