ENDOMETRIAL CANCER PATHWAY (PW:0000611)

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Description

Endometrial cancer is a common gynecological malignancy, particularly in developed countries where it ranks as the fourth most common form of cancer and the eighth cause of cancer related death in women. It is mostly sporadic accounting for approximately 90% of cases with the remaining 10% being hereditary. Endometrial cancer is generally classified as type 1 or 2 based on etiology and clinical manifestation. Most cancers are of type 1, are associated with unopposed exposure to estrogen and are

Pathway Diagram:

Ariadne Genomics Inc. Mlh1 Kras Erbb2 Pten Ctnnb1 potential EC miRNA altered epidermal growth factor/neuregulin signaling pathway ---> altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway Tp53 potential EC miRNA ---> endometrial angiogenesis potential EC miRNA ---> endometrial inflammatory response potential EC miRNA ---> endometrial tumors potential EC miRNA ---> endometrial apoptosis altered mismatch repair pathway ---> microsatellite instability altered p53 signaling pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway ---> altered expression of target genes altered phosphatidylinositol 3-kinase-Akt signaling pathway ---> altered expression of target genes altered canonical Wnt signaling pathway ---> altered expression of target genes altered p53 signaling pathway ---> altered expression of target genes altered expression of target genes Pik3ca altered epidermal growth factor/neuregulin signaling pathway ---> altered phosphatidylinositol 3-kinase-Akt signaling pathway endometrial tumors altered mismatch repair pathway altered extracellular signal-regulated Raf/Mek/Erk signaling pathway altered canonical Wnt signaling pathway altered epidermal growth factor/neuregulin signaling pathway MSH6 endometrial inflammatory response endometrial apoptosis endometrial angiogenesis microsatellite instability abnormal Watson-Crick pairing
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Genes in Pathway:

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endometrial cancer pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6907045
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:6907045
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:6907045
G Apc APC, WNT signaling pathway regulator JBrowse link 18 27,011,710 27,106,323 RGD:6907045
G Apc2 APC2, WNT signaling pathway regulator JBrowse link 7 12,258,468 12,280,459 RGD:6907045
G Axin1 axin 1 RGD:6907045
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6907045
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:6907045
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6907045
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6907045
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:6907045
G Ctnna1 catenin alpha 1 JBrowse link 18 27,923,229 28,055,972 RGD:6907045
G Ctnna2 catenin alpha 2 JBrowse link 4 107,880,611 109,042,724 RGD:6907045
G Ctnna3 catenin alpha 3 JBrowse link 20 25,063,124 26,640,428 RGD:6907045
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:4143515
RGD:6907045
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6907045
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6907045
G Elk1 ELK1, ETS transcription factor JBrowse link X 1,287,875 1,304,822 RGD:6907045
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:6907045
G Foxo3 forkhead box O3 JBrowse link 20 46,428,078 46,519,156 RGD:6907045
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6907045
G Hras Harvey rat sarcoma virus oncogene JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:4143515
RGD:6907045
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:4143515
RGD:6907045
G Myc myelocytomatosis oncogene JBrowse link 7 102,586,313 102,591,240 RGD:6907045
G Nras neuroblastoma RAS viral oncogene homolog JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:6907045
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:4143515
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 16 20,415,109 20,424,982 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 5 135,069,972 135,145,633 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 JBrowse link 10 55,013,686 55,078,986 RGD:6907045
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:4143515
RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:6907045
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:6907045
G Tcf3 transcription factor 3 JBrowse link 7 12,146,642 12,168,400 RGD:6907045
G Tcf7 transcription factor 7 (T-cell specific, HMG-box) JBrowse link 10 37,616,033 37,646,027 RGD:6907045
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:6907045
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:4143515
RGD:6907045

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Gene Grouppotential EC miRNApotential EC miRNAs

Pathway Gene Annotations

Disease Annotations Associated with Genes in the endometrial cancer pathway
Disease TermsGene Symbols
2-HydroxyglutaricaciduriaSos2
Aberrant Crypt FociApc , Ctnnb1
Abnormalities, MultipleCtnnb1 , Gsk3b , Kras , Mapk1 , Pten
Activated PI3K-delta SyndromePik3cd
Acute Kidney InjuryBad , Egf , Egfr , Gsk3b , Myc , Tp53
Acute Lung InjuryEgfr
AdenocarcinomaApc , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Kras , Myc , Pik3ca , Pten , Tcf7l2 , Tp53
Adenocarcinoma of EsophagusPik3ca , Tp53
Adenocarcinoma of LungBraf , Egfr , Erbb2 , Foxo3 , Hras , Kras , Map2k1 , Myc , Pik3ca , Sos1 , Tp53
Adenocarcinoma, Bronchiolo-AlveolarEgfr , Kras , Tp53
Adenocarcinoma, Clear CellTp53
Adenocarcinoma, FollicularKras
AdenomaApc , Ctnnb1 , Kras , Tp53
Adenoma, ColorectalApc
Adenoma, Liver CellCtnnb1 , Hras , Pten
Adenomatous Polyposis ColiAkt1 , Apc , Egfr
Adenomatous Polyposis Coli, AttenuatedApc
Adenomatous PolypsApc
Adrenal Gland NeoplasmsCtnnb1 , Tp53
Adrenocortical CarcinomaBraf , Ctnnb1 , Egfr , Tp53
Adrenocortical Carcinoma, HereditaryTp53
Adrenocortical Carcinoma, PediatricTp53
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aging, PrematureTp53
AIDS-Associated NephropathyEgf
Alzheimer DiseaseAkt1 , Apc , Bad , Ctnnb1 , Egf , Egfr , Elk1 , Foxo3 , Gsk3b , Hras , Pik3r1 , Tp53
AmeloblastomaBraf
Amphetamine-Related DisordersAkt1
Amyotrophic Lateral SclerosisAkt1 , Casp9 , Gsk3b , Tp53
Angina, UnstableAkt1
AnisometropiaPten
AnodontiaAxin2
Aortic Valve InsufficiencyEgfr
Aortic Valve StenosisEgfr
Aortic Valve, Calcification ofAkt1
Aplasia Cutis Congenita with Epibulbar DermoidsKras
Arrhythmogenic Right Ventricular Dysplasia, Familial, 13Ctnna3
Arsenic PoisoningTp53
Arthritis, ExperimentalAkt1 , Egfr , Gsk3b , Nras , Pik3cd
Arthritis, JuvenileEgf , Kras , Mapk1 , Tcf7l2
Arthritis, RheumatoidFoxo3
AsthmaCdh1 , Ctnna3 , Egfr , Pten
AstrocytomaAkt1 , Braf , Kras , Tp53
AtaxiaPten
Ataxia-Oculomotor Apraxia 3Pik3r5
AtherosclerosisAkt1
AtrophyMapk3
Autism Spectrum DisorderMapk3
Autistic DisorderApc , Egf , Hras , Pten
Autoimmune Lymphoproliferative SyndromeNras
Autoimmune Lymphoproliferative Syndrome, Type IVKras , Nras
Bacterial InfectionsCasp9
Balkan NephropathyTp53
Bile Duct NeoplasmsEgfr
Bipolar DisorderAkt1 , Gsk3b
Bone Diseases, DevelopmentalTp53
Bone Marrow NeoplasmsTp53
Brain InjuriesAkt1 , Bad , Elk1 , Gsk3b
Brain IschemiaAkt1 , Bad , Casp9 , Map2k1 , Mapk1 , Mapk3 , Tp53
Brain NeoplasmsCcnd1 , Tp53
Breast AdenocarcinomaAkt1 , Kras , Pik3ca , Tp53
Breast Cancer, FamilialPik3r3
Breast NeoplasmsAkt1 , Akt2 , Apc , Apc2 , Bad , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mlh1 , Myc , Pdpk1 , Pik3ca , Pik3r1 , Pten , Raf1 , Tp53
Breast-Ovarian Cancer, Familial, Susceptibility To, 1Akt1 , Pik3ca
Burkitt LymphomaMyc , Pik3r1 , Tcf3
BurnsBad , Ccnd1 , Gsk3b
Cafe au lait Spots, MultipleMlh1 , Sos1
CalcinosisCtnnb1 , Erbb2
CarcinogenesisBraf , Erbb2 , Gsk3b , Kras
CarcinomaCcnd1 , Cdh1 , Egfr , Hras , Kras , Myc , Pik3r1 , Pten , Tp53
Carcinoma in SituAkt1 , Ctnnb1 , Pten
Carcinoma, Acinar CellApc
Carcinoma, Adenoid CysticCcnd1 , Cdh1 , Foxo3 , Hras , Map2k2 , Pik3ca , Pten , Tp53
Carcinoma, Basal CellErbb2 , Pik3ca , Tp53
Carcinoma, Ductal, BreastCdh1
Carcinoma, EndometrioidCdh1 , Ctnnb1 , Egfr , Erbb2 , Kras , Pten
Carcinoma, HepatocellularAkt2 , Apc , Axin1 , Braf , Ccnd1 , Cdh1 , Ctnnb1 , Egf , Egfr , Hras , Kras , Myc , Pik3ca , Pten , Tp53
Carcinoma, Intraductal, NoninfiltratingCcnd1 , Erbb2 , Tp53
Carcinoma, LobularCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Erbb2
Carcinoma, Merkel CellMyc
Carcinoma, MucoepidermoidCdh1
Carcinoma, Non-Small-Cell LungAkt1 , Apc , Braf , Egfr , Erbb2 , Foxo3 , Hras , Kras , Map2k1 , Myc , Nras , Pik3ca , Pten , Raf1 , Tp53
Carcinoma, Pancreatic DuctalEgf , Kras
Carcinoma, Renal CellAkt1 , Apc , Bad , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Map2k1 , Mlh1 , Myc , Pik3ca , Pten , Tp53
Carcinoma, Small CellTp53
Carcinoma, Squamous CellAkt1 , Ccnd1 , Cdh1 , Egfr , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Tp53
Carcinoma, Squamous Cell of Head and NeckAkt1 , Egfr , Pik3ca , Pten , Tp53
Carcinoma, Transitional CellApc , Ccnd1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Nras , Tp53
Cardiofaciocutaneous SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
Cardiofaciocutaneous Syndrome 2Kras
Cardiofaciocutaneous Syndrome 4Map2k2
CardiomegalyAkt1 , Bad , Egfr , Gsk3b , Mapk1 , Myc , Pten
CardiomyopathiesAkt1 , Ilk , Mapk1 , Mapk3 , Tp53
Cardiomyopathy, DilatedCtnna3 , Egfr , Erbb2 , Ilk , Kras , Raf1
Cardiomyopathy, Dilated, with Left Ventricular NoncompactionCtnna3
Cardiomyopathy, HypertrophicCtnna3 , Ctnnb1 , Ilk , Kras , Myc , Raf1 , Sos1 , Tp53
Cardiomyopathy, Hypertrophic, FamilialCtnna3 , Ilk , Kras , Raf1 , Sos1
Cardiovascular AbnormalitiesMap2k1
Carotid Artery DiseasesTp53
Carotid Artery InjuriesFoxo3 , Myc
CataractTp53
Caudal Duplication AnomalyAxin1
Cecal NeoplasmsCcnd1 , Ctnnb1 , Kras , Tp53
Cell Transformation, NeoplasticApc , Ccnd1 , Cdh1 , Egf , Hras , Myc , Tp53
Central Nervous System NeoplasmsTp53
Ceroid Lipofuscinosis, Neuronal, 6Gsk3b , Mapk1 , Mapk3
Cervical Intraepithelial NeoplasiaCcnd1 , Cdh1 , Ctnna1 , Mlh1 , Pten
Chemotherapy-Induced Febrile NeutropeniaTp53
ChloracneEgfr
CholangiocarcinomaApc , Egfr , Erbb2 , Kras , Pten , Tp53
Cholesteatoma, Middle EarTp53
Choroid Plexus CarcinomaTp53
Chromosome 17 DeletionTp53
Chromosome BreakageMyc
Chronic Lymphoid LeukemiaMyc
Clear-Cell Metastatic Renal Cell CarcinomaMyc
Cleft LipCdh1 , Myc
Cleft PalateEgf , Myc
Cocaine-Related DisordersIlk , Mapk1 , Mapk3
Colitis, UlcerativeCdh1 , Tp53
Colonic NeoplasmsAkt1 , Akt2 , Apc , Axin2 , Bad , Braf , Ccnd1 , Ctnnb1 , Egfr , Erbb2 , Kras , Lef1 , Mlh1 , Myc , Pik3ca , Pik3r1 , Tcf7l2 , Tp53
Colonic PolypsIlk
Colorectal Cancer, Hereditary Nonpolyposis, Type 1Mlh1
Colorectal NeoplasmsAkt1 , Apc , Apc2 , Axin1 , Axin2 , Braf , Ccnd1 , Cdh1 , Ctnnb1 , Egfr , Kras , Mlh1 , Nras , Pik3ca , Tcf7l2 , Tp53
Colorectal Neoplasms, Hereditary NonpolyposisApc , Mlh1
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Coronary Artery DiseaseAkt1
Coronary RestenosisMapk1 , Myc , Tp53
Costello SyndromeBraf , Hras , Kras , Map2k1 , Map2k2
Craniofacial AbnormalitiesCtnnb1 , Egfr , Pten , Tp53
CraniopharyngiomaBraf , Ctnnb1
Crohn DiseaseTcf7
Cystadenocarcinoma, SerousTp53
DementiaEgfr
Dementia, VascularTp53
Demyelinating DiseasesMyc , Tp53
Depressive DisorderGsk3b
Desmoid Disease, HereditaryApc , Ctnnb1
Developmental DisabilitiesPten
Diabetes MellitusPten , Tcf7l2
Diabetes Mellitus, ExperimentalAkt1 , Bad , Casp9 , Egfr , Foxo3 , Hras , Mapk1 , Mapk3 , Myc , Pik3r1 , Tp53
Diabetes Mellitus, Type 1Casp9 , Egfr
Diabetes Mellitus, Type 2Akt1 , Akt2 , Bad , Casp9 , Egfr , Gsk3b , Pik3r1 , Tcf7l2
Diabetes, GestationalTcf7l2
Diabetic CardiomyopathiesBad , Erbb2
Diabetic CystopathyBad
Diabetic NephropathiesEgf , Mapk1 , Pten , Tcf7l2 , Tp53
Diabetic NeuropathiesBad
Diabetic RetinopathyCasp9 , Egfr , Hras
Digestive System NeoplasmsApc
Disease Models, AnimalErbb2 , Kras , Mapk1 , Mapk3 , Tp53
Disease ProgressionCdh1 , Egf , Egfr , Erbb2 , Hras , Myc , Pten
Drug-Induced Liver InjuryBad , Ctnnb1
Drug-induced NeutropeniaTp53
Drug-Related Side Effects and Adverse ReactionsTp53
EdemaCasp9
EmphysemaTp53
Encephalomyelitis, Autoimmune, ExperimentalCasp9
Endodermal Sinus TumorCtnnb1
Endometrial HyperplasiaKras , Pten
Endometrial NeoplasmsCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Erbb2 , Kras , Mlh1 , Myc , Pik3ca , Pten , Tp53
EndometriosisEgfr , Kras
Enterocolitis, NecrotizingEgf
Epidermal NevusHras , Kras , Nras , Pik3ca
EpilepsyAkt1 , Ilk
Epilepsy, Temporal LobeFoxo3
Erectile DysfunctionAkt1 , Bad , Ccnd1
Esophageal NeoplasmsCcnd1 , Ctnna1 , Egfr , Erbb2 , Myc , Tp53
Esophageal Squamous Cell CarcinomaCcnd1 , Egfr , Tp53
Esophagitis, PepticEgfr
Eye AbnormalitiesApc
Fatty LiverMyc , Pten
Femoral FracturesLef1
Fetal Growth RetardationElk1
Fibromatosis, AbdominalApc
Fibromatosis, AggressiveApc
Fibromatosis, GingivalSos1
Fibromatosis, Gingival, 1Sos1
FibrosisAkt1
Gallbladder NeoplasmsApc , Egf , Egfr , Erbb2 , Kras , Tp53
Gardner SyndromeApc
Gastrointestinal NeoplasmsApc , Erbb2 , Pik3ca , Pten
Genetic Diseases, InbornCtnnb1 , Mapk1 , Pik3r2 , Pten
Genetic Predisposition to DiseaseEgf
Genomic InstabilityCcnd1
GerminomaBraf
Giant Pigmented Hairy NevusHras , Nras
GlaucomaBad
Glaucoma, Primary Open AngleTp53
GlioblastomaAkt1 , Apc , Egf , Egfr , Myc , Pten
GliomaAkt2 , Bad , Braf , Egfr , Erbb2 , Pik3ca , Pten , Raf1 , Tp53
GliosisMapk1 , Mapk3
GlomerulonephritisMapk1
Graft vs Host DiseaseTp53
Granulosa Cell TumorCtnnb1
Graves DiseaseTp53
Growth DisordersPik3ca
Hamartoma Syndrome, MultipleAkt1 , Egfr , Pik3ca , Pten
Head and Neck NeoplasmsEgfr , Mapk1 , Mapk3
Hearing Loss, Cisplatin-InducedGsk3b
Heart ArrestAkt1
Heart DiseasesCasp9
Heart FailureErbb2 , Gsk3b , Pdpk1 , Tp53
Helicobacter InfectionsCdh1
HELLP SyndromeErbb2
HemangiomaPten
HemangiosarcomaCcnd1 , Ctnnb1 , Hras , Kras , Myc , Tp53
HepatoblastomaApc , Ctnnb1 , Tp53
Hepatoblastoma Caused By Somatic MutationApc , Ctnnb1
HepatomegalyPten
Hirschsprung DiseaseErbb2
Huntington DiseaseEgfr , Elk1
Hydatidiform MoleMlh1
HyperalgesiaMapk1 , Mapk3 , Raf1
HyperinsulinismPten
HyperlipidemiasApc
HyperparathyroidismCcnd1 , Myc
HyperplasiaAkt1 , Apc , Ccnd1 , Egfr , Pik3ca , Tcf7l2
Hypersensitivity, ImmediateEgfr
HypertensionAkt1 , Akt2 , Bad , Egfr , Gsk3b , Kras , Pik3r1 , Pten , Tp53
Hypertension, PortalPik3r1 , Pten
Hypertension, PulmonaryEgfr , Myc , Tp53
HypertrophyMapk1 , Mapk3 , Pten
Hypertrophy, Left VentricularEgfr , Foxo3 , Myc , Pten
Hypertrophy, Right VentricularAkt1
HypoglycemiaAkt2 , Pik3r1
Hypoinsulinemic Hypoglycemia with HemihypertrophyAkt2
Hypomagnesemia 4, RenalEgf
Hypomagnesemia PrimaryEgf
HypothyroidismBad
Hypoxia-Ischemia, BrainFoxo3
Immunodeficiency 14Pik3cd
Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal DementiaEgf
Infarction, Middle Cerebral ArteryBad
InfectionCtnnb1
Infertility, FemaleMapk1 , Mapk3 , Tp53
Infertility, MaleTp53
InflammationAkt1 , Egfr
Inflammatory Bowel DiseasesApc , Apc2
Insulin ResistanceAkt2 , Bad , Egfr , Pik3r1 , Pten , Tcf7l2
Intellectual DisabilityApc , Kras , Pten
Intermittent ClaudicationBad
Intervertebral Disc DisplacementAkt1
Intestinal NeoplasmsApc , Ctnnb1
Intestinal PolypsApc , Ccnd1
Intimal HyperplasiaFoxo3
IschemiaAkt2 , Raf1 , Tp53
Ischemic Attack, TransientBad , Casp9 , Elk1 , Ilk , Pten
Juvenile Polyposis SyndromePten
KeratosisTp53
Keratosis, SeborrheicPik3ca
Kidney DiseasesEgf , Mapk1
Kidney NeoplasmsAkt1 , Braf , Ccnd1 , Erbb2 , Mapk1 , Mapk3 , Raf1
Kidney Reperfusion InjuryMyc
Language Development DisordersPten
Laryngeal NeoplasmsEgfr
LeiomyomaMyc , Pten
LEOPARD SyndromeBraf , Pten , Raf1
LEOPARD SYNDROME 3Braf
LEOPARD syndrome, 2Raf1
LeukemiaBad , Ccnd1 , Nras , Pten , Tp53
Leukemia, B-CellMyc
Leukemia, ExperimentalNras
Leukemia, Hairy CellMap2k1
Leukemia, Lymphocytic, Chronic, B-CellCcnd1 , Lef1 , Tp53
Leukemia, Megakaryoblastic, AcutePten , Tp53
Leukemia, Megakaryoblastic, of Down SyndromeNras , Tp53
Leukemia, Myeloid, AcuteCcnd1 , Cdh1 , Ctnna1 , Kras , Myc , Nras , Tp53
Leukemia, Myelomonocytic, ChronicNras
Leukemia, Myelomonocytic, JuvenileKras , Nras
Leukemia, Promyelocytic, AcuteAkt1 , Myc , Nras
Leukemia-Lymphoma, Adult T-CellNras , Tp53
Leukoplakia, OralTp53
Lewy Body DiseaseElk1
Li-Fraumeni SyndromeTp53
Li-Fraumeni Syndrome 2Tp53
Li-Fraumeni-Like SyndromeTp53
Lichen Planus, OralTp53
Lip NeoplasmsTp53
Lipodystrophy, Familial PartialAkt2
LipomaPten
LipomatosisPten
Liver CirrhosisCtnnb1
Liver Cirrhosis, ExperimentalEgf , Ilk , Myc
Liver Diseases, ParasiticKras , Tp53
Liver InjuryMyc
Liver NeoplasmsApc , Braf , Ccnd1 , Ctnnb1 , Hras , Kras , Myc , Pik3ca , Raf1 , Tp53
Liver Neoplasms, ExperimentalCcnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Map2k1 , Myc , Tp53
Liver Reperfusion InjuryBad
Long QT SyndromeCtnna3 , Ilk , Pten
Low Tension GlaucomaTp53
Lung DiseasesEgfr
Lung NeoplasmsAkt1 , Apc , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pten , Raf1 , Tp53
Lung Reperfusion InjuryMyc
Lupus Erythematosus, SystemicTcf7
Lupus NephritisEgf
Lymphatic MetastasisCdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Pten , Tp53
LymphomaKras , Mlh1 , Nras , Pten , Tp53
Lymphoma, B-CellNras
Lymphoma, B-Cell, Marginal ZoneTp53
Lymphoma, Large B-Cell, DiffusePdpk1 , Pik3ca , Pik3cb , Pik3cd
Lymphoma, Mantle-CellCcnd1 , Ctnnb1 , Gsk3b , Pik3cd
Lymphoma, Non-HodgkinBraf , Ccnd1 , Tp53
Lymphoma, T-CellTp53
Lymphoma, T-Cell, CutaneousBraf , Tp53
Lynch Syndrome IIMlh1
Macrocephaly Autism SyndromePten
Macular DegenerationBad
Malformations of Cortical DevelopmentAkt3 , Pik3ca
Mammary Neoplasms, AnimalApc , Ccnd1 , Cdh1 , Egfr , Erbb2 , Hras , Pik3r1
Mammary Neoplasms, ExperimentalAkt1 , Akt2 , Bad , Casp9 , Ccnd1 , Cdh1 , Ctnnb1 , Egfr , Erbb2 , Hras , Ilk , Myc , Pik3r1 , Pten , Tp53
Mandibular NeoplasmsBraf
Marijuana AbuseAkt1
Median NeuropathyErbb2
MedulloblastomaApc , Ctnnb1 , Erbb2 , Myc , Tp53
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromeAkt3 , Pik3ca , Pik3r2
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2Akt3
MelanomaBraf , Map2k1 , Map2k2 , Nras , Pik3ca , Pten , Tp53
Melanoma, Cutaneous Malignant, Susceptibility To, 1Braf , Nras , Pik3ca , Pten , Tp53
MeningiomaAkt1 , Pten
Meningioma, FamilialPten
Mental Retardation, Autosomal Dominant 19Ctnnb1
MesotheliomaApc , Cdh1 , Egfr , Tp53
Mesothelioma, MalignantEgfr , Raf1 , Tp53
MetaplasiaAxin2 , Egf
Microphthalmia, Syndromic 1Cdh1
Microsatellite InstabilityBraf
Monoclonal B-Cell LymphocytosisApc
Mood DisordersAkt1
Motor Skills DisordersPten
Mouth NeoplasmsErbb2 , Hras , Kras , Nras , Pik3ca , Tp53
Muir-Torre SyndromeMlh1
Multiple MyelomaCcnd1 , Kras , Nras , Tp53
Multiple Organ FailureMapk1
Muscular AtrophyAkt1 , Ctnnb1 , Gsk3b
Mycoplasma InfectionsCdh1
Myelodysplastic SyndromesCtnna1 , Myc , Nras , Tp53
Myeloproliferative DisordersKras , Nras
Myocardial InfarctionAkt1 , Gsk3b , Mapk1 , Tp53
Myocardial IschemiaCcnd1 , Erbb2
Myocardial Reperfusion InjuryAkt1 , Akt2 , Bad , Casp9 , Gsk3b , Mapk1 , Pten , Tp53
Myoclonus, Familial CorticalMyc
Myopathy, Congenital, with Excess of Muscle SpindlesHras
Nasopharyngeal carcinomaAkt2 , Ccnd1 , Erbb2 , Kras , Pik3ca , Pten , Tp53
Nasopharyngeal NeoplasmsCcnd1 , Egfr , Tp53
Nematode InfectionsPik3r1
Neoplasm InvasivenessCdh1 , Ctnnb1 , Egf , Egfr , Hras , Mapk1 , Mapk3 , Pten
Neoplasm MetastasisAkt2 , Cdh1 , Ctnnb1 , Egf , Egfr , Erbb2 , Kras , Mapk1 , Mapk3 , Mlh1 , Myc , Pten , Tp53
Neoplasm Recurrence, LocalEgfr , Erbb2
NeoplasmsErbb2 , Kras , Myc , Tp53
Neoplasms, ExperimentalCcnd1 , Erbb2 , Hras , Kras , Nras , Tp53
Neoplasms, Germ Cell and EmbryonalErbb2 , Mlh1
Neoplasms, Multiple PrimaryMlh1
Neoplastic ProcessesHras
Neoplastic Syndromes, HereditaryApc , Axin2 , Cdh1 , Ctnna1 , Mlh1 , Pik3ca , Pten , Tp53
Nerve DegenerationCdh1 , Ctnnb1 , Mapk1 , Mapk3
Nerve Sheath NeoplasmsTp53
Nervous System DiseasesCasp9 , Tp53
NeuroblastomaHras , Kras , Myc , Nras , Tp53
Neurocutaneous MelanosisNras
Neuroectodermal TumorsMyc
Neuroendocrine TumorsBraf
NeurofibrosarcomaNras
Nevus, PigmentedNras
Nevus, Sebaceous of JadassohnHras , Kras , Nras
No-Reflow PhenomenonCtnnb1
Nonseminomatous Germ Cell TumorBraf
Noonan like syndromeSos1
Noonan SyndromeBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Noonan syndrome 3Kras
Noonan Syndrome 4Sos1
Noonan Syndrome 5Raf1
Noonan Syndrome 6Nras
Noonan Syndrome 7Braf
NOONAN SYNDROME 9Sos2
Nose NeoplasmsTp53
ObesityAkt1 , Akt2 , Bad , Egfr , Foxo3 , Myc , Pik3r1
Odontogenic MyxomaTp53
Oligodontia-Colorectal Cancer SyndromeAxin2
Optic Atrophy, Hereditary, LeberTp53
Oral Submucous FibrosisTp53
Orofacial Cleft 1Cdh1
Oropharyngeal NeoplasmsTp53
Osseous Heteroplasia, ProgressiveCtnnb1
OsteoarthritisBad
Osteoarthritis, KneeCtnnb1
OsteoporosisMyc
OsteosarcomaEgfr , Myc , Tp53
Ovarian Epithelial CancerPik3ca , Tp53
Ovarian NeoplasmsAkt1 , Akt2 , Braf , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3r1 , Pten , Tp53
Paget's Disease, MammaryErbb2
PainAkt1
Pancreatic CarcinomaKras
Pancreatic NeoplasmsAkt2 , Apc , Cdh1 , Ctnnb1 , Egf , Egfr , Ilk , Kras , Myc , Pten , Tcf7l2 , Tp53
PancreatitisEgf
Pancreatitis, ChronicBad
Pancreatitis, Experimental, Acute Kras
Papillary Renal Cell Carcinoma, SporadicMyc
PapillomaCcnd1 , Egfr , Erbb2 , Hras
Papilloma, Choroid PlexusTp53
Paranasal Sinus NeoplasmsTp53
ParaplegiaAkt1
Parkinson DiseaseAkt1 , Egf , Egfr , Erbb2 , Gsk3b
Parkinsonian DisordersBad , Egfr
Patterned Dystrophy of Retinal Pigment EpitheliumCtnna1
Penile NeoplasmsCcnd1 , Hras , Kras , Pik3ca , Tp53
Periampullary AdenomaApc
Peripheral Nervous System DiseasesCasp9
PeritonitisGsk3b
Phyllodes TumorCtnnb1 , Egfr , Tp53
PilomatrixomaCtnnb1
PneumoniaEgf
Pneumonia, PneumococcalMapk1 , Mapk3
PoisoningGsk3b
Polycystic Kidney Disease, Type 1Myc
Polycystic Kidney DiseasesMyc
Polycystic Kidney, Autosomal DominantMyc
Polycystic Kidney, Autosomal RecessiveAkt1 , Egfr , Myc , Pik3ca
PolydactylyPten
PolyploidyTp53
Pre-EclampsiaErbb2
Precancerous ConditionsCcnd1 , Cdh1 , Egf , Hras , Tp53
Precursor B-Cell Lymphoblastic Leukemia-LymphomaCcnd1 , Tcf3 , Tp53
Precursor Cell Lymphoblastic Leukemia-LymphomaCcnd1 , Kras , Myc , Nras , Tcf3 , Tp53
Precursor T-Cell Lymphoblastic Leukemia-LymphomaKras
Primary MyelofibrosisTp53
ProlactinomaMyc
Prostate Cancer, FamilialCdh1
Prostate Cancer, SomaticPten
Prostatic HyperplasiaBad , Myc , Pten
Prostatic Intraepithelial NeoplasiaCcnd1 , Cdh1 , Kras , Myc , Pten
Prostatic NeoplasmsAkt1 , Apc , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Erbb2 , Foxo3 , Gsk3b , Ilk , Kras , Map2k1 , Mapk3 , Mlh1 , Myc , Nras , Pik3ca , Pik3cd , Pik3r1 , Pten , Tp53
Proteus SyndromeAkt1 , Pten
PsoriasisTp53
Psychoses, Substance-InducedAkt1
Pten Hamartoma Tumor Syndrome with Granular Cell TumorPten
PterygiumTp53
Pulmonary Disease, Chronic ObstructiveEgfr , Tp53
Pulmonary FibrosisBad , Cdh1 , Egf , Egfr
Pulmonary Valve StenosisHras
Radiation Injuries, ExperimentalMapk1 , Mapk3
RASopathiesBraf , Hras , Kras , Map2k1 , Map2k2 , Nras , Raf1 , Sos1
Rectal NeoplasmsApc , Egfr , Nras , Pik3ca
RecurrenceErbb2 , Hras , Kras
Renal FibrosisKras , Mapk1 , Myc
Reperfusion InjuryAkt1 , Bad , Casp9 , Ccnd1 , Egf , Pik3r1 , Pten , Tp53
Respiratory Distress Syndrome, AdultApc
Retina Reperfusion InjuryBad
Retinal DetachmentCasp9
Rhabdoid TumorMyc
RhabdomyosarcomaTp53
Salivary Gland NeoplasmsCcnd1 , Cdh1
SarcomaPik3ca , Tp53
Sarcoma Family Syndrome of Li and FraumeniTp53
Sarcoma, ExperimentalKras , Nras
Sarcoma, KaposiTp53
Sarcoma, MyeloidKras
SchizophreniaAkt1 , Egf , Egfr , Elk1 , Gsk3b , Pik3cb , Tp53
Sebaceous Gland NeoplasmsLef1
Sebaceous Nevus Syndrome and HemimegalencephalyHras , Kras , Nras
SeizuresBad , Ccnd1 , Pten
SeminomaHras , Kras
SepsisBad , Gsk3b , Mapk1 , Mapk3
Septic PeritonitisPik3r1
Sezary SyndromeBraf , Mapk1 , Pten , Tp53
Shock, HemorrhagicBad , Mapk1 , Myc
SHORT SyndromePik3r1
Skin DiseasesPten
Skin NeoplasmsAkt1 , Ctnnb1 , Hras , Tp53
Small Cell Lung CarcinomaEgfr , Pten , Tp53
Small-For-Size SyndromeBad
Smith-Magenis SyndromeAxin2 , Erbb2 , Grb2
Spinal Cord InjuriesAkt1 , Egfr , Foxo3 , Tp53
Spinal Cord Reperfusion InjuryBad
Splenic NeoplasmsHras
Spondylocostal Dysostosis 5Mapk3
Squamous Cell Carcinoma of the TongueEgfr , Tp53
Status EpilepticusCcnd1 , Foxo3 , Gsk3b
Stevens-Johnson SyndromeCtnnb1
Stomach DiseasesPten
Stomach NeoplasmsApc , Ccnd1 , Cdh1 , Ctnna2 , Egfr , Erbb2 , Hras , Kras , Mapk1 , Mapk3 , Myc , Pik3ca , Tp53
Stomach UlcerBad , Egf
StrokeAkt1 , Ctnnb1
Substance Withdrawal SyndromeMapk1 , Mapk3
Substance-Related DisordersCtnna3 , Pten
Tachycardia, VentricularRaf1
TeratomaCtnnb1
Testicular Germ Cell TumorHras
ThrombosisPik3cb
ThymomaTp53
Thymus NeoplasmsTp53
Thyroid Cancer, FollicularBraf , Hras , Nras , Pten
Thyroid Cancer, MedullaryKras
Thyroid cancer, papillaryBraf
Thyroid Carcinoma, AnaplasticTp53
Thyroid NeoplasmsBraf , Ccnd1 , Hras , Kras , Tp53
Tobacco Use DisorderEgfr
Tongue NeoplasmsHras , Tp53
Transplant RejectionMyc
Trigeminal Nerve InjuriesTp53
Trigeminal NeuralgiaMapk1 , Mapk3
Tumor Predisposition SyndromeApc , Cdh1 , Mlh1 , Pten , Tp53
Turcot SyndromeApc , Mlh1
Ureteral ObstructionAkt1
Urethral ObstructionMapk1
Urinary Bladder NeoplasmsAkt1 , Casp9 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mlh1 , Myc , Pten , Tp53
Urinary IncontinenceMapk1
Urogenital NeoplasmsTp53
Urologic NeoplasmsCcnd1 , Erbb2 , Tp53
Uterine Cervical NeoplasmsCcnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egfr , Erbb2 , Hras , Kras , Mlh1 , Myc , Nras , Pten , Tp53
Uterine NeoplasmsCtnnb1 , Kras
VACTERL/VATER Association with HydrocephalusPten
VaricoceleCasp9
Ventilator-Induced Lung InjuryAkt1
von Hippel-Lindau DiseaseCcnd1
Vulvar Lichen SclerosusTp53
Vulvar NeoplasmsMlh1 , Tp53
Wallerian DegenerationErbb2
Weight GainPik3ca
Wilms TumorCtnnb1 , Erbb2 , Myc
Wounds and InjuriesEgf
Xeroderma PigmentosumTp53
Zollinger-Ellison SyndromeEgf
Pathway Annotations Associated with Genes in the endometrial cancer pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2
adenosine signaling pathwayAkt1 , Bad , Braf , Elk1 , Hras , Map2k2 , Mapk1 , Pdpk1 , Pik3ca
aldosterone signaling pathwayKras , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
altered epidermal growth factor/neuregulin signaling pathwayEgf , Egfr , Erbb2
altered extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Kras , Map2k1 , Raf1
altered insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt2
altered integrin mediated signaling pathwayIlk
altered mismatch repair pathwayMlh1
altered p53 signaling pathwayTp53
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pten
altered phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Pik3ca , Pten
altered Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Tcf7l2
Alzheimer disease pathwayBad , Casp9 , Gsk3b , Mapk1 , Mapk3
amyotrophic lateral sclerosis disease pathwayBad , Casp9 , Tp53
angiotensin II signaling pathwayPdpk1
apoptotic cell death pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
arrhythmogenic right ventricular cardiomyopathy pathwayCtnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Lef1 , Tcf3 , Tcf7 , Tcf7l2
B cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
basal cell carcinoma pathwayApc , Apc2 , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
bladder cancer pathwayBraf , Ccnd1 , Cdh1 , Egf , Egfr , Erbb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Tp53
Bone morphogenetic proteins signaling pathwayGsk3b , Mapk1
brain-derived neurotrophic factor signaling pathwayGrb2
calcium/calcium-mediated signaling pathwayEgfr , Erbb2
cell cycle pathway, mitoticCcnd1 , Gsk3b , Myc , Tp53
ceramide signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tp53
cetuximab pharmacodynamics pathwayEgfr
chemokine mediated signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
chronic myeloid leukemia pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
colorectal cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Gsk3b , Kras , Lef1 , Map2k1 , Mapk1 , Mapk3 , Mlh1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
cytokine mediated signaling pathwayEgf , Egfr
E-cadherin signaling pathwayAkt1 , Akt2 , Ccnd1 , Cdh1 , Ctnna1 , Ctnnb1 , Egf , Egfr , Pik3ca , Pik3r1
eicosanoid signaling pathwayAkt1 , Egf , Egfr , Pik3r5
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaIlk , Pdpk1
endocytosis pathwayEgf , Egfr , Hras
endometrial cancer pathwayAkt1 , Akt2 , Akt3 , Apc , Apc2 , Axin1 , Axin2 , Bad , Braf , Casp9 , Ccnd1 , Cdh1 , Ctnna1 , Ctnna2 , Ctnna3 , Ctnnb1 , Egf , Egfr , Elk1 , Erbb2 , Foxo3 , Grb2 , Gsk3b , Hras , Ilk , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Mlh1 , Myc , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
endothelin signaling pathwayAkt1 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Raf1
Entamoeba histolyca infection pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
ephrin - ephrin receptor bidirectional signaling axisGrb2 , Hras , Map2k1 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Pik3r5
epidermal growth factor/neuregulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
erlotinib pharmacodynamics pathwayEgfr
erythropoietin signaling pathwayGrb2 , Hras , Pik3r1 , Sos1
FasL mediated signaling pathwayAkt1 , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
Fc epsilon receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
Fc gamma receptor mediated signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
fibroblast growth factor signaling pathwayAkt1 , Cdh1 , Grb2 , Mapk1 , Mapk3 , Pdpk1 , Pik3ca , Pik3r1 , Sos1
forkhead class A signaling pathwayAkt1
G1 phase pathwayCcnd1
G1/S transition pathwayCcnd1
gefitinib pharmacodynamics pathwayEgfr
glioma pathwayAkt1 , Akt2 , Akt3 , Braf , Ccnd1 , Egf , Egfr , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
glutamate signaling pathwayMapk1 , Mapk3
glycogen biosynthetic pathwayGsk3b
gonadotropin-releasing hormone signaling pathwayEgfr , Elk1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1 , Sos1 , Sos2
granulocyte-macrophage colony-stimulating factor signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
Hedgehog signaling pathwayAkt1 , Gsk3b , Map2k1 , Pik3ca , Pik3r1
hepatitis C virus infection pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Egf , Egfr , Grb2 , Gsk3b , Hras , Kras , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
Huntington disease pathwayCasp9 , Tp53
hypoxia inducible factor pathwayAkt1 , Elk1
influenza A virus infection pathwayAkt1 , Akt2 , Akt3 , Casp9 , Gsk3b , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca , Pik3cb , Pik3cd , Pten
insulin responsive facilitative sugar transporter mediated glucose transport pathwayAkt1 , Akt2 , Gsk3b
insulin signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Elk1 , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
insulin-like growth factor signaling pathwayAkt1 , Bad , Grb2 , Hras , Pdpk1 , Pik3ca , Pik3r1 , Raf1 , Sos1
integrin mediated signaling pathwayIlk
interleukin-1 signaling pathwayPik3ca , Pik3r1
interleukin-2 signaling pathwayGrb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3r1 , Raf1 , Sos1
interleukin-23 signaling pathwayPik3ca , Pik3r1
interleukin-3 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-4 signaling pathwayAkt1 , Grb2 , Pik3ca , Pik3r1
interleukin-5 signaling pathwayGrb2 , Pik3ca , Pik3r1
interleukin-6 signaling pathwayAkt1 , Grb2 , Myc , Pik3ca , Pik3r1 , Sos1 , Sos2
intrinsic apoptotic pathwayBad , Casp9
Jak-Stat signaling pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Grb2 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Sos1 , Sos2
Leishmania infection pathwayElk1 , Mapk1 , Mapk3
long term depressionBraf , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
long term potentiationBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
measles infection pathwayAkt1 , Akt2 , Akt3 , Ccnd1 , Gsk3b , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Tp53
melanoma pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Ccnd1 , Cdh1 , Egf , Egfr , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tp53
mismatch repair pathwayMlh1
mitogen activated protein kinase signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Egf , Egfr , Elk1 , Erbb2 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Raf1 , Sos1 , Sos2 , Tp53
mTOR signaling pathwayAkt1 , Akt2 , Akt3 , Braf , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
Mycobacterium tuberculosis infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Raf1
myocarditis pathwayCasp9 , Ccnd1
N-cadherin signaling pathwayAxin1 , Ctnna1 , Ctnnb1 , Pik3ca , Pik3r1
nerve growth factor signaling pathwaySos1
neurotrophic factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Foxo3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2 , Tp53
NOD-like receptor signaling pathwayMapk1 , Mapk3
non-small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Foxo3 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tp53
Notch signaling pathwayCcnd1 , Myc
nuclear factor kappa B signaling pathwayPik3ca , Pik3r1
nuclear factor, erythroid 2 like 2 signaling pathwayGsk3b , Pten
p53 signaling pathwayAkt1 , Casp9 , Ccnd1 , Gsk3b , Pten , Tp53
p53-dependent G1/S DNA damage checkpoint pathwayTp53
pancreatic cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Egf , Egfr , Erbb2 , Ilk , Kras , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Tcf7l2 , Tp53
panitumumab pharmacodynamics pathwayEgfr
Parkinson disease pathwayCasp9
phosphatidylinositol 3-kinase class I signaling pathwayFoxo3 , Hras , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten
phosphatidylinositol 3-kinase-Akt signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Foxo3 , Gsk3b , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pten , Raf1
phosphoinositide metabolic pathwayEgfr , Erbb2 , Pik3ca , Pik3cd , Pik3r1 , Pten
platelet-derived growth factor signaling pathwayBraf , Elk1 , Grb2 , Hras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1
prion diseases pathwayElk1 , Map2k1 , Map2k2 , Mapk1 , Mapk3
prostate cancer pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ccnd1 , Ctnnb1 , Egf , Egfr , Erbb2 , Grb2 , Gsk3b , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Raf1 , Sos1 , Sos2 , Tcf3 , Tcf7 , Tcf7l2 , Tp53
protein kinase C (PKC) signaling pathwayPdpk1
Ras family mediated signaling pathwaySos1
Ras mediated signaling pathwayErbb2
Reelin signaling pathwayAkt1 , Gsk3b , Pik3ca , Pik3r1
renal cell cancer pathwayAkt1 , Akt2 , Akt3 , Braf , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
S phase pathwayCcnd1
scatter factor/hepatocyte growth factor signaling pathwayGrb2 , Pik3r1
small cell lung cancer pathwayAkt1 , Akt2 , Akt3 , Casp9 , Ccnd1 , Myc , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Pten , Tp53
sphingosine 1-phosphate signaling pathwayAkt1 , Akt3 , Elk1 , Mapk1 , Mapk3
syndecan signaling pathwayEgfr , Hras , Mapk1 , Mapk3
T cell receptor signaling pathwayAkt1 , Akt2 , Akt3 , Grb2 , Gsk3b , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1 , Sos1 , Sos2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayBraf , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Raf1
thyroid cancer pathwayBraf , Ccnd1 , Cdh1 , Ctnnb1 , Hras , Kras , Lef1 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Myc , Nras , Tcf3 , Tcf7 , Tcf7l2 , Tp53
titanium dioxide nanoparticle response pathwayTp53
Toll-like receptor signaling pathwayAkt1 , Akt2 , Akt3 , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Toxoplasma gondii infection pathwayAkt1 , Akt2 , Akt3 , Bad , Casp9 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
Trail mediated signaling pathwayMapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3
transforming growth factor-beta Smad dependent signaling pathwayAxin1 , Ctnnb1 , Foxo3 , Grb2 , Pdpk1 , Sos1
transforming growth factor-beta superfamily mediated signaling pathwayMapk1 , Mapk3 , Myc
trastuzumab pharmacodynamics pathwayEgfr
Trypanosoma cruzi infection pathwayAkt1 , Akt2 , Akt3 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type 2 diabetes mellitus pathwayAkt2 , Mapk1 , Mapk3 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5
type II interferon signaling pathwayAkt1 , Map2k1 , Mapk1 , Mapk3 , Pik3ca , Pik3r1
vascular endothelial growth factor signaling pathwayAkt1 , Akt2 , Akt3 , Bad , Braf , Casp9 , Ctnna1 , Ctnnb1 , Grb2 , Hras , Kras , Map2k1 , Map2k2 , Mapk1 , Mapk3 , Nras , Pdpk1 , Pik3ca , Pik3cb , Pik3cd , Pik3r1 , Pik3r2 , Pik3r3 , Pik3r5 , Raf1
vinblastine pharmacodynamics pathwayTp53
vincristine pharmacodynamics pathwayTp53
vindesine pharmacodynamics pathwayTp53
vinorelbine pharmacodynamics pathwayTp53
Wnt signaling pathwayApc , Apc2 , Axin1 , Axin2 , Ccnd1 , Ctnnb1 , Gsk3b , Lef1 , Myc , Tcf3 , Tcf7 , Tcf7l2 , Tp53
Wnt signaling, canonical pathwayApc , Axin1 , Axin2 , Ctnnb1 , Gsk3b , Lef1 , Tcf7 , Tcf7l2
Phenotype Annotations Associated with Genes in the endometrial cancer pathway

References Associated with the endometrial cancer pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: